KEGG   ORTHOLOGY: K16172
Entry
K16172                      KO                                     
Symbol
IRS1
Name
insulin receptor substrate 1
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04213  Longevity regulating pathway - multiple species
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04935  Growth hormone synthesis, secretion and action
map04960  Aldosterone-regulated sodium reabsorption
map05010  Alzheimer disease
map05206  MicroRNAs in cancer
map05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04022 cGMP-PKG signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04151 PI3K-Akt signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04152 AMPK signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04150 mTOR signaling pathway
    K16172  IRS1; insulin receptor substrate 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K16172  IRS1; insulin receptor substrate 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04923 Regulation of lipolysis in adipocytes
    K16172  IRS1; insulin receptor substrate 1
   04920 Adipocytokine signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04935 Growth hormone synthesis, secretion and action
    K16172  IRS1; insulin receptor substrate 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K16172  IRS1; insulin receptor substrate 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
  09149 Aging
   04211 Longevity regulating pathway
    K16172  IRS1; insulin receptor substrate 1
   04212 Longevity regulating pathway - worm
    K16172  IRS1; insulin receptor substrate 1
   04213 Longevity regulating pathway - multiple species
    K16172  IRS1; insulin receptor substrate 1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K16172  IRS1; insulin receptor substrate 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K16172  IRS1; insulin receptor substrate 1
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K16172  IRS1; insulin receptor substrate 1
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K16172  IRS1; insulin receptor substrate 1
   04932 Non-alcoholic fatty liver disease
    K16172  IRS1; insulin receptor substrate 1
   04931 Insulin resistance
    K16172  IRS1; insulin receptor substrate 1
Genes
HSA: 3667(IRS1)
PTR: 459985(IRS1)
PPS: 100971596(IRS1)
GGO: 101132740(IRS1)
PON: 100442255(IRS1)
NLE: 100607873(IRS1)
HMH: 116810145(IRS1)
MCC: 707870(IRS1)
MCF: 102117978(IRS1)
MTHB: 126932885
MNI: 105473988(IRS1)
CSAB: 103217981(IRS1)
CATY: 105586974(IRS1)
PANU: 100999369(IRS1)
TGE: 112636552(IRS1)
MLEU: 105543176(IRS1)
RRO: 104656078(IRS1)
RBB: 108538753(IRS1)
TFN: 117094439(IRS1)
PTEH: 111527547(IRS1)
CANG: 105518803(IRS1)
CJC: 100387742(IRS1)
SBQ: 101035868(IRS1)
CIMI: 108304802(IRS1)
CSYR: 103259285(IRS1)
MMUR: 105862871(IRS1)
LCAT: 123643492(IRS1)
PCOQ: 105808835(IRS1)
OGA: 100958778(IRS1)
MMU: 16367(Irs1)
MCAL: 110292727(Irs1)
