Actinoplanes sp. N902-109: L083_2961 Help Entry L083_2961         CDS       T02655                                  Symbol rapC Name (GenBank) polyketide synthase   KO K16420   rapamycin polyketide synthase A/B/C Organism actn  Actinoplanes sp. N902-109 Pathway actn01052   Type I polyketide structures Brite KEGG Orthology (KO) [BR:actn00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01052 Type I polyketide structures     L083_2961 (rapC)  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:actn01008]     L083_2961 (rapC) Polyketide biosynthesis proteins [BR:actn01008]  Polyketide synthase (PKS)   Modular type I PKS    cis-AT PKS     Rapamycin PKS      L083_2961 (rapC) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ketoacyl-synt Acyl_transf_1 Ketoacyl-synt_C KR PKS_DH_N KAsynt_C_assoc PP-binding PS-DH CurL-like_PKS_C adh_short RhiE-like_linker Thiolase_N ADH_zinc_N_2 Epimerase SpnB_Rossmann ADH_zinc_N Polysacc_synt_2 DUF7080 GDP_Man_Dehyd ADH_N NmrA Docking ACP_syn_III_C Motif Other DBs NCBI-ProteinID:  AGL16471 UniProt:  R4LB52 LinkDB All DBs Position complement(3382307..3400885) Genome browser AA seq 6192 aa AA seqDB search MSEQDKVVEYLRWTTAELHTTRAKLEAATAAATEPLAIVGMACRLPGGVASPEDLWRLVE SGTDAITGFPADRGWTTEPGQGGFLDDAAGFDAAFFGISPREALAMDPQQRLLLEVCWEA FERAGIEPGSLRGSDTGVYIGAYPDGYGIGADLGGFGTTAGSPSVLSGRVSYFFGLEGPA ITVDTACSSSLVALHQAAYALRTEECSLALVGGVTVMATPEVFAQFAMQDGLAADGRSKA FSDSADGAGFSEGVGVLLVERLSDAQAKNHQILAVVRSSAVNQDGASNGLTAPNGPSQQR VIRQALANASLNPADVDVVEAHGTGTTLGDPIEAQALLATYGQDRTVPLLLGSVKSNLGH TQAAAGVAGVIKMVLALQHGIVPQTLHVDQPSRHVDWTTGAVELATSNQPWPSSNRPGRA GVSSFGISGTNAHVILEAAPAPDPASGDGVDMPTSGAAGLAGTAAGLAGAPAAGVAGTAV VPLAISARSEAAVTDLSTRLRAYLRANPDTDLHTIATTLATTRSTFDHRAVLLGDDTITG TATPDPCVVFVFSGQGAQRADMGAELAAAFPVFADIHQRVWDLLHVDKSLDVDDTGYAQP ALFALQVALFGLLESWGVRPDAVIGHSIGELAAAHLAGVWSLEDACTLVSARARLMQALP PGGVMVAVPVSEEEARTVLRDGVEIAAVNGPSSVVLSGDEDAVLQAVAGFLKWTRLSTSH AFHSARMDPMLDEFRAAAGRLTYHQPTVEMAAGQQVTTPDYWVRQVREAVRFGEQVAAYE DAVFVEIGPGRNLARLIDGVAMLNGENETHAALTGLSQLFVRGVTPDWSAVLGATTGRVL DLPTYPFQHERYWAGATRLANVSGAGLEAVQHPLLGAVVAWPGTGGVVLTGRLSLATHAW LADHAVRGSVQLPGTGFVELVVRAAGEAGCDAVDELVIETPLVLPPSGGVQLSVAVAEPD DAGRRPVTVFSRADDNDVWTRHATATVSASDGSPAHPQLSSWPPAGAEPVDLTGFYERLA AVGYEYGPAFQGLQAAWRTGDTVYAEVALAEPEAEEAGGFAVHPALLDGALHAGLLDPPG TVRPLSSWNSIRIQSTGQSTVRVTMTPATEGWSVSVSDDTGRPVATIGSLVTRPAADGDD LLAVSWTEIPAPSSPTSDAAEVFTALPDDSTDVLTQTRTLTTQVLTAIQTWLDHDDGTLI IRTNTGLAGAAVSGLVRSAQSEHPGRFILVESNDENLPNPAALATLNEPRLRITDGRLHA PRLTRVNPQPSNETGWDPHGTVVITGGSGTLAGILARHLVHHKGMHHLLLLSRTTPDQTL LNELGDHVETATCDISDRTALQQVLAGRTLTAVIHTAGVIDDGVIETMTPQRLNTVLQPK VDGAWHLHELTRDQPLTAFIVYSSAAAILGSPGQSNYAAANAFLDALAEQRHTQGLPAQS LAWGLWADTSTLTAQLTDADHDRLRRGGALALSAEHGMRLFDAATHRTEAVLVAAQLDAM PDGDVPPLLRSLHRTVTRRAAGSSVRWLALAPDEREKALLTMVRDNAAKVLGHADARAVA PTATFRDLGVDSLTAIELRNRLAKAADLRLATTIVFDYPTPAALAAHLGELLSGASPAPQ RPVGVPAGADEPLAIVGMACRLPGGVTSPEDLWRLVESGTDAITGLPADRGWDLDAVAAK SYCGQGGFLDDVAGFDAAFFGISPREALAMDPQQRLLLETAWETLERAGIEPGSLRGSDT GVFMGAYPGGYGAGADLGGFGTTSGAASVLSGRVSYFFGFEGPAMTVDTACSSSLVALHL AAQALRNGECSLALTGGVSVLAAPDIFVEFAHQRGLAADGRSKAFADSADGTGWAEGIGV LLVERLSDAQAKNHHILAVVRSSAVNQDGASNGLTAPNGPSQQRVIRQALANASLNPADV DVVEAHGTGTTLGDPIEAQALLATYGQDRTVPLLLGSVKSNLGHTQAAAGVAGVIKMVLA LQHGIVPQTLHVDEPSRHVDWTTGWVELATSNQPWPSSDRPGRAAVSAFGISGTNAHVIL EAAPAPAPASASASAGDGDAPTLGDTSGLAGAAAASLGGATAASLGGVAAAGLAGAAVLP