Astyanax mexicanus (Mexican tetra): 103027186 Help Entry 103027186         CDS       T05042                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism amex  Astyanax mexicanus (Mexican tetra) Pathway amex04020   Calcium signaling pathway amex04260   Cardiac muscle contraction amex04261   Adrenergic signaling in cardiomyocytes amex04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:amex00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103027186 (ryr2b)    04020 Calcium signaling pathway     103027186 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     103027186 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     103027186 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:amex04040]     103027186 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:amex04990]     103027186 (ryr2b) Ion channels [BR:amex04040]  Voltage-gated cation channels   Ryanodine receptor    103027186 (ryr2b) Domain-containing proteins not elsewhere classified [BR:amex04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    103027186 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Plasmodium_Vir Motif Other DBs NCBI-GeneID:  103027186 NCBI-ProteinID:  XP_049320174 Ensembl:  ENSAMXG00000011163 LinkDB All DBs Position 14:complement(32285257..32399928) Genome browser AA seq 4912 aa AA seqDB search MGATEGEEDFQFLRTSDELVLRCCSSVPLQQKLCLAVEGFGCRLCFLESTSNSKNVPADL SRCVFVLDRCVSVRALQQMIANHEDLQIKSSEAAGRRTLLYGQALLLRHALSDMYLSCLS SSGLSADKLAFDVGLQEDVEGEACWWTVHPASKQRSEGEKVRVGDDLILVSVSSERYLHV SWSAGVCDDAGVSSVDAAFQQTLWSVAPVSSGTAEAQGHLRGGDTLRLLHGHTDECLTIP PAGRGEEQRRSVHFEGGSASSQARSLWRVEMLCVSWSGSHTRWGQSFRLRHVTTGRYLGL LRDGGLQLVEREQADIKSTAFCLRPAKDAGQEYVDVVRKREGMGAPEVKYGDSVCFVQHV DTCLWLTYQTSDLKRRKEEKGLHKQAILHSEGHMDDGLTLSRSQREESQAAGLIRSSAFL FSSFIRGLDERANISSSELQIDRLSLSLQDLIRYFRSPGEGQGHEAKQSSIRALKNRQHL FQEEGIITLVLDCIDHLHLYSSAAHFARVAGKEAGDAWEAILSSLYELLAALIRGNRNNC SQFSTSLDWLVSRLEKLEASTGILEVLHCVLKESPEALNFIKEGHIRSIISLLDKHGRNP KILDVLCSLCVCHGMAVRCNQNLICDALLPERDLLLQSRLVNQVTSIRPNIYLCMGDDSA QHRKWYYEVVVEKAQPFVTAEPTHLRVGWACTAGYRPSPTGGHGWGSNGVGDDLCSYGFD GLHLWTGGTGRRVSSLNQHLLREDDVISCCLDLSASCISFRVNGQPVQGMLENFTADGLL FPVVSFSAGVRVRLLFGGKQGEFKFLPPSGFSPCAEALLPGGRCRLELCEEFTRFQGSGQ CDLLGPTVPLGPVIFTPTPVDTSQLVLPPQLELIRERLAENLHELWLLDKIEQGWTHGPV RDDSKKVHPGLAEFSKLPEQERQSNLQAAENTIRTLLALGAHIGLSEDHAEENVKYVRLS NKYELCNGYRPAPVDQSGISLSAGQEALVEALTENEHNLWARERIRQGWSYATQLDVKGK RSPQLVPFSLLEERIKCCSREAARDALGTLLGLGYAVESTEHQQALTGPEVKTAGEETFR IFRVEHSFAVWDGKWYFEFEVVTDGEMSVGWAQPGSKPDVELGSDDQAFVFDGCKGQWWH GSAVRLGRPWQEGDVIGCLLDLSQKTMMVTLNGELQLNSSGSEIAAKDFSVSGGFLPVCS LGVNQVGRLNLGRQFDSLKYFSVCGLQEGYQPFGLNMSRDLPLWMSWKEPMFVSILEDHT SIQVTRTDGTADCPPALRVSQKSVVAPDSTAVEFYRLSMPIECAQVFSKPAEGAVPASSS