MPAH: 110321270(Irs1)
RNO: 25467(Irs1)
MCOC: 116088647(Irs1)
ANU: 117722352(Irs1)
MUN: 110547502(Irs1)
CGE: 100755710(Irs1)
MAUA: 101832053(Irs1)
PROB: 127226500(Irs1)
PLEU: 114696438(Irs1)
MORG: 121446925(Irs1)
MFOT: 126512943
AAMP: 119820738(Irs1)
NGI: 103727788(Irs1)
HGL: 101708189(Irs1)
CPOC: 100716939(Irs1)
CCAN: 109696750(Irs1)
DORD: 105982400(Irs1)
DSP: 122107464(Irs1)
PLOP: 125350245(Irs1)
NCAR: 124979751
MMMA: 107138750(Irs1)
OCU: 100339981
OPI: 101526197(IRS1)
TUP: 102496620(IRS1)
GVR: 103586161(IRS1)
CFA: 486148(IRS1)
CLUD: 112669817(IRS1)
VVP: 112925532(IRS1)
VLG: 121496830(IRS1)
NPO: 129523419(IRS1)
AML: 100477645(IRS1)
UMR: 103662712(IRS1)
UAH: 113250390(IRS1)
UAR: 123778092(IRS1)
ELK: 111143995
LLV: 125095145
MPUF: 101684695(IRS1)
MNP: 132013605(IRS1)
MLK: 131827381(IRS1)
NVS: 122902369(IRS1)
ORO: 101367978(IRS1)
EJU: 114210848(IRS1)
ZCA: 113920032(IRS1)
MLX: 118011983(IRS1)
NSU: 110574308(IRS1)
LWW: 102729040(IRS1)
FCA: 101087257(IRS1)
PYU: 121014485(IRS1)
PBG: 122481851(IRS1)
LRUF: 124516592
PTG: 102965599(IRS1)
PPAD: 109264970(IRS1)
PUC: 125911117
AJU: 106972296
HHV: 120249142(IRS1)
BTA: 538598(IRS1)
BOM: 102284664(IRS1)
BIU: 109571355(IRS1)
BBUB: 102416637(IRS1)
BBIS: 104986454(IRS1)
CHX: 102184858(IRS1)
OAS: 101102293(IRS1)
BTAX: 128069000(IRS1)
ODA: 120854447(IRS1)
CCAD: 122426865(IRS1)
MBEZ: 129537506(IRS1)
SSC: 100512686(IRS1)
CFR: 102512682(IRS1)
CBAI: 105064075(IRS1)
CDK: 105088301(IRS1)
VPC: 102533840(IRS1)
BACU: 103011761(IRS1)
LVE: 103074278(IRS1)
OOR: 101271463(IRS1)
DLE: 111171885(IRS1)
PCAD: 102992290(IRS1)
PSIU: 116756739(IRS1)
NASI: 112396733(IRS1)
ECB: 100061987(IRS1)
EPZ: 103547143(IRS1)
EAI: 106827854(IRS1)
MYB: 102247525(IRS1)
MYD: 102752666(IRS1)
MMYO: 118661524(IRS1)
MLF: 102442509(IRS1)
MNA: 107525521(IRS1)
PKL: 118709201(IRS1)
EFUS: 103289256(IRS1)
HAI: 109396328(IRS1)
DRO: 112307950(IRS1)
SHON: 118975374(IRS1)
AJM: 119044737(IRS1)
PDIC: 114494358(IRS1)
PHAS: 123828676(IRS1)
MMF: 118625363(IRS1)
RFQ: 117025871(IRS1)
PPAM: 129080305(IRS1)
PALE: 102891583(IRS1)
PGIG: 120597107(IRS1)
PVP: 105294748(IRS1)
RAY: 107497246(IRS1)
MJV: 108397189(IRS1)
TOD: 119256266(IRS1)
SARA: 101542323(IRS1)
LAV: 100664968(IRS1)
TMU: 101356151
ETF: 101650216(IRS1)
DNM: 101437367(IRS1)
MDO: 100021838(IRS1)
GAS: 123242758(IRS1)
SHR: 100918116(IRS1)
AFZ: 127553038
PCW: 110200253(IRS1)
OAA: 103170729(IRS1)
GGA: 107051846
PCOC: 116230914(IRS1)
MGP: 100539255(IRS1)
CJO: 107318049(IRS1)
TPAI: 128081773(IRS1)
LMUT: 125697843(IRS1)
NMEL: 110397421(IRS1)
APLA: 101796950(IRS1)
ACYG: 106036186(IRS1)
CATA: 118247238(IRS1)
AFUL: 116492767(IRS1)
TGU: 105759506(IRS1)
LSR: 110483660(IRS1)
SCAN: 103815658(IRS1)
PMOA: 120508576(IRS1)
OTC: 121341146(IRS1)
PRUF: 121357951(IRS1)
GFR: 102044407(IRS1)
FAB: 101810426(IRS1)
OMA: 130256705(IRS1)
PHI: 102101540(IRS1)
PMAJ: 107208936(IRS1)
CCAE: 111933626(IRS1)
CCW: 109145556(IRS1)
