KEGG ORTHOLOGY: K00070

ORTHOLOGY: K00070

Entry

K00070                      KO

Symbol

HSD3B

Name

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Module

M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R01837

3beta-hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase

R02216

pregnenolone:NAD+ 3-oxidoreductase

R02499

testosterone delta5-delat4-isomerase

R02840

cortisol delta5-delat4-isomerase

R03327

17alpha-hydroxypregnenolone:NAD+ 3-oxidoreductase

R04163

21-hydroxypregnenolone:NAD+ 3-oxidoreductase

R04678

16alpha-hydroxyandrost-4-ene-3,17-dione delta5-delat4-isomerase

R04849

11-deoxycortisol delta5-delat4-isomerase

Disease

H00216

Congenital adrenal hyperplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
   04925 Aldosterone synthesis and secretion
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
   04927 Cortisol synthesis and secretion
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     K00070  HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase

Other DBs

GO:	0003854 0004769

Genes

HSA:	3283(HSD3B1) 3284(HSD3B2)

PTR:	457165(HSD3B2) 469446

PPS:	100982464(HSD3B2) 100983009 100990187

GGO:	101141070 101141801 101146563(HSD3B2)

PON:	100451655 100452394 100455460

PPYG:

129015890 129015909 129015918

NLE:	100596087 100605995(HSD3B2) 100606563 100607955

HMH:	116469522 116469530(HSD3B2)

SSYN:

134733865 134733875 134734675(HSD3B1)

MCC:	712686(HSD3B2) 713091 713272 715337

MCF:	102129873 102133592 102134747 102135110(HSD3B2)

MTHB:

126931035 126931104 126931154 126951788

MNI:	105479071 105479074 105479078 105479082 105479084(HSD3B2)

CSAB:

103224104 103224109(HSD3B2)

CATY:

105599590 105599597(HSD3B2)

PANU:

100999145 101018740 101019096(HSD3B2)

TGE:	112624233 112634262(HSD3B2)

MLEU:

105541296(HSD3B2) 105541330

RRO:	104654599 104654602 104654605

RBB:	108528160 108528161 108528164

TFN:	117074250 117074256

PTEH:

111549589 111549591

CANG:

105505264 105505267

CJC:	100387484 100389654 100400416 100405879

SBQ:	101042680 101051416

CIMI:

108297130 108301104

ANAN:

105721680(HSD3B2) 105721706 110567017

CSYR:

103258418(HSD3B2)

MMUR:

105869786(HSD3B2)

LCAT:

123635118(HSD3B2)

PCOQ:

105809629(HSD3B2)

OGA:

100966795

MMU:	100043456(Hsd3b8) 100043461(Hsd3b9) 15492(Hsd3b1) 15493(Hsd3b2) 15494(Hsd3b3) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)

MCAL:

110288898 110290813 110290978 110291292 110291371 110291888

MPAH:

110315378 110319834 110319836 110320478 110320490

RNO:	24470(Hsd3b5) 29632(Hsd3b2) 360348(Hsd3b1) 682974(Hsd3b3)

MCOC:

116093252 116094199 116094200 116094201

ANU:	117707219 117707246 117707247 117707273 117707523

ASYL:

127682169 127682171 127682173 127682174 127682178

MUN:	110542496 110543775 110544885 110544899 110563733 110563735 132656956 132656957 132656958 132656961 132656962 132656967 132657118

CGE:	100770922 113830678 113833179 113833198

MAUA:

101837099 101842851(Hao2) 121138738 121142382

PROB:

127232674 127232675

PLEU:

114688199 114688619 114688620 114688621 114688750 114688751 114688752 114698547

MORG:

121437803 121437911 121438015 121438017

MFOT:

126490105 126510847

AAMP:

119801286 119801287 119801288 119801289

NGI:	103728305 103732007 103738837

HGL:	101707488(Hsd3b1) 101707858

CPOC:

