| Entry |
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| Symbol |
rapA
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| Name |
(KEGG) rapamycin polyketide synthase A
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| KO |
| K16420 | rapamycin polyketide synthase A/B/C |
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| Taxonomy |
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| Lineage |
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group |
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| Organism |
Streptomyces rapamycinicus
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| AA seq |
8563 aa
MSRAELVRPIYDLLRANAERLGDKIAYVDSRLALTHAELATRTGRIAGHLVDMGVDRGDR
VAILLGNRVENIESYLAIARASAVAVPLNPDATEAEVAHFLSDSGAVAVITDSAHLDDVR
RTAPAANIVLVGEERTPPGVRSFAELATTEPLRPPRDDLGLDEPAWMLYTSGTTGTPKGV
LSTQGSGLWSAAYCDIPAWELTENDVLLWPAPLFHRLALHLCLLATTAVGATARIMNGFV
ASEVLEELTEHRCTVLVGVPTMSRYLLGAADTFEPRTSSLKMGLVAGSVAPASLIEGFED
VFGVPLLDTYGCTETSGSLTVNWLSGQRIPGSCGLPVPGLSLRFVDPISGADVADGEEGE
LWASGPSIMIGYHEQPEATAEVLSDGWYRTGDLARRSETGHVTITGRIKELIIRGGENIH
PHEIEAVALDVPGVKDAAAAGKQHPVLGEIPVLYVVPETGGVDTDMVLAVCRERLSYFKV
PEEIYRVDAIPRTASGKVKRSSLTEKPAELLAGASGGETLHRLEWIPLDPPKQASPDGRH
VVVRVDSLPSDAADLAGAVRDLAQSWLADKRRADSTLVFVTRRAVHTGPSDLPVPEHAAA
WDAIRREQTENPGVFVVIDVDFDDADPDPDDTLLRALAGLGEPQLALRDGNPLVPRLAHA
NTADSDSLTIPEDRAWLLEHSRSGTLRDLALVPADTAERPLRPGEVRIAVRAAGLNFRDV
LIALGTYPGEGLMGGEAAGVVLEVGPEVHDLTPGDRVFGLVGSAFGGVAITDRRLLGAIP
DTWSFTTAASIPIVFATAYYGLVDLSGLSAGETVLIHATAGGVGMAATQSACRHLGPRIH
ATASAAKQHILREAGLEDTRIADSRTLAFREAFLNTTDGQGVDVVLNSLSGDFVDASLDL
LPRGGRFLEMGKTDIRDADRITADRPGTTYQAFDLLDAGPDRLREIIAELLELFAQGVLR
PLPVLTWDIRKARDAFSWMSRARHTGKITFTIPRRLDPDGTVLIADGAGALTGTVARHLV
AEQGVRHLLLLSRSTPDEALINELIESGARVDTAVCDVSDRAGLVRTLAGIAPERPLTAV
IHTGGPAVAHESHQLHRLTKGLDLAAFVVFSQDAPASVDALARSRRAEGLPITAIAWGIP
EAEAVVVRGPLLGRAMASADSAHIVTRLNTVGLRALAAADTLPPLLQNLVGAHTDTTEQQ
AWSRQFLAAEAAREQALRDLVRSSVTDILGLSAADRYAPDKTSREMGIDSLTSVELRNSL
AKATGLRLPATLVFDYPTPAVLVVRLGELFTGESPAPERAVSAVGQGEPLAIVGMACRLP
