Astyanax mexicanus (Mexican tetra): 103025966 Help Entry 103025966         CDS       T05042                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism amex  Astyanax mexicanus (Mexican tetra) Pathway amex04020   Calcium signaling pathway amex04260   Cardiac muscle contraction amex04261   Adrenergic signaling in cardiomyocytes amex04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:amex00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103025966 (ryr2a)    04020 Calcium signaling pathway     103025966 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     103025966 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     103025966 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:amex04040]     103025966 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:amex04990]     103025966 (ryr2a) Ion channels [BR:amex04040]  Voltage-gated cation channels   Ryanodine receptor    103025966 (ryr2a) Domain-containing proteins not elsewhere classified [BR:amex04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    103025966 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  103025966 NCBI-ProteinID:  XP_049320482 Ensembl:  ENSAMXG00000042327 LinkDB All DBs Position 15:complement(41851513..42200176) Genome browser AA seq 5078 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATLHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGTAQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSHSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GEEQRRTVHYEGGAVSTHARSLWRLETLRVAWSGSHTRWGQPFRLRHVTTGKYLSLLDDK GLQLMEKEKADVKSTAFCFRSSKEKLDFGLRKEVDGMGVPDIKYGDSVCYIQHVDTGLWL TYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNRFIRG LDTLSKKGKTSMLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKNRQNLFQEE GMINLVLECIDRLHVYSSAAHFAEVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLANHVSSMRPNIFLGVSEGSAQYRK WYYELIVDNVEPFVTAEATHLRVGWASTPGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVSSPNQHLLCADDVVSCCLDLSAPSISFRINGQPVQGMFENFNSDGLFFPVV SFSAGVKVRYLLGGRHGEFKFLPPTGYAPCFEAVLPREKLRVEQSQEYKQDHAGTRDLLG PTVSLSQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIDLGWMYGAIRDDNK RQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGVADERAVEKVKRLKLSAKYEL SSGYKPTPMDLSHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNKRNPRL VPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADITTMSAERFRIFRAEK SYSVNAGKWYFELEVVTAGEMRVGWARPGCLPDLELGSDDQAFVFDGFKAQRWHQGNEHF GRSWLAGDVVGCMVDMNEHTMMFTLNGEVLLDDSGSELAFKDFEVWEGFIPVCSLGVTQV GRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDITMWLSKRLPQFIPVPTGHEHIEVTR IDGTVESSPCLKVTQRSFGSQNSNTDIVFYRLSMPIECAEGFAKSAGGTLPANGSFFSPK KDLEDFETVSDFEVLMKSAHGHMGSNGPEKDKDEFNNHKDYNQEKPSKLKQRFMLKRSKP DFNTSNSSARLSEEVMADERDDFEYLMQTSTYYYSVRIFPGQEPSSVWVGWVTSDFHQYD PAFQLDKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESNNPGQGRNNNGLEIGCMVDTA SGLLTFTTNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSE KKNPVPQCPPRLHVQFLTPVLWSRVPNHFLRSEVSRVNERHGWMVQCSDPLQFMSLHIPE ENRSVDILELTEQRDLLKFHYHTLRLYSAVCALGNNRVAGALCSHVDESQLLSAIQNKYM PGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTDETKSITLFPDEKKKHGLPGIGLS TSLRPRMRFSSPDFVSAVAGSNGGPVAGGDCFQYSPEFPLETLKSRTMEMLTEAVQEGSL HVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLRTILQLIEPSVFSQSTGSEGATGTP DKEGGPGEGRSEGGPAIAGGEEEDGTKSGLPKEGLLQMKLPEPVKLQMCLLLQYLCDCQV RHRIEAVVAFSDDFVASLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLG FKDEKQECPCPEDIRDQLLEFHEDLMTHCGIEMDDDKAGEADGDFTIRGRLLSLVEKVAY LKKKMADMPKKKKAKKPSTLQQLISETMVRWAQECVIEDPELVRAMFVLLHRQYDGIGGL VRALPKTYTINAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLSDIMNNKVFYQH PNLMRALGMHETVMEVMVNVLSGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHL SYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCV MLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGE GGNGLLAAMEEAIKISEDPSRDGPSPTSEDSKTLSDAVEDEEDDTIHMGNAIMTFYAALI DLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFPMPTLAKDGSVVEPDM SAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALAL NRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAV CGKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGAASDE ELHLSRKLFWGIFDALARKRYDAELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSMD AEGNFNPQPVDTSNVNIPEKLDHFINKYAEHSHEKWSMEKFGNGWVHSEQLCEASKVHPL LKPYKGLSEKDKEVYRWPIRETLKTMLSWGWSIERTRESDPASLHSRTRRISLSSQLSIE GAHGFSPRPVDMSNVTLSRDLHSMAELLAENYHNIWAKKKKLELEAKGGGSHPLLVPYDT LTAKEKSKDREKAQDILKFLQINGYTVSRAMKEQELDTPSIEKRFAYTFLQQLITYVDEA HEHMLEFDVSTRPKGEKIPHEQQMKFFGKVVLPLVDQYFKNHRLYFLSTAVRPIGSGGHA SNKEKEMVTSLFCKLGVLVRHRISLFGNDSTSIVNCLHILGQTLDARTVMKTGLETVKAA LRAFFENAAEDLERTMENLRQGQFTHTRTQPKGVTQIINYTTVALLPVLSSLFEHIGQNL FGEDLILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFPVAFLEPNLN KFNSYSIYNTKGSKDRTASGLPTQVEEVCPLVPSLEKALEEIMELAESGMRYTQMPHVME VVLPMLCSYMSHWWEHGPESNPEHAESCCTSLTSEHMNALLGNILKIIYNNLGIDEGAWM KRLAVFSQPIISKARPQLLKSHFLPLMEKLKKKAATVLLDEEHTKAEGRGEMSEAELLIL DEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREE QNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSMQTSLIVAALKRLLPV GLNICAPGDQELIALAKNRFTQKDTEDEVREIIRNNLHLQGKYRVFLFKKLVKRLIIVLK WMKSRQARLATSDMPPHKRMPLRKRSTTLDLHHRHPRVLLSAMKKSASVDHAPKLGKPAP RAPENLPAPRHRETHLTACGMFGCSTLLEDPAIRWQMALYKDMPNRSEDTSDPEKTVERV LDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQG YEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEDEGVKRIDPLHQLIQLFSRTALTEKCKL EEDSLYMAYADIMAKSCHDEEEDEEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQT ISASKGEMGLMVASTLKLGIAVLNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVL DLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNY LRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVF NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIDLLKELMDLQKD MVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDP DGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFN VAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSASKE ESEREKPEDESPEMGFFSVTTVRTALLALRYNIMLLMKVLSMKSLKKQLKKAKKMTVKDM VTTLASFYWSVLMGLLHFAFSVARGFFRIVYNSFLGGSLVEGAKTMKVSELLANMPDPTQ DEVRGESEEAERKPVDKTSPEENLADLAVATEDTDVLSDIFGLDLRREGGQYKLMPHNPN ASLTELLNTPVPPPPTPSPELRRRHQTKSSSSSTEEKEGLEETKSVPEKAEGEDGEKKEV QKEVLQKKKSRHHHSSRSDEPDLQESAFWKKIIAYQRKLLNYFARNFYNMRMLALFVAFA INFILLFYKVSTSSAVLEEKQVIYSASSDTGLRWDPLGEAPPDRPVTVHFVLEESSGYME PTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQ WDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHEKRKPK KDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMG FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPDMKCDDM LTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDA FGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKD ETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15237 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcggtgaaggcgaggatgagatccagttcttgcgcaccgatgatgaggtg gtgctgcagtgttcagccacgcttcataaggagcagcagaagctgtgtttggctgctgag ggctttgggaacaggctctgcttcctggagtccacctctaactctaagaatgttccgccg gatctgtccatatgcacgtttgtgctggagcagtcgctgtcggtccgtgccctgcaggag atgctggccaacacagaggaaaaggcagaggggacagcacagggcgggggtcatcgcact cttctctacggccacgctgtcttactcaggcactcctacagcggaatgtatctctgctgt ctgtccacctctcactcctcaacagataaactagcgtttgatgtggggcttcaagaagac acaacaggtgaagcctgctggtggactatacaccccgcctccaagcagaggtcagaaggt gagaaggtgcgagtgggtgatgacctcatcctcgtcagtgtgtcctcggagcgatacctg cacttgtcgtatggaaatggcagcttgcatgtggacgcagcctttcaacaaaccctgtgg agcgtagcgccaatctgctctgggagtgaggtcgctcagggcttcctgattggtggagac gtcttgcggttgttgcacggtcacatggacgagtgtctgactgttccttcaggagagcat ggagaagagcagcgcaggacggtgcactatgagggcggagccgtgtccacccacgcccgc tcgctgtggcggctcgagacgctgagagtagcgtggagcgggagtcacactcggtggggt cagccgttccggttacgtcacgtgaccacggggaaatacctcagcctgctggatgataaa ggtcttcagctgatggagaaggagaaggccgacgtcaaatccaccgccttctgcttccgc tcgtctaaggagaagctggatttcgggctgaggaaggaggtggatgggatgggtgttcct gatattaaatatggagattctgtgtgctatatccagcacgtggacacagggctctggcta acctaccaatcagtggacgccaagtgtgctcgcatgggcggagtccagaggaaggctata atgcaccatgaaggtcatatggacgacgggctgaccctctctcgctcccaacacgaagaa tctcgcactgccagagttatccgcagcacagtcttcttattcaaccgctttatcagggga ttggacactcttagtaaaaaggggaagacctccatgctggatctgcccattgagtcggtc agtctgagtctgcaggatctgattggttacttccagccgccggacgagcacctagaacac gaggacaagcagaaccgactccgagccctgaagaaccgccagaacctctttcaggaggag ggaatgataaacctggtgctggagtgtattgatcgtctacatgtgtacagcagtgcagct cattttgcggaagtggcgggacgggaagctggagagtcctggaagtccattctcaactcc ctctatgaactactggctgctttgatcaggggtaacaggaagaactgtgctcagttttcc