100379573(Hsd3b1) 100725531 100725801

CCAN:

109702728 109702729

DORD:

105991916 105991917

DSP:	122118370 122118374

DMER:

138816599 138817117

PLOP:

125344738 125345248 125345249 125345254 125345257 125345259 125345261 125355478 125355479 125355483

NCAR:

124964015 124990189 124992819

MMMA:

107156205(Hao2) 107156207 107156209

ITI:	101959454 101959938 101960216

OCU:	100346986 100347914

OPI:	101522373 101522782

TUP:

102470981

GVR:	103584548 103607308

CFA:	483146(HSD3B2)

CLUD:

VVP:

VLG:

NPO:

AML:	100464280(HSD3B1)

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:	114208061(HSD3B2)

ZCA:	113909475(HSD3B2)

MLX:	118000525(HSD3B2)

NSU:	110580487(HSD3B2)

LWW:

102742748

FCA:	100616070(HSD3B2)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	281824(HSD3B1)

BOM:

BIU:

BBUB:

BBIS:

CHX:	100860869(3BHSD)

OAS:	100190978(HSD3B1)

BTAX:

CSUM:

ODA:

CCAD:

MREE:

OVR:

MBEZ:

SSC:	445539(HSD3B1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:

DDP:

DLE:

PCAD:

PSIU:

PPHC:

NASI:

ECB:	100034078(HSD3B2)

EPZ:	103548379(HSD3B2)

EAI:	106832920(HSD3B2)

MYB:	106723550(HSD3B2)

MMYO:

118672875(HSD3B2)

MLF:	106694328(HSD3B2)

MDT:	132220682(HSD3B2)

MYUM:

138996082(HSD3B2)

PKL:

118727130

EFUS:

103291359(HSD3B2)

MNA:	107545288(HSD3B2)

DRO:	112314004(HSD3B2)

SHON:

118981952(HSD3B2)

AJM:

119041699

PDIC:

114489256

PHAS:

123804497(HSD3B2)

MMF:

118637661

PPAM:

129063973

HAI:	109389868(HSD3B2)

RFQ:	117014453(HAO2)

PALE:

102891879

PGIG:

120585109

PVP:

105296358

RAY:	107518830(HSD3B2)

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:	100659049(HSD3B2)

TMU:

101358325

ETF:	101663671(HSD3B1)

DNM:

101447815

MDO:

100012668

GAS:

123247232

SHR:	100913530(HSD3B2)

AFZ:

127559197

PCW:	110219672(HSD3B2)

TVP:	118856490(HSD3B2)

PBRV:

138162150

OAA:

100080135

TACU:

119938651(HSD3B2)

GGA:	396015(HSD3B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

125684639(HSD3B1)

NMEL:

110398845

APLA:

101803865(HSD3B1)

ACYG:

106045741(HSD3B1)

CATA:

118259816(HSD3B1)

AFUL:

116502173

TGU:	751770(HSD3B1)

LSR:

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

128144955(HSD3B1)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CBOY:

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:	102367786(HSD3B1)

AMJ:	109280168(HSD3B1)

CPOO:

109319128(HSD3B1)

GGN:	109304596(HSD3B1)

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100561899(hsd3b1)

ASAO:

132766487(HSD3B1)

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

APRI:

131193284(HSD3B1)

PTEX:

113444507

NSS:

113417241

VKO:

123033249

PMUA:

114587929(HSD3B2)

PRAF:

128404595(HSD3B2)

ZVI:	118075222(HSD3B2)

HCG:

128345684

GJA:

107114856

STOW:

125425234(HSD3B2)

EMC:

129345698

XLA:	734818(hsd3b1.L)

XTR:

100490622

NPR:

108802532

RTEM:

120928726

ACAT:

141129472(HSD3B1)

BBUF:

120994332

DTC:

141091417

PWL:	138248956(HSD3B1)

