KEGG   Amycolatopsis mediterranei U32: AMED_8289
Entry
AMED_8289         CDS       T01269                                 
Symbol
ddlA
Name
(GenBank) D-alanine-D-alanine ligase
  KO
K15739  D-alanine---(R)-lactate ligase [EC:6.1.2.1]
Organism
amd  Amycolatopsis mediterranei U32
Pathway
amd01502  Vancomycin resistance
amd02020  Two-component system
Brite
KEGG Orthology (KO) [BR:amd00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    AMED_8289 (ddlA)
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01502 Vancomycin resistance
    AMED_8289 (ddlA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes [BR:amd01504]
    AMED_8289 (ddlA)
Enzymes [BR:amd01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.2  acid-alcohol ligases (ester synthases)
    6.1.2.1  D-alanine---(R)-lactate ligase
     AMED_8289 (ddlA)
Antimicrobial resistance genes [BR:amd01504]
 Gene sets
  Vancomycin resistance modules
   Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]
    AMED_8289 (ddlA)
SSDB
Motif
Pfam: Dala_Dala_lig_C Dala_Dala_lig_N ATP-grasp ATP-grasp_4 ATP-grasp_3 CPSase_L_D2 ATPgrasp_ST
Other DBs
NCBI-ProteinID: ADJ49987
UniProt: A0A0H3DIG1
LinkDB
Position
complement(9115498..9116526)
AA seq 342 aa
MNRLKVGIIFGGASEEHPVSVKSAQEVARHLDTGKYEPFWIGITKDGAWKLGDGPGESWE
AGRTVVLSPDRSVPGLLVLEDGKYETIGLDVVLPVLHGKLGEDGAMQGLLELSGIPYAGC
DVPSSALCMDKSLAYVVAASAGIATPKFRTVLAGDDAGAFTYPVFVKPARSGSSFGVSKV
SGREELAAAISTAAQYDAKVLIEEAVVGSEVGCAVLGNGRELFAGEVDRIALSHGFFRIH
QEEQPESGSENSTPIVPADVPAETRARVQQTAKAIYRALGCKGLARVDMFLTDDGTVVLN
EVNTLPGLTSYSRYPRMMAAAGVPLSALIDRLVSLAMTGAAR
NT seq 1029 nt   +upstreamnt  +downstreamnt
atgaataggctcaaggtcgggatcatcttcgggggcgcctccgaggaacaccccgtctcg
gtgaaatccgcgcaagaggtcgcgcggcacctcgacaccgggaagtacgaaccgttctgg
atcgggatcacgaaggacggcgcctggaaactcggtgacggcccgggcgaaagctgggaa
gccgggcggacggtcgtgctgtcgccggaccggagcgtgccgggcttgctggtcctcgaa
gacggcaagtacgagacgatcggcctggacgtggtgctgcccgtgctgcacggcaagctc
ggcgaggacggcgcgatgcagggcctgctggagctttccgggatcccgtacgcgggctgc
gacgtcccgagttccgcgctgtgcatggacaaatccctcgcttacgtcgtcgccgcgagc
gcgggcatcgcgacgccgaaattccggaccgtcctggcgggcgacgacgccggcgcgttc
acctatcccgtcttcgtgaagccggcgcgctcgggttcttccttcggcgtcagcaaggtt
tccggccgggaagaactggccgccgcgatcagcaccgcggcgcagtacgacgcgaaggtg
ctgatcgaagaggccgtcgtcggcagcgaggtcgggtgcgccgttctggggaacggccgc
gagctgttcgccggagaggtcgaccggatcgccctctcccacggctttttccggatccac
caggaagagcagcccgaaagcggctccgagaactcgacgcccatcgtgcccgccgacgtt
ccggcagagacccgggcgcgagtccagcagacggcgaaggccatctaccgcgctctggga
tgcaaagggctggcacgggtcgacatgttcctcaccgacgacggcacggtggtcctcaac
gaggtcaacaccctgcccggcttgacgtcgtacagccgctacccccggatgatggcggcc
gccggcgtgccgctgtccgcgctgatcgaccggctcgtttccctggccatgaccggggcc
gcccggtga

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