Anguilla anguilla (European eel): 118209433 Help Entry 118209433         CDS       T07545                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b isoform X1   KO K04961   ryanodine receptor 1 Organism aang  Anguilla anguilla (European eel) Pathway aang04020   Calcium signaling pathway aang04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:aang00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118209433 (ryr1b)    04020 Calcium signaling pathway     118209433 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:aang01009]     118209433 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:aang04147]     118209433 (ryr1b)    04040 Ion channels [BR:aang04040]     118209433 (ryr1b) Protein phosphatases and associated proteins [BR:aang01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      118209433 (ryr1b) Exosome [BR:aang04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    118209433 (ryr1b) Ion channels [BR:aang04040]  Voltage-gated cation channels   Ryanodine receptor    118209433 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  118209433 NCBI-ProteinID:  XP_035240615 LinkDB All DBs Position 12:complement(38907710..39012570) Genome browser AA seq 5110 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVVLQCTATVLKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICSFILEQSLSVRALQEMLANTVEMTDAVDLDRWSSQGGGHRTLLYGHAILLRHTHS SMYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYASGDLMVDASFMQTLWNMNPVCSGCELAEGFLTGGHVLRLFHGHMDECLA ISSADQGDDRRNAQYEGGAVCSQARSLWRLEPLRISWSGGHMKWGQPFRVRHITTGRYLC LDEEKGLMVLDPDRANTKMSAFCLRASKEKTEVAHKRDVEGMGTPEIKYGESMCFVQHVS TSLWLTYASVDAKAARLGLMKRKAILHQEGHMDDAMCVSRSQTEESQAARMIYSTNGLFN HFIKGLDSLRGKNKPSTPVSLPLDGVVLSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQ NLFQEEGMITLVLDCIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRA NCALFCDNLDWIVSKLDRLEASSGILEVLHCVLIESPEVLNIIQENHIKSIISLLDKHGR NHKVLDVLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTSIVNYVSSVRPNIFLGTCEG STQYKKWYFEVIVDYVEPFVTPQAAHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYG FDGQHLWSGHVPRQVASPNPHMLAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDG LFFPTISFSAGVKARFLLGGRHGDFKFLPPPGYAPCYEALLPKDRMRIEPIKEYKHDFDG VRNLLGPTQSLTHTSFTPCPVDTVQIVLPPHLERIREKLAENIHELWAVTRIEQGWTYGL FRDDNKKLHPCLVDFQSLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKIKL PKTYIMSSGYKPAPLDLSHVKLTPNQNTLVEKLAENGHNVWARDRVRQGWTYSIVQDILN KRNPRLVPYNLLDEKTKKTNRDSVCAAVRTLIGYGYNIEPPDQESSGHGVENTRGDKVRL FRAEKSYAVTHGKWYFEFEAVTVGEMRVGWARPSVRSDIDLGTDELAYVFNGFKAQRWHV GNEPFGRQWQSGDVVGCMIDLTEQNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSL GLSQVGRINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPTDHHH IEVTRIDGTEETAPCLKLIHKTFGSQNANTDMMFLRLSMPVEFHETFKVPAGTTPLTRAL TIPEEEVVEVDPDSEFEVLKKSASRKEQEEKEKEPSVPKDVPVKAENEKDASTEKVKRRG