KEGG   Antechinus flavipes (yellow-footed antechinus): 127550395
Entry
127550395         CDS       T08818                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
afz  Antechinus flavipes (yellow-footed antechinus)
Pathway
afz00562  Inositol phosphate metabolism
afz01100  Metabolic pathways
afz01521  EGFR tyrosine kinase inhibitor resistance
afz04012  ErbB signaling pathway
afz04014  Ras signaling pathway
afz04015  Rap1 signaling pathway
afz04020  Calcium signaling pathway
afz04062  Chemokine signaling pathway
afz04064  NF-kappa B signaling pathway
afz04066  HIF-1 signaling pathway
afz04070  Phosphatidylinositol signaling system
afz04072  Phospholipase D signaling pathway
afz04360  Axon guidance
afz04370  VEGF signaling pathway
afz04613  Neutrophil extracellular trap formation
afz04650  Natural killer cell mediated cytotoxicity
afz04658  Th1 and Th2 cell differentiation
afz04659  Th17 cell differentiation
afz04660  T cell receptor signaling pathway
afz04664  Fc epsilon RI signaling pathway
afz04666  Fc gamma R-mediated phagocytosis
afz04670  Leukocyte transendothelial migration
afz04722  Neurotrophin signaling pathway
afz04750  Inflammatory mediator regulation of TRP channels
afz04919  Thyroid hormone signaling pathway
afz04933  AGE-RAGE signaling pathway in diabetic complications
afz04935  Growth hormone synthesis, secretion and action
afz05012  Parkinson disease
afz05022  Pathways of neurodegeneration - multiple diseases
afz05135  Yersinia infection
afz05167  Kaposi sarcoma-associated herpesvirus infection
afz05170  Human immunodeficiency virus 1 infection
afz05171  Coronavirus disease - COVID-19
afz05200  Pathways in cancer
afz05205  Proteoglycans in cancer
afz05206  MicroRNAs in cancer
afz05214  Glioma
afz05223  Non-small cell lung cancer
afz05225  Hepatocellular carcinoma
afz05231  Choline metabolism in cancer
afz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
afz05417  Lipid and atherosclerosis
Module
afz_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:afz00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    127550395
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    127550395
   04014 Ras signaling pathway
    127550395
   04015 Rap1 signaling pathway
    127550395
   04370 VEGF signaling pathway
    127550395
   04064 NF-kappa B signaling pathway
    127550395
   04066 HIF-1 signaling pathway
    127550395
   04020 Calcium signaling pathway
    127550395
   04070 Phosphatidylinositol signaling system
    127550395
   04072 Phospholipase D signaling pathway
    127550395
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    127550395
   04650 Natural killer cell mediated cytotoxicity
    127550395
   04660 T cell receptor signaling pathway
    127550395
   04658 Th1 and Th2 cell differentiation
    127550395
   04659 Th17 cell differentiation
    127550395
   04664 Fc epsilon RI signaling pathway
    127550395
   04666 Fc gamma R-mediated phagocytosis
    127550395
   04670 Leukocyte transendothelial migration
    127550395
   04062 Chemokine signaling pathway
    127550395
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    127550395
   04919 Thyroid hormone signaling pathway
    127550395
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    127550395
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    127550395
  09158 Development and regeneration
   04360 Axon guidance
    127550395
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127550395
