KEGG   Arvicola amphibius (Eurasian water vole): 119812102
Entry
119812102         CDS       T08327                                 
Symbol
Pik3r2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
aamp  Arvicola amphibius (Eurasian water vole)
Pathway
aamp01521  EGFR tyrosine kinase inhibitor resistance
aamp01522  Endocrine resistance
aamp01524  Platinum drug resistance
aamp04012  ErbB signaling pathway
aamp04014  Ras signaling pathway
aamp04015  Rap1 signaling pathway
aamp04024  cAMP signaling pathway
aamp04062  Chemokine signaling pathway
aamp04066  HIF-1 signaling pathway
aamp04068  FoxO signaling pathway
aamp04070  Phosphatidylinositol signaling system
aamp04071  Sphingolipid signaling pathway
aamp04072  Phospholipase D signaling pathway
aamp04081  Hormone signaling
aamp04140  Autophagy - animal
aamp04145  Phagocytosis
aamp04150  mTOR signaling pathway
aamp04151  PI3K-Akt signaling pathway
aamp04152  AMPK signaling pathway
aamp04210  Apoptosis
aamp04211  Longevity regulating pathway
aamp04213  Longevity regulating pathway - multiple species
aamp04218  Cellular senescence
aamp04360  Axon guidance
aamp04370  VEGF signaling pathway
aamp04380  Osteoclast differentiation
aamp04510  Focal adhesion
aamp04517  IgSF CAM signaling
aamp04518  Integrin signaling
aamp04550  Signaling pathways regulating pluripotency of stem cells
aamp04611  Platelet activation
aamp04613  Neutrophil extracellular trap formation
aamp04620  Toll-like receptor signaling pathway
aamp04625  C-type lectin receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
aamp04650  Natural killer cell mediated cytotoxicity
aamp04660  T cell receptor signaling pathway
aamp04662  B cell receptor signaling pathway
aamp04664  Fc epsilon RI signaling pathway
aamp04666  Fc gamma R-mediated phagosome formation
aamp04668  TNF signaling pathway
aamp04670  Leukocyte transendothelial migration
aamp04722  Neurotrophin signaling pathway
aamp04725  Cholinergic synapse
aamp04750  Inflammatory mediator regulation of TRP channels
aamp04810  Regulation of actin cytoskeleton
aamp04910  Insulin signaling pathway
aamp04914  Progesterone-mediated oocyte maturation
aamp04915  Estrogen signaling pathway
aamp04917  Prolactin signaling pathway
aamp04919  Thyroid hormone signaling pathway
aamp04923  Regulation of lipolysis in adipocytes
aamp04926  Relaxin signaling pathway
aamp04929  GnRH secretion
aamp04930  Type II diabetes mellitus
aamp04931  Insulin resistance
aamp04932  Non-alcoholic fatty liver disease
aamp04933  AGE-RAGE signaling pathway in diabetic complications
aamp04935  Growth hormone synthesis, secretion and action
aamp04960  Aldosterone-regulated sodium reabsorption
aamp04973  Carbohydrate digestion and absorption
aamp05010  Alzheimer disease
aamp05017  Spinocerebellar ataxia
aamp05020  Prion disease
aamp05100  Bacterial invasion of epithelial cells
aamp05135  Yersinia infection
aamp05142  Chagas disease
aamp05146  Amoebiasis
aamp05160  Hepatitis C
aamp05161  Hepatitis B
aamp05162  Measles
aamp05163  Human cytomegalovirus infection
aamp05164  Influenza A
aamp05165  Human papillomavirus infection
aamp05166  Human T-cell leukemia virus 1 infection
aamp05167  Kaposi sarcoma-associated herpesvirus infection
aamp05168  Herpes simplex virus 1 infection
aamp05169  Epstein-Barr virus infection
aamp05170  Human immunodeficiency virus 1 infection
aamp05171  Coronavirus disease
aamp05200  Pathways in cancer
aamp05203  Viral carcinogenesis
aamp05205  Proteoglycans in cancer
aamp05206  MicroRNAs in cancer
aamp05207  Chemical carcinogenesis - receptor activation
aamp05208  Chemical carcinogenesis - reactive oxygen species
