KEGG   Aotus nancymaae (Ma's night monkey): 105719128
Entry
105719128         CDS       T10127                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
anan  Aotus nancymaae (Ma's night monkey)
Pathway
anan00562  Inositol phosphate metabolism
anan01100  Metabolic pathways
anan01521  EGFR tyrosine kinase inhibitor resistance
anan04012  ErbB signaling pathway
anan04014  Ras signaling pathway
anan04015  Rap1 signaling pathway
anan04020  Calcium signaling pathway
anan04062  Chemokine signaling pathway
anan04064  NF-kappa B signaling pathway
anan04066  HIF-1 signaling pathway
anan04070  Phosphatidylinositol signaling system
anan04072  Phospholipase D signaling pathway
anan04360  Axon guidance
anan04370  VEGF signaling pathway
anan04613  Neutrophil extracellular trap formation
anan04650  Natural killer cell mediated cytotoxicity
anan04658  Th1 and Th2 cell differentiation
anan04659  Th17 cell differentiation
anan04660  T cell receptor signaling pathway
anan04664  Fc epsilon RI signaling pathway
anan04666  Fc gamma R-mediated phagocytosis
anan04670  Leukocyte transendothelial migration
anan04722  Neurotrophin signaling pathway
anan04750  Inflammatory mediator regulation of TRP channels
anan04919  Thyroid hormone signaling pathway
anan04933  AGE-RAGE signaling pathway in diabetic complications
anan04935  Growth hormone synthesis, secretion and action
anan05012  Parkinson disease
anan05022  Pathways of neurodegeneration - multiple diseases
anan05135  Yersinia infection
anan05167  Kaposi sarcoma-associated herpesvirus infection
anan05170  Human immunodeficiency virus 1 infection
anan05171  Coronavirus disease - COVID-19
anan05200  Pathways in cancer
anan05205  Proteoglycans in cancer
anan05206  MicroRNAs in cancer
anan05214  Glioma
anan05223  Non-small cell lung cancer
anan05225  Hepatocellular carcinoma
anan05231  Choline metabolism in cancer
anan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
anan05417  Lipid and atherosclerosis
Module
anan_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:anan00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105719128 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105719128 (PLCG1)
   04014 Ras signaling pathway
    105719128 (PLCG1)
   04015 Rap1 signaling pathway
    105719128 (PLCG1)
   04370 VEGF signaling pathway
    105719128 (PLCG1)
   04064 NF-kappa B signaling pathway
    105719128 (PLCG1)
   04066 HIF-1 signaling pathway
    105719128 (PLCG1)
   04020 Calcium signaling pathway
    105719128 (PLCG1)
   04070 Phosphatidylinositol signaling system
    105719128 (PLCG1)
   04072 Phospholipase D signaling pathway
    105719128 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105719128 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    105719128 (PLCG1)
   04660 T cell receptor signaling pathway
    105719128 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    105719128 (PLCG1)
   04659 Th17 cell differentiation
    105719128 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    105719128 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    105719128 (PLCG1)
   04670 Leukocyte transendothelial migration
    105719128 (PLCG1)
   04062 Chemokine signaling pathway
    105719128 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    105719128 (PLCG1)
   04919 Thyroid hormone signaling pathway
    105719128 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    105719128 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105719128 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    105719128 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105719128 (PLCG1)
   05206 MicroRNAs in cancer
    105719128 (PLCG1)
   05205 Proteoglycans in cancer
    105719128 (PLCG1)
   05231 Choline metabolism in cancer
    105719128 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105719128 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    105719128 (PLCG1)
   05214 Glioma
    105719128 (PLCG1)
   05223 Non-small cell lung cancer
    105719128 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    105719128 (PLCG1)
   05171 Coronavirus disease - COVID-19
    105719128 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105719128 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105719128 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    105719128 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    105719128 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105719128 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105719128 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105719128 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:anan04131]
    105719128 (PLCG1)
Enzymes [BR:anan01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105719128 (PLCG1)
Membrane trafficking [BR:anan04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105719128 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105719128 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 105719128
NCBI-ProteinID: XP_021521438
Ensembl: ENSANAG00000002038
LinkDB
Position
Unknown
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLSEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactct
aagaagtcgcagcgacccgagcggaagacctttcaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatcgagggggccattgatattcgcgaaatcaaggag
atccgcccagggaagacctcacgggactttgatcgctatcaagaggaccccgctttccgg
ccggaccagtcacactgctttgtcattctctatggaatggaattccgcctgaagaccctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagattgagaggtggctccggaagcag
ttttactcagtggatcggaatcgggaggatcgtatatcagccaaggacctgaagaacatg
ctgtcgcaggtcaactaccgggtccccaacatgcgcttcctccgagagcgactgacggac
ctggagcagcgcagcggggacatcacctacgggcagttcgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgtcgagtgtcccttcctgagttccagcagttcctccttgac
taccagggggagctgtgggctgttgatcgcctccaggttcaggagttcatgctcagcttc
ctccgagaccccttgcgagagattgaggagccatactttttcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcgcagctggacgctgtgtgcccggac
accatgaacaaccctctttcccactactggatctcctcctcccacaacacgtacctgacc
ggggaccagttctccagtgagtcctccctggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggtccagatgggatgccagtcatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgcacaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctttccattgaggaccactgcagcattgcc
cagcagagaaacatggcccagtacttcaagaaggttctgggggacacacttctcaccaag
cccgtggatatctctgccgatgggctcccttcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacatccgtgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaatgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagcttggggcagggcgtgac
gggcggcacatcgctgagcgcctgcttactgagtactgcatcgagaccggggcccctgac
ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcccggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgattccctctatgacctcatcacacactaccag
caggtgcccctgcgctgcaatgagtttgagatgcgactttcagaacctgttccacagacc
aacgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctaatgcgtgtcccccgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgagggcaagatcaagcattgccgtgtccagcaggag
ggacagactgtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaagcacccgctataccgcaagatgaagctgcgttatcccatcaatgaggaggca
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctacgtagaggcaaaccctatgccaactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagggaggacgagctgaccttcaccaagagtgctatcatccagaac
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg
ttcccatcaaactatgtggaagagatggtcaaccccgtggccctggagccggagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcttggatgtaccagct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcatcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctctctgagggg
aagatgatggaacggaggaagaagatcgccctggagctctctgagcttgtcgtctactgc
cgacctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcgtccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagccagctcgtggcgctcaacttc
cagacccctgacaagcctatgcagatgaaccaggccctcttcatgacaggcaggcactgt
ggctacgtgctgcagccaagtaccatgcgggacgaggccttcgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctgtattgaggtgctgggggcccgacatctg
ccgaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg
ccggccaagcccttccacttccagatcagtaaccctgaatttgcctttctgcgtttcgtg
gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccagta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagcgaggacctg
gagttggcctccctgctgatcaagattgacattttccctgccaagcaagagaacggtgac
ctcagtcccttcagtggtacatccctgcgggagcggggttcagatgcctcaggccagctg
tttcatggccgagcccgggaaggctcctttgagtcccgctaccagcagccatttgaggac
ttccgcatctcccaggagcatctcgcagaccattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccggctctag

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