Anoplopoma fimbria (sablefish): 129113876 Help Entry 129113876         CDS       T09102                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism afb  Anoplopoma fimbria (sablefish) Pathway afb04020   Calcium signaling pathway afb04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:afb00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     129113876    04020 Calcium signaling pathway     129113876  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:afb01009]     129113876   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:afb04147]     129113876    04040 Ion channels [BR:afb04040]     129113876 Protein phosphatases and associated proteins [BR:afb01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      129113876 Exosome [BR:afb04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    129113876 Ion channels [BR:afb04040]  Voltage-gated cation channels   Ryanodine receptor    129113876 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  129113876 NCBI-ProteinID:  XP_054482335 LinkDB All DBs Position 24:complement(11184458..11232446) Genome browser AA seq 5017 aa AA seqDB search MAEGADGEEEIQFLRTDDQVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNIPP DLAICCFILEQSLSVRALQEMLSNSSVDESSQGGGHRTLLYGHAILLKHTHSSMYLCCLT TSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHL SYASGDLMVDASFMQTLWTMTPVMSGCELAEGFLTGGYVLRLFHGHMDECLAIPGAEQGD DQRRVAYYEGGAVCSHARSLWRLEPLRIGWSGGHIKWGQSFRIRHITTGRYLCLDEEKGL LIVDPEKANSKMSAFCFRISKEKIELIQKRDVEGMGTPEIKYGESMCFVQHVSTGLWLTY AAVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEESQAARMIFSTSGLFNQFIKGLD ALGGKNKSSNSTSLPMDTVVLSLQDLIFYFRPPEEELEHEDKQFKLRSLKNRQNLFQEEG MITHVLDCVDRLNVYNTAAHFSEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALFCD NLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDV LCSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIINYVTSMRPNIFLGTCEGSTQYKKW YFEVMVDEVEPFLTAQPYHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGIHLW SGRVPRHVATPNQHILAAEDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDSLFFPVVS FSAGVKLRFLLGGRHGDFKFLPPPGYAPCYEAVLPRDRLRIEPIKEYKHDFDAIRNLLGP TQSLSHTAFTPGPVDTIQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGPFRDDNKK LHPCLVDFQSLPEPEKNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKKNKLPKTYMQS SGYKPAPLDLSYVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIVQDIMNKRNPRLV PYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHGPATGDKIRVFRAEKSYAI TQGKWYFEFEAVTVGEMRVGWARPSVRADTELGADELAYVFNGFKAQRWHVGNEPFGRQW LSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSLGLSQIGRIN LGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFINAPTDHPHMEVSRVDGT VETAPCLKVTHKTFGSQNANTDLLFFRLSMPVEFHETFKVPAGTTLLTRTMTIPEDEVLE VDPDSDFEILKKSASRKEQEEEKKEPSVPKEIPANKNGENEKDASTEKSKKKGFLFKAKK