| Entry |
|
|---|
| Symbol |
rapC
|
|---|
| Name |
(KEGG) rapamycin polyketide synthase C
|
|---|
| KO |
| K16420 | rapamycin polyketide synthase A/B/C |
|
|---|
| Taxonomy |
|
|---|
| Lineage |
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group |
|---|
| Organism |
Streptomyces rapamycinicus
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| AA seq |
6260 aa
MPEQDKVVEYLRWATAELHTTRAKLEALAAANTEPLAIVGMACRLPGGVSSPEDLWRLVE
SGTDAISDFPADRGWDVENLYDPDPDASGKSYCVQGGFLDSAGGFDASFFGISPREALAM
DPQQRLVLEVSWEAFERAGIEPGSLRGSDTGVFIGAYPGGYGAGAGADLEGYGTTSGPSV
LSGRVSYFFGLEGPAITVDTACSSSLVALHQAGYALRQGECSLALVGGVTVMATPDVFTE
FARQRGLATDGRSKAFADSADGAGFSEGIGVLLVERLSDAEAKGHQVLAVVRSSAVNQDG
ASNGLTAPNGPSQQRVIQTALSNAGLTTAEVDVVEGHGTGTTLGDPIEAQAVIATYGQDR
EQPLLLGSLKSNIGHTQAAAGVSGVIKMVMALRHALVPRTLHVDEPSRHVDWTAGAVELV
TENQPWPEIGRPRRAGVSSFGVSGTNAHVILESAPPTQAEDAAQPVEAPVMGSEPVPLVI
SAKTLPALNAHEDRLRAYLAASPGVDMRAVASTLAMTRSMFEHRGVLLGDGTVSGTAVSD
PRVVFVFPGQGSQRAGMGEELAAAFPVFARIHQQVWDLLDVPDLDVNETGYAQPALFALQ
VALFGLLESWGVRPDAVIGHSVGELAAAYVSGVWSLEDACTLVSARARLMQALPAGGVMV
AVPVSEDEARAVLGEGVEIAAVNGPSSVVLSGDEAAVLQAAEGLGKWTRLATSHAFHSAR
MEPMLEEFRAVAEGLTYRTPQVSMAVGDQVTTAEYWVRQVRDTVRFGEQVASYEDAVFVE
LGADRSLARLVDGVAMLHGDHEAQAAVGALAHLYVNGVSVEWSAVLGDVPVTRVLDLPTY
AFQHQRYWLEGTDRATAGGHPLLGSVVRLAEASGVLFTARVSRSGDLWLRDQTVLPATVF
VEMALAAADEVGCGLVEDLSVEALLLLPDDGAVEVQTWVGEPDEGGRRRLSVHARYGDGE
PWTCLATATLATTTGVAAAAVGWQAGGVWPPAGPVPVGTSAPSLRAVWRLGSDIFTEVAL
DDAHDATRFVRHPGLMTAALTTVGEETPAVWQGLTLHAGNPGELRVRLTSHDDGTLSAEA
TDSTGLPVLTARSLTLRTVPVYEPATSTDDLLTLTWAGIPTPQQTGLTVGAFEDLAADGD
VPVPEVAVFTALPDSDDPLEQTRKLTAQVLHTLQEWLGGERFSDSTLVVRTGTGLAAAGV
SGLMRSAQSEHPGRFVLVESDDALTQDQLAAAVGLDEPRLRVSDGRYEVPRLTRTHAEEP
EPERTWDPDGTVLITGGSGVLAGIAARHLVTERGVRHLLLLSRSAPDEALIGELGELGAR
VETAACDVSDPAALTQVLAGVSPEHPLTAVIHTAGVVDDGVVESLTVQRLETVLRPKADG
AWNLHELTRDADLAAFVMYSSAAGVLGSAGQGNYAAANAFLDALAEQRHAEGLPALAVAW
GLWEDASGLTAQLTDTDRDRIRRGGLRAISAEHGMGLFDSASRHSEPVLVAAPMEPVRDA
EVPALLRSLHRPIARRAAAAGGARWLAALAPAEREKALLKLVSDGAATVLGHADTSTIPA
TTAFKDLGINSLTAVELRNSLAKATELRLPATLVFDYPTPAALAARLDELFTGENPVPVR
GPVSAVAQDEPLAIVGMACRLPGGVSSPEDLWRLLESGTDAVSGFPTDRGWDVENLYDMA
GKSHRAEGGFLDAAAGFDAGFFGISPREALAMDPQQRLVLEVSWEAFERAGIEPGSVRGS
DTGVFMGAYPGGYGIGADLGGFGATASSVSVLSGRVSYFFGLEGPAFTVDTACSSSLVAL
HQAGYALRQGECSLALVGGVTVMATPQTFVEFSRQGGLASDGRCKAFADAADGTGWAEGV
GVLLVERLSDARRNGHQVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRAALSNAGLSTA
EVDVVEAHGTGTTLGDPIEAQALIATYGQDRDQPVLLGSVKSNLGHTQAAAGVSGVIKMV
MALQHGLVPRTLHVDEPSRHVDWSAGAVQLVTENQPWPDMGRARRAGVSSFGISGTNAHV
ILESAPPTQPADNAVIERAPEWVPLVISARTQSALTEHEGRLRAYLAASPGVDMRAVAST
LAMTRSVFEHRAVLLGDDTVTGTAVSDPRAVFVFPGQGSQRAGMGEELAAAFPVFARIHQ
QVWDLLDVPDLEVNETGYAQPALFAMQVALFGLLESWGVRPDAVIGHSVGELAAAYVSGV
WSLEDACTLVSARARLMQALPAGGVMVAVPVSEDEARAVLGEGVEIAAVNGPSSVVLSGD
EAAVLQAAEGLGKWTRLATSHAFHSARMEPMLEEFRAVAEGLTYRTPQVSMAVGDQVTTA
EYWVRQVRDTVRFGEQVASYEDAVFVELGADRSLARLVDGVAMLHGDHEIQAAIGALAHL
YVNGVTVDWPALLGDAPATRVLDLPTYAFQHQRYWLEGTDRATAGGHPLLGSAVRLAEAS
GVLFTARVSRSGDLWLRDQTVLPATVFVEMALAAADEAGCGLVEDLNVEALLLLPDDGAV
QVQTWVSEPDEAGRHRLSIHARYSDSEPWTRLATATLATRGTVSGWQAGEAWPPTGAVPV
ETGVPSLRGVWRRGNEVFAEVALDSTHDATTYALHPALLTAALTTAGEETPAAWQALTLH
ARNPAELRVRLISHDDGTLSVDATDSTGLPVLTVRSLTLRTVPVYEPATSTDDLLTLTWA
EIPAPQETGLTVGRFEDLVSDADVPVPEVAVFTALPDSSENPLEQTRVLTAQVLQAVQTW
LGGERFTDSTLVVRTGTRLAAAGVSGLMRSAQSEHPGRFVLVESDDDTLAPDQLAATVGL
DEPRLRVSGDRYEAPRLARVNASGSEPEAVWDPDGTVLITGGSGVLAGIAARHLVAERGV
RHLLLLSRSAPDEALINQLGELGARVETAACDVSDRAALAQVLAGVSPEHPLTAVIHTAG
VLDDGVVESLTAQRLDTVLRPKADGAWHLHELTRNTDLAAFVMYSSAAGVMGGGGQGNYA
AANAFLDALAEERRAEGLPAIRGGLGLWEDTSGLTTQLTDTDRDRIRRGGLRTITAEYGM
RLFDTASRHGNPILVAAPMDPVWDAEVPALLRSLHRPVARRAASTSDSSARWLAALAPAE
REDALLKLVRDSAALVLGHADASTIPAAAAFKDLGIDSLTAVELRNSLAKATGLRLPNTT
VFDYPTPAILATRLGELFTGENPAPVRPSVSVVGQDEPLAVVGMACRLPGGVSSPEDLWR
LVESGTDAISGFPADRGWDAESLFDPDPDASGKSYCVEGGFLDSAGSFDAGFFGISPREA
LAMDPQQRLIMEVSWEAFERAGIEPGSVRGTHRRLHGRVRGGYGAGADLGGFAATASATS
VLSGRVSYFFGLEGPAITVDTACSSSLVALHQAGYALRQGECSLALVGGVTVMATPQSFV
EFSRQRGLASDGRCKAFADSADGTGWAEGVGVLLVERLSDAQAKGHQVLAVVRSSAVNQD
GASNGLTAPNGPSQQRVIQAALSNAGLAAHEVDVVEAHGTGTTLGDPIEAQALIATYGQD
RERPLLLGSLKSNIGHAQAASGVSGVIKMVMALQHNTVPRTLHVDEPSRHVDWAAGAVEL
VRENQPWPGTDRPRRAGVSSFGVSGTNAHVILESAPPAQPAEEAQPVETPVVASDVLPLV
ISAKTQPALTEHEDRLRAYLAASPGADIRAVASTLAVTRSVFEHRAVLLGDDTVTGTAVT
DPRIVFVFPGQGWQWLGMGSALRDSSVVFAERMAECAAALREFVDWDLFTVLDDPAVVDR
VDVVQPASWAMMVSLAAVWQAAGVRPDAVIGHSQGEIAAACVAGAVSLRDAARIVTLRSQ
AIARGLAGRGAMASVALPAQDVELVDGAWIAAHNGPASTVIAGTPEAVDHVLTAHEAQGV
RVRRITVDYASHTPHVELIRDELLDITSDSSSQTPLVPWLSTVDGTWVDSPLDGEYWYRN
LREPVGFHPAVSQLQAQGDTVFVEVSASPVLLQAMDDDVVTVATLRRDDGDATRMLTALA
QAYVHGVTVDWPAILGTTTTRVLDLPTYAFQHQRYWLKSVDRAAADGHPLLGTVVALPGS
DGVVLTGRVSLATHTWLADHAVRGSVLLPGTAFVELVVRAADEVECDVVDELVIETPLLL
PQTGGVQLSVSVAEADESGHRTVTVFSQADNTDAWIRHVSATISTSDTPLSLPESDTWPP