FLFKAKKAAQISPPPVVPTVPRLVEDVVPDDRDDPEIILNTTTYYYSVRIFAGQEPSSVW VGWVTPDYHQFGHSFDLGKVRTVTVTVGDDKGNIHDSMKHSNCYMVWGGDFSNTSQQARF SQEDMVIGCLVDLATGLMTFTANGKEVNAFYQVEPNTKLFPAVFVEPTSQNMLQLELGKL KNIMPISAAMFHSERKNPVPQCPPRLDVQMLKPVIWSRMPNHFLSPEVSRVSERHGWMVE CIEPLTMMALHIPEENRCIDVLELSERLDLLKFHYHTLMLYCGVCALGNNRVAHALCSHV DESQLFYAIENTFLPGPLRSGYYDLLISIHLESAKRARLLTNKEFIVPMTPETLSITLYP DVDRAHALPGVGLTTCLRPKPHFSHVNFVGTDPDLYTLSPVIPLESLKIKAISMLTEAVM DGTQAMRDPVGGSVEFHFVPILKLVSTLLIMGIFDDDDVKHILKMIEPNVFNGGEAAGEE PEEEEEEEEEAETGKEEGEEVKEEEEGQEGELEDEGMGGEEEEALEVEEMEGEDEELKQL EGEKEEGEEEEQAKEEGEGEGEKVDGEKTEEEKEVEAGETEAKEEEESPEEGLLQMTLPE SVKLQMCNLLQYFCDCELRHRVEAIIAFSDQFVNQLQSNQRARYNLLMQAFTMSAAETAR RTREFRSPPQEQVIMLTNFKHGPEEEDCPVPEEVRETLNEFHNSLLAHCGVHIEEEEEEE EVDTSLRGRLLSLVDKVKTFRKKKEEEEEPEPEEEPKPSTLQELISHTMIHWAQESFIQN PELVRLMFSLLHRQYDGLGELIRALPKAYIINGVSVQDTMDLLECLGQIRSLLIVQMGPE EERLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTNC CRFLCYFCRISRQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQE QDLEMVVTYLAGCGLQSCPMLLSKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANV VVRLLIRRPECFGPALRGEGGNGLLAAIEEAIKISEDPARDGPTVKKDRRFPMFGGEEQQ EENRVHLGNAIMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVIS LPVHIPAIGKDGNIIEPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLEVGFLPDMR ATASLDTAAFSTTEMALALNRYLCSAVLPLLTKCAPLFAGTEHRAIMIDSMLHTIYRLSR GRALTKAQRDIIEDCLMSLCKYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERC WKYYCLPNGWANFGVTSEEELHLSRKLFWGIFESLAHKRFDAELFKIAMPCICAIAGAIP PDYVDASFTSTEKKASVDAEGNFDPKPVETTNTIIPEKLDAFINKYAEHTHDKWAFEKIQ SNWTYGELLDENEKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMIAWEWTLEKARDGEEE RAEKATRKISQTAQATYDPSHGYSPQPIDVSGMALSRELQSMAEQLAENYHNTWGRKKKL ELQSKGGGTHPLIVPYDTLTAKEKARDREKAQDLLKFLQLNGYAVTRGLKDMEQDISSIE KRFAYGFLQKLLKWMDIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKN HCLYFLSTPAKVLGSGGHSSNKEKEMIASIFCKLAALVRHRVSLFGTDASAVVNCLHILS RSLDARTVMKSGPEIVKAGLRSFFESAADDIEKMVENLKLGKVSSRNQVKGVAQNINYTT IALLPVLTSLFDHIAQHQFGDDVILDDLQISCYRIMCSIYSLGTVKNPHVEKHRPALGEC LAHLAAAMPVAYMEPHLNEFNSYSVYTTKTPRERAILGLPNNVQELCPDIPELDVLMKEI GDLAESGARYTEMPHVIEITLPMLCNYLPHWWERGVENYPEQEDQLCTEVTSEQLNQLLG SIMKIVVNNLGIDEASWMKRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEE HLRMEGKTEADSEEGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRM VGEVFIFWSKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKAGDGESGGSDVERSKKK KRGDRYSVQTSLIVAALKKMLPIGLNMCSPADQELINMAKIRYSLKDTDEEVREFLQNNL HLQGKVEDPSMRWQMALYKETSGKAEDAENPEKVVKRVQEVSAVLYHIEVTEHPFKSKKM VWHKLLSKQRRRAVVACFRMTPLYNIPRHRASNMFLDGYKRNWIETEGYSFEDRMIDDLS KTMEEEEEEEEETESKPDPLHQLILHFSRTALTEKTKLDEDYLYMAYADIMAKSCHIGEE DEGGEEGGEDEMSFEVRQTEMEKEMEKQRLLYQQSRLHARGAAEMVLQMISACKGEPGAM VSSTLKLGISILNGGNCDVQQRMLDYLKDKKDVGFFLSAQALMQTCSVLDLNAFERQNKA EGLGMVSEEGTNMKLERDEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTI NIIICTVDYLLRLQESISDFYWYYSGKDIIDEPGKRNFSKAMTVAKQIFNSLTEYIQGPC TGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQMHPREGPRNGDHFWSRTNSEDSSQIGLL KELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVA SDAFMDYVTDPRGLISKKDFQKAMDSQKQYSTSEIQFLLSCSEADENEMINFEEFADRFQ EPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVLNYFRPFLGRIEIMGASRRIERI YFEISEANRTQWEMPQVRESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMNIASQISE VEEEEKEDEDEEEGGGGEGNGGAEGGEGDEANGEDGPPESSSAFADFLNSVVEFMHMFTF RNLRRQYRRVRKMTIREMVVGLVTFFWTILMGMLHFIYSVCKGFFLLIWSTLFGGGLVEG AKKMTVTEILASMPDPTQDEVHGDLPPEPGARVEQEAGGAADAMDVGAGEEEEEDSKEKE GGRLPGFDTPGGLGDIGEPTTVEPPTPEGTPLAKRKLLTGSEEEEAEPEAPAEEPAPEPE KADTENGEKAEKEPEEKEEEPKEVEVEEEKEKVKTKTQKEKKTAGEDAFELWNELEVQRI KFMNYLSRNFYNLRFLALFIAFALNFILLFYKVSETPRGEEELEGSAMFEGSGMFEGSGG EAEGSGVEDGGDEEDEESLVYFFLEESTGYMQPALFCLAILHSVISFLCIIGYNCLKVPL VIFKREKELARKLEFDGVYVTEQPEDDDIKGQWDRLVLNTPSFPTNYWDKFVKRKVLEKY GDIYGRERIAELLGMDLASLDVSAQQQEKKPEADSSAFTWITSIDVKYQIWKFGVVFTDN TFLYLCWYLVMSLLGHYNNFFFASHLLDIAMGVKTLRTILSSVTHNGKQLMMTVGLLAVV VYLYTVVAFNFFRKFYNMSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD EYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGSDY FDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 15333 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggtggagagggagaggaggagattcagttcttgcggacggatgaccaggtg gtgctgcagtgcactgcgaccgtgctgaaggagcagattaagctgtgcctgtcctgcgag ggcttcggaaaccgcctctgcttcctggaaaccacgtccaacgcccagaatgttccgccc gacctggcgatctgctccttcatcctggagcagtccctgtccgtcagagccctacaggag atgctggccaacaccgtggagatgacggatgcagtcgatttggacagatggtcctctcag ggaggggggcaccggacgctgctatacggccacgccattctgctgcggcacacccactcc agcatgtacctcagctgcctgaccacgtcgcgctcgctcacggacaagctggcctttgac gtgggtctccaggaggactccacaggggaggcctgctggtggaccattcatcccgcctcc aaacagaggtcagagggggagaaggtccgggtgggagacgacctcatcttggtcagcgtg tcgtccgagagatacctgcacctgtcctacgccagtggagacctgatggtggacgcctcc ttcatgcagaccctgtggaacatgaaccccgtgtgctccgggtgcgagctggccgagggg tttctgacaggggggcacgtcctcaggctcttccacggtcatatggacgagtgtttggcc atctcctcggccgaccagggagacgaccgcagaaacgctcagtacgagggcggggcagtt tgcagccaggcccgatctctgtggaggctggagcccctgcgaatcagctggagcgggggc catatgaagtggggccagccgttccgcgtgcgccacatcaccacgggccggtacctgtgc ctggacgaggagaagggcctcatggtgctggacccagacagagccaacaccaagatgtcc gccttctgtctgcgggcctcaaaggagaagacggaggtggctcacaagcgggacgtggag ggcatgggcaccccggagataaagtatggggagtccatgtgcttcgtgcagcacgtctcc accagcctgtggctcacctacgcgtccgtggacgccaaggccgcccgcctcgggctcatg aagaggaaggctattctgcaccaggaggggcacatggacgacgccatgtgtgtgtcccgc tcgcagacggaggagtcgcaggctgcccgtatgatatacagcaccaacggcctcttcaac catttcatcaagggtctggactctctgagagggaaaaacaagccctccaccccggtgtcc ctccccctggacggggtggtcctctccctgcaggacctcatcttctacttccgccccccc gaggaggagctggagcacgaggagaagcagaccaagctgcgctccctccggaaccgacag aacctcttccaggaggagggcatgatcacgctggtgctggactgcatcgatcggctgaac gtgtacaacactgctgcccacttctctgagttcgctggggaggaagccgcagagtcctgg