VICHARELDEGEVDSDFEVLMKSVHRYTGSRDELNNHKDHTQEKPSKLKQRFLLKKKPEL NTSGSSARLLEEVLAIERDDCNQLTGCTKYYYSLKILNGQEPSCVWVGWITSTFHPPEQP FDLEKVHTVMVTLGDDWGKVLESVRRSCCYMVCAAAEGSSLSHSRSSSGLEIGCLVDTAT GLLTFTANGKDMETFFQVEPGTKLFPAVFAKATSLDVFQFQLGRIKGVLPLSAGMFRSER NNAVPQCPPRLSVQRLTRARWARLPDHSPHVQLTRLGEGHGWRAQCTDSLQVMTLYIPEE ERCLDILELSELEHLLKFHEHTLNLYSALCAHGNLHVSHALCSYIDQSQLLFALQCPRMP GTLRESFYNLLTSAHLSAHASAQQATTHEYIVPMTDATRSIALFKSDGKRHSLPGSDIST SLRPRMHFSSPCFISSSNPIQAGSPPGFPLDILKGVTTAMLEEAVHAVGQSVRDPIGGSI ELLLVPLLQLLHTLLLMGVFQGSDLRRVLSLILPSAYMGENDMERWADGDEEGRDGEKKD EDKERWVSVPLLELQMKLPEAVKLKLCHLLQYLCDCQVRHRVEAVLAFSDDLVDHLQDNQ RYRYNEVMEALNMSAALTARKTKEFRSPPQEQMNMLLNFQESQQECPCPEEIKDLLWDFH IDLRRHCEVEVEDEDQATKDEVDPPNRYRLKGLVDRIVRLKRRMSGIVEEDIVTKSVSLQ QLISDTMLRWAHEGLLENPTLVRAAFSLLQWQYAGLSGQMAAPLRKAYCISQSSVEDTLY LQEALGRIRSLLRARMGREEEELMIRGLGDIMKNKVFYQHPNLMRALGMHETVMEVMVNV LGARESKEIMFPKMVAHCCRFLCYFCRISRHNQKAMFDHLSYLLDHSSVGLASPSMRGST PLDVAAASVMDNYELALSLTEADLEKVVQYLAGCGLRSCSLLVSKGYPDIGWNPVEGERY LDFLRFAVFCNGESVEENAYVVVRLLIRRPECFGPALRGEGGDGLLATMEEAIRISEDQN RDGSSRVYYSSSTLDTLDDEDDDIIHMGHAIMTFYSALIDLLGRCAPEMHLIEAGKGEAV RIRAILRSLIPVKDLEGVISIPFSLPFVDTDGSVMEPDMSRLFCPDHKAAMVLFLDRVYG VQDQNFLLCLLKNGFLPDLKAAVTMDTSGLGGTDMALALNRYVCVAVLPFLSKNSSLLCD PTPVQTTAVDALLQELYSLSKASGLTKAQRDSIQDCLLCVCGKLKPSLVQPLLQNLVLDV PQLTENTKMPLKLLTNHYEHSWKYYCMTGAQGGSGSASEEELQLSRKLFWAVFRALSKKS FAADLFELTLGCLSAVSGAIPPDHTDPSYAGGLEGNSSLDSEGRFCPQPLDTSNVIVPET LDYVVNKYAEHTHEKWSLEKFASGWAHGEQKCESSKVHPLLKPYRALSERDKESYRGAIK ETVKSMLVLGWTIERTKEGEARGLHNLARRISQSGQLSFEGTSTFSPKPADTSCITLTWD QYAMAEQLAENYHNIWAKRKLQELQAKGGGSHSLLVPYEVLSAREKSRVRERAQDVLKFF HMIGYTVWREQTPADTDSPATASRFAYCLLQQALSITDQAQEQMLELEVVQARGQMGRTE KIPHEQQIFFFTKVLLPLIDQYFKNHHIYFLSRTLCSLSSSAHASIKETEMVTSLFCKLG ALTRRRISLFGKDAQSVVSCLQILARSLQHRAVIRTPGESVQSALCVFFKDAEVDLELAV ESVNAGPYGQSRSQARGDAELLTYITTALIPVLTALFQHTEHCHSSEQLMVGEVRGCCYR ILCSLYTLGTCNHSFMERQRPVLGECLAALSAAFPVCFLELSLTTSSDEEREAADMLCTS LPSLQDAFSEVEDLAEAGSAARHAALSRVMEVTLPLLCSYVCRWGEAADPGSSELDGSCS SVTTRDTNVLLGQALSIIQSQLGTPDCSWIKRIAVFVQPLVCKSEPRLLKSHFLPLMEKL KKRAESVLQEEERMKTEGCSDLAEAELAIQSKFTVMVQDLYAFYPLLIPFVDNHRMSWLR EMNEEAERLFFLVAEVFIFWAKSHNFKWEEQNFVVQNDINNLNFLVGGGRSQKGGVAEDE RRRMKRSKDERYSAHTSLIVAALKKLLPVGLNRCCHDDRDLVAVAKGRFSEKDTEEEVRA CVRYNLQEEITDGLADSLRVERVLTIARVLFFLEQVEHPQRSKRAVWQKLLSKQRKRAVV ACLRMTPLYNLPRHRAVGLFLLGYRKIWVEAEEEDCENKLIEDLAKTTGIGMLEEGRREG MKEKEKIDPLHQLITFFRQSAQTERRKLDEDTLYLAYADIMAKSCQNDDGDDNDEEVKSF EEKELEKQRLLFQQARLHDRGAAEMVLQKLSGSRGTMGLMVASTLKLGIAILNGGNTAVQ QKMLDYLREKRDVGFFHSLAGLMQSCSVLDLNAFERQIKAEGLEVAAKDSAGDKVMADEQ LTCDLFRFLQLLCEGHNAGFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWHYSG KDVIDDHGQRNFSKAIRVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHM QMKLSQDSSQIDLLKELMDLLKDMVVMLLSLLEGNVVNGMIGKQMVDMLVESSSNVEMIL