KEGG   Arvicanthis niloticus (African grass rat): 117703352
Entry
117703352         CDS       T08817                                 
Symbol
Plcg1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
anu  Arvicanthis niloticus (African grass rat)
Pathway
anu00562  Inositol phosphate metabolism
anu01100  Metabolic pathways
anu01521  EGFR tyrosine kinase inhibitor resistance
anu04012  ErbB signaling pathway
anu04014  Ras signaling pathway
anu04015  Rap1 signaling pathway
anu04020  Calcium signaling pathway
anu04062  Chemokine signaling pathway
anu04064  NF-kappa B signaling pathway
anu04066  HIF-1 signaling pathway
anu04070  Phosphatidylinositol signaling system
anu04072  Phospholipase D signaling pathway
anu04360  Axon guidance
anu04370  VEGF signaling pathway
anu04613  Neutrophil extracellular trap formation
anu04650  Natural killer cell mediated cytotoxicity
anu04658  Th1 and Th2 cell differentiation
anu04659  Th17 cell differentiation
anu04660  T cell receptor signaling pathway
anu04664  Fc epsilon RI signaling pathway
anu04666  Fc gamma R-mediated phagocytosis
anu04670  Leukocyte transendothelial migration
anu04722  Neurotrophin signaling pathway
anu04750  Inflammatory mediator regulation of TRP channels
anu04919  Thyroid hormone signaling pathway
anu04933  AGE-RAGE signaling pathway in diabetic complications
anu04935  Growth hormone synthesis, secretion and action
anu05012  Parkinson disease
anu05022  Pathways of neurodegeneration - multiple diseases
anu05135  Yersinia infection
anu05167  Kaposi sarcoma-associated herpesvirus infection
anu05170  Human immunodeficiency virus 1 infection
anu05171  Coronavirus disease - COVID-19
anu05200  Pathways in cancer
anu05205  Proteoglycans in cancer
anu05206  MicroRNAs in cancer
anu05214  Glioma
anu05223  Non-small cell lung cancer
anu05225  Hepatocellular carcinoma
anu05231  Choline metabolism in cancer
anu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
anu05417  Lipid and atherosclerosis
Module
anu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:anu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    117703352 (Plcg1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    117703352 (Plcg1)
   04014 Ras signaling pathway
    117703352 (Plcg1)
   04015 Rap1 signaling pathway
    117703352 (Plcg1)
   04370 VEGF signaling pathway
    117703352 (Plcg1)
   04064 NF-kappa B signaling pathway
    117703352 (Plcg1)
   04066 HIF-1 signaling pathway
    117703352 (Plcg1)
   04020 Calcium signaling pathway
    117703352 (Plcg1)
   04070 Phosphatidylinositol signaling system
    117703352 (Plcg1)
   04072 Phospholipase D signaling pathway
    117703352 (Plcg1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    117703352 (Plcg1)
   04650 Natural killer cell mediated cytotoxicity
    117703352 (Plcg1)
   04660 T cell receptor signaling pathway
    117703352 (Plcg1)
   04658 Th1 and Th2 cell differentiation
    117703352 (Plcg1)
   04659 Th17 cell differentiation
    117703352 (Plcg1)
   04664 Fc epsilon RI signaling pathway
    117703352 (Plcg1)
   04666 Fc gamma R-mediated phagocytosis
    117703352 (Plcg1)
   04670 Leukocyte transendothelial migration
    117703352 (Plcg1)
   04062 Chemokine signaling pathway
    117703352 (Plcg1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    117703352 (Plcg1)
   04919 Thyroid hormone signaling pathway
    117703352 (Plcg1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    117703352 (Plcg1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    117703352 (Plcg1)
  09158 Development and regeneration
   04360 Axon guidance
    117703352 (Plcg1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117703352 (Plcg1)
   05206 MicroRNAs in cancer
    117703352 (Plcg1)
   05205 Proteoglycans in cancer
    117703352 (Plcg1)
   05231 Choline metabolism in cancer
    117703352 (Plcg1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117703352 (Plcg1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    117703352 (Plcg1)
   05214 Glioma
    117703352 (Plcg1)
   05223 Non-small cell lung cancer
    117703352 (Plcg1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    117703352 (Plcg1)
   05171 Coronavirus disease - COVID-19
    117703352 (Plcg1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117703352 (Plcg1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    117703352 (Plcg1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    117703352 (Plcg1)
   05022 Pathways of neurodegeneration - multiple diseases
    117703352 (Plcg1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    117703352 (Plcg1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    117703352 (Plcg1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117703352 (Plcg1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:anu04131]
