Amycolatopsis methanolica: AMETH_5177
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Entry
AMETH_5177 CDS
T03230
Symbol
aceE
Name
(GenBank) pyruvate dehydrogenase E1 component
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
amq
Amycolatopsis methanolica
Pathway
amq00010
Glycolysis / Gluconeogenesis
amq00020
Citrate cycle (TCA cycle)
amq00620
Pyruvate metabolism
amq00785
Lipoic acid metabolism
amq01100
Metabolic pathways
amq01110
Biosynthesis of secondary metabolites
amq01120
Microbial metabolism in diverse environments
amq01200
Carbon metabolism
amq01210
2-Oxocarboxylic acid metabolism
Module
amq_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
amq00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
AMETH_5177 (aceE)
00020 Citrate cycle (TCA cycle)
AMETH_5177 (aceE)
00620 Pyruvate metabolism
AMETH_5177 (aceE)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
AMETH_5177 (aceE)
Enzymes [BR:
amq01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
AMETH_5177 (aceE)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_C_1
Transketolase_N
Transketolase_C
Motif
Other DBs
NCBI-ProteinID:
AIJ25269
UniProt:
A0A076MWN8
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Position
5340612..5343419
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AA seq
935 aa
AA seq
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MAPQNDQAAGTGASTDRAPARVRVIRDGLAAHLPDIDPEETAEWLDSFDEALARGGQQRA
RYLMLRILERARERNVGVPPLTATDYVNTIPTENEPWFPGDEEIERRYRAYIRWNAAIMV
HRAQRPGVSVGGHISTYASSAALYEVGFNHFFRGKDHSGGGDHVFIQGHASPGIYARAYL
EGRLSEQQLDGFRQELSHAGEGGGLPSYPHPRLMPGFWEYPTVSMGLGPMNAIYQARFNR
YLRDRGIKDTSDQHVWAFLGDGEMDEPESRGLIHVAAGEGLDNLTFVINCNLQRLDGPVR
GNGKIIQELEAYFRGAGWNVIKVIWGREWDALLHADRDGALVNLMNQTPDGDYQTYKAND
GAYVREHFFGRDPRTKDLVKDMSDADIWNLKRGGHDYRKVYAAYKAAMEHHGQPTVILAH
TIKGYGLGPAFEGRNATHQMKKLTLDDLKLFRDAQRIPISDEELERDPKLPPYYHPGANS
PEIEYMVGRRKTLGGFVPERRNRAKPLVLPGDKVYEAIRKGSGKQEVATTMAFVRLVREL
AKDAEIGHRIVPIIPDEARTFGLDSMFPTAKIYNPHGQTYTSVDANLMLAYKESEHGQLL
HEGINEAGSTSSFTAVGTSYATHGEPMIPIYIFYSMFGFQRTGDGLYAAADQMARGFVLG
ATAGRTTLTGEGLQHADGHSLLLAHTNPAVVAYDPAWSFEIAHIVKDGLRRMYGEGGPDG
NGENVFYYMTVYNEPYRQPAEPENLDVEGLLKGLYRYAEAPSGDGPEAQILVSGVTMPDA
LKAQTMLADEWGVRAAVWSATSWSELRREAVEIDRDNLLHPGDSPRVPYVTEALSGATGP
VVAVSDWMRAVPDLIRPWVPTDMVTLGTDGFGFSDTRPAARRHFLVDAESITVATLAALA
KRGEVAQEKVVEAARKYRIHDVSAAGPQLTDAGNA
NT seq
2808 nt
NT seq
+upstream
nt +downstream
nt
ttggccccccagaacgaccaggccgcaggcaccggcgccagcaccgatcgggccccggcc
cgggtccgcgtcatccgtgacggattggcggcccacctgcccgacatcgaccccgaggag
acagccgagtggctggactcgttcgacgaggcactcgcccggggcggccagcagcgggct
cgctacctgatgctgcggatcctggagcgcgcccgcgagcgcaacgtcggtgtcccgccg
