Entry Name ABC transporters - Actinoplanes sp. SE50/110
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Actinoplanes sp. SE50/110 [GN:
ase ]
Gene ACPL_1437 scbA; Metal ABC transporter substrate-binding lipoprotein [KO:K09815 ]
ACPL_1821 livM; High-affinity branched-chain amino acid transport system permease protein livM [KO:K01998 ]
ACPL_1940 dasA; yurO-like Uncharacterized ABC transporter extracellular-binding protein [KO:K17329 ]
ACPL_2009 frlN; sn-glycerol-3-phosphate transport system permease protein ugpA [KO:K10118 ]
ACPL_2010 yurO; yurO-like uncharacterized ABC transporter extracellular-binding protein [KO:K10117 ]
ACPL_2188 oppB; Dipeptide transport system permease protein dppB [KO:K13890 ]
ACPL_2189 oppC; Oligopeptide transport system permease protein appC [KO:K13891 ]
ACPL_2451 lsrC; Autoinducer 2 import system permease protein lsrC [KO:K10561 ]
ACPL_2466 potD; Spermidine/putrescine-binding periplasmic protein 2 [KO:K11069 ]
ACPL_2467 potH; Spermidine/putrescine transport system permease protein potB [KO:K11071 ]
ACPL_2468 potI; Spermidine/putrescine transport system permease protein potC [KO:K11070 ]
ACPL_2619 potD; Spermidine/putrescine-binding periplasmic protein [KO:K11069 ]
ACPL_2779 chvE; Multiple sugar-binding periplasmic receptor chvE [KO:K10546 ]
ACPL_2780 araH; putative multiple sugar transport system permease protein [KO:K10547 ]
ACPL_2781 araG; L-arabinose transport ATP-binding protein araG [KO:K10548 ] [EC:7.5.2.-]
ACPL_3088 chvE; putative multiple sugar transport system substrate-binding protein [KO:K10546 ]
ACPL_4167 rbsA; ribose transport system ATP-binding protein [KO:K10562 ] [EC:7.5.2.-]
ACPL_4617 dasC; multiple sugar transport system permease protein [KO:K17331 ]
ACPL_4750 metI; putative D-methionine transport system permease protein metI [KO:K02072 ]
ACPL_5117 araH; putative multiple sugar transport system permease protein [KO:K10547 ]
ACPL_5118 araG; L-arabinose transport ATP-binding protein araG [KO:K10548 ] [EC:7.5.2.-]
ACPL_5119 chvE; putative multiple sugar transport system substrate-binding protein [KO:K10546 ]
ACPL_5187 fepD; Vitamin B12 import system permease protein btuC [KO:K23186 ]
ACPL_5188 fepG; Vitamin B12 import system permease protein btuC [KO:K23187 ]
ACPL_5189 fepC; iron complex transport system ATP-binding protein [KO:K23188 ]
ACPL_558 msmK; Spermidine/putrescine import ATP-binding protein potA [KO:K10112 ] [EC:7.5.2.-]
ACPL_565 rfbA; O-antigen export system permease protein rfbA [KO:K09692 ]
ACPL_611 frcB; fructose transport system substrate-binding protein [KO:K10552 ]
ACPL_613 frcA; Spermidine/putrescine import ATP-binding protein potA [KO:K10554 ]
ACPL_636 modB; putative sulfate transport system permease protein cysT [KO:K02018 ]
ACPL_6401 malF; maltose/maltodextrin transport system permease protein [KO:K15771 ]
ACPL_7168 occM; Octopine transport system permease protein occM [KO:K10006 ]
ACPL_7169 gluD; Arginine transport system permease protein artQ [KO:K10007 ]
ACPL_7659 livG; Spermidine/putrescine import ATP-binding protein potA [KO:K01995 ]
ACPL_7660 livF; branched-chain amino acid transport system ATP-binding protein [KO:K01996 ]
ACPL_7969 pstA; Phosphate transport system permease protein pstA [KO:K02038 ]
ACPL_7970 pstC; Phosphate transport system permease protein pstC [KO:K02037 ]
ACPL_8014 msiK; Spermidine/putrescine import ATP-binding protein potA [KO:K10112 ] [EC:7.5.2.-]
ACPL_883 dppB; Glutathione transport system permease protein gsiC [KO:K15581 ]
ACPL_884 dppC; Oligopeptide transport system permease protein oppC [KO:K15582 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