GGVSSPEDLWRLVESGTDAISGFPTDRGWDVDGLFDPDPDASGKSYCVQGGFLDTAAGFD
ASFFGISPREALAMDPQQRLVLEVSWEAFERAGIEPGSVRGSDTGVFMGGFPGGYGAGAD
LEGFGATAGAASVLSGRVSYFFGLEGPAITVDTACSSSLVALHQAGYALRQGECSLALVG
GVTVMPTPQSFVEFSRQRGLSADGRCKAYADAADGTEWAEGVGVLLVERLSDAQAKGHQV
LAVVRGSAVNQDGASNGLSAPNGPSQQRVIRAALSNAGLAPHEVDVVEAHGTGTTLGDPI
EAQAVIATYGQDREQPVLLGSLKSNIGHAQAAAGVSGVIKMVMALRHGFVPRTLHVDEPS
RHVDWSAGAVELVAENRSWPATGRPRRAGVSAFGVSGTNAHVILEGAPAQSVDDAAGSTP
VVDSELVPLVVSAKSLPALAEVEGRLRAYLAASPGADVRAVGSTLAVTRSLFEHRAVLLG
DDSVTGTGTAVSDPRVVFVFPGQGWQWLGMGSALRTSSMVFAERMAECAAALSEFVDWDL
FAVLDDPAVVARVDVVQPASWAVMVSLAAVWQAAGVRPDAVVGHSQGEIAAACVAGAVSL
RDAARVVTLRSQVIARGLAGRGAMASVALPAQDVELVDGAWVAARNGPASTVVAGAPEAV
DRVLAVHEARGVRVRRIAVDYASHTPHVELIRDELLGVIAGVDSRAPVVPWLSTVDGTWV
EGPLDAEYWYRNLREPVGFEPAAGQLQAQGDTVFVEVSASPVLLQAMDDDVVTVATLRRD
DGDATRMLTALAQAYVEGVTVDWPAVLGTTAARVLDLPTYAFQHQRYWLKGVDRAAADGH
PLLGTVVALPGSDGVVLTGRVSLATHAWLADHAVRGSVLLPGTAFVELVVRAAGEVGCDV
VDELVIETPLLLPQTGGVQMSVSVAEADESGHRAVMVFSQADNTDTWTRHVTATVSTSDS
TVSQPEFAAWPPPAGAEPLDLSDFYDQLTGAGYEYGPAFQGLRTAWRDGNTVFAEVALAE
EQAQEAARFAVHPALLDAALHASNLSTLDTAEQGVRLPFSWNQVWVHATGPVMLRVAITR
TADGWSVLVADDSGRPVASVGSLVTRVVTADALGSAADELLALTWMEIPAPQGTGLTVGR
FEDLVSGGDVPVPEVVVFTALPGSSETPLDPLDPLAQTRTLTAQVLQAVQAWLAGEGFTN
STLVVRTGTGLAAAGVSGLMRSVQSEHPGRFVLVECDDDTLTPDQLAATVGLDEPRLRVC
DGRFEVPRLARANTPESSPLTIPDSRAWLLEQPRSGTLRDLALVPTDTAERPLQSGEVRV
DVRAAGLNFRDVVVALGMVDDKRLAGGEAAGVVLEVGPEVQDLAPGDRVFGLVGGGFGRS
AIADRRMLGVIPDGWSFTTAASVPVVFATAYYGLVDLAGLSAGESVLIHAAAGGVGMAAT
QIARHLGARIYATASTGKQHILREAGLEDTHIADSRTLSFQETFLNNTHGQGVDVVLNSL
SGDFVDASLDLLPRGGRFIEMGKTDIRDPHQVTADRPGTTYQAFDLMDAGPDRLREIITE
LLTLFTQGVLLPLPVQAWDIRQARDAFSWMSRARHIGKIVLTIPRRPDPDGTILITGGSG
VLAGILARHLAAEHGARHLLLLSRTTPDQALIKELAELGAHVDTATCDVSDRAGLARVLA
GVSPEHPLTAVIHTAGALDDGVVESLTTQQLDTVLRPKADGAWHLHELTQNTDLAAFVMY
SSAAGVLGSAGQGNYAAANAFVDALAEQRRGEGLPALAVAWGLWEDTSGLTAKMTDTDRD
RIRRGGLRAISAGRGMGLLDAASRHGEPVLLAASMEPVRDVEVPALLRLLHRPVARRAAS
TGDSSVQWLARLAPVEREKALLKLVCDGAATVLGHADASTIPATGAFRDLGVDSLTAVEL