LAISARTESALADLTTRLRAYLTANPNTDLHTTATTLATTRSSFDHRAVLLGDDTITGTA AVDPRVVFVFSGQGSQRTDMGAELAAAFTVFADIHQHVWDLLNVDDSLNIDDTGYAQPAL FALQVALFGLLESWGVRPDALVGHSIGELAAAYVAGVWSLEDACTLVSARARLMQALPPG GVMVAVPISEEEARTVIRDGVEIAAVNGPSSVVLSGDEDAVLQAVAGFPRWTRLSTSHAF HSARMDPMLEEFRAAADQLTYHQPTIEMAAGNQVATPDYWVRQVRDAVRFGDQVAAYQDA VFVEIGPGRNLARLIDGVTMLNGENETHAALTGLSQLFVRGITPDWQAVLGASTERVLDL PTYPFQHEHYWLSSANRTEGHPLLGLPVRPATTGDVIFSAGLSRTSDPWLQDLTVLPAAA FVEMALAAADEVGADHVENLSLETLPLIPDDSTLHLQTWISAEETGQHRLTVHARYNDNE PWTQLATATLTTTPAPTPHHSPDNPHTTVNLDDNLDPSPYTLHPALLDTALTTTAHQTAA EWHHLSLHATGATELHVHHTNNTLIALDPTGTPVLTAERITHRAVPIHQPTTSELLSVTW TEIPAPPDRTQDVTAQPGDGVTVLTARPGNGDVLAETRALTARVLAAVQAHTDGILVVWT GTGPVGAAVSGLVRTAQSEQPGRFVLVESDDPLTEEHLAVLAGLDEPRLRITGDRIEAPR LTRVSAEPVEETVWDPEGTVVITGGSGALAGILARHLVHEKGMRRLLLLSRSTPDQTLLT DLGDHVETAICDVSDRAALEQVLTGRTLTAVIHTAGTIDDGVIESMTPERLDTVFRPKID GAWHLHQLTRNAGLAAFIMYSSAAGVMGNPGQGNYAAANAFLDELAVQRRAAGLPALALA WGPWEADGGLAGRLSDADRDRIRRSGLRAISAGHGMRLFDAAIQHSEPLLVAAPAAERQP VARRTASASESSVFWLLRLTPAERGQELLKLVRDSAATVLGHADGRTIPSAAAFRDLGVD SLTAVELRTILARTTDLQLPTTVVFDYPTPSSLAGHLNDLITGEHADSTPRAVAVVGQEE PLAIVGMACRLPGGVASPEDLWRLVESGKDAISGFPTDRGWDTDGLYDPNLDAIGKTYCV QGGFLETAAEFDAAFFGISPREALAMDPQQRLVLETSWEAFERAGIDPLSVRGTDTGVFI GAYPGGYGMGADLGGFAATAGAGSVLSGRVSYFFGLEGPAMTVDTACSSSLVALHQAGYA LRQGECSLALVGGVTVMASPQSFVEFSRQRGLAADGRSKAFADAADGTGWAEGVGVLLVE RLSDARRNGHRVLAVVKGSAVNQDGASNGLSAPNGPSQQRVIRQALANAGLAPADVDVVE AHGTGTKLGDPIEAQAVIATYGQERSTPLLLGSLKSNIGHTQAAAGVAGVIKMVMALQHQ TVPRTLHVDEPTRHVDWSAGAVDVVTSNQPWPSSDRPGRAGISAFGVSGTNAHVILESAP DEPAPQIAGPAPVVADVTPLVLSAKTLPALKDLETRIRAYATTAEDERAVAATLATTRPV FEHRAVLIGEDTITGPTLTDPRTVFVFPGQGWQWLGMGVQLRESSVVFASRMAECATALS EFVDWDLFTALDDPAVVDRVDVVQPVCWAVMVSLAAVWQAAGVTPNAVVGHSQGEIAAAV VAGSLSLRDGARVVAQRSQLIARGLAGHGAMASIALPADEITLVEGAWIAALNGPASTVI AGTPEAVEAVLAAQDARVRRIAVDYASHTPQVEAIRDELLVLTADVDSQAPAVPWLSTVD GTWVDGPLSVDYWFRNLREQVGFAQAVETLGDAVFVEVSASPVLIQSMGDAATVATLRRD DDSPTRMAASLAEAFVQGVGVDWAAVLGAGGERVLDLPTYPFQRQHYWAIAEQLTDVSGA GLDAVRHPLLGAVVALPGSDGVVLTGRVSLATHAWLADHAVRGSLLLPGTVFVELVARAA AETGCVTIDELVIETPMVLPATGEVQLSVAVGGAADDGHRQVTVFSRHTVTPGTAGTAGT AGTAGTAGTAGTAGTDREKTDAEAWTRHVTATVSGADEPTGQPALAEWPPPGAQPMDVST FYDELLPVGYEYGPAFQGLRAAWRDGDTVYADVALAGEQTAEAARYGVHPALLDAALQAN MLNTTGPKGNVVGLPFSWNTIRVHAAGTTSLRVASTRQDESWSLRVADSTGRPVASIGSI VTRPVTAGATTGLLAMTWTELPDLAPVERAGAGAGRAVGGPGDRPAVQVFTARPGSEQDV PAETRTLTGRVLDAMQTWLGATDGTLVVATGTGPASAAVSGLVRSAQSEHPGRFVLVESE TPATQEQLAVAAASGEPRLRIVDGRFEAPRLARSTGSLVVPEGDGWMLRQPGSGTLQDLA LAPTDVTERPLLPGEVRVEVRAAGLNFRDVVVALGLVDDARLAGGEAAGVVREVGPGVAD LAVGDRVFGLMAGGFGPIAIGDRRMLAVIPDDWSFTTAASVPVAFATAYYALVDLARVRP GEAVLIHAAAGGVGMAATQLARHLGAEIFATASSGKQHLLRAAGLDDSRVADSRTTGFRD TFLGSTHGAGVDVVLNSLSGEFVDASLDLLIRGGRFIEMGKTDIRDPRQVAAEGPGTTYQ AFDLLDAGPDRLREILAELLALFERGVLQPLPVRAWDIRQAREAFSWMSRGRHVGKIVLT VPRRLDGHGTVLITGGSGVLAGILARHLVREYDARHLLLVSRSAPDEGLLAELGERVEVV RCDVSDRTALESVLAGRTLTAVIHTAGALDDGVIESQSAERIDTVLRPKADAAWHLHELT RDMDLTAFIMYSSAAGIMGNAGQGNYAAANAFLDELAVQRQAAGLPALSLAWGLWADTSG LTARLTGSDLDRIRRSGQRTLTAEHGLRLFDAAVRDGAPLVLAAAASPVVTGEVPALLRD LETVRRPAGRAVAPSPGTATRDQRPLGERLAERAGAERHRLMLDLVLAHAATVLGHSSAD SVQPDRPFKELGMDSLTAIELRNHLVAETGLRLPATMVFDFPTADALAGHLVDKLGLPTA HMAEVDDNAKPAAADEPWVNEPIAVVSMACRLPGGIDSPDGLWQLVESGTDAISGFPADR GWDLTNFYSTDPQGGFLTGAAEFDAAFFGISPREALGMDPQQRLLLETTWEAIERAQLDP RSLRGRDVGVYVGGAAQGYGVGFTGEPQDNAITASSISLLSGRLSYALGLQGPGVTVDTA