KEGG   REACTION: R13470
Entry
R13470                      Reaction                               
Definition
(22S)-Hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD+ <=> 3,22-Dioxochol-4-en-24-oyl-CoA + NADH + H+
Equation
C23015 + C00003 <=> C23016 + C00004 + C00080
Comment
22-hydroxy-3-oxochol-4-en-24-oyl-CoA dehydrogenase
Reaction class
RC00089  C23015_C23016
Enzyme
1.1.1.-
Pathway
rn00984  Steroid degradation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R13470  (22S)-Hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD+ <=> 3,22-Dioxochol-4-en-24-oyl-CoA + NADH + H+
Orthology
K28219  (22S)-hydroxy-3-oxochol-4-en-24-oyl-CoA dehydrogenase [EC:1.1.1.-]
Reference
1  [PMID:33826843]
  Authors
Yuan T, Werman JM, Yin X, Yang M, Garcia-Diaz M, Sampson NS.
  Title
Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis  Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA.
  Journal
ACS Infect Dis 7:1739-1751 (2021)
DOI:10.1021/acsinfecdis.1c00069
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