Ailuropoda melanoleuca (giant panda): 100474121 Help Entry 100474121         CDS       T01329                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism aml  Ailuropoda melanoleuca (giant panda) Pathway aml00230   Purine metabolism aml01100   Metabolic pathways aml01522   Endocrine resistance aml04015   Rap1 signaling pathway aml04020   Calcium signaling pathway aml04022   cGMP-PKG signaling pathway aml04024   cAMP signaling pathway aml04062   Chemokine signaling pathway aml04072   Phospholipase D signaling pathway aml04081   Hormone signaling aml04082   Neuroactive ligand signaling aml04114   Oocyte meiosis aml04211   Longevity regulating pathway aml04213   Longevity regulating pathway - multiple species aml04261   Adrenergic signaling in cardiomyocytes aml04270   Vascular smooth muscle contraction aml04371   Apelin signaling pathway aml04540   Gap junction aml04611   Platelet activation aml04713   Circadian entrainment aml04714   Thermogenesis aml04720   Long-term potentiation aml04723   Retrograde endocannabinoid signaling aml04724   Glutamatergic synapse aml04725   Cholinergic synapse aml04727   GABAergic synapse aml04742   Taste transduction aml04750   Inflammatory mediator regulation of TRP channels aml04911   Insulin secretion aml04912   GnRH signaling pathway aml04913   Ovarian steroidogenesis aml04914   Progesterone-mediated oocyte maturation aml04915   Estrogen signaling pathway aml04916   Melanogenesis aml04918   Thyroid hormone synthesis aml04921   Oxytocin signaling pathway aml04923   Regulation of lipolysis in adipocytes aml04925   Aldosterone synthesis and secretion aml04926   Relaxin signaling pathway aml04927   Cortisol synthesis and secretion aml04928   Parathyroid hormone synthesis, secretion and action aml04934   Cushing syndrome aml04935   Growth hormone synthesis, secretion and action aml04970   Salivary secretion aml04971   Gastric acid secretion aml04972   Pancreatic secretion aml04976   Bile secretion aml05032   Morphine addiction aml05163   Human cytomegalovirus infection aml05166   Human T-cell leukemia virus 1 infection aml05200   Pathways in cancer aml05207   Chemical carcinogenesis - receptor activation aml05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:aml00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100474121 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100474121 (ADCY8)    04371 Apelin signaling pathway     100474121 (ADCY8)    04020 Calcium signaling pathway     100474121 (ADCY8)    04072 Phospholipase D signaling pathway     100474121 (ADCY8)    04024 cAMP signaling pathway     100474121 (ADCY8)    04022 cGMP-PKG signaling pathway     100474121 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     100474121 (ADCY8)    04081 Hormone signaling     100474121 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100474121 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     100474121 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100474121 (ADCY8)    04062 Chemokine signaling pathway     100474121 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     100474121 (ADCY8)    04923 Regulation of lipolysis in adipocytes     100474121 (ADCY8)    04912 GnRH signaling pathway     100474121 (ADCY8)    04913 Ovarian steroidogenesis     100474121 (ADCY8)    04915 Estrogen signaling pathway     100474121 (ADCY8)    04914 Progesterone-mediated oocyte maturation     100474121 (ADCY8)    04921 Oxytocin signaling pathway     100474121 (ADCY8)    04926 Relaxin signaling pathway     100474121 (ADCY8)    04935 Growth hormone synthesis, secretion and action     100474121 (ADCY8)    04918 Thyroid hormone synthesis     100474121 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     100474121 (ADCY8)    04916 Melanogenesis     100474121 (ADCY8)    04925 Aldosterone synthesis and secretion     100474121 (ADCY8)    04927 Cortisol synthesis and secretion     100474121 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100474121 (ADCY8)    04270 Vascular smooth muscle contraction     100474121 (ADCY8)   09154 Digestive system    04970 Salivary secretion     100474121 (ADCY8)    04971 Gastric acid secretion     100474121 (ADCY8)    04972 Pancreatic secretion     100474121 (ADCY8)    04976 Bile secretion     100474121 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     100474121 (ADCY8)    04727 GABAergic synapse     100474121 (ADCY8)    04725 Cholinergic synapse     100474121 (ADCY8)    04720 Long-term potentiation     100474121 (ADCY8)    04723 Retrograde endocannabinoid signaling     100474121 (ADCY8)   09157 Sensory system    04742 Taste transduction     100474121 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     100474121 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     100474121 (ADCY8)    04213 Longevity regulating pathway - multiple species     100474121 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     100474121 (ADCY8)    04714 Thermogenesis     100474121 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100474121 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     