KEGG   Apodemus sylvaticus (European woodmouse): 127686195
Entry
127686195         CDS       T10613                                 
Symbol
Plcg1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
asyl  Apodemus sylvaticus (European woodmouse)
Pathway
asyl00562  Inositol phosphate metabolism
asyl01100  Metabolic pathways
asyl01521  EGFR tyrosine kinase inhibitor resistance
asyl04012  ErbB signaling pathway
asyl04014  Ras signaling pathway
asyl04015  Rap1 signaling pathway
asyl04020  Calcium signaling pathway
asyl04062  Chemokine signaling pathway
asyl04064  NF-kappa B signaling pathway
asyl04066  HIF-1 signaling pathway
asyl04070  Phosphatidylinositol signaling system
asyl04072  Phospholipase D signaling pathway
asyl04360  Axon guidance
asyl04370  VEGF signaling pathway
asyl04613  Neutrophil extracellular trap formation
asyl04650  Natural killer cell mediated cytotoxicity
asyl04658  Th1 and Th2 cell differentiation
asyl04659  Th17 cell differentiation
asyl04660  T cell receptor signaling pathway
asyl04664  Fc epsilon RI signaling pathway
asyl04666  Fc gamma R-mediated phagocytosis
asyl04670  Leukocyte transendothelial migration
asyl04722  Neurotrophin signaling pathway
asyl04750  Inflammatory mediator regulation of TRP channels
asyl04919  Thyroid hormone signaling pathway
asyl04933  AGE-RAGE signaling pathway in diabetic complications
asyl04935  Growth hormone synthesis, secretion and action
asyl05012  Parkinson disease
asyl05022  Pathways of neurodegeneration - multiple diseases
asyl05135  Yersinia infection
asyl05167  Kaposi sarcoma-associated herpesvirus infection
asyl05170  Human immunodeficiency virus 1 infection
asyl05171  Coronavirus disease - COVID-19
asyl05200  Pathways in cancer
asyl05205  Proteoglycans in cancer
asyl05206  MicroRNAs in cancer
asyl05214  Glioma
asyl05223  Non-small cell lung cancer
asyl05225  Hepatocellular carcinoma
asyl05231  Choline metabolism in cancer
asyl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
asyl05417  Lipid and atherosclerosis
Module
asyl_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:asyl00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    127686195 (Plcg1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    127686195 (Plcg1)
   04014 Ras signaling pathway
    127686195 (Plcg1)
   04015 Rap1 signaling pathway
    127686195 (Plcg1)
   04370 VEGF signaling pathway
    127686195 (Plcg1)
   04064 NF-kappa B signaling pathway
    127686195 (Plcg1)
   04066 HIF-1 signaling pathway
    127686195 (Plcg1)
   04020 Calcium signaling pathway
    127686195 (Plcg1)
   04070 Phosphatidylinositol signaling system
    127686195 (Plcg1)
   04072 Phospholipase D signaling pathway
    127686195 (Plcg1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    127686195 (Plcg1)
   04650 Natural killer cell mediated cytotoxicity
    127686195 (Plcg1)
   04660 T cell receptor signaling pathway
    127686195 (Plcg1)
   04658 Th1 and Th2 cell differentiation
    127686195 (Plcg1)
   04659 Th17 cell differentiation
    127686195 (Plcg1)
   04664 Fc epsilon RI signaling pathway
    127686195 (Plcg1)
   04666 Fc gamma R-mediated phagocytosis
    127686195 (Plcg1)
   04670 Leukocyte transendothelial migration
    127686195 (Plcg1)
   04062 Chemokine signaling pathway
    127686195 (Plcg1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    127686195 (Plcg1)
   04919 Thyroid hormone signaling pathway
    127686195 (Plcg1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    127686195 (Plcg1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    127686195 (Plcg1)
  09158 Development and regeneration
   04360 Axon guidance
    127686195 (Plcg1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127686195 (Plcg1)
   05206 MicroRNAs in cancer
    127686195 (Plcg1)
   05205 Proteoglycans in cancer
    127686195 (Plcg1)
   05231 Choline metabolism in cancer
    127686195 (Plcg1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127686195 (Plcg1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    127686195 (Plcg1)
   05214 Glioma
    127686195 (Plcg1)
   05223 Non-small cell lung cancer
    127686195 (Plcg1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    127686195 (Plcg1)
   05171 Coronavirus disease - COVID-19
    127686195 (Plcg1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    127686195 (Plcg1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    127686195 (Plcg1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    127686195 (Plcg1)
   05022 Pathways of neurodegeneration - multiple diseases
    127686195 (Plcg1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127686195 (Plcg1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    127686195 (Plcg1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127686195 (Plcg1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:asyl04131]