KFFDMFLKLKELVSSDAFKEYDPDRQGLISKKDFQRAMEGYKRYTPSETEFILSCVETNE SKLLDYRAFVSRFHEPAKDIGFNVAVLLTNLSEHMPHDGQLRNFLELADSVLSYFQPHLG RIEIMGSGKRIERVYFEISESSRTQWEKPQVKESKRQFIFDIVNEGGEKEKMELFVNFCE DTIFEMQLAAQISGSGHGEEARGKEEDGAEESQGKDENVYAENSNPEEPKDFLSSSLSKM TEILLTPLYGLMLVFSLLSIRNLRKNMKKTSVKGLFLAIFFFFQSILTGIIRTIFATICF FFYILYLVFLSGWIINIAKETKLSELVYHLRDPTLDEVTEENEGVSEVRDQTHALSSRDI LRAVSVDLSAVSRNPQLLTDIFGLQLRKEGGQYTLLTRESDGSLGDLVDPSKFQTMVSEE DSEEQEKQSETEKAEGEEDEKKDKRKEQKARRRSRMANLDKAAEQEVQESAAWKTICSQK TKLLNYFARHFYNIRVLALCVAFTINFILLFYKVSSSKAEEESGSDLREEWSGDSGAVCF VLGESGYMEPVLHCLAVLHTLIAFCSIIGYYCLKVPLVIFKREKELARNLEFDGLYVTKQ PSEDDIKGQWDRLVINTPSYPSNYWDKFVKRKVMEKYSELYGSDRISELLGLDKTALDFS SEAQERRKPVRESLITTLLSAVDMKYQIWKLGVVFTDNSFLYLTWYMLLSVLGHYNNFFF AAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDG EPLDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDESEFYRVVFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSEYFDAVPHGFESHTLQEHNLANYL FFVMYLINKDVTEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLSKEIP NT seq 14739 nt NT seq  +upstreamnt  +downstreamnt atgggagccacagagggagaagaggacttccagtttctccggacgtcagatgagctggtg ttgcgatgctgctcatctgtgccgctccagcagaagctgtgtttggcagtggagggcttc ggctgccgtctctgcttccttgagtccacatccaactcgaagaatgttccggctgacctg tctcgctgtgtgtttgtgctggaccggtgtgtgtccgtccgtgcactgcagcaaatgatt gccaaccatgaggacctacaaatcaagtcttcagaagctgctggtcgtcgcactctcctt tatggtcaggcacttctactaagacacgcgctcagcgatatgtatctgagctgtctatcc tcctctggactctccgctgataaactggcatttgacgttggacttcaggaagatgtagaa ggtgaggcctgttggtggacggtccaccctgcttccaagcagaggtcagaaggtgagaaa gtacgggtgggtgatgacctcattttggtcagcgtctcttctgaaagatacctgcatgtc tcgtggagtgcgggagtgtgtgatgatgctggggtcagcagtgtggatgcagcatttcag cagactctgtggagtgtggctccggtctcctccggcactgctgaagctcagggccacctg agaggaggggacaccctgcgactgctgcacggccacacagatgagtgtctgaccattcca cctgctggacgtggagaggagcagcgcagatctgttcattttgaaggcggctctgcatca tcacaagctcgttctctctggagggttgagatgttgtgcgtctcctggagtggaagtcac actcgttgggggcagtcgttccgtttgcgtcacgtcaccacagggagatatttaggtctg ttaagggatggaggattacagctagtggagagagagcaggcagacatcaaatccactgct ttctgtctccgtccagctaaggatgctggccaggagtatgtggacgtcgtcagaaagaga gagggaatgggggcacctgaggtcaaatacggagactctgtttgctttgttcagcatgtt gacacctgcctgtggctcacctaccagaccagtgatttaaagagaaggaaagaagagaag gggctgcataaacaggccattctgcattcagaggggcacatggacgatgggctcacgctc tcgcgctcccagagggaggagtctcaagctgctggtctcatacgcagctccgccttcctt ttttcaagctttataaggggattggacgagagggctaacatttcatcctcagagctccaa attgacagattgagtctgagcttgcaggacttgattagatacttccgttcccctggagaa ggtcagggtcatgaggcgaagcagagcagcatcagagcactgaagaacagacagcacctg tttcaggaagagggtatcattactctggttctggactgcattgatcacctgcatctgtac agcagcgcagcacattttgccagggttgctgggaaagaggcaggagatgcatgggaggca