KEGG   PATHWAY: aplc00533
Entry
aplc00533                   Pathway                                
Name
Glycosaminoglycan biosynthesis - keratan sulfate - Acanthaster planci (crown-of-thorns starfish)
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
aplc00533  Glycosaminoglycan biosynthesis - keratan sulfate
aplc00533

Other DBs
GO: 0018146
Organism
Acanthaster planci (crown-of-thorns starfish) [GN:aplc]
Gene
110981316  [KO:K03368] [EC:2.4.3.2 2.4.3.4]
110982962  [KO:K00781] [EC:2.4.3.6]
110988060  [KO:K00717] [EC:2.4.1.68]
110988559  [KO:K01022] [EC:2.8.2.21]
110988984  [KO:K01022] [EC:2.8.2.21]
Reference
PMID:11030741
  Authors
Funderburgh JL.
  Title
Keratan sulfate: structure, biosynthesis, and function.
  Journal
Glycobiology 10:951-958 (2000)
DOI:10.1093/glycob/10.10.951
Reference
PMID:14706853
  Authors
Seko A, Yamashita K.
  Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
  Journal
FEBS Lett 556:216-20 (2004)
DOI:10.1016/S0014-5793(03)01440-6
Reference
PMID:12511560
  Authors
Seko A, Dohmae N, Takio K, Yamashita K.
  Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
  Journal
J Biol Chem 278:9150-8 (2003)
DOI:10.1074/jbc.M211480200
Related
pathway
aplc00510  N-Glycan biosynthesis
aplc00512  Mucin type O-glycan biosynthesis
KO pathway
ko00533   

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