AQAQPMNVADFYDRLMAEGYEYGPAFQGLQAAWRDGDTVYAEVALAEEQAQEAARYDVHP
ALLDAALHACTLNTPDAEEGVGLPFSWNHVQVHATGPATLRVAVTQEADGWSLRVADDTG
RPVATIGSLITRPVTADTLGSTTDDLLTLTWTVIPPPQETSLPMVRYEDLADGNMPVPDV
VVFTALPNSSENPLGPRPAGPADPLAQPDTDRQVLKPFQTWLPGTFTDSTLVVRTGTGLA
AAAVSGLMRSAQSEHPGRFILVESDDDTLTLRQLAATVGLDEPRLRINDGRYEAARLART
NTTPEDTPLTIPDSRAWLLEQPRSGTLQDLALVPTDTAEQPLRPGEVRIDVRAAGLNFRD
VVVALGMVNDNRPTGGEAAGVVLEVGPDVQDLAPGDRVFGVVGGSFGPAAIADRRMLAVI
PDGWSFTTAASVPVVFATAYYGLVDLAGLSEGESVLIHAAAGGVGMAATQIARHLGARIY
ATASTGKQHILREAGLEDTHIADSRTLSFQETFLNNTHGQGVDVVLNSLSGDFVDASLDL
LPRGGRFVEMGKTDIRDPHQVTADRPGTTYQAFDLMDAGPDRLREIITELLTLFTQGVLL
PLPVQAWDIRQARDAFSWMSRARHIGKIVLTIPRRPDPDGTILITGGSGVLAGILARHLA
AEHGARHLLLLSRTTPDQALIKELAELGAHVDTATCDVSDRAGLARVLAGVSPEHPLTAV
IHTAGALDDGVVESLTTQQLDTVLRPKADGAWHLHELTQNTDLAAFVMYSSAAGVIGGAG
QGNYAAANAFLDALAEQRRAEGLPALALAWGLWDDTSGLTSGLTDTDHDRIRRSGMRTIT
AEHGMRLFDGASRHGEPVLFAAAMSPLRGDVEVPALLRGLQTVKRPQSRTAARNEVGSQP
LSARLTGRTSVEQHRIMLELVLERRSVLGHSSADAIATDTSFKDLGMDSLTAIELRNRLV
AETGLQLPATMVFDYPTANALAAHLLGKLDIPPVQQRLEAPAPSTVTGPADPVADEPSAN
EPIAIVAMACRLPGGVSSPEGLWHLVESGTDAISGFPTDRGWDVEGLFDPDPDAAGKSYC
VQGGFLDTAADFDAPFFGISPREALGMDPQQRLLLETTWEAIERAQIDPKSLRGRDVGVY
VGGAAQGYGVGVDQQHDNGITGSSVSLLSGRVSYALGLEGPGVTVDTACSSSLVALHLAS
QALRQRECSLALVSGVSVMSSPAMFVEFSRQRGLSSDGRCKSFAASADGTIWSEGVGVLV
VERLSDARRLGHRVLATVRGSAVNSDGASNGLTAPNGTSQQRVIRQALANAGLTASDVDV
VEAHGTGTKLGDPIEAEAILATYGQERSAPAWLGSLKSNIGHAMAASGVLSVIKMVEAMA
HGSLPRTLHVDAPSPHVDWTSGSVALLTEHQPWPDDTKLRRAGVSSFGLSGTNAHVVLEQ
YQAPAPPVTPVTPAPPVTPVTPVTPNEPGPLPWVLSAQSPKALREQAGRLYASLAGDSEW
NSLDIGYSLATTRSDFAHRAVAVGSGREDFLRALSKLADGAPWPGLTTATATAKARRVAF
LFDGQGTQRLGMGKELYDSYPAFARAWDTVSAGFDKHLDHSLTDVCFGEGGSTTAGLVDD
TLYAQAGIFAMEAALFGLLEDWGVRPDFVAGHSIGEATAAYASGMLSLENVTTLIVARGR
ALRTTPPGAMVALRAGEEEVREFLSRTGAALDLAAVNSPEAVVVSGEPEPVADFEAAWTA
SGREARKLKVRHAFHSRHVEAVLDEFRTALESLKFRAPALPVVSTVTGRLIDQDEMGTPE
YWLRQVRRPVRFQDAVRELAEQGVGTFVEVGPSGALASAGVECLGGDASFHAVLRPRSPE
DVCLMTAIAELHAGGTAIDWAKVLSGGRAVDLPVYPFQHQSYWLAPAAPDATAVAPVVEE
EGGEYDEPSYADEPRTMLELVHMEVASLLGMADPGVILDDSSFLELGFDSLSAVRLRNRL
SKATGLDLPSTLLFEHPTSAELAAHLDALLDSDIDAAGVYALLEEINELDAEAVDMTAAE
HKAISELLEQLSAKWRTRNE |
|---|
| Reference |
|
|---|
| Authors |
Schwecke T, Aparicio JF, Molnar I, Konig A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortes J, Lester JB, et al. |
|---|
| Title |
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. |
|---|
| Journal |
|
|---|