CBRC: 103614638
ETL: 114068746(IRS1)
ZAB: 102067323(IRS1)
SVG: 106854141(IRS1)
MMEA: 130573986(IRS1)
HRT: 120757352(IRS1)
FPG: 101922249(IRS1)
FCH: 102052001(IRS1)
CLV: 102083619(IRS1)
EGZ: 104127063(IRS1)
NNI: 104016496(IRS1)
PLET: 104614146(IRS1)
EHS: 104502575(IRS1)
ACUN: 113483461(IRS1)
TALA: 116964778(IRS1)
PADL: 103917904(IRS1)
AFOR: 103905134(IRS1)
ACHC: 115347412(IRS1)
HLE: 104832290(IRS1)
AGEN: 126039537
GCL: 127020000
CCRI: 104164059(IRS1)
CSTI: 104557822
MUI: 104533222(IRS1)
BREG: 104639857(IRS1)
FGA: 104073643(IRS1)
LDI: 104339929(IRS1)
MNB: 103773776(IRS1)
OHA: 104337997(IRS1)
NNT: 104412554(IRS1)
SHAB: 115611753(IRS1)
DPUB: 104296507(IRS1)
PGUU: 104466655
ACAR: 104527276(IRS1)
CPEA: 104392276(IRS1)
CVF: 104291056(IRS1)
RTD: 128911036(IRS1)
CUCA: 104063698(IRS1)
TEO: 104369678(IRS1)
BRHI: 104487845(IRS1)
AAM: 106485843(IRS1)
AROW: 112976098(IRS1)
NPD: 112947867(IRS1)
TGT: 104566717(IRS1)
DNE: 112988889(IRS1)
SCAM: 104144662(IRS1)
ASN: 102372136(IRS1)
AMJ: 102574179(IRS1)
CPOO: 109308621(IRS1)
GGN: 109288184(IRS1)
PSS: 102455771 102463626(IRS1)
CMY: 102945843(IRS1) 119565054
CCAY: 125628580 125642789(IRS1)
DCC: 119861884(IRS1)
CPIC: 101931522(IRS1)
TST: 117882685(IRS1)
CABI: 116829822(IRS1)
MRV: 120372250(IRS1)
ACS: 100565100(irs1) 103282162
ASAO: 132770665(IRS1) 132777483
PVT: 110078456(IRS1) 110082325
SUND: 121925778(IRS1) 121934423
PBI: 103048511 103055013(IRS1)
PMUR: 107286667(IRS1)
CTIG: 120299722 120311443(IRS1)
TSR: 106542051(IRS1) 106556223
PGUT: 117658926 117678362(IRS1)
APRI: 131197369 131200818(IRS1)
PTEX: 113436854(IRS1)
NSS: 113409938(IRS1)
VKO: 123024780(IRS1)
PMUA: 114582338 114597807(IRS1)
PRAF: 128399792 128414584(IRS1)
ZVI: 118093487(IRS1) 118095226
HCG: 128329046 128351639(IRS1)
GJA: 107116003(IRS1)
STOW: 125437863(IRS1) 125444504
EMC: 129332056(IRS1) 129340365
XLA: 108711802(irs2.L) 108718134 399299(irs1.L)
XTR: 100495320(irs1) 394823(irs2)
NPR: 108796838(IRS1) 108800291
RTEM: 120933665 120936639(IRS1)
BBUF: 120986661 120997794(IRS1)
BGAR: 122924053 122934374(IRS1)
MUO: 115458282 115479023(IRS1)
GSH: 117350893 117366964(IRS1)
DRE: 559281(irs1)
PTET: 122359362(irs1)
LROH: 127177122(irs1)
OMC: 131520610(irs1)
PPRM: 120478817(irs1)
RKG: 130077911(irs1)
MAMB: 125248458(irs1)
CIDE: 127495986
TROS: 130564634(irs1)
TDW: 130428812(irs1)
MANU: 129438351(irs1)
IPU: 108267519(si:ch73-335l21.1) 108278298
IFU: 128621416(irs1)
PHYP: 113539873 113544564(irs1)
SMEO: 124394801(irs1)
TFD: 113642529(irs1)
TVC: 132857878(irs1)
AMEX: 103025632(irs1) 103042975
CMAO: 118798903(irs1)
EEE: 113588983(irs1) 113591002
CHAR: 105909303(irs1)
TFS: 130522307(si:ch73-335l21.1) 130537259(si:ch211-284e13.4)
LCO: 104923989
TBEN: 117488102(si:ch73-335l21.1) 117490546(si:ch211-284e13.4)
PGEO: 117458793(si:ch211-284e13.4) 117463936(si:ch73-335l21.1)
GACU: 117534032(si:ch211-284e13.4) 117552674(si:ch73-335l21.1)