attctgagctcactctatgagcttctggccgccctgatccgaggcaatcgaaacaactgc tcccagttctccacctctctagactggctggtcagcagattagagaagctggaggcttcc actggaatcctagaagtgctgcactgtgtgttaaaggagagtccagaggccttgaatttc atcaaagagggtcacatcagatctatcatctcactgttagataaacacggacgcaacccg aagatcctggacgttctgtgttcgctgtgtgtatgtcatggaatggcggttcgctgtaac cagaacctgatctgtgacgcacttctgcccgagagagacttgctgctgcagtcacgactc gtcaaccaggtcaccagcatccgtccaaacatctacctctgcatgggcgatgactccgct cagcacaggaaatggtactatgaggtggtggtggaaaaggcgcagccttttgtaacagct gaacctactcacctgagagtgggctgggcctgcactgcagggtaccgcccttctccgaca ggaggtcatggctgggggtcaaatggagtaggggatgacctctgctcctatggatttgat ggactgcatctgtggacaggaggcactgggcgaagagtgagctcactcaatcagcacctt ctgagagaggacgatgtcatcagctgttgccttgacctttccgcttcctgcatctccttc cgggtcaacgggcagccggtgcagggcatgctggagaacttcacagctgatgggctgctg tttccagtggtgagcttttcagctggagtcagggtgcgtctgctcttcggaggaaagcag ggagagtttaagtttctgccccctagtggattctcaccatgcgctgaagccttgctcccc ggggggcgctgtagattggagctgtgtgaagagttcactcgatttcaaggcagtggccag tgtgacctcttaggccctacagtgccactcggcccagtgatctttaccccaacaccagtg gacaccagtcagttggtgttacctccccagctggagctgatcagagagcgtcttgctgaa aaccttcatgagctctggctcctggacaagatcgagcagggatggacccatggaccagtc agagatgacagtaaaaaggttcaccctggacttgctgagttttccaaacttccagaacaa gagaggcagagcaacctgcaggccgctgaaaacaccatcaggaccctcttggcccttggt gcccatatcgggctgtctgaggaccacgctgaggagaatgtgaaatacgtcaggctctca aacaagtatgagttgtgcaacggctacagacctgctccagtagatcagtctggaatatcc ctgtccgctggccaggaggctttggtggaggcgctgactgagaacgagcacaacctgtgg gccagagagcgcatcagacagggttggagctacgcaacacaactggatgttaagggtaaa aggagtccccagctggtgccgttttctctgctagaggagagaattaagtgctgcagtaga gaggcagcgagggatgccttggggactctgcttggacttggatacgctgtagagtcaaca gaacaccagcaagctcttacaggccctgaagtgaaaactgcaggtgaggagacgtttcgg atcttccgtgtggaacactcctttgctgtctgggatgggaagtggtattttgagtttgag gtggtcactgatggagagatgagtgtgggctgggcacagcctggcagtaaaccggatgtg gagctgggctcagatgaccaggcctttgtgtttgatggctgtaagggtcagtggtggcat ggcagtgccgtgagactaggtcgtccctggcaggagggggatgtgattggctgtttgttg gatttatctcagaagaccatgatggtcactctaaatggagagcttcagctgaacagcagt ggctctgagatcgctgcaaaagacttcagtgtatctggtggtttcctccctgtgtgtagt ttgggtgtgaaccaagtgggacgtctgaatttaggccggcagtttgactcgctgaaatac ttcagtgtttgtgggctccaggaagggtaccagcctttcggcctcaacatgagtagagac cttcctctgtggatgagctggaaggaacccatgtttgtttctatactggaggaccacact tccatacaggtgacccgcactgatggaacagcagactgccccccagctctgagggtctcc cagaagtcagtggtggcgccagacagcactgcagtagagttctatcgtctgagcatgccc atagagtgtgcgcaggtgttctcgaaacctgcagagggcgctgttcctgccagcagcagc gtgatctgccacgcccgagagctggacgaaggggaggtggactctgactttgaggtgctg atgaagtcggtgcacaggtacacaggaagcagggatgagctgaacaaccacaaggaccac acccaggagaaaccctccaaactcaaacaacggtttcttttgaagaagaagccagagttg aacactagtggctcctcagcacggttactggaggaggtgctggcaatcgagagggatgac