| Entry |
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| Symbol |
JAK3
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| Name |
(RefSeq) tyrosine-protein kinase JAK3 isoform X1
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| KO |
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| Organism |
aml Ailuropoda melanoleuca (giant panda)
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| Pathway |
| aml04550 | Signaling pathways regulating pluripotency of stem cells |
| aml04658 | Th1 and Th2 cell differentiation |
| aml05166 | Human T-cell leukemia virus 1 infection |
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| Brite |
KEGG Orthology (KO) [BR:aml00001]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
100474005 (JAK3)
04151 PI3K-Akt signaling pathway
100474005 (JAK3)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
100474005 (JAK3)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
100474005 (JAK3)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
100474005 (JAK3)
04659 Th17 cell differentiation
100474005 (JAK3)
04062 Chemokine signaling pathway
100474005 (JAK3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100474005 (JAK3)
05203 Viral carcinogenesis
100474005 (JAK3)
09162 Cancer: specific types
05223 Non-small cell lung cancer
100474005 (JAK3)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100474005 (JAK3)
05161 Hepatitis B
100474005 (JAK3)
05162 Measles
100474005 (JAK3)
05169 Epstein-Barr virus infection
100474005 (JAK3)
09163 Immune disease
05340 Primary immunodeficiency
100474005 (JAK3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:aml01001]
100474005 (JAK3)
Enzymes [BR:aml01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
100474005 (JAK3)
Protein kinases [BR:aml01001]
Non-receptor tyrosine kinases
JAK family [OT]
100474005 (JAK3)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
4:complement(12983451..13000807)
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| AA seq |
1104 aa
MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDHSAEELCVWAAKA
SGILPVYHSLFALATEDLSCWFPPSHVFSVEDSGTQVLVYRLRFYFPNWFGLEKCHRFRL
RKDLASAILDLPVLEHLFAQHRNDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQQ
PEELLKTVSYKVCLPPDLRDLIQGLSFVTRKRIRRTVRRALRRVTACQADRHSLMAKYIM
DLERLDPARAVETFLVSLPGAADGQDAQGLLRVAGDSGIAWSPGGQEALQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTSDSRHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDCFLLTVCVQTP
LGPDYKGCLIRRDPTGTFSLAGLGRPHSSLRELLAACWDGGLHVDGVALNLTVCCTPKPK
EKSNLTVVRRGCNPPTSSPVQAQSQCQLSQMTFHKIPPESLEWHENLGHGSFTKIYRGCR
HEVVEGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ
EFVHLGALDTYLLKSGHLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGNLPFIKLSDPGVSPTVLNREMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS
GIPMPISTLDPAKKLQFYEEQQQLPAPKWMELATLIQQCMAYESGQRPSFRAIIRDLNSL
ITSDYELLSDPTPGALAPRDGLWNGAQLYAYQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFEREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLGSCRCVHRDLAARNILVESE
THVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYGNKSCSPSAEFLRMMECDRDVPALCRLLDLLAEGQRLPAPPACPGEVHELMKLCWAP
SPQDRPTFSALGPQLDALWSASRG |
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| NT seq |
3315 nt +upstreamnt +downstreamnt
atggcgcctccaagcgaggagacacccctgatccctcagcgttcctgcagcctctcgtct
tcagaggctggtgccctgcatgtgctgctgccccctcggggccctggacccccgcagcgt