AALISPPPVVPTMPRLMEDVVPDDRDDVDIILNTTTYYYSVRVFAGQEPSGVWVGWITPD YHQYDQHFDISKVRNVTVTVGDDKGNIHDSLKRSNCYMVWGGEFGGTQQTRVSQEDFVIG CLIDLETGLMTFTANGKEINTFYQVEPNTKLFPAVFVLPSSQNMIQFELGKLKNIMPISA AMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNNFLSPDTGRVSERLGWGVHCQEPLTMM ALHIPEENRCIDILELSERMDLLKFHYHTLKLYGLVCALGNNRVAHALCSHVDESQLFYA IEDTYLPGPMRSGFYDLLISMHLESAKRNRLGTNKEFIVPMTDNTRSITLYSDKSHALPG VGLTTCLRPKLHFSSIGFVGTDQDIYTLSPVIPLQTLKTKALNMLTEAVQDGVQAMRDPV GGSVEFHFVPILKLISTLLIMGVFDDEDVTHILKMLEPTVFSGKKAEEPQEDIGEEEEEF EDDGLGEEDEEEMEEEEQLEMKSIKEIKEENKEERLEQGLFQMKLPESVKLQMCTLLQYF CDCELRHRVEAITAFSDQFVSQIQSNQRQRYNELMLAFTMSAAETARKTREFRSPPQEQV NMLMNFKNCAEDEECPVPDEVREALLTFHNALLAHCGVHIEEEEQEEEVDNSLRGRLVRL LAKVKKIREKKVEVEPEPQEDKKPSTLQELISHTMIHWAQESFIQNPELVRMMFSLLHRQ YDGLGELMRALPKAYTINAVSIHDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMS NKVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRVVTNCCRFLCYFCRISRQNQ RSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVKYLAGCGL QSCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPA LRGEGGNGLLAAIEEAIKISEDPARDGPSVKKDRRFPMFGGEEQHEENRVHLGNAIMSFY SALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPSFGKDNSII EPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFCTTEM ALALNRYLCSAVLPLITKCAPLFAGSDHRAIMIDSMLHTIYRLSRGRAFTKAQRDIIEEC LMALCKHLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGV SSEEELHLTRKLFWGIFESLAHKKFDAEIFKISMPCICAIAGAIPPDYVDASYSSKTEKK ASVDAEGNFDPKPVETTNTIIPERLDPFINKFAEYTHDRWAFEKIQNNWSYGEVLDENAK THPMLRPYKTFSEKDKEIYRWPIKESIKAMLAWEWTLDKAREEDESEKKKAVSRKISQTA QATYDPSHGYSPQPIDITHMALSRDLQSMAEQLAENYHNTWGRKKKLELQSKGGGTHPLL VPYDTLTAKEKARDREKAYELLKFLQLNGYAVTRGLKDMESDISSIEKRFAYGFLQKLLK WMEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILMPLINQYFKNHCLYFLSTPAKVL GSGGHSSNKEKEMIASIFCKMSALVRHRVSLFGTDASAIVNCLHILARSLDARTVMKSGP EIVKAGLRSFFESAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSLFD HIAQHQFGDDVMLDDLQMSCYRIMCSIYSLGTVKNPHVERQRPALGECLAHLAAAMPVAY LEPHLNEFNAFSVYTTKTPRERAILGLPNEVQELCPDIPELDALLKEIGDLAESGARYTE MPHVIEITLPMLCNYLPRWWERGLENFPEMESQICTDVTSESLNQLLGSIMKIVVNNLGI DEASWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTSKVVAEEDHLRMEGKSEGDE EDGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTYPDPDAEELFRMVGEVFIFWSKSH NFKREEQNFVVMNEINNMSFLTADSKSKMSKGGDSEGGGSDTERTKKKRRGDRYSVQTSL IVAALKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLHLQGKVDNPSMR WQMALYKEMAGKAEDADAPMKVVKRVQEVSAVLYHLEVTEHPFKSKKMVWHKLLSKQRRR AVVACFRMTPLYNIPRHRASNMFLEGYKRNWLHSEGYSFEDRMIDDLSKAMEQEEGDEEE ERETKPDPLHQLILHFSRTALTEKSKLDTDHLYMAYAEIMAKSCHIGEEEEGGEEMMENA EDEMSFEEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGPMVTTTLKLGISILNG GNSEVQRKMLEYLRDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAEGLGMVSEEGTSKS SYYEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQE SISDFYWYYSGKDIIDEPGKKNFSKAMTVAKQIFNSLTEYIQGPCTGNQQSLAHSRLWDA IVGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDML VESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYSPSEI QFLLSCSEADENDMIHYEEFANRFQEPAKDIGFNIAVLLTNLSEHVPHDIRLQNFLEQAD SVLNYFRPFLGRIEIMGASRKIERIYFEITEVNRKQWEMPQVRESKRQFIFDVVNGGESE KMEMFVNFCEDTIFEMNIASQISEQEEEGKGEEDDEPDEVGGEGGQAGGANGGGDEDNNG EEGQPESSSAFADFINSVLCFFSIFTFRNLRRQYRRVRKMTLKEIVVALTTFFWTILMSI LHFIYNVCKGFFMIIWQTLFGGGLVEGAKNITVTEILASMPDPTQDDVHGDGPGEPRTGE EQDTGGVTDTGETGSGEEEEEDTQEKEGGRIPGIDAPGGLGDMGVESPVEPPTPEGTPIT KRKKQPEETDASQKPPEPVPVVETPPEPEKADVENGEKAEKDAQSKEEERPEERKRSAKK KEKKPKREGGFQIWNELETQRNKFMNYLSRNFYNLRFLALFLAFALNFILLFYKVSDSPP DGDEMEGSGMSEGSGMFEGSGFFEGSGEEAEGSGMNEGDEDEEEVPIYFYLEESTGYMQP ALSFIAALHTVISFICIIGYNCLKIPLVIFKREKELARKLEFDGLFITEQPEDDDIKGQW DRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGVDLASLDVSQQHEKKQEEP DSSVFAWMTTVDIKYQIWKFGVVFTDGTFLYLCWYTIMSLLGHYNNFFFACHLLDIAMGV KTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKGEDGDEPDMKCDDMM TCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAF GELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLDEHNLANYMFFLMYLINKDE TEHTGQESYVWKMYQERCWDFYPAGDCFRKQYEDQLS NT seq 15054 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggtgcagatggagaggaagagattcagtttctgcgtacggatgatcaggtg gtgctacagtgcactgcatctattcttaaggagcagatcaagctgtgtctgtcatgcgaa ggatttggaaatcgcctgtgtttcctggagaccacctccaatgctcagaatatccctcca gaccttgctatctgctgcttcattttggaacagtctctttctgtgcgagcattacaggaa atgctctccaattcttctgtggatgagtcatcacaaggtgggggtcaccgcaccctgctg tacggacatgccatcctcctgaagcacactcactccagcatgtacttgtgctgtttgact acttcgcgctcactgacagacaaactggcttttgatgtgggtttgcaggaagactccaca ggggaggcctgctggtggaccatccatccagcctccaagcagaggtctgaaggcgagaag gtcagggtgggagatgacctcattcttgtcagtgtgtcttcagagcgatacctgcatctg tcctacgccagtggtgacttaatggtagatgcctctttcatgcaaacactgtggacaatg acccctgtgatgtctggatgtgaactggctgaaggttttctgaccggaggctatgtgctc aggctgtttcacggtcacatggacgagtgtttggcaatcccaggagctgaacaaggggac gaccagcgcagagttgcttattatgaaggcggggcagtatgcagtcacgctcgttcctta tggagacttgagcctctccgtatcggttggagcgggggccacattaaatggggccagtct ttccggatacgtcacataacaacaggccgatacctttgtctggatgaggagaagggactg ctgatagtggaccctgagaaggcaaattccaagatgtcagccttctgcttcagaatttca aaggaaaaaatcgaattgatccaaaagcgagatgtggaaggcatgggcacgcccgagatt aagtatggagagtccatgtgcttcgttcagcatgtttcaactggcctctggctcacatat gctgctgttgatgccaaatctgcccgcctgggtcctctaaagagaaaggccatactccat aaagaaggtcacatggatgatgcactcacagtggctcgatctcagaccgaagagtcccaa gctgccaggatgattttcagcacatcaggcctctttaaccagttcatcaaaggattagat gctttgggtgggaaaaacaaatcttccaactccacatccctccctatggacacagtggtg ctctccctgcaggacctcatcttttacttccgaccccccgaggaggagctggagcacgag gacaaacagttcaagctccgctccctcaagaacagacagaacctcttccaggaagaggga atgattactcatgtcctggactgcgttgatcgcctcaatgtctacaacacagcagcacac