aamp05210  Colorectal cancer
aamp05211  Renal cell carcinoma
aamp05212  Pancreatic cancer
aamp05213  Endometrial cancer
aamp05214  Glioma
aamp05215  Prostate cancer
aamp05218  Melanoma
aamp05220  Chronic myeloid leukemia
aamp05221  Acute myeloid leukemia
aamp05222  Small cell lung cancer
aamp05223  Non-small cell lung cancer
aamp05224  Breast cancer
aamp05225  Hepatocellular carcinoma
aamp05226  Gastric cancer
aamp05230  Central carbon metabolism in cancer
aamp05231  Choline metabolism in cancer
aamp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
aamp05415  Diabetic cardiomyopathy
aamp05417  Lipid and atherosclerosis
aamp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:aamp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    119812102 (Pik3r2)
   04014 Ras signaling pathway
    119812102 (Pik3r2)
   04015 Rap1 signaling pathway
    119812102 (Pik3r2)
   04370 VEGF signaling pathway
    119812102 (Pik3r2)
   04630 JAK-STAT signaling pathway
    119812102 (Pik3r2)
   04668 TNF signaling pathway
    119812102 (Pik3r2)
   04066 HIF-1 signaling pathway
    119812102 (Pik3r2)
   04068 FoxO signaling pathway
    119812102 (Pik3r2)
   04070 Phosphatidylinositol signaling system
    119812102 (Pik3r2)
   04072 Phospholipase D signaling pathway
    119812102 (Pik3r2)
   04071 Sphingolipid signaling pathway
    119812102 (Pik3r2)
   04024 cAMP signaling pathway
    119812102 (Pik3r2)
   04151 PI3K-Akt signaling pathway
    119812102 (Pik3r2)
   04152 AMPK signaling pathway
    119812102 (Pik3r2)
   04150 mTOR signaling pathway
    119812102 (Pik3r2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    119812102 (Pik3r2)
   04517 IgSF CAM signaling
    119812102 (Pik3r2)
   04518 Integrin signaling
    119812102 (Pik3r2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    119812102 (Pik3r2)
   04140 Autophagy - animal
    119812102 (Pik3r2)
  09143 Cell growth and death
   04210 Apoptosis
    119812102 (Pik3r2)
   04218 Cellular senescence
    119812102 (Pik3r2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119812102 (Pik3r2)
   04550 Signaling pathways regulating pluripotency of stem cells
    119812102 (Pik3r2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119812102 (Pik3r2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119812102 (Pik3r2)
   04613 Neutrophil extracellular trap formation
    119812102 (Pik3r2)
   04620 Toll-like receptor signaling pathway
    119812102 (Pik3r2)
   04625 C-type lectin receptor signaling pathway
    119812102 (Pik3r2)
   04650 Natural killer cell mediated cytotoxicity
    119812102 (Pik3r2)
   04660 T cell receptor signaling pathway
    119812102 (Pik3r2)
   04662 B cell receptor signaling pathway
    119812102 (Pik3r2)
   04664 Fc epsilon RI signaling pathway
    119812102 (Pik3r2)
   04666 Fc gamma R-mediated phagosome formation
    119812102 (Pik3r2)
   04670 Leukocyte transendothelial migration
    119812102 (Pik3r2)
   04062 Chemokine signaling pathway
    119812102 (Pik3r2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119812102 (Pik3r2)
   04923 Regulation of lipolysis in adipocytes
    119812102 (Pik3r2)
   04929 GnRH secretion
    119812102 (Pik3r2)
   04915 Estrogen signaling pathway
    119812102 (Pik3r2)
   04914 Progesterone-mediated oocyte maturation
    119812102 (Pik3r2)
   04917 Prolactin signaling pathway
    119812102 (Pik3r2)
   04926 Relaxin signaling pathway
    119812102 (Pik3r2)
   04935 Growth hormone synthesis, secretion and action
    119812102 (Pik3r2)
   04919 Thyroid hormone signaling pathway