CSSSLVALHLACQALRQRECSIALVGGVSVIATPDVFAEFSRQGGLAADGRCKSFAAAAD GTSWSEGAGMLVLERLSEATRRGHRVLAVVRGSAVNSDGASNGLTAPNGMSQQRVIRQAL AGAGLAASDVDVVEAHGTGTRLGDPIEAEAILATYGQNRATPAWLGSLKSNIGHTMAASG VLGVIKMVEAMRHGTMPRTLHADEPSPHVDWAAGRVALLTGNQPWPDDEKPRRAGVSSFG LSGTNAHVVLEQHREPAPAAPPRDNGPVPWVLSAQSPKALQQQAGRLHAALAADPGWHPL DVAFSLATTRSAFTHRAAVVGAGREALLDALAELASGPARPAHPGVPGKPPRIAFLFDGQ GTQRLGMGRELYERFPAFAGTWDEVSAGFDKHLEHPLKDVYFGAGEAGELADDTGYAQAA IFTVEVALVELLQQWGVRPDFVAGHSIGEVAAAYVSGMFSLDDATQLVVARGRALRSAPP GAMVALRASEAEAREFLAGTGGELDLAAVNSPEAVVVSGAPDAVAAFTAAWTASGRRARE LRVSRAFHSRHVAGVLEEFRSVLESLTFRTDPALPIVSTVTGRRIDPAELATPQYWLDQV CRPVRFQDAVIELAGAGADVFVEIGASGTLASAGTETLGDEAVFHALQHPRTPEDVALLT AVAGLHAGGTGVDWAAVLAGGRAVDLPVYPFQHQTYWLAPVASAGAAPAPRTDPDELPEP AYATEPATMLELVQYEVAAVLGMPDPTAVSGQTAFLDLGFDSLSAVRLRNRLTKATGVEL PATLLFDHPTPAELAAHLDDQLVTDIDAAGVHALLEEIDGLDALSLDMTTAEQQAISDLL QKLSAKWTIDHD NT seq 18579 nt NT seq  +upstreamnt  +downstreamnt atgtccgagcaagacaaagtggtcgagtacctgcgctggacgacggcggagctgcacacg acccgcgccaagctggaagcggccaccgctgccgccaccgagcccctcgcgatcgtgggc atggcctgccggctgccgggcggggtggcctcgccggaggacctgtggcggctcgtcgag tcgggcacggacgcgatcaccggcttccccgccgaccgcggctggacaaccgaacccggg cagggcggcttcctcgacgacgccgccggtttcgacgccgcgttcttcgggatcagcccg cgcgaggccctggccatggacccgcagcagcgcctgctcctggaagtctgctgggaggcc ttcgaacgcgccggcatcgagcccggctcgctgcgcggcagcgacaccggcgtctacatc ggcgcctatcccgacggctacgggatcggcgccgacctcggcggcttcggcaccacggcc ggctcaccgagcgtgctgtccggccgggtgtcgtacttcttcggcctcgaaggacccgcc atcacggtcgacaccgcctgctcctcctcgctggtcgccctgcaccaggccgcgtacgcc ctgcgcaccgaggaatgctcgctggcactggtcggcggcgtgacggtgatggcgacgccg gaggtcttcgcgcagttcgcgatgcaggacggcctggccgccgacgggcgcagcaaagcc ttttcggacagcgcggacggtgcgggattctccgagggcgtcggtgtgctgctcgtcgag cgcttgtccgatgcccaagccaagaaccatcagatccttgccgtcgtacgaagttcagct gtcaaccaggacggcgcctccaacggcttgacagcacccaacggcccctcgcagcaacgg gtcatccgccaagccctcgccaacgcctcactcaaccccgcagacgtcgacgtcgtcgaa gcccacggcaccggcaccaccctgggcgacccgatcgaagcccaagctctgctggccacc tacgggcaagaccgcaccgtcccgctactgctgggctcggtgaagtccaacctcggccac acccaggccgcagcaggcgtcgccggtgttatcaagatggtgctggccctgcagcacggc atcgtcccccagacgcttcacgttgaccagccatcacgacatgttgactggacaaccggt gcagtcgagttggcaacgtcgaatcaaccgtggccctcgtcgaatcggccgggacgcgcg ggtgtgtcgtcgttcggcatcagcggcacgaacgcccacgtcatcctcgaagccgcccct gcccctgatccggcctcgggtgatggcgttgacatgccgacctccggcgccgccggcctc gccggaaccgccgccggccttgcgggagcacccgccgccggcgttgccggaacggcagtg gtgccgctggccatctcggcccgctcggaagctgctgtcaccgacctgtcgacccggttg cgcgcctaccttcgcgccaaccccgacaccgacctgcacaccatcgccacgaccctcgcc acgacccgatcgacgttcgaccaccgtgccgtactgctcggcgacgacaccatcaccggc accgccaccccggacccctgcgtcgtgttcgtgttctccggccaaggcgcacaacgcgcc gacatgggcgccgaactcgccgcggcgttcccggtgttcgccgacattcatcaacgtgtg tgggatctgctccatgttgacaagagccttgatgttgacgacacgggttatgcccagccg gcgttgttcgccttgcaagtcgccctgttcgggttgctggagtcctggggtgtgcgcccg gacgcggtgatcggccactccatcggcgaactcgccgccgcccacctcgccggcgtctgg tcactcgaagacgcctgcaccctcgtgtccgcacgcgcccggctcatgcaagcactaccg cccggcggcgtcatggtcgcagtgccggtctccgaggaagaagcccgcaccgtcctgcgc gacggtgtggagatcgccgcggtcaacggcccatcgtcggtggtgctctccggcgacgag gacgccgtgctgcaggccgtcgccgggttcctgaaatggacccggctgtcgaccagccac gccttccactccgcacgcatggacccgatgctggacgagttccgtgcggctgctggacga ctgacctaccaccagccgacagtcgagatggccgccgggcagcaggtcaccacaccggac tactgggtgcgtcaggtccgcgaggcggtccgcttcggtgagcaggtcgcggcgtacgaa gacgcggtcttcgtggaaatcggaccgggccgcaacctcgcccggttgattgacggcgtc