KEGG   Apodemus sylvaticus (European woodmouse): 127682169
Entry
127682169         CDS       T10613                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 isoform X1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
asyl  Apodemus sylvaticus (European woodmouse)
Pathway
asyl00140  Steroid hormone biosynthesis
asyl01100  Metabolic pathways
asyl04913  Ovarian steroidogenesis
asyl04925  Aldosterone synthesis and secretion
asyl04927  Cortisol synthesis and secretion
asyl04934  Cushing syndrome
Module
asyl_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
asyl_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
asyl_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
asyl_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:asyl00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    127682169
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    127682169
   04925 Aldosterone synthesis and secretion
    127682169
   04927 Cortisol synthesis and secretion
    127682169
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    127682169
Enzymes [BR:asyl01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     127682169
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     127682169
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA KR RmlD_sub_bind Ldh_1_N Ufm1 Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 127682169
NCBI-ProteinID: XP_052034521
LinkDB
Position
4:65180817..65186140
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIIWMLVQEKELQEVRALDKVFRPETKEEFSKLQTKAKVTVLE
GDILDAQCLRRACQGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLEACVQASVSAF
VFCSSVDVAGPNSYKEIVLNGREEEHHESTWPDPYPYSKKMAEKAVLAANGSLLKNGGTL
HTCALRPMYIYGERSSIISNIIISALKNKGILCVTGKFSIVNPVYVGNAAWAHILAVRGL
RDPKKSPNIQGQFFYISDDTPPQSYDDLNYTLSKEWGLRLDSSWSLPLPLLYWLAFLLET
VSFLLSPVYRYRPLFNCHLVTLSNSKFTFSYKKAQRDLGYEPLVSWEEAKQKTSAWIGTL
VEQHKETLDPKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctgggtggagctgcttggtgacaggagcaggaggatttcttggccagagaatcatc
tggatgttggtgcaagagaaagaactgcaggaggtcagggctctggacaaagtcttcaga
ccagaaaccaaggaggaattctctaagctgcagacaaaggccaaagtgacagtgttggaa
ggagacattcttgatgcccagtgcctgagaagagcctgtcaaggcatctctgttgtcatc
cacactgctgctgtcattgatgtcacaggtgtcatacccaggcagaccatcctagatgtc
aatctgaaaggtacccagaacctactggaggcctgtgtccaagccagtgtgtcagccttc
gtcttctgcagctcagttgacgttgcaggacccaactcctacaaggagatcgtcctgaac
ggccgtgaggaagagcatcatgaaagcacatggcctgacccatacccatacagcaaaaag
atggctgagaaggcagtgctggcagccaatgggagcctcctgaagaacggtggcactttg
cacacttgtgccctaaggcccatgtacatttatggggagagaagttcaatcatttctaac
ataataattagtgccctgaaaaataagggtattctgtgtgttactggcaaattctccata
gtcaacccagtatatgtgggtaatgcagcatgggctcacattctggctgtcaggggcctt
agagaccccaagaagtcaccaaatatccaaggacaattcttctacatctcagatgacact
cctccccaaagctatgatgatttaaattacaccctgagcaaggaatggggactccgcctt
gattctagttggagccttcccctgcccctgctctactggcttgccttcctgctggaaact
gtgagcttcctgctgagtccagtctacaggtatcgacctctctttaactgtcacttggtc
acactgtcaaatagcaagttcactttttcctacaagaaagctcagcgagacctgggttat
gagccacttgtcagctgggaggaagccaagcagaaaacctctgcatggatcgggacacta
gtggagcagcacaaggagacactggacccaaagtctcagtga

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