    127686195 (Plcg1)
Enzymes [BR:asyl01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     127686195 (Plcg1)
Membrane trafficking [BR:asyl04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    127686195 (Plcg1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    127686195 (Plcg1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 127686195
NCBI-ProteinID: XP_052040133
LinkDB
Position
5:146246167..146278623
AA seq 1290 aa
MAGVATPCANGCGPGTPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLENITLRT
GERPEHCQVSLSEFQQFLLEYQGELWAVDRLQVQDFMLSFLRDPLREIEEPYFYLDELVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGSEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMINPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGISLRERASDASSQLFHVRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgtcgcgaccccttgcgccaacggctgcgggcccggcacgccctcggaagcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccagaacggaagaccttccaggtcaagttggagacgcgccagatc
acatggagccgcggcgcggacaaaatcgaggggtccattgatatccgggaaatcaaggag
atccgcccagggaagacttctcgggactttgaccgctaccaagaagaccctgccttccgc
ccagatcagtcacactgctttgtcatcctctatggaatggaattccgcctcaagaccctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacactgcaggcagccacacccctgcaaattgagaggtggctccggaagcag
ttctattcggtggatcgtaaccgagaggatcgtatatcagccaaggacttgaagaacatg
ctgtcacaggtcaactaccgggtccccaatatgcgcttcctccgagagcggctgacggac
cttgagcagcgtagtggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagtgcccagaagacgatggaccttcccttcttggaaaacatcactttgaggact
ggagaacggccagagcattgccaggtgtccctttctgagttccagcagttccttcttgaa
taccagggggagctgtgggctgtcgaccggctccaggtgcaggactttatgctcagcttc
cttcgagaccctttgcgagagattgaggagccatacttctatttggatgagcttgtcacc
tttctgttctccaaagagaacagtgtgtggaactcacagctggatgctgtgtgcccagac
accatgaacaacccactctctcactattggatctcttcctcacataatacgtacctgact
ggggaccagttctccagcgagtcctccctggaagcctatgctcgatgcctgaggatgggc
tgccgctgcattgagttggactgctgggatgggccagatgggatgccagtcatctaccat
gggcatactctgaccaccaagatcaagttctcagatgtcctgcataccatcaaggagcat
gctttcgtagcctcagagtacccagtcatcttgtccattgaggaccactgcagcattgcc
cagcagaggaacatggctcagcacttcagaaaggtgcttggtgacacactccttaccaag
cctgtggacattgctgctgatgggcttccttctcccaaccagctcaagaggaagatcctt
attaagcacaagaagctggctgagggcagtgcctatgaggaggtgcctacctctgtgatg
tactctgagaacgacatcagtaactccatcaagaatggtatcctctacttggaggacccc
gtgaatcatgagtggtatcctcactactttgttctgactagcagcaagatctactactct
gaggagaccagcagtgaccagggaagtgaggatgaagaggagccaaaggaggccagcggc
agcacagagctgcattccagcgagaagtggttccacgggaagcttggggctgggcgtgac
gggcggcacattgccgagcgcctgctcactgagtactgcatagagactggggctcccgat
ggctccttcctagtgcgagaaagtgagaccttcgtgggtgactacacgctgtctttttgg
cggaatgggaaagtccagcactgccgcatccactcccggcaggatgctgggactcctaag
ttcttcttgacagataaccttgtctttgactctctctatgacctcatcacacattatcag
caagtacccctgcgctgcaatgaatttgagatgcgcctctcagagcctgttccacagacg
aatgcccatgaaagcaaagagtggtaccatgcaagcctgactagagctcaggctgaacat
atgctgatgcgagtgccccgggatggggccttcctggtgcggaaacgcaacgagcctaac
tcatatgccatctctttccgggctgagggaaagatcaagcactgccgagtacaacaggaa
ggccagactgtgatgctggggaactctgagtttgacagcctggttgacctcatcagctat
tatgagaagcaccccctgtaccgcaaaatgaagctgcgctaccccatcaatgaggaggca
ctggagaagattgggacagctgaacccgattatggggcactctatgagggccgcaaccct
ggtttctatgtggaggcaaaccctatgccaactttcaagtgtgcagtaaaagccctcttt
gactacaaggcccagagagaggatgagctgacgtttaccaagagtgccatcatccagaat
gtggaaaagcaagacggtggctggtggagaggggactatggtgggaagaagcagctgtgg
ttcccctcaaactatgtggaagagatgatcaacccagcagtcctagagccggagagggag
catctggatgagaacagcccactgggggacctgctgcgaggggtcttggatgtgccagcc
tgtcagattgccattcgtcctgagggcaaaaacaaccggctcttcgtcttctccatcagc
atgccgtcagtggctcagtggtccctagatgttgcagctgactcacaggaagagttacag
gactgggtgaaaaagatccgtgaagttgcccagactgcagatgccaggcttactgagggg
aagatgatggagaggaggaagaagattgccttggagctttccgagcttgtggtctactgc
cggcctgttccctttgatgaagagaagattggcacagaacgtgcttgttaccgggacatg
tcctcctttccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccaatacaaccggctgcaactttctcgcatctaccccaagggccaaaggctggactcc
tccaattatgatcctctgcccatgtggatctgtggcagccagcttgtagcactcaatttt
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggctggtgggcattgt
ggatatgtgctgcagccaagcaccatgagagacgaagcctttgacccctttgataagagc
agtctccgaggtctggaaccctgtgtcatttgcattgaggtgctgggggccaggcatctg
ccaaagaatggccggggtattgtgtgtccttttgtggagatcgaggtagctggggctgag
tatgacagcatcaagcaaaagacagagtttgtagtggacaacggactgaaccctgtgtgg
cctgctaagcccttccacttccagatcagtaacccagagtttgcttttctgcgctttgtg
gtgtacgaggaagacatgtttagtgaccagaacttcttggctcaggctactttcccagta
aaaggcctgaagacaggatatagagcagtgcctttgaagaacaactacagtgaagacctg
gagttggcttccctgctcatcaagattgacattttccctgctaaggagaatggtgacctc
agtccttttagtggcatatccctaagggaacgggcctcagacgcctccagccagctgttc
catgtacgggcccgggaagggtcctttgaagccagataccagcagccatttgaagatttc
cgcatatcgcaggagcatcttgcagaccattttgacagtcgggaacgaagggccccaaga
aggactcgggtcaatggagacaaccgcctctag

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