tgtaaccaacttacaggctgcactaagtactactattctttaaagatcctaaatggccaa gagccgtcctgtgtttgggttggctggattacctcaaccttccaccctcctgagcaaccc tttgacctggaaaaagttcacactgtgatggttacactgggagatgactggggcaaggtc cttgagagtgtcaggcgcagttgctgttacatggtttgcgcagcagcagagggcagcagt ctctctcacagtcgcagtagcagtggactggagattggctgtctggtcgacacagcgact ggacttcttaccttcaccgctaatggaaaagatatggaaacctttttccaggtggagcca ggcaccaagctgttcccagctgtttttgccaaagcaaccagtttagatgtcttccagttt cagcttggacggatcaagggtgtacttccactgtctgctgggatgttccggagcgagagg aataatgcagtgcctcagtgtccacccaggctgtccgtgcagcgcctgacccgtgcaaga tgggcccgattacctgaccacagtccacatgtgcagctgactcgactaggggagggccac ggttggagagcacagtgcaccgacagtctgcaggtcatgaccctgtatatcccggaggag gagaggtgtcttgacattctagaactctccgaactcgagcacctcctcaagttccacgaa cacacactcaacctctactctgccctctgtgcccatggaaacctacatgtaagccatgcc ctgtgcagctacatcgaccaatcacagctcctctttgccctgcagtgtcctagaatgcct ggcaccctgcgagagagtttctacaaccttttaaccagtgcccacctcagtgcccatgcc agtgctcaacaggccaccactcacgagtacatcgtgcccatgaccgacgccacacggagc attgccctctttaaaagtgacggcaaacgccacagcctcccaggaagtgacatcagcacc tcgctacgacccagaatgcacttctcctcaccttgttttatcagctctagcaaccctatc caggctggcagtcctccagggtttccactggacatcctgaagggtgttaccacagccatg ctggaggaggcggtgcacgcagtggggcagagtgtgagagatcctatagggggcagcata gagctgctgctcgttcctctcctccagctgctccacacactgctcctcatgggtgtgttt cagggctccgatctgagacgtgtgctttcactcattttaccctctgcctatatgggagaa aacgacatggaaagatgggcggatggagatgaagaaggtagagatggtgagaaaaaagac gaggacaaggagagatgggtcagtgttcctcttctggagctacagatgaagcttccagag gcagtgaaactaaagctgtgtcacctgctgcagtacctgtgcgactgtcaggttcggcac agggttgaggctgtgttggcgttctccgatgaccttgtggatcatctccaggataaccag cgctaccgttacaacgaggtcatggaggcactcaacatgtcggcggctctcaccgctcgc aagaccaaggagttccgctctccacctcaagaacagatgaacatgttgctgaatttccag gagagtcagcaggagtgtccatgtcctgaggagatcaaagacctcctctgggactttcac atagacctgaggagacactgtgaagttgaggttgaggatgaagaccaggccactaaagat gaggtggatccacctaataggtataggttgaaaggcctggtggatagaatcgttcgccta aagcggaggatgtctggaattgtggaagaggatattgtgactaagtcagtctctcttcag cagctgatctcagacaccatgctgcgctgggctcacgaagggctgctggagaatcccact ctggtacgggctgctttcagtctgctgcagtggcagtacgccggactatccggacagatg gccgccccactccgcaaagcctactgcatcagccagagctctgtagaggacaccctgtac ctgcaggaggcgctagggagaatccgctctctgctcagggccagaatgggcagagaagaa gaggaactcatgattcgaggacttggtgacatcatgaaaaacaaggtgttctaccagcat ccgaacctgatgagggctctgggaatgcatgagactgtcatggaggtgatggtcaatgtc cttggtgcaagagagtccaaggaaatcatgtttccaaagatggtggcccactgttgcaga ttcctgtgctatttctgccggatcagccgacataaccagaaggccatgttcgatcacctc agctacctcctggaccacagcagcgtgggacttgcatccccctccatgcgaggctccacc cccctggacgtagctgcagcttcagtcatggacaactatgaactggcactgtccctcaca gaagcagacctggagaaggtggtgcagtatttggcaggctgtggtttgcgtagttgttct ctactggtctccaaaggctacccagacatcggttggaatcctgtggaaggagagagatac