    119812102 (Pik3r2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    119812102 (Pik3r2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    119812102 (Pik3r2)
  09156 Nervous system
   04725 Cholinergic synapse
    119812102 (Pik3r2)
   04722 Neurotrophin signaling pathway
    119812102 (Pik3r2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    119812102 (Pik3r2)
  09158 Development and regeneration
   04360 Axon guidance
    119812102 (Pik3r2)
   04380 Osteoclast differentiation
    119812102 (Pik3r2)
  09149 Aging
   04211 Longevity regulating pathway
    119812102 (Pik3r2)
   04213 Longevity regulating pathway - multiple species
    119812102 (Pik3r2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119812102 (Pik3r2)
   05206 MicroRNAs in cancer
    119812102 (Pik3r2)
   05205 Proteoglycans in cancer
    119812102 (Pik3r2)
   05207 Chemical carcinogenesis - receptor activation
    119812102 (Pik3r2)
   05208 Chemical carcinogenesis - reactive oxygen species
    119812102 (Pik3r2)
   05203 Viral carcinogenesis
    119812102 (Pik3r2)
   05230 Central carbon metabolism in cancer
    119812102 (Pik3r2)
   05231 Choline metabolism in cancer
    119812102 (Pik3r2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119812102 (Pik3r2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119812102 (Pik3r2)
   05212 Pancreatic cancer
    119812102 (Pik3r2)
   05225 Hepatocellular carcinoma
    119812102 (Pik3r2)
   05226 Gastric cancer
    119812102 (Pik3r2)
   05214 Glioma
    119812102 (Pik3r2)
   05221 Acute myeloid leukemia
    119812102 (Pik3r2)
   05220 Chronic myeloid leukemia
    119812102 (Pik3r2)
   05218 Melanoma
    119812102 (Pik3r2)
   05211 Renal cell carcinoma
    119812102 (Pik3r2)
   05215 Prostate cancer
    119812102 (Pik3r2)
   05213 Endometrial cancer
    119812102 (Pik3r2)
   05224 Breast cancer
    119812102 (Pik3r2)
   05222 Small cell lung cancer
    119812102 (Pik3r2)
   05223 Non-small cell lung cancer
    119812102 (Pik3r2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119812102 (Pik3r2)
   05170 Human immunodeficiency virus 1 infection
    119812102 (Pik3r2)
   05161 Hepatitis B
    119812102 (Pik3r2)
   05160 Hepatitis C
    119812102 (Pik3r2)
   05171 Coronavirus disease
    119812102 (Pik3r2)
   05164 Influenza A
    119812102 (Pik3r2)
   05162 Measles
    119812102 (Pik3r2)
   05168 Herpes simplex virus 1 infection
    119812102 (Pik3r2)
   05163 Human cytomegalovirus infection
    119812102 (Pik3r2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119812102 (Pik3r2)
   05169 Epstein-Barr virus infection
    119812102 (Pik3r2)
   05165 Human papillomavirus infection
    119812102 (Pik3r2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    119812102 (Pik3r2)
   05100 Bacterial invasion of epithelial cells
    119812102 (Pik3r2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    119812102 (Pik3r2)
   05142 Chagas disease
    119812102 (Pik3r2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119812102 (Pik3r2)
   05017 Spinocerebellar ataxia
    119812102 (Pik3r2)
   05020 Prion disease
    119812102 (Pik3r2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119812102 (Pik3r2)
   05418 Fluid shear stress and atherosclerosis
    119812102 (Pik3r2)
   05415 Diabetic cardiomyopathy
    119812102 (Pik3r2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    119812102 (Pik3r2)
   04932 Non-alcoholic fatty liver disease
    119812102 (Pik3r2)
   04931 Insulin resistance
    119812102 (Pik3r2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119812102 (Pik3r2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119812102 (Pik3r2)