ttctcagagtatgctggagaagaagccgcagagtcgtggaaggagatagtcaatttactg tatgagttgcttgcttctttgatcagaggtaatcgtgccaactgtgccctgttctgtgat aacctcgactggctggtcagtaaattggatcgtttggaggcatcttcaggaatcctggag gtgttgtattgtgtcctgattgagagtccagaggtgctgaacattatccaggaaaatcac atcaaatccatcatctctctgctggacaagcatggacgcaatcataaggttttggatgtg ctctgctctctgtgtgtgtgtaatggggtggcggtgaggtcaaatcagaacctcatcaca gagaatctgcttccaggtcgtgacctcctacttcaaaccaacattatcaattatgttacc agcatgagacccaacattttccttggaacttgtgaaggatccactcagtacaagaagtgg tattttgaggtgatggtggacgaagtggagccgttcctcacagctcagccatatcacctg cgtgtgggttgggctctgacggagggctacagtccttaccctggtggaggggagggctgg gggggcaacggggtcggggatgacctctactcctacggtttcgacgggattcacctctgg tcaggacgtgttccgcgtcatgttgccacaccaaatcagcacatcctggcagcagaggat gtggtcagctgttgtttggatctgagcgtgcccagtatttccttccgaatcaatgggcat cccgtccagggcatgtttgagaacttcaacctggacagcttgttcttccctgttgtcagc ttctctgcaggcgtcaagttgcgattccttctcggagggcgtcatggggattttaagttc ctcccgcctccaggatatgctccatgctatgaggcagtactgccaagggaccgtctgcgg atcgagcccatcaaggagtataagcatgattttgatgccattcgcaacctgttgggtcca actcagtccctctcacataccgccttcactcctggccccgtggacaccatacagattgta cttcctcctcatttggagcgcattcgagagaagcttgcagaaaatagccatgagttatgg gctgttactcgcattgaacaaggatggacgtatggaccatttcgtgacgacaacaagaag ctgcacccctgcctggtagacttccagagtctgcctgaaccagagaagaactacaattta gcaatgtcaggagagacactcaagactctgctggcactgggctgtcatgtaggaatggga gatgagaaagcagaagagaatctgaaaaagaacaagctccccaaaacttacatgcaaagt agtggatataagccagcccctctggacctcagctatgtgaagctaactcctaatcagaac actctagtggagagactggcagaaaatggacacaatgtgtgggcaagagaccgggttcgt cagggctggacatacagtattgtgcaggatataatgaacaagcgcaatccccgtctggtt ccttacaacctgctggatgaaaagactaaaaagaccaacagggacacagtttgtgcagct gttcgcactctcatcggatatggttacaacatagaaccacctgaccaggagagcagcggg catggaccagcaactggtgataagatcagagtgttcagagcagagaaatcctatgccatt acacaggggaagtggtactttgagtttgaggctgtgacagtcggggagatgagagtgggc tgggccaggcccagtgttcgcgcagacactgaacttggtgcagatgagttggcatatgtc ttcaatggcttcaaggcccaacgttggcatgtgggaaatgagccatttggtcgacagtgg ctatctggtgatgtggtgggttgtatgattgacctcacggagatgaacatcatgttcaca ctcaacggagaaatgttgatcagcgactcaggctcggagatggcctttaaggatatcgag ataggagagggcttcatacctgtgtgcagtctgggcctgtcccagatcggcaggatcaac ttaggtcagaacgtcagcagtcttcgttattttaccatctgtggcctgcaggagggattt gaaccctttgctatcaacatgaaaagagacatcaccatgtggttcagcaagagccttccc cagttcatcaatgcgcctactgatcatcctcacatggaggtgtcccgtgttgatgggaca gtggaaactgccccctgtctcaaagtgacccacaagacatttggatcacagaacgccaac acagatttgctcttcttcagactcagcatgccagttgagtttcatgagaccttcaaagtc ccagcagggaccacccttcttacccgtacgatgacaatccctgaggatgaggtgttagag gtggatccagactctgactttgaaatactcaagaagtcagcttctcgcaaagagcaggaa gaggagaaaaaagagccctctgtgcccaaagagatacctgccaataaaaatggagaaaat gagaaggatgcctcaactgagaaaagcaagaagaaaggattcctcttcaaggctaagaag gctgcactaatatctccaccacctgttgttcccaccatgccccgcttaatggaagatgtg gtgccagatgacagggatgacgtcgacatcatcctcaacaccactacatactattattct