KEGG   Arvicola amphibius (Eurasian water vole): 119808979
Entry
119808979         CDS       T08327                                 
Symbol
Pik3r1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
aamp  Arvicola amphibius (Eurasian water vole)
Pathway
aamp01521  EGFR tyrosine kinase inhibitor resistance
aamp01522  Endocrine resistance
aamp01524  Platinum drug resistance
aamp04012  ErbB signaling pathway
aamp04014  Ras signaling pathway
aamp04015  Rap1 signaling pathway
aamp04024  cAMP signaling pathway
aamp04062  Chemokine signaling pathway
aamp04066  HIF-1 signaling pathway
aamp04068  FoxO signaling pathway
aamp04070  Phosphatidylinositol signaling system
aamp04071  Sphingolipid signaling pathway
aamp04072  Phospholipase D signaling pathway
aamp04081  Hormone signaling
aamp04140  Autophagy - animal
aamp04150  mTOR signaling pathway
aamp04151  PI3K-Akt signaling pathway
aamp04152  AMPK signaling pathway
aamp04210  Apoptosis
aamp04211  Longevity regulating pathway
aamp04213  Longevity regulating pathway - multiple species
aamp04218  Cellular senescence
aamp04360  Axon guidance
aamp04370  VEGF signaling pathway
aamp04380  Osteoclast differentiation
aamp04510  Focal adhesion
aamp04550  Signaling pathways regulating pluripotency of stem cells
aamp04611  Platelet activation
aamp04613  Neutrophil extracellular trap formation
aamp04620  Toll-like receptor signaling pathway
aamp04625  C-type lectin receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
aamp04650  Natural killer cell mediated cytotoxicity
aamp04660  T cell receptor signaling pathway
aamp04662  B cell receptor signaling pathway
aamp04664  Fc epsilon RI signaling pathway
aamp04666  Fc gamma R-mediated phagocytosis
aamp04668  TNF signaling pathway
aamp04670  Leukocyte transendothelial migration
aamp04722  Neurotrophin signaling pathway
aamp04725  Cholinergic synapse
aamp04750  Inflammatory mediator regulation of TRP channels
aamp04810  Regulation of actin cytoskeleton
aamp04910  Insulin signaling pathway
aamp04914  Progesterone-mediated oocyte maturation
aamp04915  Estrogen signaling pathway
aamp04917  Prolactin signaling pathway
aamp04919  Thyroid hormone signaling pathway
aamp04923  Regulation of lipolysis in adipocytes
aamp04926  Relaxin signaling pathway
aamp04929  GnRH secretion
aamp04930  Type II diabetes mellitus
aamp04931  Insulin resistance
aamp04932  Non-alcoholic fatty liver disease
aamp04933  AGE-RAGE signaling pathway in diabetic complications
aamp04935  Growth hormone synthesis, secretion and action
aamp04960  Aldosterone-regulated sodium reabsorption
aamp04973  Carbohydrate digestion and absorption
aamp05010  Alzheimer disease
aamp05017  Spinocerebellar ataxia
aamp05020  Prion disease
aamp05100  Bacterial invasion of epithelial cells
aamp05135  Yersinia infection
aamp05142  Chagas disease
aamp05146  Amoebiasis
aamp05160  Hepatitis C
aamp05161  Hepatitis B
aamp05162  Measles
aamp05163  Human cytomegalovirus infection
aamp05164  Influenza A
aamp05165  Human papillomavirus infection
aamp05166  Human T-cell leukemia virus 1 infection
aamp05167  Kaposi sarcoma-associated herpesvirus infection
aamp05168  Herpes simplex virus 1 infection
aamp05169  Epstein-Barr virus infection
aamp05170  Human immunodeficiency virus 1 infection
aamp05171  Coronavirus disease - COVID-19
aamp05200  Pathways in cancer
aamp05203  Viral carcinogenesis
aamp05205  Proteoglycans in cancer
aamp05206  MicroRNAs in cancer
aamp05207  Chemical carcinogenesis - receptor activation
aamp05208  Chemical carcinogenesis - reactive oxygen species
