| Entry |
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| Symbol |
rapB
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| Name |
(KEGG) rapamycin polyketide synthase B
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| KO |
| K16420 | rapamycin polyketide synthase A/B/C |
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| Taxonomy |
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| Lineage |
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group |
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| Organism |
Streptomyces rapamycinicus
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| AA seq |
10223 aa
MREDQLLDALRKSVKENARLRKANTSLRAAMDEPLAIVGMACRLPGGVSSPEDLWRLVES
GTDAISGFPADRGWDVENLYDPDPEAAGKSYCVQGGFLDSAGGFDASFFGISPREALAMD
PQQRLVLEASWEAFERAGIEPGSLRGSDTGVFMGAYPGGYGVGADLGGFGATAGAVSVLS
GRVSYFFGLEGPAVTVDTACSSSLVALHQAAYALRQGECSLALVGGVTVMATPQSFVEFS
RQRGLASDGRCKAFADSADGTGWAEGAGVLLVERLSDAQRKGHQVLAVVRGSAVNQDGAS
NGLSAPNGPSQQRVIRAALSNAGLSTAEVDVVEAHGTGTTLGDPIEAQALLATYGQDREQ
PLLLGSVKSNLGHTQAAAGVSGVIKMVMALQHVLVPRTLHVDEPSRHVDWTDGAVALVTE
NQPWPDMGRPRRAGVSSFGISGTNAHVILESAPPTQAVDDVPPAEAPVVASELVPLVISA
RTLPALVEYEDRLRAYLAASPGVDVRGVASTLAVTRSVFEHRAVLLGDDTVTGTTVSDPR
VVFVFPGQGSQRAGMGEELAAAFPVFARIHQQVWGLLDVPDLEVNETGYAQPALFALQVA
LFGLLESWGVRPDAVVGHSVGELAAGYVSGLWSLEDACTLVSARARLMQALPPGGVMVAV
PVSEDEARAVLGEGVEIAAVNGPSSVVLSGDETAVLQAAAALGKSTRLATSHAFHSARME
PMLEEFRTVAERLTYQTPRLAMAAGDRVTTAEYWVRQVRDTVRFGEQVASYEDAVFIELG
ADRSLARLVDGVAMLHTDHEAQAAISALAHLYVNGVTVDWTALLGDAPATRVLDLPTYAF
QHQRYWLEGADRAAAGGHPLLGPAVGLAEASGVLFTSQVSRSGDLWLQDQTVLPATAFAE
MALAAADETGCGLVEELTVEALLLLPDDGAVQVQTWVSEPDDAGRRQLSIHARYSDDELW
TRLATATLATTTGRVSGWQAGEAWPPAGAVPVEARVPSLRGVWRRGSEVFAEVALDDTHD
ATRFLLHPGLMTAAFAAVGEETPAAWQGLTLHARNAAELRVRLTSQDDETLSVEAVDSTG
LPVLTARSLALDAVPVNEPATSATDLLTLTWAGIATRQQQTGLTVGAFEDLAADGDAPVP
DVVVFTALPGNDDPLAQTRILTAQVLRTVQEWIGGERFSDSTLVVRTGTGLAAAAVSGLM
RSAQSEHPGRFILVESDDDALTPDQLAATVGLDEPRLRISDGRYEVPRLTRAHADEPEPE
