Entry
Name
glycoprotein 6-alpha-L-fucosyltransferase;
GDP-fucose---glycoprotein fucosyltransferase;
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase;
GDP-L-fucose-glycoprotein fucosyltransferase;
glycoprotein fucosyltransferase;
guanosine diphosphofucose-glycoprotein fucosyltransferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase;
FucT;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase;
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 6-alpha-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] [RN:
R05988 ]
Reaction(KEGG)
Substrate
GDP-beta-L-fucose [CPD:
C00325 ];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Product
GDP [CPD:
C00035 ];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
Comment
This enzyme catalyses a reaction similar to that of EC
2.4.1.214 , glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.
History
EC 2.4.1.68 created 1972, modified 2002
Pathway
ec00513 Various types of N-glycan biosynthesis
ec00533 Glycosaminoglycan biosynthesis - keratan sulfate
Orthology
K00717 glycoprotein 6-alpha-L-fucosyltransferase
Genes
CSYR : 103252886 103260912 103263350
ETF : 101638800 101647995(FUT8)
GAS : 123231761 123237730(FUT8)
XLA : 394383(fut8.L) 779338(fut8.S)
NPR : 108801723 108801942(FUT8)
DRE : 100331714(fut8b) 797512(fut8a)
SRX : 107726710 107730784 107733188 107752771
SANH : 107669464 107674109 107697788
SGH : 107548413 107553275 107559123 107592788
CCAR : 109048026 109072175(fut8a) 109087882 109113832
CAUA : 113060649 113068603 113117265 113117338 113120573
CGIB : 127933373 127938087 127976039 127983686
PTET : 122324314(fut8b) 122361859(fut8a) 122361864
LROH : 127179907(fut8a) 127182859(fut8b)
OMC : 131523000(fut8a) 131526835(fut8b)
PPRM : 120480613(fut8a) 120491948(fut8b)
RKG : 130080299(fut8a) 130096179(fut8b)
MAMB : 125269106(fut8a) 125278529(fut8b)
CIDE : 127498762 127502107
CERY : 137006328(fut8a) 137018281(fut8b)
MASI : 127409650 127411260 127415546 127455140
TROS : 130560605(fut8a) 130566311(fut8b)
TDW : 130434495(fut8b) 130437173(fut8a)
MANU : 129417332(fut8a) 129429766(fut8b)
PDAB : 135738467(fut8b) 135778058(fut8a)
IPU : 108257543(fut8b) 108270174
IFU : 128600944(fut8b) 128612442
PHYP : 113532345 113533941
SMEO : 124377374(fut8b) 124390193(fut8a)
TFD : 113651143(fut8a) 113655617(fut8b)
TVC : 132842303(fut8b) 132852848
CGAR : 128514717(fut8b) 128535639(fut8a)
NGRA : 132882646(fut8b) 132894163
TRN : 134320347(fut8b) 134325225(fut8a)
AMEX : 103043605(fut8a) 103044460(fut8b)
CMAO : 118815819(fut8b) 118823465
EEE : 113579874(fut8) 113581219
CHAR : 105894918(fut8a) 105907253(fut8b)
SPIL : 134067737(fut8a) 134097721(fut8b)
PFOR : 103133601 103133610
PLAI : 106957939(fut8) 106963015
PMEI : 106926831(fut8) 106931553
SASA : 106571665 106602554 106608211 106611223
STRU : 115159225 115162040 115172297 115174605
OTW : 112237275 112250474 112256877(fut8a) 112262442
OMY : 110498325 110504230 110521089 110529771
OGO : 123990903 123995379 124001310 124046663
ONE : 115107907 115115430 115138729 115145961
OKI : 109882645 109894294 109900289 109904275
OKE : 118362210 118369050(fut8a) 118387123 118397716
OMM : 135505812 135507938 135525616(fut8a)
OCLA : 139375009 139384026 139407876 139415634
SALP : 111954040 112075323
SNH : 120019495 120023555 120023951 120060481
CCLU : 121539578 121544670(fut8a) 121548492 121552468
OEP : 134025401(fut8b) 134026722(fut8a)
PSPA : 121324521 121330142
ARUT : 117422535 117424054
LRJ : 133352724 133352772(FUT8)