gcgatgctcaacggcgagaacgagacacacgccgcactgaccggcctgtcacaactattc gtccgaggcgttacacccgactggtcggcggtgctgggcgcgaccaccgggcgggtgctg gacctgccgacgtacccgttccagcacgagcggtactgggccggggcgaccaggctggcc aacgtgtcgggtgccgggctggaggccgtacagcatccgctgctgggcgcggtcgtggcg tggcccggcaccggcggtgtggtgctgaccggcaggttgtccttggccacgcatgcctgg ctggccgatcacgcggtgcgtggcagtgtccagctgcccggaaccggcttcgtggagctt gtcgtccgggccgccggtgaggccggttgcgacgctgtcgacgagctcgtgatcgaaacc ccgctggtgcttccgcccagcggcggggtgcaactgtccgtcgcagtcgccgagcctgac gacgccgggcgccggccggtgacggtcttctcacgggccgacgacaacgacgtctggacc cggcatgccacggcgacggtcagtgcctccgacgggtctccggcgcacccgcagctgagc tcctggccgccggcgggcgccgagccggtggacctgaccggtttctacgagcggctggcg gccgtgggttacgagtacggtccggccttccagggtttgcaggccgcgtggcggaccggg gacaccgtctacgccgaggtcgccctcgccgagccggaggccgaggaggcgggcggattc gcggtgcacccggcactgctggacggcgcactgcatgccgggctcctcgacccgcccggc accgtacgaccgctctcgtcctggaacagcatccggatccagtcaaccggtcaatcaacc gtacgcgtcacgatgacccccgccaccgagggctggagcgtcagcgtcagcgacgacacc ggccgcccggtggccacgatcggctcgctggtcacccgtccagcggccgacggtgacgac ttgctcgcggtgtcgtggaccgagatcccggcgccttcctcacccacgagcgacgcggcc gaggtgttcaccgcactgcccgacgactccaccgacgtgttgacccaaacacgcacattg accactcaagtcttgaccgccatccaaacatggctcgaccacgacgacggcaccctcatc atccgcaccaacacaggactagccggcgcggcagtatcggggctggtgcgctcagcacaa tcagaacaccccggccggttcatcctcgtggaaagcaacgacgagaacctacccaacccc gccgcgctcgccacccttaacgaaccacgcctgcgcatcaccgacggccgcctccacgca ccccgcctgacccgcgtgaaccctcaaccaagcaacgagacaggctgggacccgcacggc accgtcgtcatcaccggcggctccggcaccctggccggcatcctcgcccgccacctcgtg caccacaaaggcatgcaccacctcctgctgctctcccgcaccacccccgaccaaaccctg ctcaacgaactcggcgaccacgtcgaaaccgccacctgcgacatctccgaccgcaccgca ctgcaacaggtactggccggacgcaccctgaccgccgtcatccacaccgccggagtcatc gacgacggcgtcatcgaaaccatgacaccccaacgcctcaacaccgtcctacaacccaaa gtcgacggcgcctggcacctgcacgaactgacccgcgaccaacccctgaccgcgttcatc gtctactcctccgcagcagcaatcctcggcagccccggacaaagcaactacgccgcagcc aacgccttcctcgacgcactcgccgaacaacgccacacccaaggcctacccgcccaatcc ctggcctggggactatgggccgacaccagcaccctcaccgcccagctgaccgacgccgac cacgaccggctccgccgcggcggggcgctggccctgtccgccgaacacggcatgcggctc ttcgacgccgcaacccaccggaccgaggcggttctggtcgccgcccagctcgatgcgatg cctgacggcgatgttcccccgttgttgaggtcgctgcaccgtacggtcacccggcgcgcc gctggttcgtccgtacggtggctggccctcgccccggacgagcgcgagaaggcgctgctg acgatggtccgggacaacgccgccaaggtcctcgggcacgccgacgcccgcgccgtcgcg cccacggccacgttccgggatctgggcgtggattcgctgaccgccatcgaactgcgcaac cggctggcaaaggccgcggacctccggctggccacaacgatcgtgttcgactatccgacc ccggcggccctcgccgcgcacctgggcgagctgctctccggggcgagcccggcaccgcag cgtccggtcggcgtcccggccggcgcggacgagcccctcgccatcgtgggtatggcctgc cgcctgcccggaggcgtgacgtccccggaggatctgtggcggctggtcgaatcgggcacc gacgcgatcaccggtctgcccgccgaccgcggctgggacctcgacgccgtggcggccaag tcgtactgcggacaaggaggcttcctcgacgacgtggccggtttcgacgccgcgttcttc gggatcagcccgcgcgaggccctggccatggacccgcagcagcgcctgcttctggagacc gcctgggagaccctggagcgcgccggcatcgagcccggctcgctgcgcggcagcgacacc ggcgtcttcatgggtgcctaccccggcgggtacggtgccggggccgatctgggcggcttc ggcaccacctcgggtgcggcgagcgtgctctccggtcgggtgtcgtacttcttcggcttc gaaggcccggcgatgacggtcgacaccgcctgctcgtcgtcgttggtcgccctgcacctg gccgctcaggcgctgcgcaacggcgagtgttcactggctctgacgggtggcgtgtccgtg ctggccgcgccggacatcttcgtcgagttcgcgcatcagcgggggctggccgcagacgga cgcagcaaagccttcgcagacagcgcggacggcaccggctgggccgagggcatcggtgtg ctgctggtcgagcggctgtccgacgcccaagccaaaaaccatcacatccttgccgtcgta