RNGLAKATGLRLPATLVFDYPTPAALAARLEELFTGENPAPVRTSVSVVAQDEPLAIVGM
ACRLPGGVSSPEDLWRLLESGTDAVSGFPTDRGWDVENLFGPAVGNSYRLQGGFLDAAAG
FDASFFGISPREALAMDPQQRLVLEVSWEAFERAGIKPGSVRGTDTGVFMGAYPGGYGIG
ADLGGFGTTAGAVSVLSGRVSYFFGFEGPAFTVDTACSSSLVALHQAGYALRQGECSLAL
VGGVTVMATPQTFVEFARQGGLAGDGRSKAFADSADGAGFSEGVGVLLVERLSDARRNGH
QVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALSNAGLSTAEVDVVEAHGTGTTLGD
PIEAQALMATYGQDREQPLLLGSVKSNLGHTQAAAGVSGVIKMVMALQRGFVPRTLHVDE
PSRHVDWSAGAVQLVTENQPWPGTDRPRRAGVSSFGISGTNAHVILESALPTQPAGNTVV
ESAPEWVPLVISARTQSALAEYEGRLRAYLAASPGADTRAVASTLAMTRSVFEYRAVLIG
DDTVTGTAATDPRVVFVFPGQGSQRAGMGEELAAAFPVFARIHQQVWDLLDVPDLDVNET
GYAQPALFALQVALFGLLESWGVRPDAVVGHSVGELAAGYVSGLWSLEDACTLVSARARL
MQALPAGGVMAAVPVSEDEARAVLGEGVEIAAVNGPSSVVLSGDEAAVLQAAEGLGKWTR
LPTSHAFHSARMEPMLEEFRAVAEGLTYRTPQVAMAAGDQVMTAEYWVRQVRDTVRFGEQ
VASFEDAVFVELGADRSLARLVDGIAMLHGDHEAQAAVGALAHLYVNGVSVEWSAVLGDV
PVTRVLDLPTYAFQHQRYWLEGTDRATAGGHPLLGSVVRLAEASGVLFTARVSRSGDLWL
RDQTVLPATVFVEMALAAADEVGCGLVEDLSVEALLLLPDDGAVEVQTWVGEPDEGGRRR
LSVHARYGDGEPWTCLATATLATTTGVAAAAVGWQAGGVWPPAGAVPVGTSAPSLRAVWR
LGSDIFAEVALDDAHDATRFVLHPALMAAALTTVGEETPAVWQGLTLHAGNPGELRVRLT
SHDDGTLSAEATDSTGLPVLTARSLTLRTVPVYEPATSTDDLLTLTWAGIPTPQQTGLTV
GAFEDLAADGDVPVPEVAVFTALPDSDDPLEQTRKLTAQVLHTLQEWLGGERFSDSTLVV
RTGTGLAAAGVSGLMRSAQSEHPGRFVLVESDDALTQDQLAAAVGLDEPRLRVSDGRYEV
PRLTRTHAEEPEPERTWDPDGTVLITGGSGVLAGIAARHLVTERGVRHLLLLSRSAPDEA
LIGELGELGARVETAACDVSDPAALTQVLAGVSPEHPLTAVIHTAGVVDDGVVESLTVQR
LETVLRPKADGAWNLHELTRDADLAAFVMYSSAAGVLGSAGQANYAAANAFLDALAEQRH
AEGLPALAVAWGLWEDASGLTAQLTDTDRDRIRRGGLRAISAEHGMGLFDSASRHSEPVL
VAAPMEPVRDAEVPALLRSLHRPIARRAAAAGGARWLAALAPAEREKALLKLVCDSAATV
LGHADTSTVSVAAVFRDLGVDSLTAVELRNSLAKATGLRLPATLVFDYPTPTALAVRLGE
LFTGENPVPVRGPVSAVAQDEPLAIVGMACRLPGGVSSPEDLWRLLESGTDAVSGFPTDR
GWDVENLYDMAGKSHRAEGGFLDAAAGFDAGFFGISPREALAMDPQQRLVLEVSWEAFER
AGIEPGSVRGSDTGVFMGAYPGGYGAGADLGGFAATASATSVLSGRVSYFFGLEGPAFTV
DTACSSSLVALHQAGYALRQGECSLALVGGVTVMATPELFTEFSRQRGLASDGRCKAFAD
SADGTGWAEGVGVLLVERLSDAQAKGHQVLAVVRSSAVNQDGASNGLTAPNGPSQQRVIQ