aamp05210  Colorectal cancer
aamp05211  Renal cell carcinoma
aamp05212  Pancreatic cancer
aamp05213  Endometrial cancer
aamp05214  Glioma
aamp05215  Prostate cancer
aamp05218  Melanoma
aamp05220  Chronic myeloid leukemia
aamp05221  Acute myeloid leukemia
aamp05222  Small cell lung cancer
aamp05223  Non-small cell lung cancer
aamp05224  Breast cancer
aamp05225  Hepatocellular carcinoma
aamp05226  Gastric cancer
aamp05230  Central carbon metabolism in cancer
aamp05231  Choline metabolism in cancer
aamp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
aamp05415  Diabetic cardiomyopathy
aamp05417  Lipid and atherosclerosis
aamp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:aamp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    119808979 (Pik3r1)
   04014 Ras signaling pathway
    119808979 (Pik3r1)
   04015 Rap1 signaling pathway
    119808979 (Pik3r1)
   04370 VEGF signaling pathway
    119808979 (Pik3r1)
   04630 JAK-STAT signaling pathway
    119808979 (Pik3r1)
   04668 TNF signaling pathway
    119808979 (Pik3r1)
   04066 HIF-1 signaling pathway
    119808979 (Pik3r1)
   04068 FoxO signaling pathway
    119808979 (Pik3r1)
   04070 Phosphatidylinositol signaling system
    119808979 (Pik3r1)
   04072 Phospholipase D signaling pathway
    119808979 (Pik3r1)
   04071 Sphingolipid signaling pathway
    119808979 (Pik3r1)
   04024 cAMP signaling pathway
    119808979 (Pik3r1)
   04151 PI3K-Akt signaling pathway
    119808979 (Pik3r1)
   04152 AMPK signaling pathway
    119808979 (Pik3r1)
   04150 mTOR signaling pathway
    119808979 (Pik3r1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    119808979 (Pik3r1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119808979 (Pik3r1)
  09143 Cell growth and death
   04210 Apoptosis
    119808979 (Pik3r1)
   04218 Cellular senescence
    119808979 (Pik3r1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119808979 (Pik3r1)
   04550 Signaling pathways regulating pluripotency of stem cells
    119808979 (Pik3r1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119808979 (Pik3r1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119808979 (Pik3r1)
   04613 Neutrophil extracellular trap formation
    119808979 (Pik3r1)
   04620 Toll-like receptor signaling pathway
    119808979 (Pik3r1)
   04625 C-type lectin receptor signaling pathway
    119808979 (Pik3r1)
   04650 Natural killer cell mediated cytotoxicity
    119808979 (Pik3r1)
   04660 T cell receptor signaling pathway
    119808979 (Pik3r1)
   04662 B cell receptor signaling pathway
    119808979 (Pik3r1)
   04664 Fc epsilon RI signaling pathway
    119808979 (Pik3r1)
   04666 Fc gamma R-mediated phagocytosis
    119808979 (Pik3r1)
   04670 Leukocyte transendothelial migration
    119808979 (Pik3r1)
   04062 Chemokine signaling pathway
    119808979 (Pik3r1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119808979 (Pik3r1)
   04923 Regulation of lipolysis in adipocytes
    119808979 (Pik3r1)
   04929 GnRH secretion
    119808979 (Pik3r1)
   04915 Estrogen signaling pathway
    119808979 (Pik3r1)
   04914 Progesterone-mediated oocyte maturation
    119808979 (Pik3r1)
   04917 Prolactin signaling pathway
    119808979 (Pik3r1)
   04926 Relaxin signaling pathway
    119808979 (Pik3r1)
   04935 Growth hormone synthesis, secretion and action
    119808979 (Pik3r1)
   04919 Thyroid hormone signaling pathway
    119808979 (Pik3r1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    119808979 (Pik3r1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    119808979 (Pik3r1)