MUO:	115471398(HSD3B1)

GSH:	117358938(HSD3B1)

DRE:	373131(hsd3b2) 553532(hsd3b1)

SRX:

107712267

SANH:

107658243

SGH:

107569293

CCAR:

109048590 109052439(hsd3b1)

CAUA:

113108554 113108799

CGIB:

127965123 128019700

PTET:

122351771(hsd3b1)

LROH:

127170525(hsd3b1)

GRF:	141340889(hsd3b1)

OMC:	131546787(hsd3b1)

PPRM:

120466714(hsd3b1)

RKG:	130076948(hsd3b1)

MAMB:

125270537(hsd3b1)

CIDE:

127518655

CERY:

137035985(hsd3b1)

MASI:

127448584

TROS:

130555852(hsd3b1)

TDW:	130427658(hsd3b1)

MANU:

129451507(hsd3b1)

PDAB:

135730984(hsd3b1)

IPU:	100304475(hsd3b1)

IFU:	128609137(hsd3b1)

PHYP:

113524942(hsd3b1)

SMEO:

124379336(hsd3b1)

TFD:	113654422(hsd3b1)

TVC:	132850628(hsd3b1)

CGAR:

128524370(hsd3b1)

NGRA:

132891244(hsd3b1)

TRN:	134323829(hsd3b1)

AMEX:

103027852(hsd3b1)

CMAO:

118800102(hsd3b1)

EEE:

113587753

CHAR:

105913236 105913280 105913281

SPIL:

134078497(hsd3b1) 134095873

TRU:	101069884(hsd3b1)

TFS:	130530194(hsd3b1)

TNG:	GSTEN00029150G001

LCO:	104921488(hsd3b1)

TBEN:

117495881(hsd3b1)

CGOB:

115026845(hsd3b1)

PGEO:

117466261(hsd3b1)

GACU:

117536557(hsd3b1)

EMAC:

134867270(hsd3b1)

ELY:	117251590(hsd3b1)

EFO:	125900207(hsd3b1)

PLEP:

121949401(hsd3b1) 121963657

SLUC:

116059361(hsd3b1)

ECRA:

117953315(hsd3b1)

ESP:

116697664

PFLV:

114564020

GAT:	120833929(hsd3b1)

PPUG:

119228951(hsd3b1)

AFB:	129104536(hsd3b1)

CLUM:

117750405(hsd3b1)

PSWI:

130204482(hsd3b1)

CANA:

137782894(hsd3b1)

CVE:	137890194(hsd3b1)

MSAM:

119884914 119904488(hsd3b1)

SCHU:

122885279(hsd3b1)

CUD:	121523133(hsd3b1)

SPUL:

138592290(hsd3b1)

LMIX:

132986866(hsd3b1)

ALAT:

119025245(hsd3b1)

ASTR:

137605353(hsd3b1)

MZE:

101485719

ONL:	100534568(hsd3b1)

OAU:	116332553(hsd3b1)

OLA:	100144358(3bhsd)

OML:	112138010(hsd3b1)

CSAI:

133446387(hsd3b1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122839771(hsd3b1)

PPRL:

129360909(hsd3b1)

CVG:

107087352

CTUL:

119774713(hsd3b1)

GMU:	124871021(hsd3b1)

NFU:	107389612(hsd3b1)

KMR:	108244192(hsd3b1)

ALIM:

106531920

NWH:	119419363(hsd3b1)

AOCE:

111570570(hsd3b1)

EJA:	138200781(hsd3b1)

BFRE:

138629583(hsd3b1)

MCEP:

125017257(hsd3b1)

CSEM:

103391994(hsd3b1)

POV:

109637945

SSEN:

122785783(hsd3b1)

SSOE:

131475547(hsd3b1)

HHIP:

117755029 117755030

HSP:	118119640 118120310

PPLT:

128455946(hsd3b1)

SMAU:

118283187(hsd3b1)

LCF:

108902437

SDU:

111218347

SLAL:

111652102

XGL:	120801969(hsd3b1)

HCQ:

109522071

SSCV:

125973254(hsd3b1)

SBIA:

133511988(hsd3b1)

PEE:	133410274(hsd3b1)

PTAO:

133486409(hsd3b1)

BPEC:

110156192(hsd3b1)

ENY:	140359840(hsd3b1)

MALB:

109951646

BSPL:

114847637(hsd3b1)

SJO:	128367682(hsd3b1)

SSCO:

133993012(hsd3b1)

GMH:

115533088

SASA:

106586600

STRU:

115161098

OTW:	112240651(hsd3b1)

OMY:	100136743(hsd3b1)

OGO:	124044100(hsd3b1)

ONE:

115112196

OKI:

109869285

OKE:	118371546(hsd3b1)

OMM:	135519168(hsd3b1)

OCLA:

139403614

SALP:

111978723

SNH:	120058421(hsd3b1)

CCLU:

121536290(hsd3b1)

ELS:

105016430

OEP:	134017697(hsd3b1)

SFM:

PKI:

AANG:

AROT:

CCOG:

133116268(hsd3b1)

LOC:	102685561(hsd3b1)

PSPA:

121320746(hsd3b1)

ARUT:

117406697 117406856

PSEX:

120522925(hsd3b1)

LCM:

102345588

CMK:	103180179(hsd3b1) 121852133

RTP:	109918392(hsd3b1)

HOC:	132820585(hsd3b1)

LERI:

129702520(hsd3b1)

HAKA:

140727706(hsd3b1)

PMRN:

116954501

LRJ:

133347820

BFO:	118415735 118426116

BBEL:

109470289 109481615

LPIC:

129254859

AJJ:	139968024 139968025 139968026 139968030

AFIL:

140138346 140138347 140168992 140169339 140169916 140170474 140170475

PFLL:

139119426 139150811

DME:	Dmel_CG7724(CG7724)

DER:

6543694

DSI:	Dsimw501_GD14693(Dsim_GD14693)

DYA:	Dyak_GE19901

DSR:	110187899 110190103

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12485

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135963146 135963147

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003056

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

NVI:

CSOL:

TPRE:

FAS:

DAM:

VCAN:

CCIN:

NPT:

NFB:

NLO:

NVG:

AROA:

DCI:

CLEC:

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

PAME:

IEL:

HAMR:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

ISC:

DSV:

RSAN:

RMP:

VDE:	111247588 111254724

VJA:	111264476 111268118

GOE:	100898467 100905877

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_89375

PVUL:

126824716

LSAX:

138976104

GAE:

121389292

HRF:	124140223 124140224 124140226 124141700

HRJ:	124260823 124260824 124278058

HASI:

137256388 137284947 137293342

HCRA:

139455224 139472337 139472362 139472363 139472401

CRG:	105321517 105332656

CANU:

128186867 128188117 128188594

CVN:	111136775 111137023 111137166

OED:	125654276 125659193 125659727

MYI:

110457155

PMAX:

117333059 117333060 117333062 117333069

AIRR:

138331179 138331399 138331633

MMER:

123525098 123534278 123534660 123535125 123535257 123535266 123552007

RPHI:

132742228 132742229 132743368 132753356 132759419 132759420

DPOL:

127839711 127856352 127861538

MAEA:

128229618 128232487 128232575

OSN:

115219210

LJP:	135468058 135477165

LAK:

106151343

LLON:

135485103 135502377

» show all

Reference

PMID:2243100

Authors

Lachance Y, Luu-The V, Labrie C, Simard J, Dumont M, de Launoit Y, Guerin S, Leblanc G, Labrie F

Title

Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.

Journal

J Biol Chem 265:20469-75 (1990)

Sequence

[hsa:3283] [rno:360348 682974]

LinkDB

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