RAWDPDGTVLITGGSGVLAGIVARHLVAERGVRHLLLLSRGTPDRALLSELAELGAAVDT
AACDVSDRAELARVLARVSPEHPLTAVIHTAGVVDDGVVESLSAQRLETVFRPKADGAWH
LHELTRDADLAAFVMYSSAAGVMAGAGQGNYAAANAFLDALAEERRAEGLPALAVAWGLW
EDASGLTAQLTDTDRDRIRRGGLRAISAEHGMRLFDNASRHSEPVLVAAPMEPVRDAEVP
ALLRSLHRPNVRRAALAGGAQWLAALAPEERAKALLKVVRDTAATVLGHADARTIPVTGA
FRDLGIDSLTAVELRNGLAKVTGLRLPATLVFDYPTPAVLAARLGELFTGENPVLVRTAS
VVGQDEPLAIVGMACRLPGGVSSPEDLWRLVESGTDAISGFPADRGWDAESLFDPDPDAV
GKSYCVEGGFLDSAASFDAGFFGISPREALAMDPQQRLIMEVSWEAFERAGIEPGSVRGS
DTGVFMGAYAGGYGAGADLGGFAATASATSVLSGRVSYFFGLEGPAITVDTACSSSLVAL
YQAGYALRQGECSLALVGGVTVMATPQSFVEFSRKSGLDSDGRCKAFADSADGTGWAEGV
GVLLVERLSDAQAKGHQVLAVVRSSAVNQDGASNGLSAPNGPSQQGVIRQALANAGLTTA
EVDVVEAHGTGTTLGDPIEAQAVIATYGQDRERPLLLGSLKSNIGHAQAASGVSGVIKMV
MALQHNTVPRTLHVDEPSRHVDWAAGAVELVRENQPWPGTDRPRRAGVSSFGVSGTNAHV
ILESAPPAQPAEEAQPVETPVVASDVLPLVISAKTQPALTEHEDRLRAYLAASPGVDTRA
VASTLAVTRSVFEHRAVLLGDDTVTGTAVSDPRVVFVFPGQGWQWLGMGSALRDSSIVFA
ERMAECAPALREFVDWDLFTVLDDPAVVDRVDVVQPASWRMMVSLAAVWQAAGVRPDAVI
GHSQGEIAAACVAGAVSMRDAARIVTLRSEAIARGLAGRGAMASVALPAQDVELVDGAWI
AAHNGPASTVIAGTPEAVDHVLTAHEARGVRVRRITVDYASHTPHVELIRDELLDITSDS
SSQAPVVPWLSTVDGSWVDSPLDVEYWYRNLREPVGFHPAVGQLQAEGDTVFVEVSASPV
LLQAMDDDVVTVATLRRDDGDATRMLTALAQAYVHGVTVDWPAILGTATTRVLDLPTYAF
QHQRYWLRSVDRAAADGHPLLGTVVDLPASDGVVLTGRVSLATHTWLADHAVRGSVLLPG
TAFVDLVVRAADEVESDVVDELVIETPLLLPQTGGVQLSVSVGGADESGHRAVMVFSQAD
NTDTWTRHVTATVSTSDSTVSLPEFASWPPAQARPVSVADFYDRLAAAGTEYGPAFQGLQ
AAWRDGDTVYAEVVLAEEQAQEAARFAVHPALLDAAMHASVLHTPDTDQQSVRMPFSWNH
VQIRATDTAMLRVAATPTTDGWSVRVADDTGRPVATIGSLVTRPVTADTLGSAADDLLTL
VWTEIPTPQQSSLSVGRYEDLADGDVPVPDVAVYTARPEADGSPDPLVQTRTLTAQVLQT
AQAWLGGERFTDSTLVVRTGTGLAAAAVSGLMRSAQSEHPGRFVLVESDDDSLTLHQLAA
TVGLDEPRLRVNDGRFEVPRLARVNAAEPESETVWDPHGTVLITGGSGVLAGALARHLVT
ERGVRHLLLLSRTTADEGLLNELGELGARVETADCDVSDRAGLARVLAGVSPEHPLTAVI
QTAGALDDGVLETLTAQRLDTVLRPKADGAWHLHELTRNTGLAAFVMYSSAAGVMGNPGQ
GNLAAATAFLDALADQRRAEGLPALALAWGSSEETSDLIGLRTISAERGMRLFDSASHRG