ggctcgctggattggctgatcagtcgcctggaaagactggaggcttcatcagggattctg gaggtgctgcactgtgttctggtggagagtcctgaagctctcaacatcatcaaagaggga cacatcaaatccatcatctctctactggacaaacacggccggaaccataaggtcctggac gtgctgtgctctctgtgtgtgtgtcatggtgtggctgttcgctctaaccagcacctgatc tgtgataacctgctgcccgggagagacctgttactgcagacccgtctggccaatcacgtc agcagcatgaggccgaacatcttcctcggagtgagcgaaggctccgcccagtacaggaag tggtattatgagctgatcgtggataacgtggagccgttcgtgacggcggaggccacgcac ctgagagtgggctgggcctccacgcccgggtactcaccttacccaggtgggggtgagggc tgggggggaaacggagtcggggatgacctctactcatacggctttgatggtctacacctg tggtcaggttgtatagctcggacggtcagttctcctaatcagcacctgctgtgtgcggat gacgtggtcagctgctgtctggacctcagcgctcccagcatatccttccgtattaacggt cagccggttcagggcatgttcgagaacttcaactccgacggcctcttcttccctgtggtc agcttctccgccggcgtcaaagtgcgctacctgttgggagggcgtcatggtgagtttaag ttcctgccgccgacgggatacgccccctgttttgaggcggtgcttccccgagagaagctg agggtggagcagagtcaggaatacaagcaggaccacgcaggaaccagagatctgctgggg ccgaccgtcagtctctcccaggctgccttcacacctatacccgtggacaccagccagatc gtgttgccgcctcatctggagcgaatcagagagaagctggcagaaaacatccacgagctg tgggtcatgaacaagatcgacctgggctggatgtatggagcaataagggatgataataag aggcagcacccgtgtctggtggagttctccaagcttccggagcaggagcgcagctacaac ctgcagatgtccctagagacccttaagactctgctggcgttgggttgccatgttggagtg gcggatgaacgggctgtggaaaaagtgaagcgactgaaactctcggccaaatatgagctt tccagtggatataaacctactcccatggatctcagccatatcaaactcgcatctacacag gaggccatggtggataaactagccgagaacgcccacaatgtgtgggccagagaccgcatc cgccagggctggacatatggcatccagcaggatgtgaagaataagagaaatccacggttg gtgccttacgtccttctggatgagagaaccaagaagtccaataaggacagtctgagagag gcggtgcgcacactgctgggttacggatacaacctggaggctcccgaccaagaccatgca gcccgagcggacatcaccaccatgtcggcggagcgattccggattttccgtgctgagaag tcgtacagtgtgaacgctgggaagtggtattttgagctggaggtggtgacggcgggggag atgcgggtgggctgggctcgcccgggttgcttgccggatctggagctgggctccgacgac caggccttcgtgtttgatgggtttaaggctcagcggtggcaccaagggaatgagcacttt gggcgttcgtggctggcgggggacgtggtgggctgcatggtggacatgaacgagcacacg atgatgttcacgctgaacggagaggtgctgctggacgactcgggctctgaactcgccttc aaggacttcgaggtttgggaaggttttatcccggtgtgcagtctgggggtgactcaggtg ggccggatgaactttgggaaggacgtgagcactctgaagtacttcaccatctgtggtctg caggagggatacgaacctttcgccgtcaacatgaaccgagacatcaccatgtggctcagc aagagactgccccagtttataccagtaccaaccggacatgaacacatcgaggtcacgaga attgacggcacagtggagagctctccgtgtttgaaggtcactcagaggtcgttcgggtca cagaacagtaacacagacatcgtgttctaccggctcagcatgcccatcgagtgcgccgag gggttcgccaagtccgccggcggcaccctgcccgctaacggcagcttcttctccccgaag aaggacctggaggacttcgagacggtgtcggacttcgaggtgctgatgaagagcgcccac ggtcacatgggttcaaacggaccagagaaagacaaggacgagttcaacaaccataaagat tacaaccaggagaaaccgtccaaactcaaacagaggttcatgctgaagaggtctaaaccc gacttcaacaccagtaactcgtcagctcgtctgtcggaggaggtgatggcggatgagaga gatgattttgagtatctcatgcagacgtccacgtactactactcggtgcggatctttccg ggtcaggagccgtccagtgtgtgggttggctgggtgacctcggacttccaccagtacgac ccggcctttcagctggataaagtcagaaccgtcactgttacactcggggatgagaaggga