Arvicanthis niloticus (African grass rat): 117722352
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Entry
117722352 CDS
T08817
Symbol
Irs1
Name
(RefSeq) insulin receptor substrate 1
KO
K16172
insulin receptor substrate 1
Organism
anu
Arvicanthis niloticus (African grass rat)
Pathway
anu04022
cGMP-PKG signaling pathway
anu04068
FoxO signaling pathway
anu04081
Hormone signaling
anu04140
Autophagy - animal
anu04150
mTOR signaling pathway
anu04151
PI3K-Akt signaling pathway
anu04152
AMPK signaling pathway
anu04211
Longevity regulating pathway
anu04213
Longevity regulating pathway - multiple species
anu04722
Neurotrophin signaling pathway
anu04910
Insulin signaling pathway
anu04920
Adipocytokine signaling pathway
anu04923
Regulation of lipolysis in adipocytes
anu04930
Type II diabetes mellitus
anu04931
Insulin resistance
anu04932
Non-alcoholic fatty liver disease
anu04935
Growth hormone synthesis, secretion and action
anu04960
Aldosterone-regulated sodium reabsorption
anu05010
Alzheimer disease
anu05206
MicroRNAs in cancer
anu05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
anu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
117722352 (Irs1)
04022 cGMP-PKG signaling pathway
117722352 (Irs1)
04151 PI3K-Akt signaling pathway
117722352 (Irs1)
04152 AMPK signaling pathway
117722352 (Irs1)
04150 mTOR signaling pathway
117722352 (Irs1)
09133 Signaling molecules and interaction
04081 Hormone signaling
117722352 (Irs1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
117722352 (Irs1)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
117722352 (Irs1)
04923 Regulation of lipolysis in adipocytes
117722352 (Irs1)
04920 Adipocytokine signaling pathway
117722352 (Irs1)
04935 Growth hormone synthesis, secretion and action
117722352 (Irs1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
117722352 (Irs1)
09156 Nervous system
04722 Neurotrophin signaling pathway
117722352 (Irs1)
09149 Aging
04211 Longevity regulating pathway
117722352 (Irs1)
04213 Longevity regulating pathway - multiple species
117722352 (Irs1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
117722352 (Irs1)
09164 Neurodegenerative disease
05010 Alzheimer disease
117722352 (Irs1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
117722352 (Irs1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
117722352 (Irs1)
04932 Non-alcoholic fatty liver disease
117722352 (Irs1)
04931 Insulin resistance
117722352 (Irs1)
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Motif
Pfam:
IRS
PH
PH_11
Motif
Other DBs
NCBI-GeneID:
117722352
NCBI-ProteinID:
XP_034377306
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Position
17:21873237..21931464
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AA seq
1231 aa
AA seq
DB search
MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAH
HDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRL
CLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVV
AQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRT
ESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRL
HPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGF
ISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYIL
SRGGNGHRYIPGANLGTSPALLTGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSS
VASIEEYTEMMPAAYQPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDT
SNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYM
MMSPSGSCSPDIGGGSSSSSSISAAPSGNSYGKPWTNGVGGHHTHALPHAKPPVESGGGK
LLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGA
RHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLMHPHHHVLQPHMPRK
VDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQSSLHPPEPKSPGEYVNIEFGSSQ
PGYLAGPATSRSSPSVRCPPQLHPAPREETGSEEYMNMDLGPGRRATWEESGGVELGRVG
PAPPGAATICRPTRSVPNSRGDYMTMQIGCPHQSYVDTSPVAPVSYADMRTGIAAEKVSL
PRTTGAAPPPSSTASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKV
IRADTQGCRRRHSSETFSAPTRAGNTVSFGAGAAVGGSGGGGSTEDVKRHSSASFENVWL