cgaagttcagctgtcaaccaggacggcgcctccaacggcttgacagcacccaacggcccc tcgcagcaacgggtcatccgccaagccctcgccaacgcctcactcaaccccgcagacgtc gacgtcgtcgaagcccacggcaccggcaccaccctgggcgacccgatcgaagcccaagct ctcctggccacctacgggcaagaccgcaccgtcccgctactgcttggctcggtgaagtcc aacctcggccacacccaggccgcagcaggcgtcgccggcgtcatcaagatggtgctggcc ctgcagcacggcatcgtcccccagacgcttcacgttgacgagccgtcgcgtcatgttgac tggacaaccggttgggttgagttggcgacgtcgaatcaaccatggccctcgtcggatcgg ccgggacgcgcggctgtctcggccttcggcatcagcggcacgaacgcccacgtgatcctc gaggccgctcccgctcctgcaccggcctcggcctcggcctcggctggtgacggtgacgcg ccgaccctcggcgatacctccggccttgccggagctgcagccgccagccttggcggagct acagccgccagccttggcggagttgcagccgccggccttgctggagcagcagtgctgccc ctagccatctcagcccgcacggaatcagctctagccgacctgacaacccggctgcgcgcc tacctgaccgccaaccccaacaccgacctgcacaccaccgccaccaccctggccaccaca cgctcatcattcgaccaccgcgccgtcctgctcggcgatgacaccatcaccggcaccgcc gccgtggatccgcgtgtggtgttcgtgttctccggccaaggctcacaacgcaccgacatg ggcgccgaattggcagccgcgttcaccgtcttcgccgacatccatcaacacgtctgggat ctgctcaatgttgacgacagcctcaacattgacgacaccggctatgcccaaccagcgctg ttcgccctacaagtcgccctgttcgggctactcgaatcgtggggtgtgcgcccggacgca ctggtcggccactccatcggtgaactcgccgccgcctacgtcgccggcgtctggtcgttg gaagacgcctgcaccctggtgtcagcacgcgcccggctgatgcaggccctgccgcccggc ggcgtcatggtcgccgtgcccatctccgaagaagaagcccggaccgtcatacgcgacggt gtcgagatcgccgcggtcaacgggccctcttcggtggtgctctccggcgacgaagacgct gtgctgcaggcggtcgccgggttcccacggtggacccgactgtcgaccagccacgccttc cactcagcacgcatggaccccatgctcgaggaattccgcgcggccgccgatcaactgacc taccaccagccgacgatcgaaatggctgctggcaatcaagttgccacaccggactactgg gtgcgccaagtccgcgatgcggtccgcttcggtgaccaggtcgcggcgtaccaggacgcg gttttcgtggagatcgggccgggccgcaacctcgcccggttgatcgacggcgttacgatg ctcaacggcgagaacgagacacacgccgcactgaccggtctatcgcagctgttcgtccga ggcatcacacccgactggcaggccgtgctcggcgccagcaccgagcgggtgctggacctg ccgacgtacccgttccagcacgagcactactggctgagcagcgccaaccggacggagggg caccccctgctgggactgccggtccggccggccaccaccggcgatgtgatcttctcagcc ggcctctcccgcaccagcgatccatggctccaggacctgacagtgctacccgccgccgcc ttcgtcgagatggccctcgcggcggccgacgaggtcggcgccgatcacgtcgagaacctg tccctcgaaacgctgcccctgatcccagacgacagcaccctccacctgcaaacctggatc agcgccgaagaaacaggccagcaccgcctcaccgtgcacgcccgctacaacgacaacgaa ccctggacccaactcgccaccgccaccctcaccaccaccccagcacccaccccacaccac agccccgacaacccccacaccaccgtcaacctcgacgacaacctcgaccccagcccctac accctgcaccccgccctgctggacaccgcactcaccaccaccgcacaccaaacagccgcc gaatggcaccacctcagcctgcacgccaccggcgctaccgaactacacgtccaccacacc aacaacaccctcatcgccctcgaccccaccggcacacccgtcctgaccgccgaacgcatc acccaccgcgccgtaccgatccaccaacccaccaccagcgaactgctcagcgtcacctgg accgagatcccggccccgccggaccgcactcaagacgtcaccgcccaacccggggacggc gtcaccgtgctcaccgcccggccgggcaacggcgacgtgctcgccgagacccgcgccttg accgcccgcgttctcgcagccgtccaggcccataccgacggcattctggtggtgtggacg ggaaccgggccggtcggcgcagcggtgtccggcctggtccgtaccgcccagtccgagcag cccggccggttcgtcctggtggaaagcgacgacccgctcaccgaggaacacctggccgta ctcgccgggctcgacgaaccacgcctgcgcatcaccggcgaccgcatcgaagcaccccgg ctgacccgagtcagcgccgagccggtcgaagaaaccgtgtgggaccccgaaggcacggtc gtgatcaccggcgggtccggtgctttggctggcatcctggcccgccacctggtccacgag aagggcatgcgccggctgttgctgctctcgcgcagcacccccgaccaaaccctgctcacc gacctcggcgaccacgtagaaaccgccatctgcgacgtctccgaccgagccgcactcgaa caagttctcaccgggcgtacgttgacagcagtcatccacaccgccggcaccatcgacgac ggcgtcatcgagtcaatgacccccgaacgcctcgacaccgtgttccggcccaagatcgac ggcgcctggcacctgcaccaactcacccgcaacgccggcctcgccgcattcatcatgtac