ORTHOLOGY: K00070
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Entry
K00070 KO
Symbol
HSD3B
Name
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Pathway
map00140
Steroid hormone biosynthesis
map01100
Metabolic pathways
map04913
Ovarian steroidogenesis
map04925
Aldosterone synthesis and secretion
map04927
Cortisol synthesis and secretion
map04934
Cushing syndrome
Module
M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Disease
H00216
Congenital adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
04925 Aldosterone synthesis and secretion
K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
04927 Cortisol synthesis and secretion
K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
Enzymes [BR:
ko01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
BRITE hierarchy
Other DBs
RN:
R01837
R02216
R02499
R02840
R03327
R04163
R04678
R04849
GO:
0003854
0004769
Genes
HSA:
3283
(HSD3B1)
3284
(HSD3B2)
PTR:
457165
469446
PPS:
100982464
100983009
100990187
GGO:
101141070
101141801
101146563
(HSD3B2)
PON:
100450898
100451655
100452394
NLE:
100596087
100605995
(HSD3B2)
100606563
100607955
MCC:
712686
(HSD3B2)
713091
713272
715337
MCF:
102133592
102134747
102135110
(HSD3B2)
MTHB:
126931035
126931104
126931154
126951788
CSAB:
103224104
103224109
(HSD3B2)
CATY:
105599590
105599597
(HSD3B2)
PANU:
100999145
101018740
101019096
(HSD3B2)
TGE:
112624233
112634262
(HSD3B2)
RRO:
104654599
104654602
104654605
RBB:
108528160
108528161
108528164
TFN:
117074250
117074256
PTEH:
111549589
111549591
CJC:
100387484
100389654
(HSD3B1)
100400416
100405879
SBQ:
101042680
101051416
CSYR:
103258418
(HSD3B2)
MMUR:
105869786
(HSD3B2)
LCAT:
123635118
(HSD3B2)
OGA:
100966795
MMU:
100043456
(Hsd3b8)
100043461
(Hsd3b9)
15492
(Hsd3b1)
15493
(Hsd3b2)
15494
(Hsd3b3)
15495
(Hsd3b4)
15496
(Hsd3b5)
15497
(Hsd3b6)
MCAL:
110288898
110290813
110290978
110291292
110291371
110291888
MPAH:
110315378
110319834
110319836
110320478
110320490
RNO:
24470
(Hsd3b5)
29632
(Hsd3b2)
360348
(Hsd3b1)
682974
(Hsd3b3)
MCOC:
116093252
116094199
116094200
116094201
MUN:
110542496
110543775
110544350
110563733
110563735
CGE:
100770922
113830678
113833179
113833198
MAUA:
101837099
101842851
(Hao2)
121138738
121142382
PLEU:
114688199
114688619
114688620
114688621
114688750
114688751
114688752
114698547
MORG:
121437803
121437911
121438015
121438017
MFOT:
126490105
126510847
AAMP:
119801286
119801287
119801288
119801289
NGI:
103728305
103732007
103738837
HGL:
101707488
(Hsd3b1)
101707858
CPOC:
100379573
(Hsd3b1)
100725531
100725801
CCAN:
109702728
109702729
DORD:
105991916
105991917
DSP:
122118370
122118374
NCAR:
124964015
124990189
124992819
OCU:
100346986
100347914
OPI:
101522373
101522782
TUP:
102470981
GVR:
103584548
103607308
CFA:
483146
(HSD3B2)
CLUD:
112664108
VVP:
112916789
VLG:
121490669
AML:
100464280
(HSD3B1)
UMR:
103677123
UAH:
113244362
UAR:
123795008
ELK:
111143436
LLV:
125099255
MPUF:
101680243
ORO:
101378904
EJU:
114208061
(HSD3B2)
ZCA:
113909475
(HSD3B2)
MLX:
118000525
(HSD3B2)
NSU:
110580487
(HSD3B2)
LWW:
102742748
FCA:
100616070
(HSD3B2)
PYU:
121027796
PBG:
122481024
LRUF:
124514119
PTG:
102957262