100474121 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100474121 (ADCY8)    05163 Human cytomegalovirus infection     100474121 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     100474121 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100474121 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100474121 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100474121 (ADCY8) Enzymes [BR:aml01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100474121 (ADCY8) SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  100474121 NCBI-ProteinID:  XP_002917664 UniProt:  G1M362 LinkDB All DBs Position 9 Genome browser AA seq 1252 aa AA seqDB search MELSDVRYLTGPEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGG SGRRGSGKASNPAGGGPNHHAAPLSGDSALPLYSLGPGERAHSTGGTKVFPERSGSGSCS GSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT SLLQVVLQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPE DIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA FIVLLFITAIQSLLPSSRLMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLAFNSSAVFTDICSYPEYFVFT GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKE ASLLLMAVFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL VQSLNRQRQKQLLNENNATGIIKGHYNRRTLLAPSGPEPGAPAEGTDKSDLP NT seq 3759 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgatgtgcgctacctgaccggccctgaggaactctacaccatccacccg acgcccccggccggcgacggcgggagcggctcccggccgcagcggctgctgtggcagacg gcggtgaggcacatcaccgagcagcgcttcattcacggacaccggggcagcggcggcggc agcgggaggagaggctccggcaaagcctcgaaccctgcaggcggcggccccaaccatcac gcggcgccgctgtccggcgactcggcgctgcccctctactcgctgggccccggggagaga gcgcacagcaccggtggcaccaaagtcttcccggaacgcagcgggagcggcagctgcagc ggcagcgggggcgggggcgatctgggcttcctgcacctcgactgcgccccgagcaactcg gatttcttcctcaatgggggctacagctacagaggggtcatttttcccactctgcgcaac tccttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagaggcgc aaatccgaggtggtgatgaacgtgctggacgtgctgaccaaactcaccctcttggtcctg cacttgagcctggcctcggcccccatggatccgctcaagggcatcctcctgggcttcttc actggcatcgaggtggtgatctgcgccctggtggtggtcaggaaggacaccacctcgcac acgtacctgcagtacagcggcgtggtcacttgggtggccatgaccacccagatcttggcg gcaggcctcggctacgggcttctgggtgatggcatcggctacgttctcttcacgctgttc gccacctacagcatgctgccgctgccgctcacctgggccatcctagccggcctgggcacc tcgctgctgcaggtggtcctgcaggtggtcatcccccggctagcggtcatttccatcaac caggttgtggcccaggcagtgttgttcatgtgtatgaacacagctgggatcttcatcagt tacctgtcagaccgggcccagcgccaagccttcctggagacgcggaggtgtgtggaggcc aggctccgcctggagacggaaaaccaaagacaggagcgtctcgtgctatctgtgctcccc cgctttgtcgtcctggaaatgatcaatgacatgaccaatgttgaagacgagcacttgcag caccagttccatcggatctacatccatcgctatgagaacgtcagtattctttttgcagat gttaaaggatttaccaacctctcaacaaccttgtctgcccaggagctggtccggatgctc aacgagctctttgccagatttgatcgactggcccatgagcatcactgccttcgcattaaa atcctgggggactgttactactgtgtttcagggcttcctgagccccgccaggaccacgcc cactgctgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgaggtcgagg acgaagcatgatgtggacatgcggattggaatccactccggctcggtgctgtgtggcgtg ttgggcctgcggaagtggcagtttgatgtctggtcttgggatgtggacattgcaaacaaa ctcgaatctggaggaatccccgggaggattcacatttccaaagccacgctggactgcctc aacggtgactataacgtggaagagggtcatggtaaagagagaaacgaattcttgaggaag cataatattgagacctatttgattaagcagcctgaagagagtctgctgtcattgcccgaa gacatcgtcaaggagtcggtgagctcctcagacaggagaaacagtggggcgacattcaca gaaggatcctggagccccgaactgccctttgataacatagtggggaaacagaacactctg gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc ctggagcacaagtattctcaaatgagggatgaagtattcaagtcaaacttggtctgtgca tttatcgttcttctctttatcacggcgatacaaagtttgcttccttcctcaaggctgatg ccgatggccatccagttttccatcctgattatgctgcactcggctctggtcctcatcacc acggcggaggattataagtgtttgccccttgtcctccggaaaacttgctgttggattaac gagacctatttggcccggaacgtcattatctttgcatccatcttgattaacttcctgggc gccatcttgaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctggct ttcaattcctcagctgtgtttacagatatctgctcctacccagagtacttcgtgttcact ggggtgctggccatggtgacctgtgcggttttcctccgcctgaactctgtcctgaagctg gccgtgctgctgattatgatcgccatctatgccctgctcaccgagaccgtctacgcgggc ctctttctgcgctacgacaacctgaaccacagtggagaagatttcctggggaccaaggag gcgtcactgctcctgatggccgtgttcctccttgccgtgttctaccacggacagcagctg gagtatacagcccgccttgacttcctctggcgggtacaggccaaagaggagatcaatgag atgaaggagctgagggaacacaacgagaacatgctccggaacattctacccagccacgtg gcccgccacttcctggagaaagaccgagacaacgaggagctgtattctcaatcctacgat gccgtcggggtgatgttcgcctctatcccagggttcgcagacttctactctcagactgaa atgaataaccaaggagtggaatgcctgcgcctgctgaatgagatcattgctgacttcgat gagctgctcggcgaagaccggtttcaagacattgaaaagattaagaccattggcagcacc tacatggccgtgtcaggcctgtcacccgaaaaacagcaatgcgaagacaagtggggacat ttgtgcgccctggccgacttctccctcgccctgaccgagagcatacaggagatcaacaag cattccttcaacaatttcgaactccggatcggcatcagccacggctcggtggtagccggc gttatcggcgctaagaaaccgcaatatgacatttggggcaaaaccgtgaacctggcaagt cgaatggacagcacgggggtcagcggcaggatccaagtccccgaggagacctatctcatc ctgaaggaccagggctttgcctttgactaccgaggggagatctacgtgaagggcatcagt gaacaggaaggaaaaatcaaaacatactttctgctgggaagagtccaacccaacccattc atcctgcccccgagaagactgcccgggcagtactccctggccgcggtcgtcctgggcctt gtccagtccctcaacaggcaaaggcagaagcagctgctcaacgagaacaacgccacgggg atcatcaagggtcattacaaccggcggactttgttggcacccagcgggccagagcccgga gccccagccgaaggcaccgacaagtccgatttgccataa

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