aaggagatcgtcaacctgctgtatgagcttctggcctctctgattagaggaaaccgggct aactgtgctctgttctgtgacaacctggactggatcgtcagcaaactggaccgcctggag gcctcctcaggcattctggaggtgctgcactgtgttctcatcgagagtccggaggttctc aacatcatccaggagaaccacatcaaatccatcatttcactgctggacaagcacgggcgt aatcataaggttctggatgttcttcgctccctgtgtgtgtgtaacggagtggctgtgcgg tccaatcagaacctcatcacggaaaatctgcttccgggtcgtgacctgctgctgcaaacc agcatcgtcaactacgtcagcagcgtgagacccaacatctttctgggcacgtgcgagggg tccactcagtacaagaagtggtattttgaggtgatagtggactacgtggagccctttgtg acccctcaagctgctcacctgcgtgtgggctgggccctgactgaggggtacagcccctac ccggggggcggcgagggctgggggggcaacggcgtcggggacgacctctactcctatggc tttgacgggcagcacctgtggtcagggcacgtacctcggcaggtggcctcgcccaatccg cacatgctggcagcggacgatgtggtcagctgctgcctggatctgagcgtgcccagtatc tccttccgcatcaacggccaccccgtgcagggcatgttcgagaacttcaacctggacggc ctcttcttccccaccatcagcttctccgctggagtcaaggcgcgcttcctcttgggcggt cgtcacggagacttcaaattcctccctccccctgggtacgccccctgctacgaggccctt ctgcccaaagacaggatgcgcatcgagcccatcaaggagtacaagcacgacttcgacggc gtccgaaacctgctgggtcccacgcagtccctcacgcacacttccttcaccccctgcccc gtggacactgtgcagattgtactgccgcctcatctggaacgcatccgagagaagctggcg gagaacatccacgagctgtgggccgtcacccgcatcgagcagggctggacctacgggctg ttccgcgatgacaacaagaaattgcacccttgcctggtggacttccagagcctcccagag ccggagaggaactacaatctgcagatgtcaggagagactctcaagaccttgctggctctg ggatgccatgtgggcatgggagatgaaaaggcggaggaaaacctgaagaaaatcaagctt cccaaaacatacattatgagcagcggctacaaacccgcccctctggatctcagccacgtc aaactgacgcccaatcagaacaccctggtggagaagctggcggagaacgggcacaatgtt tgggcgagggacagggtgcggcagggctggacctatagcattgtgcaggacattttgaat aagcgcaaccctcgtctggtgccctacaacctgctggatgagaaaaccaagaagaccaat cgggacagcgtttgcgccgccgtgcgcactctcattggctacgggtacaacatcgagcct cccgaccaggagagcagtggtcatggggtcgagaacacgcgcggagacaaggtgcgcctg ttccgagccgagaagtcgtacgcggtgacccacgggaagtggtacttcgagttcgaggcg gtgaccgtgggggagatgagggtcgggtgggccaggcccagcgtccggtccgacatcgac ctgggcacggacgagctggcttacgttttcaacggcttcaaggctcaacgctggcacgtg gggaacgagccgttcggtcggcagtggcagtcgggcgacgtggtgggctgcatgatcgac ctgacggagcagaacatcatgttcaccctcaacggggagatgctcatcagcgactcgggc tctgagatggccttcaaggacatcgagatcggagagggcttcatccccgtgtgctcgctg ggcctgtcccaggtgggccggatcaacctgggccagaacgtcagcagcctgcgctacttc gctatctgcggcctgcaggagggcttcgagcccttcgccatcaacatgaagcgcgacatc accatgtggttcagcaagagcctgccgcagttcgtccccgtcccgacagaccaccaccac atcgaggtgacgcgcatagacgggacggaggagaccgcgccctgtctgaagctgatccac aagaccttcggctcgcagaacgccaacacggacatgatgttcctgcgcctgagcatgccc gtggagttccacgagaccttcaaggtcccggcgggcaccacgcccctcacccgcgccctc accatccccgaggaggaggtggtggaggtggaccccgactcggagttcgaggtgctgaag aagtcggccagccgcaaggagcaggaggagaaggagaaggagccgtccgtgcccaaggac gtccccgtcaaagcggagaatgagaaggacgcgtctacagagaaggtcaagaggagaggc ttcctgtttaaggccaagaaggcagcccagatctccccccctcctgtggtccccaccgta ccccgtctggtggaagacgtggtcccagacgatcgggacgacccggagatcatcctcaac accaccacctattattactcagtccggatcttcgcggggcaggagcccagttccgtgtgg