tcctcagctgccggcgtgatgggcaacccgggccagggcaactacgcggcagccaacgcc ttcctcgacgaactggccgtccagcgccgggccgcggggttgccggcgctggccctggcc tggggtccgtgggaggccgacggtggcttggcgggccggctcagcgacgccgaccgggac cggatcaggcgcagcgggctgcgggccatctccgccgggcacggcatgcggctgttcgac gccgcgatccagcacagcgaaccgctgctggtggccgcgccggccgctgaacggcaaccg gttgcccgccggaccgcctccgccagcgaatcgtccgtgttctggctgctccggctcacg cccgcggagcgtgggcaggagctgctcaagctcgtccgggacagtgccgcaacggtgctg ggacatgccgacggacgcaccatcccgtcggctgccgcgttccgggatctgggtgtcgat tcgctgaccgccgtcgagctgcgcaccatcctggccaggaccaccgacctgcagctgccc accacggtcgtcttcgactatcccaccccgagctcgctggccggacacctgaacgacttg atcacgggcgagcatgccgattcgacccccagggccgtagcggtagtgggccaggaggag ccgctcgcgatcgtgggcatggcctgccggctgccgggcggggtggcgtcaccggaggac ctgtggcggctggtcgagtcgggcaaggacgcgatctccgggttccccaccgaccgtggc tgggacacggacggcttgtacgacccgaacctggacgccatcggcaagacctactgtgtg cagggcgggttcctggagacggcggccgagttcgacgccgcgttcttcgggatcagcccg cgcgaggcgctcgccatggatccgcagcagcggctggtgctcgagacgtcctgggaagcc ttcgaacgcgccggcatcgaccccctgtcggtccgcggcaccgacaccggcgtgttcatc ggcgcctaccccggcggctacggcatgggcgccgacctcggtggcttcgcggcgaccgcc ggcgcgggcagtgtcctgtccggccgggtgtcgtacttcttcggcctcgaaggcccagcg atgaccgtggacacggcgtgttcgtcgtcgctggtggcgttgcatcaagccgggtacgcg ctgcggcagggcgaatgctcactggctctcgtcggtggcgtcaccgtcatggccagcccg cagagcttcgtcgagttctcccggcagcgggggctggccgccgacggtcgtagtaaggcg ttcgccgatgctgccgacggcacgggctgggctgaaggtgtcggcgtgttgttggtggag cggctgtcggacgctcgccgtaacggtcaccgggtcctggcggtggtcaagggttcggcc gtcaaccaggacggcgcctcgaacgggctgtccgcgccgaacgggccctcgcaacagcgc gtcatccgccaagccctcgccaacgccggcctcgcccccgccgatgtcgacgtcgtcgag gcccacggcaccggcaccaagctgggcgacccgatcgaagctcaagccgtcatcgccacc tacggacaagaacgctcgacaccgctgctgctgggctcgctcaagtcgaacatcgggcac acccaggccgcagcaggcgtcgccggtgtcatcaagatggtcatggcgctccagcaccag acggtcccacgcacacttcacgttgacgaaccgacccgacatgttgactggtccgccggt gcagttgacgtagtcacgtccaatcaaccctggccgtcgtcggaccggccgggacgggcg ggcatctccgcctttggcgtcagcggcaccaacgcccacgtcatcctggaaagcgcaccc gacgaaccggccccgcagatcgccggcccggccccggtggtggccgacgtgaccccgctg gtgctctcggcgaagaccctccccgcgctcaaagacctcgaaacccgcatccgggcgtac gcaacgacggcggaggacgaaagggcggtcgcggcaacgttggcgaccacccgcccggtg ttcgagcaccgggccgtcctgatcggtgaggacaccatcaccggacccacgctgaccgac ccccgcaccgtgttcgtgttccccggccagggctggcaatggctgggcatgggcgtccag ctacgcgagtcgtcggtggtgttcgcctcccgcatggccgagtgcgccaccgcgctcagc gagttcgttgactgggacttgttcaccgccctcgacgacccggctgtggtggatcgggtt gatgtggtccagccggtgtgctgggccgtcatggtgtcgctcgccgcggtctggcaagcc gctggtgtcacccccaacgccgtcgtcgggcactcccaaggcgagatcgccgcagcggtg gtcgcggggtcactgtcgttgcgagacggcgcacgagtggtggcgcagcgcagccagctg atcgcgcgtggcctggccggtcacggcgccatggcctccatcgctctgccggctgatgag atcaccctggttgagggtgcgtggatcgcggcgctcaacggcccggcgtccacggtcatc gccggcacgccggaagccgttgaggcggtgcttgccgcccaggacgcccgggtgcggcgc atcgcggtggattacgcctcgcacaccccgcaggttgaggcgatccgtgatgagttgctg gtgttgacggctgatgttgactcgcaggcccctgccgtgccgtggttgtcaactgttgac ggcacgtgggtggacggcccgctgagcgttgactactggttccgcaacctgcgcgagcaa gtcggcttcgcgcaggcggtggagacgctgggtgacgcggtcttcgtcgaggtgtcggca agccccgtgttgatccagtccatgggtgacgcagccaccgtggcaaccctgcgccgcgac gacgacagccccacccggatggcggcctcactggcggaggcattcgtccaaggcgtcggc gtcgactgggccgccgtgctcggagcgggcggtgagcgggttctcgacctgccgacctat cccttccagcggcagcactactgggcaatcgccgaacagctgaccgacgtgtccggtgcg ggcctggacgccgtgcggcaccccctgctcggcgcggtcgtggctctgcccggctccgac