    117703352 (Plcg1)
Enzymes [BR:anu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     117703352 (Plcg1)
Membrane trafficking [BR:anu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    117703352 (Plcg1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    117703352 (Plcg1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 117703352
NCBI-ProteinID: XP_034350777
LinkDB
Position
2:130004091..130036705
AA seq 1290 aa
MAGVGTPCANGCGPGAPSEAEVLHLCRNLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNTLRT
GERPEHCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSNMRDEAFDPFDKT
SLRGLEPCIICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIEIYPAKENGDLSPFSGTSLRERTSDASSQLFHVRAREGSFEARYQQPFEDF
RISQEHLTDHFESRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgtcgggaccccctgcgccaacggctgcgggcccggcgcgccctccgaagcc
gaggtgctgcacctctgccgcaacctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgaacggaagaccttccaggtcaagttggagacgcgccagatc
acatggagccgcggcgcggacaaaatcgaggggtccattgatatccgagaaatcaaggag
atccgcccaggaaagacttcacgggactttgaccgctaccaagaagaccctgccttccgg
ccagatcagtcacactgctttgtcatcctctatggaatggaattccgcctgaagactctg
agtctgcaagccacatctgaggatgaagtgaacatgtggatcaaaggcttaacttggctg
atggaggatacactgcaggcagccacacccctgcaaattgagaggtggctccggaagcag
ttctactcagtggatcgtaaccgagaggatcgtatatcagccaaagacttgaagaacatg
ctgtcacaggtcaactaccgggtccccaatatgcgcttcctccgagagcggttgacggac
cttgaacagcgcagtggggacatcacctatgggcagtttgctcagctgtaccgcagcctg
atgtacagcgcccagaagacgatggaccttcccttcttggaaaccaacactttgaggact
ggagagcggccggagcactgccaggtgtctctttctgagttccagcagttccttcttgag
taccagggggagctgtgggctgtggaccggctccaggtacaggaatttatgctcagcttc
cttcgagaccccttgcgagagattgaggagccatacttcttcttggatgagcttgtcacc
tttctgttctccaaagagaacagtgtgtggaactcacagctagatgctgtgtgcccagat
accatgaacaacccactctctcactattggatctcttcctcacataatacgtacctgact
ggggaccagttctccagcgagtcctccctggaagcctatgctcgctgcttgaggatgggc
tgtcgctgcattgagttggactgctgggatggaccagatgggatgccagtcatttaccat
gggcatactctcaccaccaagatcaagttctcagatgtcctgcacaccatcaaggagcat
gctttcgtagcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagagaaacatggctcagcacttcagaaaggtgcttggcgacacactccttaccaag
cctgtggacattgctgctgatgggcttccttctcccaaccagctcaagaggaagatcctt
attaagcacaagaagctggctgagggaagtgcctatgaggaggtgcctacctctgtgatg
tactccgagaatgacatcagtaactccatcaagaatggtatcctctacttggaggacccc
gtgaatcatgagtggtacccccactactttgttctgactagcagcaagatctactactct
gaggagaccagcagtgaccagggcaatgaggatgaggaggagccgaaggaggccagtggc
agcacagagctgcactcaagtgagaagtggttccatgggaagctcggggctgggcgagat
gggcggcacattgccgagcgcctgctcactgagtattgcatagagactggggctcctgac
ggctccttcctagtgcgagaaagtgagaccttcgtgggtgactacacgctgtctttctgg
cggaatgggaaagtccagcactgccgtatccactcccggcaggatgctgggactcctaag
ttcttcttgacagataaccttgtctttgactctctctatgacctcatcacacattatcag
caagtacccctgcgctgcaatgagtttgagatgcgcctttcagagcctgttccacagaca
aatgcccatgagagcaaagagtggtaccacgcaagcctgactagagctcaggctgaacat
atgctgatgcgagtaccccgggacggggccttcctggtgcggaaacgcaacgagcctaac
tcatatgccatctctttccgggctgagggaaagatcaagcactgccgagtacagcaggaa
ggccagactgtgatgctggggaactcggagtttgacagcctggttgacctcatcagctac
tatgagaagcaccccctgtaccgtaaaatgaaactgcgctaccccatcaacgaggaggca
ctggagaagatcgggacagctgaacccgattacggggcactgtacgagggtcgcaaccct
ggtttctatgtggaggcaaaccctatgccaactttcaagtgcgcagtaaaagccctcttt
gactacaaggcccagagagaggacgagctgacctttaccaagagtgccatcatccaaaat
gtggaaaagcaagatggtggctggtggcgaggcgactatggtgggaagaagcagctgtgg
ttcccctcaaactatgtggaagagatgatcaatcctgcaatcctagagccggagagggag
cacctggatgagaatagcccactgggggacttgcttcgaggggtcttagatgtgccagcc
tgtcagatcgccattcgtcctgagggcaaaaacaaccggctcttcgtcttctccatcagc
atgccatcagtggctcagtggtccctagatgttgcagctgactcacaggaagagttgcag
gactgggtgaaaaagatccgtgaagttgcccagactgcagatgccaggcttactgagggg
aagatgatggagaggaggaagaagatcgccttggagctttccgagcttgtggtctactgc
cggcctgttccctttgatgaagagaagattggcacagaacgtgcttgttaccgggacatg
tcctcctttccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcaactctctcgcatctaccctaagggccaaaggctggactcc
tccaattatgatcctctgcccatgtggatctgcggcagccagcttgtagcactcaacttt
cagaccccagacaagcctatgcagatgaaccaggcactcttcatggctggtgggcattgt
ggctatgtgctgcagccaagcaacatgagagatgaagcctttgacccctttgataagacc
agtctccgaggtctggaaccctgcatcatttgcattgaggtgctgggggccaggcatctg
ccaaagaatggccggggtattgtgtgtcctttcgtggagattgaggtggctggggcagag
tatgacagcaccaagcaaaagacggagtttgtagtggacaacggactgaaccctgtgtgg
cctgctaagcccttccacttccagattagtaacccagagtttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctactttcccagta
aaaggcctgaagacaggatatagagcagtgcctttgaagaacaactacagtgaagacctg
gagttggcctccctgctcatcaagattgaaatttaccctgctaaggagaatggtgacctc
agtcctttcagtggtacatccctaagggaacggacctcagatgcctccagccagttgttc
cacgtccgggcccgggaagggtcctttgaagccagataccagcagccatttgaagacttc
cgcatctcgcaggagcatctcacagaccattttgagagtcgggaacgaagggccccaaga
aggactcgggtcaatggagacaaccgcctctag

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