gtgggctgggtcacgcccgactatcaccagtttggccacagcttcgacctcggcaaagtg cgcactgtcacggtcactgtgggagatgacaagggaaacatccacgacagtatgaagcac agtaactgctacatggtgtggggcggggacttcagcaacacttcccagcaggcccgcttc agtcaggaggacatggtgattggctgcctggttgacctggcaaccggtctcatgaccttc acagccaatggaaaggaggtcaatgccttctaccaggtggagcccaacacaaagctgttc cctgctgtgtttgttgaacctaccagccagaacatgctgcagctggagctggggaaactc aagaacatcatgcccatctcggcggccatgttccacagcgagcggaagaacccggtgccc cagtgcccgccccggctggacgtgcagatgctgaagccggtgatctggagccgcatgccc aaccacttcctgtccccggaggtgtcgcgcgtgagcgagcgccacggctggatggtggaa tgcatcgagccgctgaccatgatggcgctccacatccctgaggagaacaggtgcattgac gttctggagctttccgaacggctggacctgctgaagttccactaccacacgctgatgctg tactgcggcgtgtgcgcgctgggcaacaaccgggtggcgcacgcgctctgcagccacgtg gacgagtcgcagctcttctacgccatcgagaacaccttcctgcccggcccgctgcgcagc ggctactacgacctgctgatcagcatccacctggagtcggccaagcgcgcccgcctgctc accaacaaggagttcatcgtgcccatgacgcccgagaccctcagcatcacgctctacccg gacgtggaccgcgcacacgccctgcccggggtgggcctcaccacctgcctgcggcccaaa ccccacttctcccacgtcaacttcgtgggcactgaccccgacctgtacaccctcagcccg gtcattcccctggagagcctgaagatcaaggccatcagcatgctgacggaggcggtgatg gacgggacgcaggccatgcgggatcccgtagggggcagcgtggagttccacttcgtgccc atcctcaagctggtcagcaccctgctgatcatgggcatctttgacgacgatgatgtgaag cacatcctcaagatgatcgagcccaacgtcttcaacgggggtgaggcggcgggcgaggag ccagaggaagaggaggaggaggaggaggaagccgaaaccggcaaggaagagggggaggag gtgaaggaggaggaggagggacaggagggagagctggaggatgaggggatggggggggag gaggaggaagccctggaggtggaggagatggaaggggaggatgaggaactgaagcagctg gagggtgagaaggaagagggagaagaagaggagcaagcaaaggaggagggagagggagaa ggagagaaggtggatggagagaagaccgaggaagagaaggaggtggaggctggtgagact gaggccaaggaggaagaggagtctccggaggaaggactcctgcagatgactcttccagag tctgtcaaactgcagatgtgtaaccttctgcagtacttctgtgactgcgagctgaggcac agggtggaggccatcatagccttctcagaccagttcgtcaaccagttacagtccaaccag cgcgcgcgctacaacctgctaatgcaagccttcactatgagcgcggccgagaccgcccgc cggacccgcgagttccgctcgcccccgcaggagcaggttattatgctcacaaatttcaag cacgggccggaagaggaagattgtcccgttccagaggaagtccgtgaaaccctgaacgag ttccacaattccctgctggctcactgtggcgtgcacattgaggaagaggaggaggaagag gaggttgacacatccctgcgcgggcggctcctcagcttggtggacaaagtcaagaccttc cgcaagaagaaggaggaggaagaggagccagagcctgaggaagagcccaaacccagcacc ctgcaggagctcatctcccacaccatgatccactgggcccaggagtcgttcatccagaac ccggagctggtgcgcctcatgttcagcctgctgcaccggcagtacgacggcctgggcgag ctgatccgggcgctgcccaaggcctacatcatcaacggcgtgtccgtgcaggacaccatg gacctgctggagtgcctgggccagatccgctcgctgctcatcgtgcagatgggccccgag gaggagaggctgatgatccagagcatcgggaacatcatgaataacaaggtgttctaccag caccccaacctgatgcgtgcgctgggcatgcacgagactgtcatggaggtcatggtcaac gtgctgggcggtgggggagactccaaggaaatacgcttcccgcagatggtgaccaactgc tgtcgcttcctgtgctatttctgccggatcagccgccagaaccagcgctcgatgttcgac cacctcagctacctgctccagaacagcggcattgggctgggcatgcgtggctccacccct ctggacgtggcggcggcgtcctgcatcgacaacaacgagctggccctggccctgcaggag caagacctggagatggtggtgacgtacctggccgggtgtggtctccagagctgtcccatg