ELY: 117246218(si:ch73-335l21.1) 117263376(si:ch211-284e13.4)
EFO: 125883633(si:ch73-335l21.1) 125898921(si:ch211-284e13.4)
PLEP: 121939025(si:ch73-335l21.1) 121952980(si:ch211-284e13.4)
SLUC: 116048982(si:ch73-335l21.1) 116064954(si:ch211-284e13.4)
ECRA: 117955928(si:ch211-284e13.4) 117962219(si:ch73-335l21.1)
GAT: 120822124(si:ch73-335l21.1) 120822445(si:ch211-284e13.4)
PPUG: 119215070(si:ch211-284e13.4) 119222532(si:ch73-335l21.1)
AFB: 129093522(si:ch73-335l21.1) 129113916(si:ch211-284e13.4)
CLUM: 117742765(si:ch211-284e13.4) 117747750(si:ch73-335l21.1)
MSAM: 119896161(si:ch211-284e13.4) 119911745(si:ch73-335l21.1)
SCHU: 122870633(si:ch73-335l21.1) 122888843(si:ch211-284e13.4)
CUD: 121504510(si:ch73-335l21.1) 121519283(si:ch211-284e13.4)
ALAT: 119027222(si:ch73-335l21.1) 119031913(si:ch211-284e13.4)
OAU: 116330213(si:ch211-284e13.4) 116330728(si:ch73-335l21.1)
OML: 112142839(si:ch211-284e13.4) 112155960(si:ch73-335l21.1)
XMA: 102224423
XCO: 114157029
PRET: 103480483
GAF: 122820335 122820623 122845027(si:ch211-284e13.4)
PPRL: 129368719(si:ch211-284e13.4) 129379495(si:ch73-335l21.1)
CVG: 107087768
CTUL: 119779217(si:ch211-284e13.4) 119783405(si:ch73-335l21.1)
GMU: 124876829(si:ch211-284e13.4) 124880703(si:ch73-335l21.1)
KMR: 108241811(si:ch73-335l21.1) 108245231(si:ch211-284e13.4)
ALIM: 106529184
NWH: 119409467(si:ch73-335l21.1) 119420295(si:ch211-284e13.4)
AOCE: 111571694
SSEN: 122766369(si:ch73-335l21.1) 122779291(si:ch211-284e13.4)
HHIP: 117752039(si:ch73-335l21.1) 117774495(si:ch211-284e13.4)
HSP: 118102283(si:ch73-335l21.1) 124854838(si:ch211-284e13.4)
LCF: 108897056(si:ch73-335l21.1)
SDU: 111233019
SLAL: 111665735
XGL: 120797377(si:ch73-335l21.1) 120802170(si:ch211-284e13.4)
SSCV: 125982105(si:ch211-284e13.4) 125991305(si:ch73-335l21.1)
SBIA: 133491645(si:ch211-284e13.4) 133494546(si:ch73-335l21.1)
PEE: 133398112(si:ch73-335l21.1) 133416420(si:ch211-284e13.4)
PTAO: 133466883(si:ch211-284e13.4) 133472768(si:ch73-335l21.1)
MALB: 109966482
BSPL: 114851205(si:ch73-335l21.1) 114869594(si:ch211-284e13.4)
SJO: 128370926(si:ch211-284e13.4) 128383280(si:ch73-335l21.1)
OTW: 112216688(irs1) 112229124 112233838 112257780 112259956(si:ch73-335l21.1)
OMY: 110490060(irs1) 110500592 110531720(si:ch73-335l21.1) 110533721(si:ch211-284e13.4) 110537392
OGO: 123994816(irs1) 124000899 124008927(si:ch73-335l21.1) 124009869
OKE: 118366019(irs1) 118368784 118390137(si:ch211-284e13.4) 118391224 118391996
SNH: 120028247(irs1) 120030427(si:ch73-335l21.1) 120043800 120049688 120057482(si:ch211-284e13.4)
CCLU: 121554386(si:ch73-335l21.1) 121567271(irs1) 121572107 121573626 121579823
AANG: 118210068(irs1) 118229152
LOC: 102684310 102696987(irs1)
PSEX: 120533058(irs1)
LCM: 102366510(IRS1) 102367331
CMK: 103180489(irs1)
CPLA: 122547493 122556246(irs1)
HOC: 132821746(irs1) 132835327
LERI: 129703280(irs1) 129715098
PMRN: 116952540
LRJ: 133353767
BFO: 118404526
CIN: 100185541
