KEGG   ORTHOLOGY: K08048
Entry
K08048                      KO                                     

Symbol
ADCY8
Name
adenylate cyclase 8 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04742  Taste transduction
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08048  ADCY8; adenylate cyclase 8
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04371 Apelin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04020 Calcium signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04072 Phospholipase D signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04024 cAMP signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04022 cGMP-PKG signaling pathway
    K08048  ADCY8; adenylate cyclase 8
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08048  ADCY8; adenylate cyclase 8
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08048  ADCY8; adenylate cyclase 8
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08048  ADCY8; adenylate cyclase 8
   04062 Chemokine signaling pathway
    K08048  ADCY8; adenylate cyclase 8
  09152 Endocrine system
   04911 Insulin secretion
    K08048  ADCY8; adenylate cyclase 8
   04923 Regulation of lipolysis in adipocytes
    K08048  ADCY8; adenylate cyclase 8
   04912 GnRH signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04913 Ovarian steroidogenesis
    K08048  ADCY8; adenylate cyclase 8
   04915 Estrogen signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04914 Progesterone-mediated oocyte maturation
    K08048  ADCY8; adenylate cyclase 8
   04921 Oxytocin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04926 Relaxin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04935 Growth hormone synthesis, secretion and action
    K08048  ADCY8; adenylate cyclase 8
   04918 Thyroid hormone synthesis
    K08048  ADCY8; adenylate cyclase 8
   04928 Parathyroid hormone synthesis, secretion and action
    K08048  ADCY8; adenylate cyclase 8
   04916 Melanogenesis
    K08048  ADCY8; adenylate cyclase 8
   04925 Aldosterone synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
   04927 Cortisol synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08048  ADCY8; adenylate cyclase 8
   04270 Vascular smooth muscle contraction
    K08048  ADCY8; adenylate cyclase 8
  09154 Digestive system
   04970 Salivary secretion
    K08048  ADCY8; adenylate cyclase 8
   04971 Gastric acid secretion
    K08048  ADCY8; adenylate cyclase 8
   04972 Pancreatic secretion
    K08048  ADCY8; adenylate cyclase 8
   04976 Bile secretion
    K08048  ADCY8; adenylate cyclase 8
  09156 Nervous system
   04724 Glutamatergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04727 GABAergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04725 Cholinergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04720 Long-term potentiation
    K08048  ADCY8; adenylate cyclase 8
   04723 Retrograde endocannabinoid signaling
    K08048  ADCY8; adenylate cyclase 8
  09157 Sensory system
   04742 Taste transduction
    K08048  ADCY8; adenylate cyclase 8
   04750 Inflammatory mediator regulation of TRP channels
    K08048  ADCY8; adenylate cyclase 8
  09149 Aging
   04211 Longevity regulating pathway
    K08048  ADCY8; adenylate cyclase 8
   04213 Longevity regulating pathway - multiple species
    K08048  ADCY8; adenylate cyclase 8
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08048  ADCY8; adenylate cyclase 8
   04714 Thermogenesis
    K08048  ADCY8; adenylate cyclase 8
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08048  ADCY8; adenylate cyclase 8
   05207 Chemical carcinogenesis - receptor activation
    K08048  ADCY8; adenylate cyclase 8
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08048  ADCY8; adenylate cyclase 8
   05163 Human cytomegalovirus infection