ggcgtggtgctgaccggcagggtgtcgctcgcgacgcatgcctggctggccgaccatgcg gtgcgcggaagcctgctgctgcccggcacggtcttcgtcgagctggtcgcgcgggccgcc gcggagaccggctgcgtcaccatcgacgaactggtgatcgagacgccgatggtgctgccg gccaccggtgaggtgcagctgtccgtggcggtcggcggtgcggcggacgacgggcaccgg caggtgacggtgttctcccggcacaccgtgacacccggcaccgcgggcaccgcgggcacc gcgggcaccgcgggcaccgcgggcaccgcgggcaccgccggcaccgaccgggagaaaacc gatgccgaagcctggaccaggcacgtcaccgccaccgtgagtggcgcggacgagccgacc gggcaacccgccctcgccgagtggccgccgcccggggcgcagccgatggacgtcagcacc ttctacgacgaactgcttccagtgggctacgagtacggccccgccttccagggtttgcgg gccgcttggcgcgacggggacaccgtctatgccgacgtggcgctggccggggagcagacg gcggaagcagcccggtacggggtgcacccggccctgctggacgccgcgctgcaggcgaac atgctcaacacgaccggccccaagggcaacgtggtgggactgccgttctcgtggaacacc atccgggttcacgccgccgggacgacctcgctgcgagtggcgtccacccggcaggacgag tcctggagcctgcgggtcgccgacagcaccggccggccggtggcctccatcggttcgatc gtgacccggccggtcaccgccggcgccaccaccggcctgctcgccatgacctggaccgag ctgccggacctcgccccggttgagcgggccggtgcgggtgcgggtcgtgcggtgggaggc ccgggcgaccggcccgcggtgcaggtcttcaccgcacggcccggctccgagcaggacgtg ccggccgagacgcgcacgctgaccggccgggtgctggacgcgatgcagacgtggctgggt gccaccgacggcacccttgtcgtggcgaccggcaccggaccggcgagcgccgcggtgtcg ggtctcgtacggtcggcgcagtccgaacacccgggccggttcgtcctggtggagagcgag accccggcgacccaagaacagctggcggtcgccgccgcctccggtgagccacggctgcgc atcgtcgacggccggttcgaggcgccccggctggcccggtcgaccggttccctggtcgtg cccgagggcgacgggtggatgctgcgccagcccggcagcggcacgttgcaggatctggct ctggcgcccaccgatgtcaccgagcggccgttgctgcccggcgaggtccgcgtcgaggtg cgcgccgccgggttgaacttccgcgacgtggtggtggccctgggcctggtcgacgatgcc cggctggccgggggcgaggccgcgggcgtggtgcgcgaggtcggccccggcgttgcggac ctggccgtgggtgaccgggtcttcggcctgatggccggtggcttcgggccgatcgccatc ggtgatcgccggatgctcgccgtgatccccgacgactggtcgttcacgacggccgcctcc gtgccggtcgcgttcgccacggcgtactacgcgctggtggatctggcccgggtgcggccc ggtgaggcggtgctgatccatgccgccgccggcggggtgggcatggcggcgacccagctc gcccggcatctcggcgccgagatcttcgcgaccgccagcagcgggaaacagcatctgctg cgggcggccgggctggacgactcgcgggtcgcggactcgcgcaccacgggcttccgggac accttcctgggctcgacgcacggcgccggggtcgacgtcgtgctgaactcgctcagcggc gagttcgtcgacgcctcgctcgatctgctgatccgcggcgggcggttcatcgagatgggc aagaccgacatccgcgacccgcggcaggtcgccgccgaggggccgggcaccacgtatcag gcgttcgacctgctggacgccggtccggaccggctgcgggagatcctcgccgaactgctg gccctgttcgagcggggcgtgctgcaaccgttgccggtgcgcgcgtgggacatccggcag gcgcgtgaggcgttcagctggatgagccggggccggcacgtgggcaagatcgttctcacc gttccgcgtcgtctcgatgggcacggcaccgtgttgatcaccggtggttcgggtgtactc gccggcattctggcccggcacctggtgcgtgagtacgacgcccggcacctgttgctggtc tcgcgtagcgcaccggatgagggtctgctggccgagctgggtgagcgggtggaggtagtg cggtgtgacgtctccgaccgtacggcgctggaaagcgtcctggccggccgtacgctgaca gcggtcatccacaccgccggcgccctcgacgacggcgtcatcgagtcgcagagcgccgag cgcatcgacaccgtgctgcggcccaaggcagacgccgcctggcacctgcacgaactgacc cgcgacatggacctcaccgcgttcatcatgtactcgtcggccgcgggcatcatgggcaac gcggggcagggcaactacgcggcggccaacgccttcctcgacgagctggccgtccagcgg caggccgcgggtctgccggctttgtcgctggcgtggggcctgtgggcggacaccagcggg ctgaccgcccggctgaccggcagcgacctcgaccggatccggcgcagcgggcagcggact ctcaccgccgagcacggcctgcggctgttcgacgccgctgtccgcgacggcgccccgctg gtgctcgccgcggcggccagcccggtggtcaccggcgaggtcccggcgttgctgcgcgat ctcgagacggtgcgacgcccggcgggccgggctgtggcgcccagccccggcacagcaacc cgcgaccagcggcccctcggcgaacggctcgccgaacgggccggcgcggaacggcaccgc ctgatgctggacctggtgctcgcgcacgcggcgaccgtactcgggcacagctcggcggac tcggtgcagccggaccggccgttcaaggaactgggcatggactcgctgaccgcgatcgag