CIN : 100175944 100176073 100176676 100178043(fut8) 100178416 100179563 100179900 100180987 100181649(fut8) 100183339 100183863 100184175 100184494 100184572 100186705 101242198 101242352 101242468 101243140 104265699 108950984 113474122 113475774
SCLV : 120325646 120326266 120328219 120328562 120336781 120338266 120346087 120346306 120347451 120347652
SPU : 100889005 100893980 115924182 115927592 575664 580837 586950 592434
LPIC : 129265353 129265354 129265355
DSI : Dsimw501_GD15979(Dsim_GD15979)
DYA : Dyak_GE17606(Dyak_FucT6)
AALB : 109426335 115253517
BCOO : 119071950 119082892 119082927 119086075
APLN : 108743011 108743012
PPYR : 116168330 116168385 116169711
MSEX : 115447191 119191307
CFEL : 113384967 113385073
API : 100160201 100163054 100166386 100166412 100166593 100166919 100168928 100169218
DNX : 107164813 107170725 107172500
AGS : 114124031 114124040 114124041
RMD : 113548007 113550567 113561252
BTAB : 109032354 109035861
FCD : 110842878 110850377 110859471
PVM : 113800245 113800264 113807364 113807374 113823026 113823031 113824372(FucT6) 113828784
PJA : 122243326 122244269 122244405 122251889 122254187 122254199 122254201 122258795 122259880 122262386 122266282
PCHN : 125038068 125041843 125041928 125042063 125042064 125042260 125042261
PMOO : 119581728 119581754 119582197 119582203 119586507 119586792
HAME : 121859776 121868621 121868622 121871672
PCLA : 123745403(FucT6) 123755284 123755324 123755528 123756324
CQD : 128688831 128693056(FucT6) 128694009 128694011 128694012 128695552 128696551 128696602 138852779 138854030
PTRU : 123516985 123519329
DSV : 119456627 119457102 119457625 119464170
RSAN : 119374071 119401617
RMP : 119165240 119165241 119165242 119167049 119172585
DPTE : 113792968 113794385
CSCU : 111636771 111638537
CVS : 136981380 136990495(FucT6)
LPOL : 106462887 106462888 106467444 106469688 106477946
CBR : CBG_09273(Cbr-fut-8)
BMY : BM_BM2138(Bma-fut-8)
HRO : HELRODRAFT_170715 HELRODRAFT_194786 HELRODRAFT_75808
PCAN : 112569733 112570148 112573092 112573093 112573094 112573096 112573097 112573099 112573665 112574450
HASI : 137294246 137294461
HCRA : 139443905 139444352
MMER : 123531529 123537392 123540557 123556946 123556956 123556961 123563024
RPHI : 132721998 132722285 132730603 132735159 132737266 132740792 132749934 132758759 132759156
DPOL : 127831268 127850559 127871832 127871838 127873148 127873229
MAEA : 128207880 128210275 128212787 128213260 128213261 128214808 128243198 128243199
LAK : 106156327 106163886 106181991
SMM : Smp_030650 Smp_138730 Smp_138750 Smp_175120.1
HMG : 100203172 100208727 101235614 101236466 101236886 101237130 101237851 105845585
HSY : 130631564 130641678 130642253
TAD : TRIADDRAFT_2213 TRIADDRAFT_3280 TRIADDRAFT_32882 TRIADDRAFT_32887 TRIADDRAFT_32914 TRIADDRAFT_49632 TRIADDRAFT_56089 TRIADDRAFT_60023
GTT : GUITHDRAFT_120848 GUITHDRAFT_139577 GUITHDRAFT_148912
» show all
Taxonomy
Reference
Authors
Longmore GD, Schachter H.
Title
Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to Asn-linked GlcNAc) 6-alpha-L-fucosyltransferase in a Golgi-rich fraction from porcine liver.
Journal
Reference
Authors
Voynow JA, Scanlin TF, Glick MC.
Title
A quantitative method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1----6fucosyltransferase activity with lectin affinity chromatography.
Journal
Reference
Authors
Uozumi N, Yanagidani S, Miyoshi E, Ihara Y, Sakuma T, Gao CX, Teshima T, Fujii S, Shiba T, Taniguchi N
Title
Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-->6fucosyltransferase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.68
ExPASy - ENZYME nomenclature database: 2.4.1.68
LinkDB
All DBs