ctatccttctcctttggggaccattcagctgaagagctgtgtgtttgggctgctaaggcc
agtggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctgc
tggttccccccgagccacgtcttctccgtggaggactcaggcacccaagtcctggtctac
aggctccgcttttacttccccaactggtttgggctagagaagtgccaccgcttcaggcta
cgaaaggacttggccagcgccatccttgacctgcccgtcctggagcacctcttcgcccag
caccgaaatgacctggtgagcggccgcctccctgtgggcctcagtctcaaggagcagggt
gaatgtctcagcctggcggtgctggacctggcccggatggcccgcgagcaggctcagcag
cctgaggagctgctaaagacggtcagctacaaggtctgcctgccccccgacctgcgcgac
ctgatccagggcctgagcttcgtgacacgcaagcgcatccggaggaccgtgcgccgggcc
ctgcgccgcgtgaccgcctgccaggctgacaggcactcgctcatggccaagtacattatg
gacctggagaggctcgacccggccagggcggtcgagaccttcctcgtgagcctccctggg
gctgctgatggtcaggatgcgcaggggctgctccgagtggctggtgacagcggcatcgca
tggagtccaggaggacaagaggccctccagcccttctgcgactttccagaaattgtggac
atcagcatcaagcaggctccgcgtgttggcccggccggggagcaccgcctggtcaccgtc
accaggacagacaaccagatcctggaggccgagttcccggggctgccggccgcgttgtcc
ttcgtggcgctcgtcgacggctacttccggctgacctctgactccaggcacttcttctgc
aaggaggttgcgccgccacggctgctggaggaggtggcagagcagtgccacggccccatc
accctggattttgccatcaacaagctcaagactgggggttcacgtccgggctcgtacgtt
ctccgccgcagtccccaggattttgactgcttcctcctcactgtctgtgtccagaccccg
ctgggtcctgattacaagggctgcctcatccggcgtgaccccacggggaccttctccctg
gctggcctaggccgtccccacagcagtcttcgagagctcttggcagcctgctgggacggt
gggctgcacgtggatggggttgcgctgaacctcacggtctgctgcacccccaaacccaaa
gaaaagtccaacctgactgtggtgcggaggggttgcaacccacccacgtcgtcccctgtt
caggcccaatcccaatgtcagctgagtcagatgacgtttcacaagatccctcctgagagc
ctggagtggcatgagaacttgggtcacgggtccttcaccaagatttaccggggttgtcgc
catgaggtcgtggagggcgaggcccgggagacggaggtgctgctcaaagtgatggatgcc
aagcataaaaactgcatggagtcatttctggaagcagcgagtttgatgagccaagtgtca
taccagcatcttgtgttgctccatggcgtgtgcatggctggagacagtatcatggtgcag
gaatttgtacacctgggagctctggacacgtacctgctcaagtctggccacctggtgcca
gccagctggaagctgcaggtgatcaagcagctggcctacgccctcaactacctggaagac
aaaggcctcccccatggcaatgtctcagcccggaaggtgctcctggctcgcgaaggggct
gatgggaacctgcccttcatcaagctgagtgaccctggtgtcagccccactgtgctaaac
cgggagatgctcactgacaggatcccctgggtggcccccgagtgtctccaggaggcccgg
acacttggcttggaagctgacaagtggggttttggtgccacagtctgggaggtgttcagt
gggatcccgatgcccatcagcaccctggatcctgccaagaagctccagttttatgaggaa
cagcagcagctgcctgcccccaagtggatggagctggccacactgatccaacagtgcatg
gcctatgagtcaggccagaggccctccttccgcgccatcatccgtgacctgaacagcctc
atcacttcagattatgagctcctctcagaccccacaccgggtgccttggcgccccgtgac
gggctatggaatggcgcccagctctacgcctaccaggaccctaccatttttgaggagaga
cacctcaagtacatctcacagctgggcaagggcaacttcggcagcgtggaactgtgccgc
tatgacccgctgggtgacaacacgggcgccctagtggcagtgaagcagcttcagcacagc
gggccagaccagcagagggacttcgagagggagatccagatcctcaaagcccttcacagc
gacttcatcgtcaagtaccgcggtgtcagctatggcccaggccgtcagagcctgcggctg
gtgatggagtacctgcccagcggctgcctgcgcgacttcctgcagcggcaccgcgcgcgc
ctcgacgccagccgcctgctcctctacgcctcgcagatctgcaagggcatggagtacctg
ggctcctgccgctgcgtgcaccgcgacctggcagcgcgtaacatcctggtggagagcgag
acgcacgtcaagatcgccgactttggcctcgccaaactgctgccactcgacaaagactac
tacgtggtccgcgagcccggccagagccccatcttctggtatgccccagagtccctctct
gacaacatcttctcacgccagtcggatgtctggagcttcggggtcgtcctgtacgagctt
ttcacctacggcaacaagagttgcagcccctcagccgagttcctgcggatgatggaatgt
gatcgagatgtccccgccctctgccgcctcctggatctgctggctgagggccagaggctg
cccgcgcctcctgcctgccctggtgaggttcatgagctcatgaagctatgctgggcccct
agcccgcaagaccggccaacattcagtgccctgggcccccagctggatgcactatggagt
gccagccgggggtag |
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