EPLLMAASLDPARAAEVPALLRSLRRPVARRAASADGGVQWLAALAPAEREKALLKVVCD
SAAVVLGHADARTIPVTGAFKDLGVDSLTAVELRNSLVKATGLRLPATMVFDYPTPTALA
ARLDELFTGENPAPVREPVPAVAQDEPLAIVGMACRLPGGVSSPEDLWRLVESGTDAVSG
FPTDRGWDVEGLFDPDPDAAGKSYRAEGGFLDTAAGFDAGFFGISPREALAMDPQQRLLL
EVSWEAFERAGIEPGSVRGSDTGVFIGAFPVGYGAGAAREGYGATAAPNVLSGRLSYFFG
LEGPAITMDTACSSSLVALHLAAQALRNGECSMALAGGVTVMATPEVFTEFARQRGLASD
GRCKAFADSADGAGFSEGAGLLLVERLSDARRNGHQVLAVVRGSAVNQDGASNGFTAPNG
PAQQRVIRQALANAGLTTAEVDVVEAHGTGTTLGDPIEAQAVIATYGQDREQPLLLGTLK
SNVGHTQAAAGVSGVIKMVMALQHSTVPRTLHVNEPSRHVDWSAGAVELVTENQSWPVTG
RPRRAGVSAFGVSGTNAHVVLESAPPAQSVNNAQPVATPVVASELVPLVISAKTLPALTE
HEDRLRAYLAASPGADMRAVGSTLALTRSVFEHRAVLLGHDTVTVTGTGTAVSNPRVVFV
FPGQGWQWLGMGSALRGSSVVFAERMAECAAALSEFVDWDLFAVLDDPAVVDRVDVVQPA
SWAVMVSLAAVWQADGVRPDAVIGHSQGEIAAACVAGAVSLRDAARSVTLRSQAIARGLA
GRGAMASVALPAHEIELVDGAWIAAHNGPASTVVAGAPEAVDRVLAVHEARGVRVRRIAV
DYASHTPHVELIRDELLDITAGIGSQAPVVPWLSTVDGTWVEGPLDVEYWYRNLREPVGF
DSAVGQLRAEGDTVFVEVSASPVLLQAMDDDVVTVATLRRDDGDATRMLTALAQAFVEGV
TVDWPAILGTATTRVPDLPTYAFQHQRFWAEGADRSVAGGHPLLGVAVELPESDGVLLTG
RVSLATHAWLADHAVRGSVLLPGTGFVELVVRAADEVGCDVVDELVIETPLLLPSSASVH
LSVSVGEADESGRRGVTVFSRADGADAWTRHVSATIGVSGAALSLPELAAWPPAQAQPVG
LGDFYDRLTGAGYEYGPAFQGLQAAWRDGDTVFAEVALAEEQAEEAARFAVHPALLDAAL
DAGILNTLDNAEQGVRLPFSWNGVQVRATGSATLRVADNPTSDGWSVRVADDSGRPVATV
DSLVTRPVTADTLGSAADDLLTVVWTEIPTPQQTGLSVGRFEDLADGDVPVPEVVVCTAL
PDSSENPLAPLDPPDPLVQTRTLTTQVLQAVQAWLAGERFTDSTLVVRTGTGLATAGVSG
LMRSAQSEHPGRFVLVECDDNLTLQQLAATVGLDEPRLRVCDGRFEVPRLARANTPESSP
LTIPGDRAWLLEQSHSGTLRDLALVPAETAERPLQSGEVRVDVRAAGLNFRDVLIALGTY
PGEAVIGAEAAGVVLEVGPEVQDLAPGDRVFGLVGGGFGAVAIADRRMLGVIPDGWSFTT
AASVPVVFATAYYGLVDLAGLSAGESVLIHAAAGGVGMAATQIARHLGARIYATASTGKQ
HVLREAGLEDARIGDSRTTGFREMVLDTTDSRGVDVVLNSLSGDFVDASLDLLPRGGRFV
EMGKTDIRDPHQVTADRPGTSYQAFDLMDAGPDRLREIIADLLALFAQGVLLPLPVRAWD
IRQAREAFSWMSRARHIGKIVLTVPQQLDANGTVLVTGGSGVLAGIAARHLVAEQGVRHL
LLLSRSTPDDALINELGELGARVDTAICDVSDRAGLARILAGVSPEHPLTAVIHTAGALD
DGVVESLTAQQLETVLRPKADGAWHLHELTRDADLAAFVMYSSAAGVLGSGGQGNYAAAN