ttggacttcctgcgatttgctgtcttctgtaatggtgaaagcgtagaggagaatgcttat gtggtggtgaggctcctgattcgtcgacctgagtgctttggacccgccctgcgaggggag gggggagatggactcttggcaacaatggaggaggccatcaggatttctgaggaccagaat agagacgggtcttccagggtgtattactctagtagtaccctggatactctggatgacgag gacgatgacatcatccacatggggcacgccataatgaccttctactcagccctcattgac ctgctgggccgctgtgcccctgaaatgcatcttatagaagccggtaagggtgaggctgtt cgtatcagagcgatcttgaggtctttgattcctgtgaaggacctggagggagtgatcagc atcccgttctccctcccctttgtggacacagatggttctgtgatggagccagacatgtcc aggcttttctgtccagaccataaagcagccatggtgctgtttctggaccgggtctatgga gtccaggaccagaactttctgctttgtttacttaagaacggcttccttcctgacctgaaa gctgctgttacaatggatacttctggtttgggtggtacagacatggctctggctctgaac cgctacgtgtgcgtggctgtgctgccgtttctgagtaagaactcgtccttgctgtgcgac cccactcctgtacagacgactgcagtggatgctctcctgcaggagctctacagcctctct aaagccagcggcctcactaaagcccagagggactctatccaggactgcttgctctgtgtt tgtggaaaactgaagccctccctggtacagcctctgctgcagaaccttgtgctggacgtt cctcagctgacagagaacaccaagatgcctcttaagttgttgaccaaccattatgagcac agctggaagtactactgcatgaccggggcacagggcggctctgggtctgcctcggaggag gagcttcagctcagcaggaagcttttttgggctgtttttcgagctctatccaaaaagtct tttgcagcagatttgtttgagctgacattaggctgcctcagtgctgtttctggagccatt cccccagaccacactgaccccagctatgctggagggctggaggggaactcctcactggac tcagagggacggttctgccctcagcctctggacacctccaacgtgatcgtgccagagacg ctggactatgtggtgaataagtatgcagaacacactcatgagaagtggtcactggagaag tttgccagtggttgggctcatggggagcagaagtgtgagagctctaaagttcatcctctc ctgaagccctacagagccttatctgagagggacaaagaaagctacagaggagccattaag gagactgtgaagagcatgctggtattgggatggaccatcgagaggacgaaggaaggagag gcaaggggtctgcataacctagccaggaggatctcacagtctgggcagctctcctttgaa ggaacctccacattcagccctaaacctgcagacaccagctgcatcacactgacctgggat cagtatgctatggctgagcagctagcggagaactaccacaacatctgggccaagaggaaa ctacaggagctgcaggctaaaggagggggcagtcactcacttctagtgccgtacgaggtc ctgagtgccagagaaaagagccgagtgcgagagcgagctcaggatgtgcttaagttcttc catatgattgggtacacagtgtggagggaacaaacgcctgcagacacagactctcctgcc actgccagtcgctttgcctactgtctgctccagcaggccctgtccatcactgaccaggca caggaacagatgctggagctggaggttgtgcaggctagagggcaaatgggaaggacagaa aagattcctcatgaacaacagatcttctttttcaccaaggtgttgttgcctctaatcgat cagtattttaagaaccaccacatctacttcctgtccagaactctgtgttccctcagtagc agtgctcatgcctctattaaagagacagagatggtcacaagtttgttctgtaaacttgga gccctgaccaggcgtaggatttctctttttggtaaggatgctcagtcagtggtgagctgc ctgcagattcttgcacgctctcttcagcacagggcagtgataaggacgccgggggagagt gtgcagtcagccctgtgcgtgttttttaaggatgcagaggtggatttggagctggctgtg gagagtgtaaatgcggggccgtacggtcagagcaggtcccaggccagaggagatgctgaa ctgctgacctacataaccactgcactcattccagtactgaccgccctgtttcagcatact gaacactgccacagctcagagcaactgatggtgggtgaagtgcggggctgctgttaccgc atcctttgcagtctctacactcttggcacatgtaatcactcttttatggaaaggcagagg ccggttctgggggaatgccttgctgctttatcagctgcttttccagtgtgtttcctggag