   05206 MicroRNAs in cancer
    127550395
   05205 Proteoglycans in cancer
    127550395
   05231 Choline metabolism in cancer
    127550395
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127550395
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    127550395
   05214 Glioma
    127550395
   05223 Non-small cell lung cancer
    127550395
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    127550395
   05171 Coronavirus disease - COVID-19
    127550395
   05167 Kaposi sarcoma-associated herpesvirus infection
    127550395
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    127550395
  09164 Neurodegenerative disease
   05012 Parkinson disease
    127550395
   05022 Pathways of neurodegeneration - multiple diseases
    127550395
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127550395
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    127550395
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127550395
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:afz04131]
    127550395
Enzymes [BR:afz01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     127550395
Membrane trafficking [BR:afz04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    127550395
 Endocytosis
  Macropinocytosis
   Phospholipase C
    127550395
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 127550395
NCBI-ProteinID: XP_051835255
LinkDB
Position
2:complement(444540396..444604059)
AA seq 1292 aa
MMAGVGAPFANGCGACAPSEAEALHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQ
ITWSRGADKIEGAVDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKT
LSLQATSEDEVNMWIKGLNWLVTDTVQAATPLQIERWLRKQFYSVDRNREDRISAKDLKN
MLSQVNYRVPNMRFLRERLTDMEQRSGDITYGQFAQLYRSLMFSAQKSMDLPFLEAGTLR
GGDRPELCRISLSEFQQFLLEYQGELWATDRLQVQEFMLSFLQDPLREIEEPYFFLDEFV
TFLFSKENNIWNSQLDSVCVDTMNNPLSQYWISSSHNTYLTGDQFSSESSLEAYARCLRM
GCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVTSEYPVILSIEDHCSI
AQQRNMAQYFKKVFGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSV
MYSENDISNSIKNGILYLEDPINHEWYPHYFVLTSSKIYYSEETNSDQGNEDEEEPKEVS
SSAELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSF
WRNGKVQHCRIHSRQDAGSPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLTEPVPQ
TNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRSEPNSYAISFRAEGKIKHCRVQQ
EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKMGTAEPDYGALYEGRN
PGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQL
WFPSNYVEEMANPATLEPEREQLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSI
SMASIAHWSLDVAADSQEDLQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVIY
CRPVPFDEDKIGTERACYRDMSSFPETKAEKYVNKTKGKKFLQYNRLQLSRIYPKGQRLD
SSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMSSGRCGYVMQPSNMRDEAFDPFDK
CSLRGIEPCAVCIEVLGARHLPKNGRGIVCPFVEIEVAGADYDNMKHKTEFVVDNGLNPV
WPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFLVKGLKTGYRAVPLKNNYSED
LELASLLIKIDIFPAKQENGEISPFGSSSFRERGSESSGQLLHGRAREGSFEARYQQPFE
DFRISQEHLADHFDSRERRALRRTRINGDNRL
NT seq 3879 nt   +upstreamnt  +downstreamnt
atgatggcaggggtcggggcccccttcgccaatggctgcggggcctgcgctccctcggag
gccgaggctcttcacctatgccggagtttggaagtaggcacagtcatgaccttgttctac
tccaagaaatcccagcgacctgagaggaaaaccttccaggtcaagttggagacccgacag
atcacgtggagtcgaggggcagataaaatcgagggagcggtcgatattcgtgaaatcaag
gagatccggcctgggaaaacctctcgtgattttgaccgttaccaggaggacccggccttc
cggcccgaccagtcccattgctttgttatcctgtatggcatggaattccgtctgaaaacg
ctgagtctgcaagccacatcggaggacgaagtgaatatgtggatcaaaggcttgaactgg
ttggtgactgacaccgtgcaggcggccacgcccctgcagatcgagaggtggctccggaag
cagttctactctgtggatcggaatcgggaagacaggatttctgccaaggatcttaagaac