ctacgcaaccacctggtggcggagaccgggctgcggttgccggccaccatggtgttcgac ttcccgacggccgacgccctcgccgggcacctggtggacaaactgggtctgccgacggcg cacatggccgaggtggacgacaacgccaagccggcagcagcggacgagccgtgggtgaac gagccgatcgccgtggtgtcgatggcgtgccggttgccgggcgggatcgactcccccgac ggcctgtggcagctggtggagtccggcaccgacgcgatctccggcttcccggccgaccgc ggctgggacctgacgaacttctactcgacggacccgcagggcggcttcctcaccggcgcc gccgagttcgacgccgctttcttcggtatcagcccgcgtgaggcgctgggcatggacccg cagcagcggctgttgctggagaccacctgggaggcgatcgagcgcgcgcagctcgatccg cgctcgctgcgcggccgggacgtgggtgtctacgtcggtggcgcggcccaggggtacggc gttggcttcacgggcgaaccacaggacaatgcgatcaccgccagctcgatcagcctgctg tccgggcggttgtcgtacgcgctggggttgcagggcccgggcgtcaccgtcgacaccgcc tgctcgtcctccctggtggccctgcacctcgcgtgtcaggcgctgcggcaacgggagtgc tcgatcgcgctggtgggcggggtctcggtgatcgccacgccggacgtgttcgcggagttc tcccgccagggtggtctggccgccgacgggcggtgcaagtcgttcgccgcggcggcggac ggcacgagctggtccgagggcgccggcatgctggtgctggaacggctctccgaggcaacc cggcggggacaccgggtcctcgccgtggtgcggggcagcgcggtgaactccgacggcgcc tccaacgggctgaccgcgcccaacgggatgtcgcagcagcgggtgatccggcaggcgctg gccggcgcgggtctggccgcctcggacgtggacgtggtcgaggcgcacgggacgggcacc cggctgggtgacccgatcgaggccgaggccatcctcgcgacgtacgggcagaaccgggcg accccggcctggctgggctcgctgaagtcgaacatcggccacacgatggcggcgtcgggc gtgctcggcgtgatcaagatggtcgaggcgatgcggcacgggacgatgccccggacgttg cacgccgacgagccgtcgccgcacgtggactgggccgccggccgggtcgcgctgctgacc ggcaaccagccgtggccggacgacgagaagccgcgccgggccggggtgtcgtcgttcggg ctcagcggcaccaacgcgcacgtggtgctggagcagcaccgggaacccgccccagcggct ccgccgcgcgacaacgggccggtgccgtgggtcctgtcggcgcagagcccgaaggcgctg cagcagcaagccggccggttgcacgccgcgctcgccgcggacccgggctggcatccgctc gacgtggccttctcgctggcgaccacccgttccgcgttcacgcaccgggcagccgtggtg ggagccggtcgcgaggcactgctggacgcgctggctgagctggcgtccggcccggcccgg cccgcgcaccccggcgtgcccggcaagcccccgcgcatcgcgttcctcttcgacgggcag ggcacccagcggctcgggatgggccgggagctgtacgagcgcttcccggcgttcgccggc acctgggacgaggtgagcgccgggttcgacaagcatctcgagcatccgctcaaggacgtc tacttcggtgcgggtgaggccggcgaactcgccgacgacaccgggtacgcccaggcggcc atcttcaccgtcgaggtcgcgctcgtcgaactgctccagcagtggggcgtacgaccggac ttcgtcgccgggcattccatcggggaggtcgccgcggcgtacgtcagcgggatgttctcg ctcgacgacgccacccagctggtggtggcgcgcggccgggcgctgcgctcggcgccgccc ggggcgatggtcgccctgcgggcgagcgaggcagaagcccgggaattccttgccggtacg ggtggggagctggacctcgcggccgtcaacagccccgaggcggtcgtcgtgtcgggcgcg ccggacgccgtggccgcgttcaccgccgcctggaccgcatccgggcggcgcgcgcgcgag ctgagggtcagccgggccttccactcccggcacgtggccggtgtgctggaggagttccgc tcggtgctggaatcgttgacgttccggaccgacccagccctgccgatcgtgtcgaccgtg accggccggcgcatcgacccggccgagctggccacgccgcagtactggctggatcaggtg tgccggccggtacgtttccaggacgccgtcatcgagctggccggcgccggcgcggacgtc ttcgtcgagatcggtgcgtcgggcacgctcgcgtcggccggcaccgagaccctcggcgac gaggccgtcttccacgccctgcaacacccgcgtacgccggaggacgtggccctgctgacg gccgtcgccgggctgcatgccggtgggaccggggtggactgggcggcggtcctggccggg ggccgcgcggtggacctgccggtctatccgttccagcaccagacgtactggctcgcaccg gtggcatcggccggcgccgcgccggcgccgcggaccgatccggacgagcttccggagccc gcgtacgccacggagccggccacgatgctggagctcgtccagtacgaggtggcggccgtg ctcggcatgcccgaccccaccgccgtgtccgggcagacggcgttcctggacctgggcttc gactcgctcagcgccgtccggctgcgcaaccggctgaccaaggccaccggggtcgagctg ccggccaccctgctgttcgaccaccccacgccggccgaactcgccgcccacctggacgac cagctggtgaccgacatcgacgcggccggcgtgcacgccctcctggaggagatcgacggg ctcgacgcgctgtccctcgacatgaccacggcggagcagcaggccatctcggacctgttg cagaaactctcggcgaaatggactattgaccatgactga

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