ctgtcgcttaccacgagcagtgatgaagagagagaagcagctgatatgctgtgcacaagc ctcccctccctgcaggacgcgttctctgaggtcgaggatctggccgaggccgggtctgct gctcgtcacgccgctctgtccagggttatggaggtcactctgccgctgctgtgcagctat gtgtgccggtggggagaagcggctgacccgggttcttctgagctggatgggtcgtgctct tctgttaccactcgagacaccaacgtcctcctaggacaagccctgtccatcatccagagc cagctgggcacacctgactgcagctggataaagcgaatcgcagtgttcgttcagcctctt gtttgtaagtcggagccccgcctcctgaagagccacttcttgcctctgatggaaaagcta aagaagagggcggagtctgtgctgcaggaagaggagcgcatgaagaccgaggggtgtagt gatcttgcagaggcagagctcgcaatccagagcaaatttacagtgatggtgcaagatctg tatgctttttaccctctactcatcccatttgtagacaatcacagaatgagctggctgaga gagatgaatgaagaggctgagaggcttttcttcctggtggccgaggttttcattttctgg gccaaatctcacaacttcaagtgggaggagcagaactttgtggtccagaatgacatcaac aacttgaactttcttgttggtggtgggaggagccaaaagggtggagtggctgaagatgag aggaggaggatgaagaggagcaaagatgagcggtactccgcacacacctcgctgatcgtg gccgctctgaagaagctcctgcctgttggtttaaaccgatgttgccatgacgatcgggac ctggttgctgtggcaaagggacggttctctgagaaagacacagaggaggaagtgcgagcg tgcgtccgctacaacctgcaggaggagattactgatggattggcagattcgctgcgtgtt gagagggttctcaccattgctcgtgtccttttcttcctggagcaggtggagcatcctcag aggagtaagagggcagtgtggcaaaagctgctgtccaagcagaggaagagagcagtggtg gcctgtttaaggatgacccctctctacaacctgcccaggcacagagcagtgggcttgttt cttctgggctacaggaagatctgggtggaagccgaagaggaggactgtgagaacaagcta attgaagatttagctaaaaccacaggaattggaatgttggaggagggaaggagagaagga atgaaggagaaggaaaagattgaccctcttcatcagctcatcaccttcttccgtcaaagt gcacagacagagagacgcaaattggacgaggacactctgtacctggcctatgctgacatc atggccaagagctgccagaatgatgatggggatgataatgatgaagaggtgaaatctttt gaggagaaggagcttgaaaagcagaggctgttgttccaacaagccagactacacgatcgt ggagctgcagagatggtcctccagaaactcagcggcagcagaggcactatgggcctgatg gtggcgtccactcttaaacttggaatagcaatcctgaatggagggaacactgctgtacag cagaaaatgctggactacctaagagagaagagggacgtgggattctttcacagcctggcc ggcctcatgcagtcctgcagtgtgttggatctgaatgctttcgagaggcagatcaaagca gagggtttagaagtggcagctaaagacagcgcaggtgataaagtgatggcagatgaacag ctgacatgcgacctcttccgatttctccagctgctttgtgaaggacataacgcaggtttt cagaattatttgaggactcagactggaaacaacaccacagtcaatatcatcatctccact gtggactacctactcagagtacaggagtccataagcgacttctactggcattactctgga aaggacgtgattgacgatcatggccaacgcaacttctccaaagccataagagtggccaag caggtcttcaacacactgacggagtatattcagggtccatgcactggaaaccagcagagt ctggctcatagtcgtctgtgggacgctgtggtgggattcttgcacgtcttcgctcacatg cagatgaaactgtctcaggactccagtcagattgacctgctaaaggagttgatggatctt cttaaagacatggtggtgatgcttctgtctttgcttgaaggtaatgtggtcaacggaatg attggcaagcagatggtagacatgctagtggagtcctcaagcaacgtcgagatgatcctc aagttctttgacatgttcctgaagctcaaagaacttgtttcttccgatgccttcaaagaa tatgacccggataggcaagggctgatctccaagaaggacttccagagggccatggagggc tacaagcgctacacaccgtctgagactgagtttattctctcctgcgtggagacgaacgaa agcaagctcctggactacagggcatttgtttcacgctttcacgagccagccaaagacatc ggcttcaacgtggccgtcctcctgaccaacctgtctgagcacatgccccatgacggccag