gtgagagtgtttgcggggcaggagcccagtggcgtgtgggtgggctggatcacacccgac tatcaccagtatgaccaacattttgacatcagcaaagtgagaaatgtaacagtcactgta ggtgatgataaaggaaacattcacgacagtctaaaacgcagtaactgctacatggtctgg ggaggagagttcggcggcacccagcagacccgagtcagtcaagaggattttgtgattggt tgtcttattgatttggaaacaggactcatgactttcactgcgaatggaaaagagatcaac accttttaccaggtggagccaaacacaaaactgttcccagccgtctttgttcttccttcc agtcagaatatgattcagtttgaactaggcaagctgaagaacattatgccgatctcagcc gccatgttccgaagtgaacgcaagaaccctgttccccaatgccctcctagactggatgtc cagatgttaaccccagtcatctggagccgcatgcccaacaacttcctgtcaccagataca ggccgtgtcagtgagaggctgggctggggggtgcattgtcaggagccactcaccatgatg gccctccacatcccagaggagaacaggtgtattgacatcctggagctgtctgaacgcatg gacttgctgaagttccactatcatactctgaagctgtacggcttagtgtgtgctttggga aacaaccgtgtggctcacgctctgtgcagccatgtggatgagtcccagctcttctacgcc atagaggacacctacctacccggaccaatgaggagcggcttctatgacctgctcatcagc atgcacctggagtctgccaagaggaaccggctgggaaccaacaaggaattcatagttcca atgacggacaatacgcgcagtatcactctgtactctgacaaatctcatgctttacctgga gtcggccttactacgtgtctgcgtcccaaactccatttctcctccattgggtttgttgga accgaccaggacatctacacactgagtccagtcatccccctacagacactaaagaccaag gccctgaacatgctgacggaggctgtgcaagatggagttcaagccatgagagatcctgtg ggaggtagtgtcgagtttcattttgttccaatcctgaagctcatcagtaccctcctcatc atgggtgtgtttgacgatgaagatgtcacacacatccttaagatgcttgagcccacagtc ttcagtggcaagaaagcagaggagcctcaggaagacatcggggaagaagaagaggaattt gaggatgatggcttgggtgaagaggatgaggaagaaatggaggaagaggaacaattagag atgaaatcgattaaggagattaaagaggagaataaagaagaacgtctagagcaaggactc ttccagatgaagctgccagagtctgtcaaattgcagatgtgtaccctactgcagtatttc tgtgactgtgagctacgtcacagagtggaggccatcactgctttttcagaccagttcgtc agccagatacagtcaaaccagaggcagcgctataatgaacttatgctggccttcaccatg agtgccgctgagactgcccgcaagacccgtgaatttcgctccccaccacaggagcaggtc aacatgctcatgaacttcaagaactgtgctgaggatgaagagtgccctgttcccgatgag gtccgcgaagctctgctgacttttcacaatgctctgctggctcactgtggtgttcatatt gaggaagaagaacaagaggaagaagtggataattctctccgtggacgactggtccgtttg ttggcaaaggtgaaaaaaatccgggagaagaaggtagaagtggagcctgaaccacaagaa gataaaaaaccaagcacattgcaggagctgatttcccatactatgatacattgggcccag gagtcatttatccagaaccctgagctggtgcgaatgatgttcagcctccttcacagacag tatgatgggctaggtgagctcatgcgtgcccttccaaaggcctacaccatcaacgcagtg tcaattcacgacaccatggatttgctggagtgcttgggccagatccgctcactgcttatc gtccagatgggtccggaagaggagaggcttatgattcaaagcatcgggaacatcatgagt aacaaagttttctatcagcaccccaacttgatgcgagccttgggcatgcatgaaaccgtc atggaggtcatggtcaatgtgcttggcggcggggactcaaaggagatcagattccctcga gtggtgacaaactgctgccgttttctctgctatttctgtcgcatcagtcgccaaaatcag cgctctatgtttgaccacctcagctaccttctccaaaacagtggcatcggcctcggaatg cggggctccactcctttggacgtggctgcagcctcttgtatcgacaacaacgagctggcg ttggctctccaagagcaagatctagagatggtggtgaagtatttagctggatgtggactt cagagctgtccaatgctactgtctaaaggctatcctgacattggctggaatccttgtgga ggagagaaataccttgactttcttcgttttgctgtgtttgtcaatggagagagcgtagaa