KEGG   REACTION: R13357
Entry
R13357                      Reaction                               
Name
S-adenosyl-L-methionine:(2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate 6-C-methyltransferase
Definition
(2R,3R,5S)-2-(S-Pantetheinyl)-carbapenam-3-carboxylate + 2 S-Adenosyl-L-methionine + Reduced acceptor <=> (2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-homocysteine + 5'-Deoxyadenosine + L-Methionine + Acceptor
Equation
C22946 + 2 C00019 + C00030 <=> C22947 + C00021 + C05198 + C00073 + C00028
Comment
three-step reaction (see R13182+R13414+R13183)
Reaction class
RC03265  C22946_C22947
Enzyme
2.1.1.394
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.394
     R13357  (2R,3R,5S)-2-(S-Pantetheinyl)-carbapenam-3-carboxylate + 2 S-Adenosyl-L-methionine + Reduced acceptor <=> (2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-homocysteine + 5'-Deoxyadenosine + L-Methionine + Acceptor
Orthology
K18537  2-(S-pantetheinyl)-carbapenam-3-carboxylate methyltransferase [EC:2.1.1.394]
LinkDB

KEGG   REACTION: R13182
Entry
R13182                      Reaction                               
Definition
S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
Equation
C00019 + C00853 <=> C00021 + C06453
Comment
the second step of two-step reaction (see R08547, R13409+R13182, ec 2.1.1.106)
the first step of three-step reaction (see R12497, R13182+R13410+R13183, ec 2.1.1.308)
the first step of three-step reaction (see R13411, R13182+R13412+R13183, ec 2.1.1.326)
the first step of three-step reaction (see R13180, R13182+R11294+R13183, ec 2.1.1.390)
the first step of three-step reaction (see R13357, R13182+R13414+R13183 / R13358, R13182+R13415+R13183, ec 2.1.1.394)
Reaction class
RC00003  C00019_C00021
RC01144  C00853_C06453
Enzyme
2.1.1.106       2.1.1.308       2.1.1.326       2.1.1.390       
2.1.1.394
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.106
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.308
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.326
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.390
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.394
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
Other DBs
RHEA: 76298
LinkDB

KEGG   REACTION: R13414
Entry
R13414                      Reaction                               
Definition
Methylcobalamin + (2R,3R,5S)-2-(S-Pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-methionine <=> Vitamin B12 + (2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5'-Deoxyadenosine + L-Methionine
Equation
C06453 + C22946 + C00019 <=> C05776 + C22947 + C05198 + C00073
Comment
the second step of three-step reaction (see R13357, R13182+R13414+R13183)
Reaction class
RC03265  C22946_C22947
Enzyme
2.1.1.394
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.394
     R13414  Methylcobalamin + (2R,3R,5S)-2-(S-Pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-methionine <=> Vitamin B12 + (2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5'-Deoxyadenosine + L-Methionine
LinkDB

KEGG   REACTION: R13183
Entry
R13183                      Reaction                               
Definition
Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
Equation
C05776 + C00030 <=> C00853 + C00028
Comment
the last step of three-step reaction (see R12497, R13182+R13410+R13183, ec 2.1.1.308)
the last step of three-step reaction (see R13411, R13182+R13412+R13183, ec 2.1.1.326)
the last step of three-step reaction (see R13180, R13182+R11294+R13183, ec 2.1.1.390)
the last step of three-step reaction (see R13357, R13182+R13414+R13183 / R13358, R13182+R13415+R13183, ec 2.1.1.394)
Enzyme
2.1.1.308       2.1.1.326       2.1.1.390       2.1.1.394
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.308
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
    2.1.1.326
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
    2.1.1.390
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
    2.1.1.394
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
Other DBs
RHEA: 76474
LinkDB

KEGG   REACTION: R13358
Entry
R13358                      Reaction                               
Name
S-adenosyl-L-methionine:(2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate 6-C-methyltransferase
Definition
(2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-Adenosyl-L-methionine + Reduced acceptor <=> (2R,3R,5S,6R)-6-(Ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-homocysteine + 5'-Deoxyadenosine + L-Methionine + Acceptor
Equation
C22947 + 2 C00019 + C00030 <=> C22948 + C00021 + C05198 + C00073 + C00028
Comment
three-step reaction (see R13182+R13415+R13183)
Reaction class
RC03266  C22947_C22948
Enzyme
2.1.1.394
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.394
     R13358  (2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-Adenosyl-L-methionine + Reduced acceptor <=> (2R,3R,5S,6R)-6-(Ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-homocysteine + 5'-Deoxyadenosine + L-Methionine + Acceptor
Orthology
K18537  2-(S-pantetheinyl)-carbapenam-3-carboxylate methyltransferase [EC:2.1.1.394]
LinkDB

KEGG   REACTION: R13182
Entry
R13182                      Reaction                               
Definition
S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
Equation
C00019 + C00853 <=> C00021 + C06453
Comment
the second step of two-step reaction (see R08547, R13409+R13182, ec 2.1.1.106)
the first step of three-step reaction (see R12497, R13182+R13410+R13183, ec 2.1.1.308)
the first step of three-step reaction (see R13411, R13182+R13412+R13183, ec 2.1.1.326)
the first step of three-step reaction (see R13180, R13182+R11294+R13183, ec 2.1.1.390)
the first step of three-step reaction (see R13357, R13182+R13414+R13183 / R13358, R13182+R13415+R13183, ec 2.1.1.394)
Reaction class
RC00003  C00019_C00021
RC01144  C00853_C06453
Enzyme
2.1.1.106       2.1.1.308       2.1.1.326       2.1.1.390       
2.1.1.394
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.106
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.308
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.326
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.390
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
    2.1.1.394
     R13182  S-Adenosyl-L-methionine + Cob(I)alamin <=> S-Adenosyl-L-homocysteine + Methylcobalamin
Other DBs
RHEA: 76298
LinkDB

KEGG   REACTION: R13415
Entry
R13415                      Reaction                               
Definition
Methylcobalamin + (2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-methionine <=> Vitamin B12 + (2R,3R,5S,6R)-6-(Ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5'-Deoxyadenosine + L-Methionine
Equation
C06453 + C22947 + C00019 <=> C05776 + C22948 + C05198 + C00073
Comment
the second step of three-step reaction (see R13358, R13182+R13415+R13183)
Reaction class
RC03266  C22947_C22948
Enzyme
2.1.1.394
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.394
     R13415  Methylcobalamin + (2R,3R,5S,6R)-6-(Methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-Adenosyl-L-methionine <=> Vitamin B12 + (2R,3R,5S,6R)-6-(Ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5'-Deoxyadenosine + L-Methionine
LinkDB

KEGG   REACTION: R13183
Entry
R13183                      Reaction                               
Definition
Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
Equation
C05776 + C00030 <=> C00853 + C00028
Comment
the last step of three-step reaction (see R12497, R13182+R13410+R13183, ec 2.1.1.308)
the last step of three-step reaction (see R13411, R13182+R13412+R13183, ec 2.1.1.326)
the last step of three-step reaction (see R13180, R13182+R11294+R13183, ec 2.1.1.390)
the last step of three-step reaction (see R13357, R13182+R13414+R13183 / R13358, R13182+R13415+R13183, ec 2.1.1.394)
Enzyme
2.1.1.308       2.1.1.326       2.1.1.390       2.1.1.394
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.308
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
    2.1.1.326
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
    2.1.1.390
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
    2.1.1.394
     R13183  Vitamin B12 + Reduced acceptor <=> Cob(I)alamin + Acceptor
Other DBs
RHEA: 76474
LinkDB

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