PPAD:
109272160
AJU:
106978496
HHV:
120247640
BTA:
281824
(HSD3B1)
BOM:
102274088
BIU:
109555859
BBUB:
102413429
BBIS:
104993819
CHX:
100860869
(3BHSD)
OAS:
100190978
(HSD3B1)
ODA:
120855999
CCAD:
122435367
SSC:
445539
(HSD3B1)
CFR:
102512447
CBAI:
105079257
CDK:
105089475
VPC:
102528409
BACU:
103015346
LVE:
103083046
OOR:
101284283
DLE:
111179902
PCAD:
102987751
PSIU:
116758472
ECB:
100034078
(HSD3B2)
EPZ:
103548379
EAI:
106832920
(HSD3B2)
MYB:
106723550
(HSD3B2)
MMYO:
118672875
(HSD3B2)
MLF:
106694328
(HSD3B2)
MNA:
107545288
(HSD3B2)
PKL:
118727130
HAI:
109389868
(HSD3B2)
DRO:
112314004
(HSD3B2)
SHON:
118981952
(HSD3B2)
AJM:
119041699
(HSD3B2)
PDIC:
114489256
PHAS:
123804497
(HSD3B2)
MMF:
118637661
RFQ:
117014453
(HAO2)
PALE:
102891879
PGIG:
120585109
PVP:
105296358
RAY:
107518830
(HSD3B2)
MJV:
108390800
TOD:
119236234
SARA:
101555226
101555490
LAV:
100659049
(HSD3B2)
TMU:
101358325
ETF:
101663671
(HSD3B1)
DNM:
101447815
MDO:
100012668
GAS:
123247232
SHR:
100913530
(HSD3B2)
PCW:
110219672
(HSD3B2)
OAA:
100080135
GGA:
396015
(HSD3B1)
PCOC:
116244326
MGP:
104915630
CJO:
107319373
NMEL:
110398845
APLA:
101803865
ACYG:
106045741
(HSD3B1)
AFUL:
116502173
TGU:
751770
(HSD3B1)
LSR:
110480744
SCAN:
103827136
PMOA:
120506495
OTC:
121339296
PRUF:
121351666
GFR:
102039409
FAB:
101817697
PHI:
102101526
PMAJ:
107211459
CCAE:
111938581
CCW:
104687106
CBRC:
103613933
ETL:
114058198
ZAB:
102062520
ACHL:
103801073
FPG:
101921564
FCH:
102052697
CLV:
102087460
EGZ:
104126518
NNI:
104008615
PLET:
104617853
PCRI:
104035039
PCAO:
104053168
ACUN:
113485872
TALA:
104357901
PADL:
103921223
AFOR:
103905431
ACHC:
115344139
HALD:
104319887
HLE:
104831735
AGEN:
126049087
GCL:
127029573
CCRI:
104162430
CSTI:
104558363
EHS:
104512760
CMAC:
104476511
MUI:
104539044
FGA:
104079993
GSTE:
104255879
LDI:
104351289
MNB:
103779544
OHA:
104327359
NNT:
104410259
DPUB:
104298412
PGUU:
104468993
ACAR:
104520429
CPEA:
104384975
AVIT:
104277939
CVF:
104293163
CUCA:
104055667
TEO:
104373662
BRHI:
104496619
AAM:
106497227
AROW:
112963963
NPD:
112960083
TGT:
104576502
DNE:
112985919
SCAM:
104150689
ASN:
102367786
(HSD3B1)
AMJ:
109280168
(HSD3B1)
CPOO:
109319128
(HSD3B1)
GGN:
109304596
(HSD3B1)
PSS:
102453952
CMY:
102934871
CPIC:
101946936
TST:
117886232
CABI:
116817817
MRV:
120396043
ACS:
100561899
(hsd3b1)
PVT:
110076926
SUND:
121922906
PBI:
103067418
PMUR:
107285816
CTIG:
120306125
TSR:
106542700
PGUT:
117661842
VKO:
123033249
PMUA:
114587929
(HSD3B2)
ZVI:
118075222
(HSD3B2)
GJA:
107114856
STOW:
125425234
(HSD3B2)
XLA:
734818
(hsd3b1.L)
XTR:
100490622
NPR:
108802532
RTEM:
120928726
BBUF:
120994332
DRE:
373131
(hsd3b2)
553532
(hsd3b1)
SRX:
107712267
SANH:
107658243
SGH:
107569293
CCAR:
109052439
CAUA:
113108554
113108799
PPRM:
120466714
(hsd3b1)
MAMB:
125270537
(hsd3b1)
IPU:
100304475
(hsd3b1)
PHYP:
113524942
(hsd3b1)
SMEO:
124379336
(hsd3b1)
TFD:
113654422
(hsd3b1)
AMEX:
103027852
(hsd3b1)
EEE:
113587753
TRU:
101069884
(hsd3b1)
TNG:
GSTEN00029150G001
LCO:
104921488
(hsd3b1)
CGOB:
115026845
(hsd3b1)
ELY:
117251590
(hsd3b1)
EFO:
125900207
(hsd3b1)
PLEP:
121949401
(hsd3b1)
121963657
SLUC:
116059361
(hsd3b1)