AFLDALAEQRRGEGLPALAVAWGLWEDASGLTAEMTDTDRDRIRRGGLRAISAGHGMGLL
DAASRHGEPVLLAAAMEPVREAEVPALLRLLHRPVARRAASTGGSSVQWLARLAPVEREK
ALLKLVCDGAATVLGHADASTIPATAAFKDLGIDSLTAVELRNSLTKATGLRLPATLVFD
YPTPTALAARLGEWFVGETPVPVRTSVSVVAQDEPLAIVGMACRLPGGVSSPEDLWRLLE
SGTDAVSGFPTDRGWDVENLFGPAAGDSYRLQGGFLDAAAGFDASFFGISPREALAMDPQ
QRLVLEVSWEAFERAGIEPGSVRGTDTGVFMGAYPGGYGIGADLGGFGATASAVSVLSGR
VSYFFGLEGPAITVDTACSSSLVALHQAGYALRQGECSLALVGGVTVMATPQTFVEFARQ
GGLAGDGRSKAFADSADGAGFSEGVGVLLVERLSDAQAKGHQVLAMLRSSAVNQDGASNG
LTAPNGPSQQRVIQAALSNAGLAAHEVDVVEAHGTGTTLGDPIEAQALLATYGQDREQPL
LLGSVKSNLGHTQAAAGVSGVIKMVMALQRGFVPRTLHVDEPSRHVDWSAGAVALVTENQ
PWPDMGRARRAGVSSFGISGTNAHVILESAPPTQPADNAVIERAPEWLPMVISARTQSAL
TEHEGRLRAYLAASPGVDMRAVASTLAITRSVFEHRAVLLGDDTVTGTAATDPRVVFVFP
GQGSQRAGMGEELAAAFPVFARIHQQVWDLLDVPDLEVNETGYAQPALFALQVALFGLLE
SWGVRPDAVVGHSVGELAAGYVSGLWSLEDACTLVSARARLMQALPAGGVMVAVPVSEDE
ARAVLGEGVEIAAVNGPSSVVLSGDEAAVLQAAEGLGKWTRLATSHAFHSARMEPMLEEF
RAVAEGLTYRTPQVSMAAGDQLTTTEYWVRQVRDTVRFGEQVASYEDAVFVELGADRSLA
RLVDGVAMLHGDHEAQAAVSALAHLYVNGVTVDWPALLGDAPATRVLDLPTYAFQHQRYW
LEGTDRMAAGGHPLLGEAVAVPGSDGVLLTGRVSLATHPWLADHAVRGSVLLPGTGFVEL
VVRAADEVGCDVIDELVIETPLLLPQTGGVQLSVAVAESDDSGRRAVTVFSRADNVDTWT
RHATVTVSNSDTTLSLPDLSAWPPAQAQPVNVADFYDQLTVVAYEYGPAFQGLQAAWRDG
DTVHAEVALAEEQAQDAARNAVHPALLDAALHAGILNTPDTEQGVRLPFSWNQVQVHAVG
SAMLRVAVTQAADGWSVRVADDTGRPVATIGSLVTRPVTADTLGSTTDDLLALTWTEIPA
PQETSLTIGRFEDLADADVPVPEVVVFTARPDSSENPLAQTRTLTAQVLQKIQAWLAEER
FTDSTLIVRIGTGLAAAAVSGLMRSGQSEHPGRFVLVESDDDTLAPDQLAATVELDEPRL
RISDGRFEVPRLTRTHAAEPESEKVWDPDGTVLITGGSGVLAGIAARHLVAERGVRHLLL
LSRSAPDGALISELGELGAQVATAVCDVSDRPGLVRVLADVSPEHPLTAVIHTAGVVDDG
VVESLTAQRLDTVLRPKADGAWHLHELTRDADLAAFVMYSSAAGVFGSAGQGNYAVANAF
LDALAEQRRAEGLPALALAWGLWEGTSGLTANLTDTDHDRIRRSGMRAISAEHGMRLFDG
ASRRRDPVLVAAAMEPVREAEVPAMLRSLHRPVARRAASGGAVRCLAALAPEERAKALVK
VVCDSAATVLGHADVDSIPVTAAFRDLGVDSLTAVELRNSLTKATGLRLPATLVFDYPTP
GALAARLEELFTGENPVQVRTPVSAVGQDEPLAIVGMACRLPGGVSSPEDLWRLVESGTD