aaagtccacgagagtattaagcgcagtaactgctacatggtgtgggctggggagagtaat aaccccggtcagggccgcaataataatggtctggagatcggctgtatggtggacacagcc agcggcctgctcaccttcaccaccaacggcaaggagctcagcacctactaccaggtggag cccagtactaagctctttcctgcagtgtttgcccaggctacaagtcctaatgtcttccag tttgagcttggacgcatcaaaaatgtgatgccgctgtcagcaggcctgtttaaaagcgag aagaagaacccggttcctcagtgtccgccccgcctccacgtccagttcctcacccccgtg ctctggagccgagtgcccaatcacttcctcaggtctgaggtctccagggtcaacgagagg cacggctggatggtgcagtgctcagatccactgcagttcatgtccctgcatatacctgaa gagaacaggtcagtggacatcctggagctgacggagcagcgtgatctcctgaagttccac taccacactctgcgtctgtactcggcggtgtgcgctctgggcaacaaccgggtcgctggc gccctctgcagccacgtggacgaatctcagctgctgtcggccatccagaacaagtacatg ccgggtctgctgcgcaccggctactacgacctgctgatcgacatccacctgagcagctac gccaccgcccgcctgatgatgaacagcgagtacatcgtccccatgaccgacgagaccaag agcatcacgctgttccccgacgagaagaagaagcacggcctcccgggcatcggcctcagc acgtcgctgcgcccgcgcatgcgcttctcctcgcccgacttcgtcagcgccgtcgccggg agcaacgggggacccgtcgccgggggcgactgcttccagtacagccccgagttccctctg gagacgctgaagagccgcaccatggagatgctgacggaggcggtgcaggagggcagcctg catgttagagatcctgtagggggcagcaccgagttcctgtttgtgccacttattaaactg ttctacacgctgctgatcatgggcatcttccataacggagatctgaggaccatcctgcag ctgatcgagcccagcgtgttctctcagagcacggggtcagagggggcgaccgggacgccc gataaagaaggcggtcctggggagggtcgttctgagggaggccctgctattgcaggaggg gaggaagaggatggaaccaagagtggcttacccaaagagggacttctgcagatgaagctt ccagaacccgtcaaactgcagatgtgtctgctgctgcagtatctgtgtgattgtcaggtg cggcaccgtatcgaggcggtggtggcgttctcggatgatttcgtggcgagtctgcaggat aaccagcgcttccgttataacgaggtcatgcaggcgctcaacatgtcggcggctctgacc gcccgcaaaaccaaagagttccgctcgcccccgcaggaacagatcaatatgctgctgggt tttaaggatgagaagcaggagtgtccgtgtcccgaggatatcagagaccagctgctggag ttccatgaggacctgatgacccactgcggtatagagatggatgatgataaggcaggggaa gctgatggagattttacgatacgagggcgtctgttgtctctggtggagaaggtggcctac ctgaagaagaaaatggccgacatgccaaagaaaaaaaaagccaagaaacccagcactctg cagcagctgatctcggagacgatggtgcgctgggcgcaggagtgtgtgatcgaggatccg gagctggtgcgggcgatgttcgtgctgctgcaccggcagtatgatgggataggagggctg gtccgggctctgcccaaaacctacaccatcaacgctgtgtccgtggaggataccattaac ctgctggcctcgctgggtcagatccgctcgctgctcagcgtccggatgggccgagaggag gagaagctcatgatccgcggactcagtgacatcatgaacaataaggtgttctaccagcac ccgaacctgatgagggctctgggcatgcacgagaccgtcatggaggtcatggtgaacgtg ctgagcggaggagagtccaaggagatcacttttcccaagatggtggctaactgctgccgt ttcctgtgctacttctgccggatcagccgtcagaaccagaaggccatgtttgatcatctg agttatcttctggagaacagcagcgtgggtctcgcgtctccgtccatgcgtggctccacc cctctggatgttgctgctgcttctgtgatggataataacgagctggccctcgcactgaga gaaccagacctggagaaagtggtgcagtatttggcggggtgtgggctgcagagctgtgtg atgttggtatctaagggttatcctgatattggatggaaccctgtggaaggagagcgctat ctggacttcctgagatttgctgtgttctgtaacggtgagagtgttgaggagaacgctaat gtggtcgtccggctcctgattcgccggccggagtgttttggccccgccctgcgtggtgaa ggtgggaacgggttgctagcggcgatggaggaagcgattaaaatatcagaggaccccagc