    K08048  ADCY8; adenylate cyclase 8
  09165 Substance dependence
   05032 Morphine addiction
    K08048  ADCY8; adenylate cyclase 8
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08048  ADCY8; adenylate cyclase 8
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08048  ADCY8; adenylate cyclase 8
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08048  ADCY8; adenylate cyclase 8
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08048  ADCY8; adenylate cyclase 8
Other DBs
RN: R00089 R00434
GO: 0008294
Genes
HSA: 114(ADCY8)
PTR: 464400(ADCY8)
PPS: 100994715(ADCY8)
GGO: 101142672(ADCY8)
PON: 100461383(ADCY8)
NLE: 100592592(ADCY8)
MCC: 695792(ADCY8)
MCF: 102144854(ADCY8)
CSAB: 103237447(ADCY8)
CATY: 105588369(ADCY8)
PANU: 101007115(ADCY8)
RRO: 104675683(ADCY8)
RBB: 108514094(ADCY8)
TFN: 117079299(ADCY8)
PTEH: 111549769(ADCY8)
CJC: 100404484(ADCY8)
SBQ: 101034552(ADCY8)
MMUR: 105882731(ADCY8)
MMU: 11514(Adcy8)
MCAL: 110310371(Adcy8)
MPAH: 110334612(Adcy8)
RNO: 29241(Adcy8)
MCOC: 116082049(Adcy8)
CGE: 113837458
PLEU: 114697724(Adcy8)
NGI: 103743923(Adcy8)
HGL: 101698293(Adcy8)
CCAN: 109678665(Adcy8)
OCU: 100337882(ADCY8)
OPI: 101523667(ADCY8)
TUP: 102472317(ADCY8)
CFA: 482045(ADCY8)
VVP: 112915982(ADCY8)
VLG: 121498514(ADCY8)
AML: 100474121(ADCY8)
UMR: 103661704(ADCY8)
UAH: 113252717(ADCY8)
ORO: 101370350(ADCY8)
ELK: 111146667
MPUF: 101693988(ADCY8)
EJU: 114211178(ADCY8)
MLX: 118015219(ADCY8)
FCA: 101087555(ADCY8)
PYU: 121042990(ADCY8)
PBG: 122495819(ADCY8)
PTG: 102948581(ADCY8)
PPAD: 109273118(ADCY8)
AJU: 106976879(ADCY8)
HHV: 120221853(ADCY8)
BTA: 535017(ADCY8)
BOM: 102272964(ADCY8)
BIU: 109568647(ADCY8)
BBUB: 102395302(ADCY8)
CHX: 102184919(ADCY8)
OAS: 101121944(ADCY8)
ODA: 120878868(ADCY8)
CCAD: 122451315(ADCY8)
SSC: 100622999(ADCY8)
CFR: 102521259(ADCY8)
CBAI: 105082946(ADCY8)
CDK: 105096450(ADCY8)
BACU: 103019172(ADCY8)
LVE: 103085845(ADCY8)
OOR: 101273171(ADCY8)
DLE: 111164400(ADCY8)
PCAD: 102975211(ADCY8)
ECB: 100057796(ADCY8)
EPZ: 103565019 103567623(ADCY8)
EAI: 106824833(ADCY8)
MYB: 102249345(ADCY8)
MYD: 102765722(ADCY8)
MMYO: 118670715(ADCY8)
MNA: 107539500(ADCY8)
HAI: 109372359(ADCY8)
DRO: 112315487(ADCY8)
SHON: 118988683(ADCY8)
AJM: 119064806(ADCY8)
MMF: 118631528(ADCY8)
PALE: 102896789(ADCY8)
PGIG: 120588721(ADCY8)
RAY: 107497689(ADCY8)
MJV: 108397669(ADCY8)
TOD: 119237825(ADCY8)
LAV: 100661616(ADCY8)
TMU: 101350704
MDO: 100026554(ADCY8)
SHR: 100923926(ADCY8)
PCW: 110216073(ADCY8)
OAA: 100077908(ADCY8)
GGA: 420328(ADCY8)
PCOC: 116227752(ADCY8)
MGP: 100548951(ADCY8)
CJO: 107310566(ADCY8)
NMEL: 110394336(ADCY8)
APLA: 101794043(ADCY8)
ACYG: 106046364(ADCY8)
TGU: 100230277(ADCY8)
LSR: 110476995(ADCY8)
SCAN: 103816719(ADCY8)
PMOA: 120505202(ADCY8)
OTC: 121337449(ADCY8)
PRUF: 121364662(ADCY8)
GFR: 102037430(ADCY8)
FAB: 101809046(ADCY8)
PHI: 102108193(ADCY8)
PMAJ: 107200813(ADCY8)
CCW: 104692638(ADCY8)
ETL: 114065892(ADCY8)
FPG: 101921528(ADCY8)
FCH: 102056487(ADCY8)
CLV: 102086133(ADCY8)
EGZ: 104134444(ADCY8)
NNI: 104016868(ADCY8)
ACUN: 113476386(ADCY8)
PADL: 103916382(ADCY8)
AAM: 106496221(ADCY8)
AROW: 112971840(ADCY8)
NPD: 112959414(ADCY8)
DNE: 112991309(ADCY8)
ASN: 102369910(ADCY8)
AMJ: 102562540(ADCY8)
CPOO: 109322048(ADCY8)
GGN: 109305202(ADCY8)
PSS: 102448969(ADCY8)
CMY: 102930804(ADCY8)
CPIC: 101947738(ADCY8)
TST: 117873819(ADCY8)
CABI: 116823168(ADCY8)
ACS: 100556578(adcy8)
PVT: 110090751(ADCY8)
PBI: 103049018(ADCY8)
PMUR: 107289979(ADCY8)
TSR: 106542281
PGUT: 117668453(ADCY8)
PMUA: 114600245(ADCY8)
ZVI: 118089989(ADCY8)
GJA: 107119214(ADCY8)
XLA: 108719413(adcy8.L) 414729(adcy8.S)
XTR: 549366
NPR: 108788952(ADCY8)
DRE: 100148976(adcy8) 560410(si:ch211-132f19.7) 560719(si:dkey-206f10.1)
IPU: 108257757 108280230(adcy8)
PHYP: 113532110 113543309(adcy8)