AISGFPTDRGWDVENLFDSDPDAAGKSYCVEGGFLATAANFDASFFGISPREALAMDPQQ
RLVLEVSWEAFERAGIEPGSVRGSDTGVFMGAFPGGYGIGADLEGYGATAGLNVLSGRLS
YFFGLEGPAVTVDTACSSSLVALHQAGYALRQGECSLALIGGVTVMATPHTFVEFSRQRG
LASDGRCKAFADSADGTGWSEGVGVLLVERLSDAQAKGHQVLAVVRSSAVNQDGASNGLS
APNGPSQQRVIRQALANAGLTTAEVDVVEAHGTGTTLGDPIEAQAVIATYGQDRDQPVLL
GSVKSNVGHTQAAAGVSGVIKMVMALQHGLVPRTLHVDEPSRHVDWTDGAVELVTENQSW
PEAGRPRRAGVSSFGVSGTNAHVILESAPPTQAVDDVRPADAPVVASVMASELVPLVISA
KTQSALAEYEGRLRAYLAASPGVDMRAVASTLAMTRSVFEHRAVIVGDDTVSGTAATDPR
VVFVFPGQGSQRAGMGAELAAAFPVFARIHQQVWDLLDVPDLEVNETGYAQPALFALQVA
LFGLLESWGVRPDAVIGHSVGELAAAYVSGLWSLEDACTLVSARARLMQALPAGGVMVAV
PVSEDEARAVLGEGVEIAAVNGPSSVVLSGDEAAVLQAAEGLGKWTRLATSHAFHSARME
PMLEEFRAVAQGLTYHAPGVVMAAGDRVMTAEYWVRQVRDTVRFGEQVASYEDAVFVELG
ADRSLARLVDGVAMLHGDHETQAAIGALAHLYVNGVTVDWTALLGDVPVTRVLDLPTYAF
QQQRYWAEVGRSADVSGAGLDAVGHPLLGAVVALPGSDGVLLTGRVSLATHAWLADHAVR
GSVLLPGTGFVELVVRAADEVGCDVVDELIVEAPLLLPQTGGVQVSVSVGEADESGHRVV
TIFSRADNADTWVRHVSAVISTSDSTVSLSEFASWPPAQAQPVDVTGFYDPLMAEGYEYG
PAFQGLQAAWRYGDTVFAEVALAEEQVREAARYPSVHPALLDAALHACTLECADAEVGVG
LPFSWDGVRVHAGGSAMLRVAVTQAADGWSVRVADEIGRPVANVGSLVTRPVTADALGSA
ADDLLALTWAEIPAPEGTGLTVGRFEELVSDGDVPVPEVAVFTALPDNDDDPLEQTRKLT
GQVLQAVQEWLGGERFSDSTLVVRTGTGLAAAGVSGLMRSAQSEHPGRFVLVESDDDALA
LDQLAAAVGLDEPRLRISDGRFEAPRLTRTHAAEPESEKVWDPDGTVLITGGSGVLAGIA
VRHLVTERGVRHLLLLSRSAPDEALINQLGELGARVETAACDVSDRAALAQVLAGVSPEH
PLTAVIHTAGVLDDGVVESLTAQRLDAVLRPKADGAWNLHELTRDADLAAFVMYSSAAGV
LGSGGQGNYAAANAFLDALAEQRHAEGLPALAVAWGLWEDASGLTAQLTDTDRDRIRRGG
LRAISAEHGMGLFDSASRHSEPVLVAAPMEPVRDAEVPALLRSLHRPVARRAAAAGGARW
LAALAPAEREKALLKLVSDGAATVLGHADTSTIPATTAFKDLGIDSLTAVELRNSLAKAT
ELRLPATLVFDYPTPTALAARLDELFTGENPAPVRGPVSAVAQDEPLAIVGMACRLPGGV
SSPEDLWRLVESGTDAISGFPTDRGWDVENLYDPDPDAPGKSYSVQGGFLDAAAGFDASF
FGISPREALAMDPQQRLMLEVSWEAFERAGIEPGSVRGSDTGVFIGAYPGGYGIGADLGG
FGTTAGAASVLSGRVSYFFGLEGPAFTVDTACSSSLVALHQAGYALRQGECSLALVGGVT
VMPTPQTFVEFSRQRGLSADGRCKAFADAADGTGWAEGVGVLLVERLSDAQANGHQILAV
VRSSAVNQDGASNGLSAPNGPSQQRVIRAALSNAGLAPHEVDVVEAHGTGTTLGDPIEAQ