  09156 Nervous system
   04725 Cholinergic synapse
    119808979 (Pik3r1)
   04722 Neurotrophin signaling pathway
    119808979 (Pik3r1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    119808979 (Pik3r1)
  09158 Development and regeneration
   04360 Axon guidance
    119808979 (Pik3r1)
   04380 Osteoclast differentiation
    119808979 (Pik3r1)
  09149 Aging
   04211 Longevity regulating pathway
    119808979 (Pik3r1)
   04213 Longevity regulating pathway - multiple species
    119808979 (Pik3r1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119808979 (Pik3r1)
   05206 MicroRNAs in cancer
    119808979 (Pik3r1)
   05205 Proteoglycans in cancer
    119808979 (Pik3r1)
   05207 Chemical carcinogenesis - receptor activation
    119808979 (Pik3r1)
   05208 Chemical carcinogenesis - reactive oxygen species
    119808979 (Pik3r1)
   05203 Viral carcinogenesis
    119808979 (Pik3r1)
   05230 Central carbon metabolism in cancer
    119808979 (Pik3r1)
   05231 Choline metabolism in cancer
    119808979 (Pik3r1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119808979 (Pik3r1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119808979 (Pik3r1)
   05212 Pancreatic cancer
    119808979 (Pik3r1)
   05225 Hepatocellular carcinoma
    119808979 (Pik3r1)
   05226 Gastric cancer
    119808979 (Pik3r1)
   05214 Glioma
    119808979 (Pik3r1)
   05221 Acute myeloid leukemia
    119808979 (Pik3r1)
   05220 Chronic myeloid leukemia
    119808979 (Pik3r1)
   05218 Melanoma
    119808979 (Pik3r1)
   05211 Renal cell carcinoma
    119808979 (Pik3r1)
   05215 Prostate cancer
    119808979 (Pik3r1)
   05213 Endometrial cancer
    119808979 (Pik3r1)
   05224 Breast cancer
    119808979 (Pik3r1)
   05222 Small cell lung cancer
    119808979 (Pik3r1)
   05223 Non-small cell lung cancer
    119808979 (Pik3r1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119808979 (Pik3r1)
   05170 Human immunodeficiency virus 1 infection
    119808979 (Pik3r1)
   05161 Hepatitis B
    119808979 (Pik3r1)
   05160 Hepatitis C
    119808979 (Pik3r1)
   05171 Coronavirus disease - COVID-19
    119808979 (Pik3r1)
   05164 Influenza A
    119808979 (Pik3r1)
   05162 Measles
    119808979 (Pik3r1)
   05168 Herpes simplex virus 1 infection
    119808979 (Pik3r1)
   05163 Human cytomegalovirus infection
    119808979 (Pik3r1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119808979 (Pik3r1)
   05169 Epstein-Barr virus infection
    119808979 (Pik3r1)
   05165 Human papillomavirus infection
    119808979 (Pik3r1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    119808979 (Pik3r1)
   05100 Bacterial invasion of epithelial cells
    119808979 (Pik3r1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    119808979 (Pik3r1)
   05142 Chagas disease
    119808979 (Pik3r1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119808979 (Pik3r1)
   05017 Spinocerebellar ataxia
    119808979 (Pik3r1)
   05020 Prion disease
    119808979 (Pik3r1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119808979 (Pik3r1)
   05418 Fluid shear stress and atherosclerosis
    119808979 (Pik3r1)
   05415 Diabetic cardiomyopathy
    119808979 (Pik3r1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    119808979 (Pik3r1)
   04932 Non-alcoholic fatty liver disease
    119808979 (Pik3r1)
   04931 Insulin resistance
    119808979 (Pik3r1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119808979 (Pik3r1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119808979 (Pik3r1)