EEE: 113584128(adcy8)
LCO: 104922014 104938356(adcy8)
NCC: 104955036(adcy8)
CGOB: 115022284(adcy8) 115028833
ELY: 117250016 117270489(si:dkey-206f10.1) 117272061(adcy8)
PLEP: 121951261(adcy8) 121955835(si:dkey-206f10.1)
SLUC: 116044740(adcy8) 116066255(si:dkey-206f10.1)
ECRA: 117953964(adcy8) 117961123(si:dkey-206f10.1)
PFLV: 114564992(adcy8) 114572973
GAT: 120808486
PPUG: 119194976(si:dkey-206f10.1) 119209002(adcy8)
MSAM: 119901661(adcy8) 119908444 119908457(si:dkey-206f10.1) 119915897
CUD: 121506508 121519638(adcy8) 121521629(si:dkey-206f10.1)
OAU: 116310796(si:dkey-206f10.1) 116316516(adcy8) 116325033
OML: 112144246(adcy8) 112156739 112158536(si:dkey-206f10.1)
CTUL: 119784215(adcy8) 119785063(si:dkey-206f10.1) 119791543
KMR: 108229092(si:ch211-132f19.7) 108246168(adcy8)
ALIM: 106527219(adcy8) 106531266
CSEM: 103380838 103396830(adcy8)
XGL: 120788729(si:dkey-206f10.1) 120798356 120799361(adcy8)
HCQ: 109518125 109518881(adcy8)
BPEC: 110155800 110165875(adcy8)
MALB: 109970259(adcy8) 109971087
SASA: 106568630(adcy8) 106611404
OTW: 112250071(adcy8) 112255820(si:ch211-132f19.7)
OMY: 110504263(si:ch211-132f19.7) 110529931(adcy8)
SALP: 111957123(adcy8) 112076728
SNH: 120022998(si:ch211-132f19.7) 120056232(adcy8)
ELS: 105023619(adcy8) 105031560
SFM: 108918520 108937764(adcy8)
PKI: 111845896(adcy8)
AANG: 118229366(si:dkey-206f10.1) 118234492(adcy8)
LOC: 102685748(adcy8) 102694194
PSPA: 121309014(adcy8)
ARUT: 117399547(adcy8)
LCM: 102346737(ADCY8)
CMK: 103183440(adcy8)
RTP: 109914598(adcy8)
BFO: 118405038
BBEL: 109476272
CIN: 100181005
SCLV: 120336024
SKO: 100370378
DME: Dmel_CG10564(Ac78C)
DER: 6546178
DSE: 6616399
DSI: Dsimw501_GD12142(Dsim_GD12142)
DAN: 6493061
DSR: 110189946
DPE: 6602992
DMN: 108152936
DWI: 6645098
DGR: 6558351
DNV: 108652084
DHE: 111599815
DVI: 6623758
CCAT: 101449938
BOD: 106622843
MDE: 101893364
LCQ: 111677112
ACOZ: 120949475
AARA: 120894424
AAG: 5563558
AALB: 109414810
CPII: 120415895
AME: 726262
ACER: 107993030
BIM: 100741339
BBIF: 117209501
BVK: 117233726
BVAN: 117158627
BTER: 100650732
CCAL: 108626074
OBB: 114874916
MGEN: 117228046
NMEA: 116426288
CGIG: 122401165
SOC: 105208160
MPHA: 105831878
AEC: 105145442
ACEP: 105621896
PBAR: 105425253
VEM: 105566125
HST: 105185447
DQU: 106740959
CFO: 105247922
FEX: 115242516
LHU: 105672367
PGC: 109856473
OBO: 105279868
PCF: 106787929
NVI: 100679362
CSOL: 105367908
TPRE: 106651649
MDL: 103569316
FAS: 105267081
DAM: 107039258
CCIN: 107268305
DPA: 109539855
ATD: 109600572
AGB: 108912049
LDC: 111504846
NVL: 108558843
PPYR: 116169542
OTU: 111419609
BMOR: 101744252
BMAN: 114249948
MSEX: 115448811
BANY: 112058332
PMAC: 106707822
PPOT: 106111023
PXU: 106114758
PRAP: 110992313
ZCE: 119829857
PXY: 105382561
API: 100161699
DNX: 107163062
AGS: 114123034
RMD: 113561352
BTAB: 109032361
DCI: 103516636
CLEC: 106663679
NLU: 111044266
FOC: 113211545
ZNE: 110834851
CSEC: 111865456
FCD: 110854056
DMK: 116932776
PVM: 113803537
HAME: 121876217
HAZT: 108672252
EAF: 111704198
DSV: 119448858
RSAN: 119381807
RMP: 119170587
TUT: 107365159
DPTE: 113796993
PTEP: 107439048
SDM: 118184219
PMAX: 117316821
LAK: 106153878
AQU: 100637659
DFA: DFA_04345(acaA)
SPAR: SPRG_05070
 » show all
Reference
PMID:8076676
  Authors
Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J
  Title
Molecular cloning of the human type VIII adenylyl cyclase.
  Journal
FEBS Lett 351:109-13 (1994)
DOI:10.1016/0014-5793(94)00836-1
  Sequence
[hsa:114]
Reference
  Authors
Roger B, Papin J, Vacher P, Raoux M, Mulot A, Dubois M, Kerr-Conte J, Voy BH, Pattou F, Charpentier G, Jonas JC, Moustaid-Moussa N, Lang J
  Title
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
  Journal
Diabetologia 54:390-402 (2011)
DOI:10.1007/s00125-010-1955-x
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