ctgctgtcgaaggggtaccccgacatcggctggaacccctgcgggggcgagcgatacctc gacttcctgcgattcgccgtcttcgtcaacggagagagcgtggaggagaacgcgaacgtg gtggtgcgtctgctgatccggagacccgagtgcttcggacccgccctcagaggggagggg ggtaacggcctgctggccgccatcgaggaggccatcaaaatctcggaggaccccgcccgg gacgggcccacggtcaagaaggaccggcgcttccccatgttcggtggggaagagcaacag gaggagaacagggtgcatcttgggaacgccatcatgtccttctactctgccctcatcgac ctgctgggccgctgtgccccagagatgcatttgatccaggccgggaaaggggaggctctg aggatcagggctattctgcgctccctggtgcccatcgaggacctggtgggggtcatcagc ctgcccgtccacatccccgccattgggaaagacgggaacatcatcgagcccaagatgtcg gccagctttgtgccggaccacaaggcctccatggtgctgttcctggacagggtttacggc atcgagaaccaggacttcctgctgcacgtgctggaggtgggcttcctgccggacatgaga gcgaccgcctcgctcgacacggcggcgttcagcaccacggagatggcgctagcgctgaac cgctacctgtgctcggccgtgctgccgctgctcaccaagtgcgcgcctctgttcgccggc accgagcaccgcgccatcatgatcgactccatgctgcacaccatctaccgcctgtcccgc ggccgtgccctcaccaaggcccagagggacatcatcgaggactgcctcatgtccctgtgc aagtacctccgcccctccatgctgcagcacctgctgaggcggctggtgttcgatgtgccc attctcaatgaatacgccaagatgcccctcaagctgttgaccaatcactacgagcgttgc tggaagtactactgcttgcccaatggctgggccaatttcggcgtgacatcagaagaggag ctgcacctctcccgaaaactcttctggggcatctttgagtcacttgcacacaagaggttt gatgcagagctgtttaagatagccatgccctgtatctgcgccattgctggggctattccg ccagattacgtggatgccagtttcaccagcactgagaaaaaggcttcagttgacgccgag ggcaacttcgaccccaaacctgtggagaccaccaacaccatcatccctgagaaactggat gccttcatcaacaaatatgcagaacacacacatgacaagtgggcttttgagaagattcag agcaactggacttatggagagctgctggacgagaacgagaagactcaccccatgctgagg ccctacaagaccttctctgagaaggacaaggagatttaccgctggcccatcaaggagtcg atcaaagccatgattgcctgggagtggactttggagaaagccagagacggagaggaggag agggctgagaaggcgacccgcaagatatcgcagacggcccaggccacctatgaccccagt catggctacagcccccagccaatcgacgtctctggcatggcgctgtcccgggaactgcag tccatggcagagcagttagcagagaactaccacaacacctggggcaggaagaagaagctg gagctccagtccaaagggggcggaacccaccccctgattgtgccctacgacactctgacc gccaaggagaaggcccgggatcgagagaaagcgcaggacctgctcaagttcctgcagctg aacggatatgctgtcaccagggggctgaaggacatggagcaggacatctcctccatcgag aagcgctttgcctacggcttcctgcagaagctgctcaagtggatggacatcgcccaggag ttcatcgctcacctggaggctgtggtgagcagtggcagagtggagaagtccccgcatgaa caggagataaaattctttgctaagatcctgcttccactggtgaaccagtactttaaaaac cactgcctgtacttcctgtccaccccggccaaagtgctggggagcggagggcactcctcc aacaaggagaaggaaatgattgccagtatcttctgtaagttggcagctctggtgagacac agagtttctctctttggaacagatgcctctgcagtggtcaactgtctgcacatcctgtca cgatcactggatgcaaggacggtgatgaagtcggggcctgagattgtgaaagcagggctg aggtccttctttgagagcgctgcggacgacattgagaagatggtggagaacctcaaactc gggaaggtgtcgagccggaaccaggtgaagggtgtggcccagaacataaactacaccacc atcgccctgcttcctgtgctcacttccctgttcgaccacatcgcccagcaccagtttgga gatgatgtcatcttggacgatctgcagatttcctgctaccgtatcatgtgtagcatctac tctctgggcactgtcaagaacccacatgtggagaaacataggccagccctgggtgagtgt ctggcccatctcgctgctgccatgcctgtggcctacatggagccccatctcaacgagttc aactcttactccgtctacaccaccaagaccccgcgggaaagagcaatcctcggcctccct