ECRA:
117953315
(hsd3b1)
ESP:
116697664
PFLV:
114564020
GAT:
120833929
(hsd3b1)
PPUG:
119228951
(hsd3b1)
MSAM:
119884914
119904488
(hsd3b1)
CUD:
121523133
(hsd3b1)
ALAT:
119025245
(hsd3b1)
MZE:
101485719
ONL:
100534568
(hsd3b1)
OAU:
116332553
(hsd3b1)
OLA:
100144358
(3bhsd)
OML:
112138010
(hsd3b1)
XMA:
102228303
XCO:
114147930
XHE:
116723048
PRET:
103477979
PFOR:
103152152
PLAI:
106939754
PMEI:
106917521
GAF:
122839771
(hsd3b1)
CVG:
107087352
CTUL:
119774713
(hsd3b1)
GMU:
124871021
(hsd3b1)
NFU:
107389612
(hsd3b1)
KMR:
108244192
(hsd3b1)
ALIM:
106531920
NWH:
119419363
(hsd3b1)
AOCE:
111570570
(hsd3b1)
MCEP:
125017257
(hsd3b1)
CSEM:
103391994
(hsd3b1)
POV:
109637945
SSEN:
122785783
(hsd3b1)
HHIP:
117755029
117755030
HSP:
118119640
118120310
LCF:
108902437
SDU:
111218347
SLAL:
111652102
XGL:
120801969
(hsd3b1)
HCQ:
109522071
BPEC:
110156192
(hsd3b1)
MALB:
109951646
BSPL:
114847637
(hsd3b1)
SASA:
106586600
STRU:
115161098
OTW:
112240651
(hsd3b1)
OMY:
100136743
(hsd3b1)
OGO:
124044100
(hsd3b1)
ONE:
115112196
SALP:
111978723
SNH:
120058421
(hsd3b1)
CCLU:
121536290
(hsd3b1)
ELS:
105016430
SFM:
108937872
PKI:
111860692
AANG:
118214002
118214003
LOC:
102685561
(hsd3b1)
PSPA:
121320746
(hsd3b1)
ARUT:
117406697
117406856
PSEX:
120522925
(hsd3b1)
LCM:
102345588
CMK:
103180179
(hsd3b1)
RTP:
109918392
BFO:
118415735
118426116
BBEL:
109470289
109481615
109483809
109485072
DME:
Dmel_CG7724
(CG7724)
DER:
6543694
DSI:
Dsimw501_GD14693
(Dsim_GD14693)
DYA:
Dyak_GE19901
DSR:
110187899
110190103
DPO:
4813984
DPE:
6603899
DMN:
108165559
DWI:
6645028
DGR:
6558385
DMO:
Dmoj_GI12485
DAZ:
108612818
DNV:
108651018
DHE:
111602930
CCAT:
101455915
BOD:
106619208
RZE:
108370312
MDE:
101899660
SCAC:
106092781
LCQ:
111691019
LSQ:
119600382
HIS:
119650207
AGA:
AgaP_AGAP006654
ACOZ:
120951979
AARA:
120897593
ASTE:
118514455
AAG:
5566270
AALB:
109407756
109418935
CQU:
CpipJ_CPIJ003056
CPII:
120432614
CNS:
116347823
BCOO:
119081235
NVI:
100120136
CSOL:
105366624
TPRE:
106650065
FAS:
105264423
DAM:
107039335
CCIN:
107268819
DCI:
103516518
CLEC:
106661338
NLU:
111044911
FOC:
113210108
TPAL:
117644725
ZNE:
110831195
CSEC:
111870363
FCD:
110862702
DMK:
116926030
PVM:
113815316
PJA:
122252315
PCHN:
125025755
HAME:
121875688
PCLA:
123764960
PTRU:
123519041
ISC:
IscW_ISCW018715
DSV:
119445622
RSAN:
119377584
119390488
RMP:
119169799
VDE:
111247588
111254724
VJA:
111264476
111268118
TUT:
107363285
DPTE:
113794090
DFR:
124490209
CSCU:
111622487
PTEP:
107437550
SDM:
118201694
HRO:
HELRODRAFT_89375
GAE:
121389292
HRF:
124140226
124141700
HRJ:
124260823
124278058
CRG:
105321517
105332656
105336240
MYI:
110457155
PMAX:
117333059
117333060
117333062
117333069
MMER:
123525098
123534278
123534660
123535065
123535125
123535257
123535266
123552007
OSN:
115219210
LAK:
106151343
» show all
Taxonomy
UniProt
Reference
PMID:
2243100
Authors
Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guerin S, Leblanc G, Labrie F
Title
Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.
Journal
J Biol Chem 265:20469-75 (1990)
Sequence
[hsa:
3283
] [rno:
360348
682974
]
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