ctgaccgcgacggactacgtcaacaccatccccacggagaacgagccgtggttcccgggc
gacgaggagatcgagcgccgctaccgggcctacatccgctggaacgcggcgatcatggtg
caccgcgcccagcgccccggcgtcagtgtcggcggccacatctccacgtacgcgtcgtcg
gcggcgctctacgaggtcggcttcaaccacttcttccggggcaaggaccactccggcggc
ggtgaccacgtcttcatccaggggcacgcctccccgggcatctacgcccgcgcctacctg
gagggccgtctcagcgagcagcagctcgacggcttccgccaagagctgtcgcacgccggc
gagggcggcggcctgccgtcgtacccgcacccgcggctgatgccgggcttctgggagtac
ccgaccgtgtccatgggcctcggcccgatgaacgcgatctaccaggcccggttcaaccgg
tacctgcgtgaccgcggcatcaaggacacctcggaccagcacgtgtgggcgttcctcggc
gacggcgagatggacgagccggagtcgcggggcctcatccacgtggccgcgggcgagggc
ctggacaacctgaccttcgtcatcaactgcaacctgcagcggctcgacggcccggtgcgc
ggcaacggcaagatcatccaggagctcgaggcgtatttccgcggcgcgggctggaacgtg
atcaaggtcatctggggccgcgagtgggacgcgctgctgcacgccgaccgcgacggcgcg
ctggtcaacctgatgaaccagacgccggacggtgactaccagacctacaaggccaacgac
ggcgcctacgtccgggagcacttcttcggccgcgacccgcggacgaaggacctggtcaag
gacatgagcgacgccgacatctggaacctcaagcgcggcggccacgactaccgcaaggta
tacgcggcgtacaaggcggcgatggagcaccacggccagccgacggtgatcctggcccac
accatcaagggctacggcctcggcccggcgttcgagggccgcaacgccacgcaccagatg
aagaagctcacgctggacgacctgaagctgttccgggacgcacagcgcatcccgatcagc
gacgaggagctggagcgcgacccgaagctgccgccgtactaccacccgggcgcgaactcg
cccgagatcgagtacatggtgggccgccgcaagaccctcggcgggttcgtgccggagcgg
cgcaaccgggccaagccgctggtgctgccgggcgacaaggtgtacgaggccatccggaag
ggctccggcaagcaggaggtcgccaccacgatggcgttcgtgcggctggtgcgcgagctg
gccaaggacgccgagatcggccaccggatcgtgccgatcatcccggacgaggcccgcacg
ttcggcctggactcgatgttcccgacggcgaagatctacaacccgcacgggcagacctac
acgtcggtggacgccaacctgatgctggcgtacaaggagtccgagcacggccagctgctg
cacgagggcatcaacgaggccgggtcgacgtcgtcgttcacggcggtcggcacgtcctac
gccacgcacggcgagccgatgatcccgatctacatcttctactcgatgttcgggttccag
cgcaccggcgatggcctgtacgcggcggcggaccagatggcgcgcggtttcgtgctgggc
gccaccgcggggcgcaccacgctgaccggtgagggtctgcagcacgccgacgggcattcg
ctgctgctggcgcacacaaacccggccgtggtggcctacgacccggcgtggtcgttcgag
atcgcccacatcgtcaaggacggcctgcgccgcatgtacggcgagggcggcccggacggc
aacggcgagaacgtcttctactacatgacggtctacaacgagccgtaccggcagccggcc
gagccggagaacctcgacgtcgaggggctgctcaagggcctgtaccggtacgcggaggcg
ccgtcgggcgacggtccggaggcgcagatcctggtgtccggcgtgacgatgccggacgcg
ctcaaggcgcagacgatgctcgccgacgagtggggcgtgcgcgcggccgtgtggtcggcg
acgtcgtggtcggagctgcggcgcgaggccgtggagatcgaccgggacaacctgctgcac
ccaggtgactcgccgcgcgtgccatacgtgacggaggccctgtccggcgcgaccggcccg
gtcgtggcggtgtcggactggatgcgcgcggtgcccgacctgatccgcccgtgggtgccg
accgacatggtcaccctgggcaccgacgggttcggcttctccgacacgcgtccggcggcg
cggcggcacttcctggtcgacgccgagtcgatcacggtcgccacgctggccgcgctcgcc
aagcgcggtgaggtcgcgcaggagaaggtggtcgaggccgcccggaagtaccggatccac
gacgtgtccgccgccggtccgcagctgaccgacgccgggaacgcctga
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