   01524 Platinum drug resistance
    119812102 (Pik3r2)
   01522 Endocrine resistance
    119812102 (Pik3r2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aamp04131]
    119812102 (Pik3r2)
Membrane trafficking [BR:aamp04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    119812102 (Pik3r2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 Ribosomal_L22e SH3_9 ODF2_C SH3_1
Other DBs
NCBI-GeneID: 119812102
NCBI-ProteinID: XP_038182430
LinkDB
Position
4:complement(105044995..105053000)
AA seq 721 aa
MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRGALQALGVADGGERCPHNVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGPSESGVTLADLAEQFSP
PEPAPPILVKLIESVEQAGLDSECYSRPELPAPRTDWSLSDVEQWDRTTLCDAVKGFLLA
LPTAVVTPEAAAEAHRALREAAGPVGPVLEPPTLPLHQALTLRFLLQHLGRVARRAPAQA
TAVRSLASAFGPLLLRTPPPGSDIDGSELGPDFPGLLLGRLLQEHVDEQDVAPPALPPKP
SKAKPAPTALANGGNPLSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYT
LTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVS
KYQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNE
TIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDL
RAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYS
LMEDEDTLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTK
HCVIYRTATGFGFAEPYNLYASLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPMA
R
NT seq 2166 nt   +upstreamnt  +downstreamnt
atggcaggcgctgagggcttccagtacagggctgtgtacccattccgccgggagcggccc
gaggacctggagctattgcctggagacctactggtggtgagccggggggccctgcaagcc
ctgggcgtggcagatggaggggagcgctgcccacacaatgtgggctggatgcctggcttc
aatgagcgtacccggcagcgaggggacttccctggaacgtatgtggagttcctaggaccc
gtcgctctggctcgaccaggacctcgcccacgaggcccccgtccattgcctgccaggccc
ttggatgggccctccgagtcaggtgtcacactggcagacctggcggagcagttctccccc
cctgagcctgctccacccattctggtcaagctgatagagtccgttgagcaagcagggctg
gacagtgagtgctacagtagaccggagctgcctgcacctcggacagactggtccctgagt
gacgtggagcagtgggaccgcaccaccttgtgtgatgctgtgaagggcttcctgctggca
ctgcctacagctgtcgtgactcctgaggctgcagcagaggcacaccgggcactgcgggag
gctgcagggcccgtggggccagtgctggaacccccaacactaccgctgcaccaggcactc
acgctgcggttcctgctgcagcacctgggccgtgtggcccgcagagctcctgcccaggcc
acagccgtccgctcgcttgctagcgcctttgggccactgttactgcgcacacctccgcca
gggagtgatattgatgggagtgagcttgggcctgacttcccagggctgctgttggggagg
ctgctgcaggaacacgtggatgagcaggatgttgcccccccagcactgccacccaaaccc
tctaaggcaaagccggcccccacagccctggccaatggaggaaacccactgtcacttcag
gatgcagagtggtactggggagacatctccagggaagaggtgaatgagaggctccgggac
acacccgatggcaccttcttggtccgggatgcatccagcaagatccaaggagagtacacg
ctcaccctcaggaaaggcgggaacaacaagctgatcaaagtcttccaccgggatggtcac
tacggcttctcggagcccctcaccttctgctccgtggtagagctcatctctcactaccgc
cacgagtcgctggcccagtataacgccaagctggacacgcgcctgctctaccctgtgtcc
aagtaccagcaggaccaggtggtgaaggaggacagcgtcgaggccgtgggtgcgcagctc
aaagtctaccaccagcagtaccaggacaagagccgcgagtacgaccagctgtacgaggag
tacacacggacctcccaggagctgcagatgaagcgtacagccatagaggccttcaatgag
accatcaagatcttcgaagaacagggccagacgcaggaaaagtgcagcaaggagtatttg
gagcgcttccggcgagagggcaatgagaaggagatgcagaggatcttgctgaactcagag
cgactcaagtctcgcattgcggagatccatgagagtcgcacgaagctggaacaggacctg
cgagcgcaggcctcggacaaccgagagatcgacaagcgcatgaacagcctcaaacccgat
ctcatgcagctacgcaagatccgggaccagtaccttgtgtggctcacccagaaaggtgcc
cgacagaggaagatcaacgagtggctgggaatcaagaacgagactgaggaccagtattca
ctgatggaggatgaggacaccctcccccaccatgaggagcgcacgtggtacgtgggcaag
atcaaccgcacacaggccgaggagatgctgagtggcaaaagggacgggaccttcctcatc
cgggagagcagccagcgcggctgttacgcatgctccgtggtggtggacggcgataccaag
cactgcgtcatctaccgcacggccacaggcttcggctttgcggaaccctacaacctgtac
gcgtctctaaaggagctggtgctgcactaccagcacgcgtcgcttgtgcagcacaacgac
gcgctcacagtcacccttgctcacccggtgcgcgcacccgggcctggcccgcccatggcc
cgctga

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