agagacggcccctcccctacatcagaggacagcaaaacacttagtgatgcagtagaggat gaggaggatgacaccatacatatgggtaatgccatcatgaccttctacgctgctctgata gacctgctgggtcgctgtgctccagagatgcatttgattcatgcaggtaaaggtgaggcg atccgtatccgagccatcctccgttctctcatccctatagaggacctggagggagtcatc agcatccccttccccatgcccaccctcgctaaagatggttctgtggtggaaccggacatg tctgcggggttctgtccggaccacaaggcagcgatggttctgtttcttgaccgtgtttac ggcatcgaagaccagaacttcctgcttcacctgctggaggtgggcttcctgcctgacctc agggccgccgcttctttggatacggcggcgctgagtgctacagacatggctctggctctg aaccggtacctgtgtacggcggttctgccgctgctgaccaagtgcgcccccctgttcgcc ggtacagagcccttcgcctcgctgatcgactccctgctgcacacggtttaccggctctct aaaggctgctgcctcaccaaggcccagcgggacgccatcgaagagtgcctgctcgccgtg tgtggtaaactgaggccttcaatgatgcagcatctgctcagacggctggtgttcgacgtt ccgctgcttaatgaacacactaaaatgcctctcaagctgttgaccaatcactatgagcgc tgctggaagtattactgcctgtccggggggtggggcagtttcggggcggcgtctgatgaa gagctgcatctctccagaaaactcttctggggaatcttcgacgctctggccagaaagagg tacgacgctgagctgtttaagctggctctgccgtgtctgagcgctgtagccggagcttta cctccagactacatggagtccaactacgtggccatgatggagaagcagtcatccatggac gcggagggcaacttcaacccacagcctgtcgacaccagcaatgttaatattccggagaaa ctggatcacttcatcaataaatacgctgagcactctcacgagaagtggtcgatggagaag tttgggaatgggtgggttcatagtgagcagttgtgtgaggcgtctaaagttcatcctctg ctgaaaccgtacaaggggctgtctgagaaggataaggaggtttaccgctggccaatcaga gagactctgaagaccatgctgtcgtggggttggagtatagagcggacgcgggagagcgac ccggccagtttacacagccgcactcgcaggatatctctgtccagccagctgtccatagag ggcgctcatggcttcagccctcgtccagtagacatgagcaacgtgaccctctcccgggac ctgcactcaatggcagagctgctggcagagaattaccacaatatctgggccaaaaagaag aaactggaactggaagccaaaggaggagggagtcatccgttactagttccctacgacact ctaactgccaaagagaaatccaaagaccgagaaaaagcgcaagacatcctcaagttcctt cagattaacggatacaccgtatcgagggctatgaaggagcaggagctggacactccgtct atagagaagcgcttcgcctacacctttctgcagcagctcatcacatacgtagatgaagct catgaacacatgctggagttcgatgtcagcacgcgaccaaagggagagaaaatccctcac gagcagcagatgaagttctttggaaaggtcgtcctgcctctcgtcgaccagtactttaag aaccatcggctctacttcctgtctactgctgtccggccaatcggcagtggaggccacgcg tccaataaggagaaagagatggtgaccagtcttttctgcaaactgggagttcttgtcagg cataggatatctctgtttggaaacgactctacctctatagtaaattgccttcatatactg ggacagacgctggacgccaggacagtgatgaagacgggtctggagacggtgaaggcggct ctacgggcgttcttcgagaacgctgcggaggatctggagagaaccatggagaacctgcgg cagggtcagttcacccacaccagaacccagcctaaaggagtgacccagatcatcaactac accaccgtcgccctgctgcccgtcctctcctcgctgttcgagcacatcggacagaacctg ttcggggaggacctcatactggatgatgtccaggtgtcctgttacaggatcttaaacagc ctctactctctcggcaccagcaaaagcatctacgtggaaaggcagcgacctgctctgggc gagtgtctggctgcgttctctggtgcgtttcctgtggcctttctggagccaaatctcaac aaattcaacagctactccatctacaacactaaaggctccaaagacagaacagcctccggt cttcccacgcaggtggaggaggtgtgtccgctggtgccgtctctggagaaagctctggag gagattatggagctggcggagtcggggatgcgctacacccagatgccccacgtcatggag gtggtgctgcccatgctctgcagctacatgtcccactggtgggagcacggacccgagagc aacccagagcacgccgagagctgctgcacctcgctgacctccgagcacatgaacgccctg