   01524 Platinum drug resistance
    119808979 (Pik3r1)
   01522 Endocrine resistance
    119808979 (Pik3r1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aamp04131]
    119808979 (Pik3r1)
Membrane trafficking [BR:aamp04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    119808979 (Pik3r1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 Laminin_I SH3_9 Nucleopor_Nup85 PI_PP_I
Other DBs
NCBI-GeneID: 119808979
NCBI-ProteinID: XP_038177510
LinkDB
Position
3:46125904..46211796
AA seq 723 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPVFTLPDLAE
QFAPPDVAPPLLIKLLEAIEKKGLECPTLYRTQSPSSPAELRQLLDCDAASVDLEVIDVQ
VLADAFKRYLLDLPNPVIPVAVYHEMMSLAQEVQSPEDHIQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQASSKNLLNTRVLSEIFSPVLFRFPASSSDNTEHLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAS
TKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELITHYRNESLAQYNPKLD
VKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKR
TAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDS
RRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNE
NNEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSV
VVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQ
QRR
NT seq 2172 nt   +upstreamnt  +downstreamnt
atgagcgccgaagggtaccagtaccgagcgctgtacgactacaagaaggagagagaggag
gacatcgacctgcatttgggggacatactgaccgtgaataaaggttccttagtggctctt
ggattcagcgatggccaggaagctcggcctgaagagattggctggttaaatggctacaat
gaaaccaccggggaaaggggagacttcccgggaacttacgttgaatatattggaaggaaa
aggatttcaccacccactcccaagccccgcccccctcggccccttcctgtagccccgggt
tcttcaaaaactgaagcagacactgagcaaccagttttcacccttcctgatctggctgag
cagttcgcccctcctgatgtcgccccacctcttcttatcaagctcctcgaagccattgaa
aagaaaggactggaatgtccaactctctaccgaacacagagccccagcagccctgcagaa
ttacgacagcttcttgattgtgatgccgcctcagtggacttggaggtgattgatgtacag
gttttagcagatgctttcaaacgctatctcttggacttaccaaatcctgtcattccagta
gctgtttaccacgaaatgatgtcgttagcccaagaagtacaaagccctgaagaccacatc
cagctgttgaagaagctcattaggtcgcctaatatacctcatcaatattggcttacgctt
cagtatctgcttaagcatttcttcaagctctctcaagcctccagcaaaaaccttttgaac
acaagagtcctctctgagattttcagccctgtgctttttagattcccagcctccagctcc
gataatactgaacacctcataaaagtgatagagattttaatctcaactgaatggaatgaa
cgacagccagcaccagcactgcccccgaagccacccaagcccacgactgtagccaacaac
ggcatgaacaacatgtccctacaggatgctgagtggtactggggagacatctcaagggaa
gaagtgaacgaaaagctccgagatacagcggatgggacttttctggtacgagacgcgtct
actaagatgcacggagattatactctgacactaaggaaaggaggaaataacaaattaatc
aaaatctttcaccgagatggaaaatatggcttctctgatccattaaccttcaactctgtg
gttgaactaataacccactaccggaatgagtctctcgctcagtataaccccaagctggat
gtgaagttactctacccggtgtccaaataccagcaggatcaggttgtcaaagaagataat
attgaagctgtagggaaaaaattacatgaatataatactcaatttcaagaaaagagtcgg
gaatatgatagattatatgaagaatacacccgcacgtcccaggaaattcaaatgaaaaga
acagctattgaagcatttaatgaaaccataaaaatatttgaagaacaatgccaaacccag
gagcggtacagcaaagaatacatcgaaaagtttaaacgggaaggcaacgagaaagaaatt
caaaggattatgcataactatgataagctaaagtctcgcatcagtgagatcattgacagt
aggaggaggctggaggaagacttgaagaagcaggcagctgagtatcgtgagatcgacaag
cgcatgaacagcattaagccagacctcattcagctgagaaagacaagagaccaatacttg
atgtggctcacgcagaagggtgttcggcagaagaagctgaacgagtggctgggcaacgaa
aacaatgaagaccaatactcactggtagaagacgacgaggacctgccccaccacgatgag
aagacttggaatgtcggaagcagcaaccgcaacaaagccgagaatctattacgagggaag
cgagatggcacttttcttgtccgggagagcagtaagcagggctgctacgcctgctctgta
gtggtagacggcgaagtcaagcattgcgtcatcaacaagactgccaccggctacggcttc
gctgagccctacaacctgtacagctccctgaaggagctggtgctccattatcaacacacg
tccctcgtgcagcacaatgactccctcaatgtcacactagcatacccggtatatgcacaa
cagaggcgatga

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