AALSNAGLAAHEVDVVEAHGTGTTLGDPIEAQAVIATYGQDRERPLLLGSLKSNIGHAQA
ASGVSVVIKMVMALQHNTVPRTLHVDEPSRHVDWAAGAVELVRENQPWPGTDRPRRAGVS
SFGVSGTNAHVILESAPPAQPAEEAQPVETPVVASDVLPLVISAKTQPALTEHEDRLRAY
LAASPGADTRAVASTLAVTRSVFEHRAVLLGDDTVTGTAVSDPRVVFVFPGQGWQWLGMG
SALRDSSVVFAERMAECAAALSEFVDWDLTVLDDPAVVDRVDVVQPASWAVMVSLAAVWQ
AAGVRPDAVIGHSQGEIAAACVAGAVSLRDAARIVTLRSQAIARGLAGRGAMASVALPAQ
DVELVDGAWIAAHNGPASTVIAGTPEAVDHVLTAHEARGVRVRRITVDYASHTPHVELIR
DELLDITSDSSSQAPLVPWLSTVDGSWVDSPLDGEYWYRNLREPVGFHPAVGQLQAQGDT
VFVEVSASPVLLQAMDDDVVTVATLRRDDGDATRMLTALAQAYVHGVTVDWPAILGTTTT
RVLDLPTYAFQHQRYWVEGVDRSAAGGHPLLGVAVELPDSNGVVLTGRVSLATHTWLADH
AVRGSVLLPGTAFVELVVRAADEVECDVIDELVIETPLLLPQTGGVQLSVSVAEADESGH
RAVTVFSRADNADTWTRHVSATISASDAPLSLPEFASWPPAQAQPTNVGDLYDRLAAAGT
EYGPAFQGLQAAWRDGDTAYAEVALAEEQAQEAARFAVHPALLDAALHASVLHTPDAEQQ
SLRMPFSWSHVQVHATGSATLRVAMTPTTDGWSVHVADDDGRPVATIGSFVTRPVTADAL
GSAADDLLRVVWTEIPIPQQTGLTTGRFEDLVDADVPVPEVVVYTARPDTDGSPDPLAQT
RTLTAQVLQAVQAWLAGERFTDSTLVVRTGTGLAAAAVSGLMRSVQSEHPGRFVLVEGDD
DTLTPDQLAATAGLDEPRLRVCDGRFEVPRLARANTPESSPLTIPDDRAWLLEQPRSGTL
QDLALVPTDTAERPLRPGEVRIDVRAAGLNFRDVLIALGTYPGEAVIGAEAAGVVLEVGP
EAHDLAPGDRVFGLVGGGFGAVAIADRRMLAVIPDGWSFTTAASVPVVFATAYYGLVDLG
GLSAGESVLIHAAAGGVGMAATQIARHLGAQIYATASAGKQHILYEAGLDGTRIADSRTT
GFREAFLNTTDGRGVDVVLNSLSGDFVDASLDLLPRGGRFVEIGKTDIRDPHRITADRPG
TTYQACDLMDVGPDRLREIITEILSLFGQGVLQPLPVQTWDIRQARDAFSWMSRARHIGK
IVLTIPRRPDPDGTILITGGSGVLAGILARHLAAEHGARHLLLLSRTAPDEALIKELAEL
GARVETAACDVSDRAGLARVLAGVSPEHPLTAVIHTAGALDDGVVESLTTQQLDTVLRPK
ADGAWHLHELTRDADLAAFVVYSSAAAVLGNEGQGNYAAANAFLDALAEQRRTQGLPALA
LAWGPWEYTGDLTAQLTGTDQDRIRCSGMRTITAEDGMRLFDTASHHGEPLLVPAVLDPT
RDGEVPALLRSLRRPIARRAASADGGVQWLAALAPAEREKALLKLVCDSAAMVLGHADAR
SIPAAGAFKDLGVDSLMAVELRNGLVKATGLRLPATLVFDYPTPTVLAARLDELFTGENP
APVRGPVSVVGQDEPLAIVGMACRLPGGVSSPEDLWRLVESGTDAVSGFPTDRGWDVENL
YDSDPEAAGKSYCVQGGFLDTAAGFDAGFFGISPREALAMDPQQRLLLEVSWEAFERAGI
EPGSVRGSDTGVFIGAFPVGYGAGFDREGYGATSGPSVLSGRVSYVFGLEGPAITMDTAC
SSSLVALHLAAQALRNGECSMALAGGVTVMATPEVFTEFARQRGLASDGRCKAFADSADG