RPGDLGGASKESAPVCGAAGGLEKSLNYIDLDLAKDVKRRSQDCPSQQQSLPPPPPQQPL
GSNEGNSPRRSSEDISTYASINFQKQPEDRQ
NT seq
3696 nt
NT seq
+upstream
nt +downstream
nt
atggcgagccctccggataccgatggcttctcagacgtgcgcaaggtgggctacctgcgc
aaacccaagagtatgcataagcgctttttcgtgctgcgggcggccagcgaggccgggggg
ccggcgcgcctggagtattatgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgagacgaacactttgccattgcggcagatagcgag
gctgagcaagacagctggtaccaggctcttctgcagctgcataatcgggcaaaggcccac
catgacggggctggaggaggctgcggtggtagctgcagcggcagctctggcgttggagag
gcaggggaggacttgagctatgacacgggcccaggacccgcgttcaaggaggtctggcag
gttatcctgaaacccaagggcctgggtcagacaaagaacctgattggcatctaccgcctc
tgcctgaccagcaagaccatcagctttgtgaagctgaactctgaggcagccgctgtggtg
ctgcagctgatgaacatcagacgctgtggccactcagagaacttcttcttcatcgaggtg
gggcgttcagctgtaacagggcccggcgagttctggatgcaagtggatgactccgtggtg
gcccagaacatgcatgagaccattctagaggccatgcgggccatgagcgatgagtttcgc
ccgcgcagcaaaagccagtcttcatccagttgctccaaccccatcagtgttcccttgcgc
aggcaccatctcaacaatcctccacctagccaggtgggtctgactcggagatctcgaact
gaaagcatcactgccacctcccctgccagtatggtgggtgggaaaccaggttccttccgg
gtgcgtgcctccagcgatggcgaaggcaccatgtcccgtccagcatcagtggatggtagt
cctgtgagtcctagcaccaacaggacccacgcccatcggcatcgaggcagctccaggctg
caccccccactcaaccacagccgctccatccccatgccttcttcgcgatgctcaccttca
gccaccagcccagtgagtctgtcatccagtagtaccagtggccatggctccacttcagac
tgtctcttcccgaggcgctctagtgcttccgtgtccggttctcctagcgatggcggtttc
atctcttctgatgaatatggttctagtccctgcgatttccgaagttccttccgcagtgtc
accccagattccctggggcacaccccaccagccaggggtgaggaggagctgagcaattat
atctgcatgggtggcaagggagcctccaccttgacagctcccaatggtcactacatcttg
tctaggggtggcaacggccatcgctacatcccaggtgctaacttggggacaagcccagcg
ctgctgactggagacgaagccgctggcgcagcagatctggataaccggtttcggaagaga
actcactctgcaggcacatcccctaccatttcccatcagaagaccccctcacagtcttca
gtggcttctattgaggaatatacagagatgatgcccgctgcctaccaaccaggaggtggc
agtggaggccgcctgcccggctaccggcattccgcctttgtgcccacccactcctatcct
gaagagggtctagagatgcaccacttggaacgtcgtggaggccaccaccgtccagacacc
tccaacctccacactgatgatggctacatgcccatgtctcctggggtggctccagtgccc
agcaaccgcaaaggaaatggggactatatgccgatgagccccaagagtgtatctgcccca
cagcagatcattaaccccatcagacgccacccgcagagagtggaccccaatggctacatg
atgatgtctcccagtggtagttgctcccctgacattggaggtgggtccagcagcagtagc
agcatcagcgcagccccttctgggaacagctatgggaagccatggacaaatggagtaggg
gggcaccatacccatgctcttcctcatgccaaaccccctgttgagagcggtggtggtaag
ctcttgccttgcacaggtgactacatgaacatgtcaccagtgggagattccaacaccagc
agcccctcagaatgctactacggcccagaagatccccagcacaagccagttctctcctac
tactcattaccaaggtcctttaagcacactcagcgccctggagagccagaggagggtgcc
aggcaccagcatcttcgtctctcttctagctctggacgccttcgctatactgcaactgcc
gaagattcttcctcttctaccagcagcgacagcctgggtgggggttactgtggggctaga
ccagagtctagcctcatgcatccccaccaccatgtcttgcagccccatatgcctcgaaag
gtagacacagctgcacagaccaacagccgcctggctcgacccacaaggctgtccttgggg
gatcccaaggcaagcaccttaccccgggtacgagagcaacaacagcagcagtcttccctg
caccctcccgagcccaaaagcccaggagaatatgtgaatattgaattcgggagtagccag
cctggctatttagctggccctgcaacttcccgtagttctccttcagttcgatgtccaccc
cagctccacccagctcccagagaagagactggctcagaagagtacatgaacatggacttg
gggccaggccggagggcaacctgggaggagagtggtggagttgagttgggcagagtaggc
cctgcacctccaggggctgctaccatttgcaggccaacccgatcggtgccaaatagccgt
ggtgactacatgaccatgcagataggctgtcctcatcaaagctatgtggatacctcacca
gtggccccagtcagctatgctgacatgcggacaggcattgctgcagagaaggtgagcctg
cctagaacgacaggagctgctcctcctccatcctccactgcctctgcttctgttacacct
caaggagcagctgagcaggctgcccactcttccttgctgggaggccctcagggacctggg
ggcatgagtgcattcaccagggtgaacctcagtcccaaccataaccagagtgccaaagtg
attcgtgcagacactcaagggtgccggaggaggcatagctctgagaccttctcagcacct
actcgggctggcaacacagtgtcctttggagcaggggctgcggtagggggcagcggtgga
ggtggcagcactgaggatgtaaaacgtcacagctctgcatcatttgagaatgtgtggctg
agacctggggacctagggggagcctccaaggagtcggctcctgtgtgcggggctgctggg
ggcttggagaagagtcttaactacatagacctggatttggccaaggacgttaagcggcgc
tctcaggactgcccctctcaacagcagtccctaccaccccctccccctcaacagccctta
ggcagcaatgagggcaactccccgagacgctccagtgaggatataagtacctatgccagc
atcaacttccagaagcagccagaggaccgtcaatag
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