SCLV: 120328915
SPU: 100890677
APLC: 110985759
SKO: 102809894
DME: Dmel_CG5686(chico)
DER: 6542588
DSE: 6611937
DSI: Dsimw501_GD22290(Dsim_GD22290)
DSR: 110183373
DPO: 4811653
DPE: 6589676
DMN: 108162201
DWI: 6652608
DGR: 6567010
DAZ: 108610418
DNV: 115563042
DHE: 111603951
CCAT: 101459143
BOD: 118681405
BDR: 105225362(Irs1)
TDA: 119687796
GFS: 119642984
AAG: 5569675
AALB: 109411294
CPII: 120414058
CNS: 116338347
BCOO: 119082059
AME: 408438
ACER: 107999616
ALAB: 122712169
ADR: 102670752
AFLR: 100865952
BIM: 100742603
BBIF: 117213506
BVK: 117233579
BVAN: 117154788
BTER: 100644779
BAFF: 126922801
BPYO: 122574297
FVI: 122535913
CCAL: 108623285
OBB: 114878683
MGEN: 117221395
NMEA: 116428644
CGIG: 122403420
SOC: 105202010
MPHA: 105833897
ACEP: 105627057
PBAR: 105427691
VEM: 105562552
HST: 105180459
DQU: 106741422
CFO: 105251794
FEX: 115242179
LHU: 105679317
PGC: 109861371
OBO: 105280708
PCF: 106792141
PFUC: 122517592
VPS: 122637625
VCRB: 124432767
NVI: 100119908
CSOL: 105368177
TPRE: 106649838
MDL: 103578429
CGLO: 123268301
DAM: 107037127
CCIN: 107268002
TCA: 103313904
SOY: 115879307
ATD: 109598230
CSET: 123318070
LDC: 111506503
NVL: 108558535
APLN: 108734879
PPYR: 116178891
OTU: 111426727
BMOR: 101745072
BMAN: 114247063
MSEX: 115441776
BANY: 112053097
PMAC: 106718294
PXU: 106126509
PRAP: 110993911
ZCE: 119840245
HAW: 110376740
HZE: 124639152
TNL: 113497656
SLIU: 111354031
OFU: 114361067
API: 100569479
DNX: 107161961
AGS: 114131651
RMD: 113547937
BTAB: 109033713
CLEC: 106667510
HHAL: 106681977
NLU: 111053511
FOC: 113218444
TPAL: 117647689
ZNE: 110835233
CSEC: 111867485
FCD: 110847979
DMK: 116921553
PJA: 122248311
PCLA: 123763636
PTRU: 123516473
EAF: 111716183
DSV: 119461122
VDE: 111246385
VJA: 111270069
TUT: 107366694
DPTE: 113791832
CSCU: 111622797
CEL: CELE_C54D1.3(ist-1)
CBR: CBG_10979(Cbr-ist-1)
BMY: BM_BM2926(Bma-ist-1)
TSP: Tsp_03690
PCAN: 112561836
GAE: 121377759
HRF: 124139711
HRJ: 124291303
CRG: 105342662
MYI: 110464153
OSN: 115210869
NVE: 5517532
ATEN: 116300822
ADF: 107342456
AMIL: 114960550
 » show all
Reference
  Authors
Sisci D, Morelli C, Cascio S, Lanzino M, Garofalo C, Reiss K, Garcia M, Russo A, Ando S, Surmacz E
  Title
The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.
  Journal
Ann Oncol 18 Suppl 6:vi81-5 (2007)
DOI:10.1093/annonc/mdm232
Reference
PMID:8513971
  Authors
Araki E, Sun XJ, Haag BL 3rd, Chuang LM, Zhang Y, Yang-Feng TL, White MF, Kahn CR
  Title
Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
  Journal
Diabetes 42:1041-54 (1993)
DOI:10.2337/diab.42.7.1041
  Sequence
[hsa:3667]
Reference
PMID:1380456
  Authors
Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, et al.
  Title
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
  Journal
EMBO J 11:3469-79 (1992)
DOI:10.1002/j.1460-2075.1992.tb05426.x
  Sequence
[rno:25467]
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