AGFSEGAGLLLVERLSDARRNGHQVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALS
NAGLSTADVDVVEAHGTGTTLGDPIEAQALLATYGQDREQPLLLGSLKSNIGHTQAASGV
SGVIKMVMALRHGFVPRTLHVDEPSRHVDWAAGAVELVRENQPWPGTDRPRRAGVSSFGV
SGTNAHVVLESAPPAQPAEEEQPVETPVVASDVLPLVISAKTQPALTEHEDRLRAYLAAS
PGADTRAVASTLAVTRSVFEHRAVLLGDDAVTGTAVTDPRVVFVFPGQGWQWLGMGSALR
DSSVVFAERMAECAAALSEFVDWDLFAVLDDPAVVDRVDVVQPASWAVMVSLAAVWQAAG
VRPDAVIGHSQGEIAAACVAGAVSLRDAARIVTLRSQAIARGLAGRAAMASVALPAHEIE
LVDGAWIAAHNGPASTVIAGTPEAVDHVLTAHEARGVRVRRITVDYASHTPHVELIRDEL
LGITAGIGSQPPVVPWLSTVDGSWVDSPLDGEYWYRNLREPVGFHPAVSQLQAQGDAVFV
EVSASPVLLQAMDDDVVTVATLRRDDGDATRMLTALAQAYVHGVTVDWPAILGTTTARVL
DLPTYAFQHQRYWVKSVDRAAADGHPLLGAVVELPESDGVLLTGRVSLATHAWLADHAVW
GRVLLPGTAFVELVVHAAGEVGCDVVDELVIETPLLLPQTGGVQLSVSVGEADESGHRVV
TVFSRADNADTWTRHVSATVRVSDTTVPPSDLTAWPPAQAKPVDVAGFYDQLTGMGYEYG
PAFQGLQAAWRDGDTVFAEVALAEEQVREAARYAVHPALLDAALHACTLNASDAEVGVGL
PFSWNGVRVHAGGSAMLRVAVTQAADGWSVRVADDIGRPVASVGSLVTRPVTADALGSAA
DDLLALTWAGIPTPQQTGLTVGRFEELVSDGDVPVPEVAVFTALPDNDDDPLEQTRKLTG
QVLQAVQEWLGGERFSDSTLVVRTGTGLAAAAVSGWMRSAQSEHPGRFVLVESDDDALAP
DQLAAAVGLDEPRLRISDGRFEAPRLTRTHAAEPESEKVWDPDGTVLITGGSGVLAGIAA
RHLVAERGVRHLLLLSRSAPDEALINQLGELGARVETAACDVSDRAALAQVLAGVSPEHP
LTAVIHTAGALDDGVVESLTAQRLDAVLRPKADGAWNLHELTRDADLAAFVMYSSAAGVL
GSAGQANYAAANAFVDALAEQRRAEGLPALAVAWGLWEDASGLTADLTDTDRDRIRRGGL
RAISAEYGMGLFDSASRHSEPVLVGAAMEPVRDAEVPALLRSLHRPIARRAASTGDSSVQ
WLAALAPEERAKALLRVVCDSAATVLGHADIDSIPVTAAFKDLGVDSLTAVDLRNSLAKA
TGLRLPPTLVFDYPTPTALAARLDELFAPAEPEPRLHEQELRRALAGISIDKFREAGVLD
TLLRLAAMEGLAVPKPDSESDDEAFVDEMDADALIKHVLEEER |
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| Reference |
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| Authors |
Schwecke T, Aparicio JF, Molnar I, Konig A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB, et al. |
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| Title |
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. |
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| Journal |
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