KEGG   Arvicanthis niloticus (African grass rat): 117707219
Entry
117707219         CDS       T08817                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
anu  Arvicanthis niloticus (African grass rat)
Pathway
anu00140  Steroid hormone biosynthesis
anu01100  Metabolic pathways
anu04913  Ovarian steroidogenesis
anu04925  Aldosterone synthesis and secretion
anu04927  Cortisol synthesis and secretion
anu04934  Cushing syndrome
Module
anu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
anu_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
anu_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
anu_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:anu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    117707219
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    117707219
   04925 Aldosterone synthesis and secretion
    117707219
   04927 Cortisol synthesis and secretion
    117707219
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    117707219
Enzymes [BR:anu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     117707219
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     117707219
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA KR RmlD_sub_bind Sacchrp_dh_NADP Ldh_1_N Ufm1
Other DBs
NCBI-GeneID: 117707219
NCBI-ProteinID: XP_034356534
LinkDB
Position
4:complement(78022043..78042283)
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIVQLLVQEKDLEEIRVLDKVFRPETREKFFNIGTNIKVTVFE
GDILDAQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACVQASVPAF
IFCSSVDVAGPNSYKEIIMNGSEEEGHESTWSDPYPYSKRMAEKAVLAANGSILKNGGRL
HTCALRPMYIYGERSPFLANIIISSLKNKGILGVIGKFSIVNPVYVGNVAWAHILAARAL
RDPKKSPNIQGKFYYISDDTPHQSYDDLNYTLSKEWGFHLDSSWSLPLPLLYWLAFLLET
VSFLLSPVYRYRPLFNRHLVTISNSKFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIRTL
VKQHRETLDTKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctgggtggagctgcctggtgactggagcaggagggtttttgggccagaggatcgtc
cagttgttggtgcaggagaaagatctggaggagatcagggtcctggacaaggtcttcaga
ccagaaaccagagagaaattcttcaacataggaacaaacatcaaggtgacagtgttcgaa
ggagacattcttgatgcccagtacctgaggagagcctgccaaggcatctctgttgtcatc
cacaccgccgccatcattgatgtcacaggtgtcattcccagacagaccatcctagatgtc
aatctgaaaggtacccagaacctactggaagcctgtgtccaagccagtgtgccagctttc
atcttctgcagctcagttgatgttgcagggcccaactcctacaaggagatcattatgaat
ggcagtgaggaagagggtcatgaaagcacatggtctgatccatacccatacagcaaaagg
atggctgagaaggcagtgctggcagccaatggaagcatcctgaaaaatggtggcaggttg
catacttgtgccttaaggcccatgtatatttatggggagagaagtccattccttgctaac
ataataattagctccctcaaaaataagggtattctgggtgttattggcaaattctccata
gtcaacccagtgtatgtgggcaatgtagcctgggcgcacattctagctgccagggccctt
cgagaccccaagaagtcaccaaatatccaaggaaagttctactacatctcagatgacacc
cctcaccaaagctatgatgatttaaattacacccttagtaaggagtggggtttccacctt
gattccagttggagccttcctctgcccctgctctactggcttgccttcctgctggaaact
gtgagcttcctgctgagtccagtctacaggtatcgacctctctttaacaggcacttggtc
acaatatcaaatagcaagttcactttctcctacaagaaagctcagcgagatctgggctat
gagccacttgtcagctgggaggaagccaagcagaaaacctcagagtggatcaggacactg
gtgaagcaacacagggagacactggacacaaagtctcagtaa

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