AVIATYGQGRGEPLLLGSLKSNVGHTQAAAGVSGVIKMVMALQHSMVPRTLHVDEPSRHV
DWSAGAVELVAENQPWPETGRPRRAGVSSFGISGTNAHVILESAPAQSVGDTAGSTPVLV
SELVPLVISAKTQPALTEHEDRLRAYLAASPGVDIRAVASTLAVTRSVFEHRAVLLGDET
VTGTAVSDPRIVFVFPGQGWQWLGMGSALRDSSVVFAERMAECAAALSEFVDWDLFAVLD
DPAVVDRVDVVQPASWAVMVSLAAVWQAAGVRPDAVIGHSQGEIAAACVAGAVSMRDAAR
IVTLRSQAIARGLAGRGAMASVALPAQDVELVDGAWIAAHNGPASTVIAGTPEAVDHVLT
ALRQRGAGAADHVDYASHTPHVELIRDELLDITSDSSSQDPLVPWLSTVDGTWVDSPLDG
EYWYRNLREPVGFHPAVSQLQAQGDTVFVEVSASPVLMQAMDDDVVTVATLRRDDGDATR
MLTALAQAYVHGVTVDWRAVLGDVPATRVLDLPTYAFQHQRYWAEAGRSADVSAAGLDAV
GHPLLGAVLAMPGSDGVMLTGRVSLATHAWLADHAVRGSVLLPGTGFVELVVRAADEVAC
DVVDELIVEAPLLLPQTGGVQLSVSVGEADESGHRAVTVFSRADSADAWVRHVSATVSVS
DTTVPTSDLTAWPPAQAKPVDVAGFYDQLTRAGYEYGPAFQGLQAAWRDGDTVFAEVALA
EEQTQDAARFAVHPAVLDAALHAGILNTPDADRDTVRLPFSWNHVQVHVTGSATLRVAMT
RVADGWGVRVADDIGRPVATIGSLVTRPVAADALGSAVDDLFALTWTEIPVSQQVGVTVG
KFEDLADGEVPMPDVVVFTALPDSGDPLAQTRRLTAEVLQAVQVWLAGERFTDSTLVVRT
GTGLAAAAVSGLMRSAQSEHPGRFVLVESDDDTLTPDQLAATVGLDEPRLRVIDGRYEAP
RLTRTGVAEPEPEGVWDPDGTVLITGGSGVLAGIAARHLVAERGVRHLLLLSRSAPDEAL
ISELAELGAAVVDTAVCDVSDRAGLARVLAGVSPDHPLTAVIHTAGVLDDGVVESLTARR
LDTVLRPKADGAWNLHELTRDIDLAAFVMYSSAAGVLGSAGQGNYAVANAFVDALAEQRR
AEGLPALALAWGLWEDASGLTAKLTGTDHDRIRRSGLRTITAERGMRLFDIASRQGEPVL
VATPMEPVREVEVPALLRLLHRPVARRAASTGDSSAQWLVGLAPEERAKALLKVVRDSAA
TVLGHADARSIPATGAFKDLGVDSLTAVELRNSLTKATGLRLPATMVFDYPTPADLAARL
GDLMNPRVQSTTLLAEIDRIEKMFTSVTFDDRQASAIKDRLSSVLNKWQRISSPEEVSTT
ALSSASASEILDFIDREFGDPTA |
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| Reference |
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| Authors |
Schwecke T, Aparicio JF, Molnar I, Konig A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB, et al. |
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| Title |
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. |
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| Journal |
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