ctggggaacatcctcaagatcatctacaacaacctgggcatcgacgagggagcctggatg aagagactcgcggtcttctcccagccaatcatcagcaaggcccgcccccagctgctgaag agccacttcctgccgctgatggagaagctgaagaagaaggcggcgacggttcttctggat gaagagcacaccaaggctgaggggcggggcgagatgtcggaggcggagctgctgatcctg gacgagttcaccatcctggtgcgagacctgtacgccttctacccactgctcatcagattc gtcgactacaacagagcgaagtggctgaaagagccgaaccccgaggctgaggaactgttc cgcatggtggccgaggtcttcatcttctgggccaaatcacacaattttaaacgggaggag cagaacttcgtggttcagaacgagatcaacaacatgtccttcctcataactgataccaag tctaaaatgtccaagggggcagtgtctgatcaggagaggaagaagatgaagaagaggggg gatcgctactccatgcagacgtctctgatcgtagcggcgctgaagaggcttctgcctgtg gggctgaacatctgcgcccccggagaccaggagctcatcgccctcgccaagaaccgcttc acccagaaagacactgaggatgaggttcgggagatcatccggaataaccttcacctgcag ggcaagtatcgagtcttcctcttcaaaaagctggtgaagcgtctcatcatcgtcctgaag tggatgaagagtcgccaggccaggctggccacttcagacatgcccccccacaaacgcatg cccctccgcaagcgctccaccaccctcgacctccatcatcgccacccgcgggtgctgctg agcgccatgaagaaatctgcatctgtggaccacgcccccaagcttggaaagcccgccccc cgggcacctgagaacctgcccgccccccggcaccgcgagacccaccttactgcatgcggc atgtttggatgtagcacactgctggaggatcctgcaattcgctggcagatggccctgtat aaagacatgcccaaccgcagcgaggacacgtcggacccggagaagaccgtggagagagtg ctggatatcgctcatgttctcttccatctggaccaggtggagcatcctcagaggagtaag aaggccgtgtggcacaagctgctgtccaagcagaggaagcgggcagtggtggcatgcttc aggatggctcctctatataacctacccagacacagagcggtgaacctgttcctgcagggt tatgagaaatcctggatcgagacggaggagcattattttgaagataaactcatcgaggat ttggctaagccgggtggagaggagccgtcggaggaggatgaaggggttaaacgcatcgac cccctacatcagctcatccaactgttcagcaggacagcactcaccgagaaatgtaaattg gaagaggacagcctgtacatggcttatgctgatatcatggctaagagctgccatgatgag gaggaagatgaagaggaggaagtgaagagttttgaagagaaagagatggagaagcagaag ctgctgtatcagcaggctcgactacatgaccgaggagctgctgagatggtgctgcagacc ataagcgccagcaaaggtgagatgggactgatggtggcgtccacactgaagcttggtatt gccgtcctgaatggtggaaactccactgtacagcagaaaatgctggattatctgaaggat aagaaggatgtgggatttttccagagcctggcgggactgatgcagtcctgcagcgttctg gacctgaatgcttttgagaggcagaataaagctgaaggtttgggcatggtgacagaagaa ggatcagtcatcacccatgagcgtggcgagaaggtgatgcaggacgacgagttcacctgc gacctgttccgcttcctgcagctgctctgtgaaggacacaactcagatttccagaactat ctgagaacacagacaggaaacaacacaacagttaacatcatcatctccaccgtggactac cttctccgagtgcaggaatcaataagcgatttctactggtactattctgggaaggatgtg attgacgagcagggtcagcgtaatttctccaaggccatcaatgtggccaagcaggtcttc aatactcttacagagtatattcagggtccttgcaccggtaaccagcagagtttggctcac agtcgactctgggacgctgtggttggtttcctccatgtttttgctcatatgcagatgaaa ctgtctcaggattcgagtcagattgacctgctgaaggagctcatggacctgcagaaggac atggttgtgatgctgctgtctatgttagagggaaacgtcgtaaacggcaccatcgggaag cagatggtggacatgctggtagaatcctccaacaacgtggagatgatcctcaagttcttc gacatgttcctcaaactcaaagacctgacgtcatccgacgccttcaaagagtacgacccg gacgggaagggggtgatctctaaacgagactttcacaaagccatggagagccacaagcac tacacccaatcagagacggagttcctgctgtcctgcgccgagacggacgagaacgagctg