atgctgtcccaggtcaactaccgagttcccaacatgcggttcctgagggaacggttgacg
gacatggagcagcggagcggggacatcacctatggccagtttgcccagctctaccgcagc
ctcatgttcagtgcccagaaatcgatggaccttcctttcctggaagccggcaccctgagg
ggcggggatcgacccgagctctgcagaatttccctgtcggaatttcagcagtttctcctg
gaataccagggggagctgtgggccactgacaggctgcaggtgcaggagttcatgctcagc
ttcctccaggacccacttcgggaaatcgaggagccctacttcttcctggatgagtttgtt
accttcctgttttccaaagagaataacatctggaactcccagctggattcggtgtgcgtg
gacaccatgaacaaccctctgtctcagtattggatctcttcatctcacaacacgtacctg
accggggaccagttctccagcgagtcctccttggaggcctatgcgcggtgcctccgaatg
ggctgccgatgcatcgagttggactgctgggatgggccagacgggatgccagtcatttac
catggacacaccctcaccaccaagatcaagttctctgatgttctgcacactatcaaggag
cacgccttcgtgacctcggagtaccccgtgatcttgtccattgaggatcattgcagcatt
gctcagcagagaaacatggcccagtacttcaagaaagtatttggggacacgcttctcacc
aagcccgtggacattgcggctgacggtctgccttcgcccaaccagctcaagagaaaaatc
cttatcaagcacaagaagctggcagagggcagtgcctacgaggaggtgcccacgtcggtg
atgtactcggagaacgacatcagcaattccatcaagaacggcatcctctatttggaagac
cccattaatcacgagtggtacccgcactattttgtactgaccagcagcaaaatctattac
tcagaggagaccaacagtgaccagggcaacgaggacgaggaggagccaaaggaggtgagc
agcagtgccgagctgcactccagcgagaaatggttccacgggaagctcggggccggtcgg
gacgggcgacacatcgccgagcggctgcttaccgagtactgcattgagaccggggccccc
gacggttcctttctggtccgggagagcgagacctttgtgggggactacaccctgtccttc
tggcggaacgggaaggtgcagcactgccggatccactcccgtcaggacgcgggcagcccc
aagttcttcctcacagacaacctggtgtttgactcgctctatgacctcatcacccactac
cagcaggtgccgctgcggtgcaacgagttcgagatgcgcctcacggagcccgtgcctcag
actaatgcgcacgagagcaaagagtggtaccatgccagtctgacccgagcccaggcggag
catatgctgatgcgggtgccccgggacggggccttcctcgtgcgaaagcggagcgagccc
aactcctacgccatctccttccgggcagaagggaagatcaaacattgccgggtccagcag
gaggggcagacggtgatgctggggaactccgagtttgacagccttgtagatctcatcagt
tactatgagaagcatccactgtatcgaaagatgaagctccggtaccccatcaatgaggag
gcactggagaagatgggcacggcggaacctgactatggagctctgtatgaaggacggaat
ccaggtttctacgtggaggcaaatcctatgccaacttttaagtgtgctgtcaaagccctc
tttgactacaaggcacagcgggaagatgagctgacctttacgaagagtgccatcatccag
aatgtggaaaagcaggagggaggctggtggaggggagactacggagggaagaagcagctc
tggtttccatccaactatgtggaagagatggccaatcctgccactttagagcctgagagg
gagcagttggatgagaacagccccctgggagatctgctccgtggagtcctggatgtgccc
gcctgccagatcgctatccgccccgaggggaagaacaaccgactctttgtgttctcgatc
agcatggcatccattgcccattggtccttggatgtggctgctgattcccaggaggaccta
caggactgggtgaaaaagatccgagaggttgcccagactgcggatgcccggctcacggag
ggaaagatgatggaacgaaggaagaaaattgccttagagctgtctgaacttgtcatttac
tgtcggcccgtccccttcgatgaggataagattggcactgagcgggcctgttaccgagac
atgtcatccttccctgagaccaaggcagagaaatacgtgaataagaccaaaggcaagaag
ttcttgcagtataatcggcttcagctgtcacgcatttaccccaagggccaacggctggac
tcttccaactatgaccctttgcccatgtggatttgtggcagccaacttgtggccctcaac
ttccagactccagacaaacccatgcagatgaaccaggccttattcatgtccagtgggcgt
tgtggctacgtgatgcagccaagcaacatgagagatgaagccttcgacccctttgacaag
tgtagcttgcgtgggatagagccatgtgcggtctgcattgaggtcctgggggcccggcac
ctccccaagaacggccgtggcatcgtgtgtccttttgtggagattgaggtggctggagcc
gactatgacaacatgaagcacaagacggaatttgtggtggacaatggtctgaaccccgtt
tggccggcaaagcccttccacttccagatcagcaaccccgagtttgctttcctgcgcttt
gtggtatatgaagaagatatgttcagtgaccagaatttcttggctcaggccaccttcctg
gtgaaaggcctaaagacaggatacagagcggtgcctttgaagaataactacagtgaggac
ttggagttggcctctctgcttatcaaaatagatatatttcctgccaagcaggagaacggg
gagatcagtccctttggcagctcgtcgttccgagaacggggctccgaatcttctggccag
ctgctccacggccgagcccgggagggctcctttgaagctcgctaccagcagcccttcgag
gacttccgcatctcccaggagcacctagcagaccactttgacagccgggaacgaagggca
cttcggagaactcgtatcaatggagacaaccgcctctag

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