gagaatgccaatgtggtggtgcgtctcctcattcgcaggcctgagtgcttcggtccagcc ctgagaggagagggtggtaatggtttgctggctgcaatagaggaggccatcaaaatatca gaggaccctgcaagggatggtcctagtgttaaaaaagacagacgcttccccatgtttgga ggagaggagcagcatgaggagaacagggtgcacctgggaaatgccatcatgtccttctac tctgcccttattgacttgctgggacgctgtgctccagagatgcacttgatccaggctggt aagggtgaggccctgagaatcagagccatcctgaggtctctggtccccattgaggatctt gtgggagtcatcagccttccagttcagattccttcttttggaaaagacaacagcatcata gaaccaaagatgtcagctagttttgtgcccgatcacaaggctcccatggttctgttcctg gacagagtgtatggtattgacaaccaggatttcttgctccatgtgttggaggtcggcttt cttcccgacatgagggctgctgcttctctggacacggttgctttctgcactacagagatg gcccttgctttgaaccgctacctgtgttcagctgtgctgccactgatcaccaagtgtgcc ccactctttgctggcagcgaccaccgagccataatgattgattctatgttgcacacaatc taccggctgtctcgtggacgagccttcacaaaggcccaaagagacatcattgaagagtgc ctcatggctttgtgcaaacatctacgtccatccatgcttcagcacctgctaagacggctg gtgtttgatgtgcccattctcaacgagtatgccaaaatgcctctgaagcttttgaccaat cactatgagcgttgttggaaatattattgcctccctaatggttgggccaacttcggagtc tcatcagaagaggagctgcatctgacccgcaaactgttctgggggatctttgaatcgcta gcacacaagaaatttgatgctgagattttcaaaatttcaatgccatgcatctgcgccatc gctggagcaattccacccgactacgtagatgccagctactcatcaaaaacagagaaaaag gcatcagtggatgcagagggaaactttgatcctaaaccagtagagaccacaaacactatc atccccgagagactggatccctttatcaacaaatttgctgaatatacacatgatagatgg gcctttgaaaagatccagaataactggtcatatggagaggtgctggatgaaaatgcaaaa actcatccaatgctcagaccatacaaaactttctcagaaaaggacaaagagatctaccgt tggccaatcaaagagtcaatcaaagccatgcttgcatgggaatggaccctcgataaagca agagaggaagatgagtcagagaagaagaaggcagtatcacgaaaaatctcacagactgca caggcaacctatgacccaagccatggctacagtccacagcccatcgacatcacacacatg gctctttcaagagacctgcagtctatggcagagcaactggcagaaaattaccacaacacc tggggacgaaagaaaaagttggagctgcagtccaagggaggtggaacgcatcctctgctg gtgccctatgacactctgacagccaaagaaaaggcacgagacagagagaaggcttatgaa ctgcttaaattcctgcagcttaatggatatgctgtcacaaggggcctgaaagatatggag tctgacatctcatccatcgagaagagatttgcttatggtttcctgcagaagctgttgaaa tggatggaaattgcccaggagttcatcgctcatcttgaggctgttgtaagcagtggacga gtggaaaagtctcctcatgagcaggaaatcaaattctttgccaagatcttgatgcctcta atcaaccaatatttcaaaaaccactgcctctacttcttgtcgacgcctgcaaaagttctg ggtagcggtgggcattcttccaataaagagaaggagatgattgcaagtatcttctgtaaa atgtctgctctggtgaggcacagagtttctctctttggaacggacgcttcagcaattgtt aactgtcttcacattctggcacggtcgttggatgcaaggacggtaatgaagtcagggcct gagattgtgaaagcagggctgaggtccttctttgagagtgctgctgatgacatagagaag atggtagagaacctcaaactgggcaaagtatccaaaggcaatcagcaagtgaaaggcgtc tcccagaacattaactacacaaccattgccctgctcccagtgctcacctccctgtttgat cacattgctcagcaccagtttggagatgatgtcatgctggatgatctacagatgtcctgc tatcgcatcatgtgtagcatctactcccttgggactgtcaagaatccacatgttgagagg cagagaccagctctcggagaatgtttagctcaccttgcagcagctatgccagtggcctac ttagagccccatctgaatgaattcaatgcgttctctgtctacaccacaaagacacccaga gaaagagccatcttgggccttcccaatgaggtccaggagttatgtccagacatcccagag