ctgcggaactttctggagctagcggacagtgtgctgagctacttccagcctcatctgggc aggattgagataatgggcagtgggaagcgcatcgagagggtctactttgagattagcgag tcgagccgcacgcagtgggaaaaaccacaggtgaaggagagcaaacgccagttcatcttt gacattgtgaacgagggaggagagaaagaaaagatggagctgttcgttaacttctgcgag gacaccatttttgagatgcagctggctgcgcagatctctggctctggccacggggaggag gccagggggaaggaagaggatggagcagaagaaagccaggggaaagatgaaaacgtctat gcagaaaactccaacccagaagagccaaaagactttctatcttcttctttatcaaagatg acagagatcctcctgacccctctgtacggcttaatgttggtcttttctctcctctccata aggaatctgaggaagaacatgaaaaagacgtctgtgaagggcttatttttggccatcttt ttcttcttccagagtatactaacaggcataattcgcactatttttgccactatttgcttc ttcttctacatcctttacctggttttcttgagcgggtggatcattaatatagctaaagag actaaactttctgagctcgtctatcatttacgggaccccaccctggatgaggtcacagag gagaacgagggggtcagtgaggtcagagatcagacacatgccctttcatctagagacatc ctgcgggcagtgagtgttgatctgtcagcggtgtccagaaatcctcagctgctgacggac atatttggccttcagctgaggaaggagggagggcagtacacactgctgaccagggagtca gacggcagcctcggtgacctggttgatccctccaaattccagacgatggtgtctgaggaa gattcggaggagcaggagaagcagtcagagacagaaaaagctgaaggagaagaggatgag aagaaagacaagaggaaggagcagaaggccagaagaagaagcagaatggccaacttagac aaggcagctgagcaggaggttcaggaatcagctgcttggaaaaccatctgctctcagaag accaagctgctgaactattttgccaggcatttctacaatatacgggtgctcgcactgtgt gtggccttcaccatcaatttcatcctactgttctacaaggtatcctccagtaaggctgaa gaggaaagtgggagtgatctcagggaggagtggagtggagattcaggggctgtgtgtttt gttctgggggaaagcggatacatggagcctgttctccactgtctcgctgttttacacact ctgattgctttctgctccatcattggctactactgtctgaaggttcctttagtgatcttc aaacgggagaaggagctggcacgtaacctggagttcgacggcctctatgtgaccaagcag ccctctgaggacgacatcaaaggccagtgggacagactggtcattaacactccatcctac cccagtaattactgggataaatttgtgaagaggaaggtgatggagaagtacagtgagttg tatggctcagatcggatcagtgagctgctgggtttggataaaacagcgctggacttcagc tctgaggctcaggaacgaagaaaaccagtcagagagagtctcatcaccaccctactgagt gctgttgatatgaagtatcaaatatggaagttaggagtggtcttcactgataattccttc ctgtatctaacctggtacatgctgctgtcagtcctggggcactacaataatttcttcttc gctgcacatctactggacatcgccatgggcttcaaaacgctacgtaccatcctatcatct gtcactcacaacggcaaacagctggtgctgactgtgggactgctggcagtggtggtgtat ctctacactgtagttgcttttaacttcttccggaagttctacaacaagagtgaagatggg gagcctttggacatgaaatgtgacgatatgctgacgtgttacatgtttcacatgtatgtc ggggttcgagctggaggagggatcggtgatgaaatcgaggatccagcaggagatgagtct gagttttaccgcgtggtttttgatatcaccttcttcttctttgtgattgtcatccttctg gccatcattcaaggtctgatcattgatgccttcggagagttaagggatcaacaggaacag gtgaaagaggacatggagactaaatgctttatctgtggcattgggagtgaatactttgac gcagttcctcacgggtttgagtctcatactctgcaagaacacaacttggccaactatctg ttctttgtgatgtacctcatcaataaagatgtgacagagcacacgggacaggagtcatac gtatggaagatgtaccaggagcgctgctgggagttctttccggttggagactgcttccgt aaacagtatgaagatcagctcagtaaagagattccataa

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