aacaacgttcaggagctgtgcccggacatccccgagctggacgtcctgatgaaggagatc ggggacctggcggagtcgggcgcccgctacacggagatgccccacgtgatcgagatcacc ctgcccatgctgtgcaactacctgccccactggtgggagaggggggtggagaactacccc gagcaggaggaccagctctgcaccgaggtcacctccgagcagctcaaccagctgctgggc agcatcatgaagatcgtggtcaacaacctgggcatcgacgaggcctcctggatgaagagg ctggctgtgtttgcccagcccatcgtcagccgggccaagcccgagatgctgaagtcgcac ttcatccccaccatggagaagctgaagaagcgcagcgggaaggtggtggccgaggaagag cacctgcgcatggaggggaagactgaggccgacagcgaggagggaaccatccgcgacgag ttcgccgtgctctgccgcgacctctacgccctctaccccctgctcatccgctacgtggac aacaacagggcaagatggctgacttgtccagatcctgatgcggaggaacttttcaggatg gtgggagaggtgttcattttctggtccaagtctcacaacttcaagcgggaggagcagaac ttcgtggtgatgaacgagatcaacaacatgtcgttcctcacggccgacagcaagagcaag atgagcaaggccggagacggagagtctggcggctcggacgtggagcgttccaagaagaag aagcgcggggaccgctactcggtgcagacctctctcatcgtggcggccctgaaaaagatg ctccccatcggcctcaacatgtgctcccctgccgaccaggagctcattaacatggccaag atcagatactccctgaaagacacggatgaggaagtgagagagtttctgcagaacaacttg catctccagggcaaggtggaagacccctccatgcgctggcagatggctctgtacaaggag acctctgggaaggcggaggacgcggagaacccggagaaggtggtgaagagagtccaggag gtctctgctgtgctgtatcacatcgaggtgacagagcaccccttcaagtctaagaagatg gtgtggcacaagctcttgtcaaaacagcgccgcagggcagttgtggcctgtttcagaatg acacccttgtacaacattcccagacacagagcatccaacatgttcctggatggctataaa cgcaattggatagagacggagggatactcatttgaagacaggatgattgacgacttgtct aaaaccatggaggaagaggaagaggaggaagaagagactgaatcaaagccagatcccctt caccagctgatccttcacttcagtcgcactgctcttacagaaaagactaaactcgacgaa gattatttatacatggcatatgccgatatcatggcaaagagctgccacattggtgaggaa gacgaagggggagaggaggggggcgaggatgagatgtcctttgaggtgcgacagacagag atggagaaagagatggagaagcagaggctcctgtaccagcagtccaggcttcacgcccgt ggagctgcagagatggtgctgcagatgatcagtgcctgcaaaggtgagcctggtgccatg gtgtcctccaccctcaagctgggcatctccatcctgaacggcgggaactgcgacgtgcag cagagaatgctggactatctgaaggacaagaaggatgtgggattcttcctgagcgcgcag gccctgatgcagacctgcagtgtgctggacttgaatgcctttgagaggcagaataaggcc gagggactgggaatggtgtcagaggagggaaccaacatgaagctagaacgtgatgagaag gtcatggccgacgatgagttcacctgtgacctcttccgcttcctgcagttgctctgtgag ggtcacaacaacgatttccagaactatctgcgcactcagacgggcagcaccaccaccatc aacataatcatctgtactgtggactacctgctgcggctacaggagtccatcagtgacttc tactggtactattctgggaaggacatcatcgatgagccgggcaagaggaacttctctaaa gctatgacggtggccaagcagatcttcaacagcctgacagagtacatccagggtccgtgt acaggtaaccagcagtccctggcccacagcaggctgtgggacgcggtcgtgggcttcctc cacgtcttcgctcacatgatgatgaagctggcgcagatgcatcctcgagaaggacctcga aatggagatcatttctggagtagaacaaactcggaggattccagtcagataggcctactg aaggagcttctggaccttcagaaggacatggtggtcatgttgctgtctctgctagagggt aatgttgtgaatggcaccattgcccgtcagatggtggacatgctggtggagtcgtccagc aacgtggagatgatacttaagttcttcgacatgttcctcaaactgaaggacattgtggcc tctgacgccttcatggactacgtgaccgacccgcgcgggctcatctccaagaaggacttc cagaaggccatggacagccagaagcagtactctacgtccgagatccagttccttctctcc tgctccgaggcggatgagaacgagatgatcaactttgaagagtttgccgaccgcttccag