ctggatgctctgctgaaggagattggggacttggccgagtcgggggctcgttatactgag atgcctcatgtgattgaaatcaccctgcccatgctgtgcaactacctgcctcgctggtgg gagagaggacttgagaacttcccagagatggagagccagatctgcactgacgtcacatcc gaaagcctcaatcagctgctgggcagcatcatgaaaattgttgtcaacaacttgggtatc gatgaagcctcttggatgaagaggttggctgtgttttcacagcccattgtaagccgggca aagccagaaatgctcaagtcccacttcatccccacaatggagaagttgaagaaacgcact tcaaaggtggtggctgaagaggaccatttgcggatggaggggaaatcagagggggacgag gaagacggcaccatacgtgatgagtttgccgtcctctgcagagacttgtatgccctctac cctctacttattcgctacgtggacaacaacagggcaagatggctgacatacccagaccca gatgcagaagagctcttccgaatggttggcgaggtctttatcttctggtccaaatcccat aacttcaaacgagaggaacagaactttgttgtgatgaatgagatcaacaacatgtcgttc ctcaccgctgacagcaaaagcaaaatgagcaagggcggggactcagagggtggaggctca gatactgaacgtaccaagaagaaaagacgcggcgatcgttactcggtgcagacttcactt attgtggctgccttgaaaaagatgctccccataggcctcaacatgtgctctcccgccgat caggagcttatcaacttggccaagatcagatactctttgagagacactgatgaagaagtg agagagttcctgcagaacaaccttcatcttcagggcaaggtggacaacccgtccatgcgc tggcagatggctctgtataaggagatggcaggaaaggcagaagatgctgacgctcccatg aaagtcgtcaaaagagtgcaggaggtttctgctgtcctctaccacctggaagttacggag cacccgttcaaatcgaagaagatggtttggcacaaactgctgtccaagcagagacgcagg gctgtggtcgcttgctttaggatgacgccactatacaacatcccaaggcatagggcttca aacatgttcctcgagggatacaaacgcaattggcttcactctgagggttactcatttgaa gacaggatgatagacgacttatccaaagcaatggagcaagaagaaggagacgaagaagag gaaagagaaacaaagccagatcccctccaccagcttattctgcatttcagtcgtactgcg ctgacagaaaaaagtaaacttgatacagatcatctttatatggcatatgcagaaattatg gcaaagagttgccatattggtgaggaagaagaagggggagaggaaatgatggaaaatgct gaggatgagatgtcctttgaggaaaaagaaatggaaaaacaaaggctcttgtaccagcag tccagacttcataatcgtggtgctgcagagatggtcctgcagatgatcagtgcctgcaaa ggtgagactggaccgatggtgactacaaccctcaagctgggtatctctatccttaacggc ggaaacagtgaggttcaacggaaaatgctggagtacttgagggataagaaggatgtaggc ttctttttgagtgtccaggcactgatgcagacatgctctgtcctggatctaaatgccttt gagaggcagaacaaggcagagggactgggcatggtttcagaggagggcactagtaagtct tcatactatgagaaagtgatggcagatgatgagttcacctgtgacctcttccgtttcctg cagctgctttgtgagggtcacaataacgatttccagaactacttgcggacacagacgggc agcacgactaccatcaacatcatcatctgcaccgtcgattacctcctcagactccaggag tctatcagtgatttctactggtattactccggcaaggacatcattgatgaacccggcaaa aagaatttctccaaagctatgacagtggcaaaacagattttcaacagcctaactgaatac attcagggtccatgcactggcaaccagcagtccctggcccatagcaggctgtgggatgca attgttgggttccttcatgtctttgcccatatgatgatgaagctggcacaggactccagc cagattggtctgctgaaggagcttcttgacctacagaaagacatggttgttatgttgctc tcactgttagagggaaacgtggtaaatggtacaattgcacgccagatggtagacatgctg gtagaatcttccagcaacgtggagatgatcctcaagttcttcgacatgttcctcaaactg aaggacatcgtggcttcggatgctttccgcgattacgtcacagatcctcgagggctgatc tccaagaaggacttccagaaggccatggacagtcagaaacagtactccccctctgagatc cagttcctgttgtcctgctcagaagcagacgagaatgacatgatccactatgaggagttc gcaaatcgctttcaggaacctgcaaaggacatcggattcaacatcgcagtgctgctcacc aacctctctgagcacgtcccccatgacatcaggctacagaacttcctggaacaagcagat