KEGG   REACTION: R13481
Entry
R13481                      Reaction                               
Definition
(7aS)-7a-Methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxyl-CoA + H2O <=> (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA
Equation
C23009 + C00001 <=> C23020
Comment
HIEC-CoA hydrolase
Enzyme
4.1.-.-
Pathway
rn00984  Steroid degradation
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.-  Carbon-carbon lyases
    4.1.-.-
     R13481  (7aS)-7a-Methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-4-carboxyl-CoA + H2O <=> (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA
Orthology
K28227  HIEC-CoA hydrolase [EC:4.1.-.-]
Reference
1  [PMID:30194104]
  Authors
Horinouchi M, Koshino H, Malon M, Hirota H, Hayashi T.
  Title
Steroid Degradation in Comamonas testosteroni TA441: Identification of  Metabolites and the Genes Involved in the Reactions Necessary before D-Ring  Cleavage.
  Journal
Appl Environ Microbiol 84 (2018)
DOI:10.1128/AEM.01324-18
Reference
2  [PMID:28377529]
  Authors
Crowe AM, Casabon I, Brown KL, Liu J, Lian J, Rogalski JC, Hurst TE, Snieckus V, Foster LJ, Eltis LD.
  Title
Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other  Bacteria.
  Journal
mBio 8 (2017)
DOI:10.1128/mBio.00321-17
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