ctggactacgaggagttcgtcgagcgcttccacgaaccggccaaagacatcggcttcaac gtggccgtcctcctcaccaacctatcggagcacatgcctcacgactcgcggctgcagacc ttcctggagctggcggagagcgtgctgaactacttccagccctacctgggccgcatcgag atcatgggcagcgccaagcggatcgagcgcgtgtacttcgagatcagcgagtccagccgg acgcagtgggagaagccgcaggtcaaagagtccaagcgccagttcatcttcgacgtggtg aacgagggaggagagaaggagaagatggagctgttcgttaatttctgcgaggacaccatc ttcgagatgcagctggcggcgcagatgtccgacgccggggaacgctcggccagcaaggag gagagcgagagggagaaacccgaggacgagagccctgagatgggcttcttctcggttacg actgtacgaaccgccctgctcgccctccgctacaacatcatgctcctcatgaaggtgctg tccatgaagagtctgaagaagcagctgaagaaggcgaagaagatgacggtgaaggacatg gtgaccacgttggcgtccttctactggagcgtgctgatgggtttgctgcatttcgcgttc agcgtggcgcgaggcttcttccgcatcgtctacaacagcttcctgggtggcagcctggtg gagggagccaagaccatgaaggtgtcagagctgctggccaacatgccggacccgacgcag gacgaggtgcggggcgagagcgaggaggcggagaggaagcctgtggataaaacctcacct gaggagaacctggcggacctggcggtggccaccgaggacacggacgtgctgtcggatata ttcgggctggatttgaggcgggagggcgggcagtataaactgatgccgcataaccccaac gccagcctgacggagctgctcaacacacctgtacctccaccgcctacaccctcacctgaa ctccgcaggagacaccagacaaaaagttcctcttcttcgacggaggagaaagaaggcctg gaggagaccaagtccgtccccgagaaagcagagggggaggatggagagaagaaggaagtg cagaaggaagttctccagaaaaagaagtcccggcaccaccactcctccagatcagacgag ccggatcttcaggagtccgccttctggaagaagatcatcgcttaccaacgcaagctgcta aactattttgcacggaatttctacaacatgagaatgttggctctgtttgtggccttcgcc atcaacttcatcctgctgttctataaggtgtccacgtcctcagcagtgctggaggagaag caggttatttatagtgcatcttcagacactgggctacgctgggaccctctgggcgaagcg ccccctgatcgcccggtaacggtgcactttgtactggaggagagcagcggctacatggag cccacgctgaggatcctcgccatcctccacaccattatctcctttttctgcatcatcggg tattactgcctcaaggttcctctggtgatctttaagagggagaaggaggtggccaggaag ctggagtttgacgggttgtatattacagagcagccgtctgaggatgacatcaaaggccag tgggacagactggtcataaacacacagtctttcccgaacaactactgggataagtttgtg aagcggaaggtaatggataagtatggagagttttatggtcatgatcggatcagtgagctg ctggggatggataaagctgcgctggacttcagcgacgcccacgagaagaggaaacccaag aaggacagctcattggctgctgtattgaactcagtggacgtgaagtaccagatctggaag ctgggagtcgtcttcactgataattcgttcctgtaccttgcctggtacatgaccatgtcc atattgggccactacaataacttcttctttgctgctcatctgctggacatcgccatgggc tttaagaccctgaggaccatcctgtcttccgtcactcacaatggcaaacagctggtgttg acggtgggcttgctggcggtggtggtctatctctacactgtggtggccttcaacttcttc cgcaaattctacaacaagagtgaagacggagagtctccagacatgaagtgtgacgacatg cttacgtgttatatgttccatatgtacgttggtgtacgagcaggtgggggcatcggtgac cagatcgaggatccagcaggcgatgaatacgagatttaccgcatcatcttcgacatcacc ttcttcttctttgtcattgtcatcctgctcgccatcattcagggtctgatcattgatgct tttggtgagctcagagatcagcaggagcaagtaaaagaagacatggagaccaagtgcttc atctgcgggatcggaaacgactacttcgacacggttcctcacggcttcgagacacacacc ttacaggagcacaacttggccaactatctgttttttgtgatgtatctcattaataaggat gaaacggagcacacaggccaggagtcctacgtctggaaaatgtaccaggaacgctgctgg gaattcttcccggccggagactgcttccgcaaacaatacgaggaccagctcaactaa

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