gagccggccaaggacatcggcttcaacatcgccgtgctgctcaccaacctgtcggagcat gtgccccacgacacgcggctgcagaacttcctggagcaggccgagagcgtgctgaactac ttccgcccgttcctgggccgcatcgagatcatgggcgccagcaggaggatcgagcgcatc tacttcgagatcagcgaagccaaccgcacgcagtgggagatgcctcaggtgcgcgagtcc aagcggcagttcatcttcgacgtggtgaacgagggcggcgagtcggagaagatggagctc ttcgtcaacttctgcgaggacaccatctttgagatgaacatcgcctcgcagatctccgag gtggaggaggaggagaaggaggacgaggatgaggaggaaggaggaggaggggagggaaac ggaggggcagagggaggggaaggcgacgaggccaacggagaggacggcccgcccgagtcc agctctgcctttgccgacttcctgaacagcgtggtggagttcatgcacatgttcactttc cgcaacctgcggcgccagtaccggcgcgtgaggaagatgaccatccgggagatggtggtg ggcctggtcaccttcttctggaccatcctgatgggcatgctgcacttcatctacagcgtg tgcaagggcttcttcctcctcatctggagcacgctgttcggtggtggcctggtggagggc gccaagaagatgaccgtgaccgagatcctggccagcatgcccgacccaacgcaggacgag gtgcacggggacctgccccccgaaccaggggccagggtggagcaggaggccggtggagca gcagacgccatggatgtgggcgcaggtgaggaagaggaggaggacagcaaggagaaggaa ggaggccggctgccaggctttgacacccctggggggctcggagacatcggcgagcccacc acggtcgaaccccccacccctgagggcaccccattagccaagagaaagctgctgactggc tcagaggaagaggaagctgaaccagaggcacctgcagaggaaccagcgccagaaccagag aaagctgacactgagaatggagagaaggctgaaaaggagccagaggaaaaagaggaggag ccgaaagaggtggaggtggaggaggagaaagagaaggtgaagacaaagacccagaaagaa aagaagactgcaggagaggacgcctttgagctctggaacgagctggaggtccagaggatc aagttcatgaactacctctcccgtaacttctacaacctacgcttcctggctctcttcatc gccttcgctctcaacttcatcctgctcttctacaaggtgtcagagactcccagaggtgag gaggagcttgagggctcagcgatgttcgaaggctccgggatgttcgagggttccgggggc gaggcggaaggttctggagtggaggatggaggagatgaggaggatgaggaaagcctggtg tacttcttcctggaggagagtactggatacatgcagccagcgctgttctgcctcgccatt ctgcactccgtcatctccttcctctgcatcatcggatacaactgcctcaaggttcccctg gttatctttaagagagagaaggaactggctcgcaagctggagtttgacggtgtgtacgtc accgagcagcctgaggatgacgacatcaagggccagtgggacagactggtgctcaacaca ccctctttcccgaccaactactgggacaagtttgtgaagagaaaggtgctggagaagtac ggtgatatctacggcagagagaggatcgctgagctcttgggaatggacctggcctctctg gacgtcagtgctcagcaacaggagaagaaaccagaggccgacagttccgcattcacctgg atcacctccattgacgtcaagtaccagatctggaagtttggggtggttttcacggacaat accttcctctacctgtgttggtacctggtgatgtcactgctcggccactacaacaacttt ttcttcgccagtcacctgctggacatcgccatgggagtgaagaccctgcgcaccatcctg tcctcggtcacccacaatggcaaacagctgatgatgacggtgggactactggctgtggtg gtgtatctctacactgtagtggccttcaacttcttccgcaagttctacaacatgagcgag gacgaggacgagccggacatgaagtgtgatgacatgatgacgtgctatctgttccacatg tatgtgggtgtgcgagctggtgggggtattggagatgagattgaagaccctgcaggagat gagtacgagctgtaccgcgtggtctttgacatcactttcttcttcttcgtcatcgtcatc ctgctggccatcattcagggtctgattattgatgcctttggagagctgagagaccaacag gagcaagtcagagaggatatggagactaagtgcttcatctgcgggatcgggagcgactac ttcgacacgacgccacatggctttgagacacacaccctggaagagcacaacttggccaac tacatgttcttcctgatgtacttgatcaataaggatgaaactgagcacacaggacaggaa tcctacgtctggaagatgtaccaggaacgctgctgggatttcttcccggctggagactgt ttcaggaagcaatacgaggatcagctgggttga

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