agtgtgctgaactatttccgaccattccttggccgtattgagataatgggcgccagcaga aagattgagcgcatctactttgaaatcactgaagtgaaccgcaaacagtgggagatgccg caggtcagagagtccaaacgtcagtttatctttgatgttgtcaatggcggtgaatcagag aagatggaaatgtttgtgaacttctgtgaagacaccatctttgagatgaatatagcctca caaatttcagagcaggaggaagagggaaagggggaggaagatgatgagccagatgaagtt ggaggtgagggaggacaagcggggggagcaaacggaggaggcgatgaagacaataacgga gaggaagggcagcctgaatcaagctctgcctttgcagatttcataaatagcgtgctatgc ttctttagcattttcaccttccgtaaccttcgcagacaatatcgcagagtgaggaagatg accctcaaggagatcgtggtggctttgaccacctttttctggaccatcctaatgagcata ctacacttcatttacaatgtgtgcaaaggcttctttatgatcatctggcaaacactgttc ggaggtggcctagtggagggtgctaaaaatatcaccgtcactgagattctagcaagcatg ccggacccaacgcaggatgatgtgcacggagacggaccaggggagccaaggacaggggag gaacaagacactggtggtgtaacggacactggggagactgggagtggagaggaggaagag gaggatacccaggaaaaagagggtgggaggataccaggcattgatgctccaggtggactt ggagacatgggtgttgaatcacctgttgaacctccaacacctgaaggaactcccataaca aagagaaaaaagcaaccagaagagactgacgctagccagaaaccgcctgaacctgttcct gtagtggaaactcctccagaacctgaaaaggctgatgttgagaatggagagaaagcagag aaagatgcccagagtaaggaggaagaaaggccagaagaacgaaagagatctgccaaaaag aaggaaaagaagccgaaaagggaaggaggttttcaaatctggaatgagctggaaacccaa agaaataaattcatgaactacctctccagaaacttctacaacttgcgttttttggcgctg ttcctcgcatttgccctgaacttcattctgctgttctacaaggtgtctgacagcccacct gacggtgacgagatggaaggatctggaatgtcggagggaagcgggatgttcgaaggctct gggttctttgaaggctcaggggaagaggctgagggatctggaatgaatgaaggagatgag gacgaggaagaagtcccaatttatttctatttggaggagagcactggctacatgcagcca gcattgtccttcattgccgccttgcacacagtcatctcattcatctgtatcattggctac aactgcctcaagattccactggtgatcttcaaaagggagaaagaacttgcaagaaaactg gagtttgacggcctctttatcactgagcagcctgaggatgatgacattaagggccagtgg gaccgactggtcctgaatacaccctctttcccaaacaactattgggataaatttgtcaag agaaaggttttggataagtacggcgacatttatggcagagaaagaattgctgagctcctg ggtgttgacttagcctccctggatgtgagtcaacaacatgagaagaaacaggaggagcca gacagctctgtgtttgcatggatgaccaccgttgacatcaagtaccaaatctggaaattt ggtgttgtgttcacagacggtaccttcctatatctctgttggtacacgattatgtccctg ctcggccattacaacaacttcttcttcgcctgccacttgctggacattgccatgggtgtc aagactctgcgcactattctgtcctcagtcacacacaatggcaaacagctgatgatgaca gtgggcttgttggctgtggtggtgtacctctacactgtagtcgccttcaatttcttccga aagttttacaacaagggcgaggacggggatgaaccggatatgaaatgcgacgacatgatg acttgttacctgttccacatgtacgtgggtgtgcgtgccggtggaggaatcggagatgag atagaggatcctgctggagatgaatacgagctatatcgagtggtctttgatataactttc ttcttcttcgtcattgtcatcctactggccattattcagggtctgatcattgatgccttt ggagaactcagagaccaacaagagcaggtcaaggaagacatggagacaaaatgcttcata tgtggcattgggagtgactactttgatacaacaccgcacggctttgagacccacactttg gatgaacacaacctggccaattacatgttcttcttaatgtaccttatcaacaaagatgag acggagcacactgggcaggagtcgtacgtgtggaagatgtaccaggagcgttgctgggac ttctaccctgctggagattgtttcagaaagcaatatgaggatcaactctcttag

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