KEGG   Bison bison bison (American bison): 104979900
Entry
104979900         CDS       T08726                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis01521  EGFR tyrosine kinase inhibitor resistance
bbis01522  Endocrine resistance
bbis04010  MAPK signaling pathway
bbis04012  ErbB signaling pathway
bbis04014  Ras signaling pathway
bbis04015  Rap1 signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04068  FoxO signaling pathway
bbis04071  Sphingolipid signaling pathway
bbis04072  Phospholipase D signaling pathway
bbis04140  Autophagy - animal
bbis04148  Efferocytosis
bbis04150  mTOR signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04210  Apoptosis
bbis04218  Cellular senescence
bbis04270  Vascular smooth muscle contraction
bbis04370  VEGF signaling pathway
bbis04371  Apelin signaling pathway
bbis04540  Gap junction
bbis04550  Signaling pathways regulating pluripotency of stem cells
bbis04613  Neutrophil extracellular trap formation
bbis04620  Toll-like receptor signaling pathway
bbis04650  Natural killer cell mediated cytotoxicity
bbis04660  T cell receptor signaling pathway
bbis04662  B cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04720  Long-term potentiation
bbis04722  Neurotrophin signaling pathway
bbis04730  Long-term depression
bbis04810  Regulation of actin cytoskeleton
bbis04910  Insulin signaling pathway
bbis04912  GnRH signaling pathway
bbis04915  Estrogen signaling pathway
bbis04916  Melanogenesis
bbis04917  Prolactin signaling pathway
bbis04919  Thyroid hormone signaling pathway
bbis04921  Oxytocin signaling pathway
bbis04926  Relaxin signaling pathway
bbis04929  GnRH secretion
bbis04934  Cushing syndrome
bbis04935  Growth hormone synthesis, secretion and action
bbis05010  Alzheimer disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05132  Salmonella infection
bbis05135  Yersinia infection
bbis05160  Hepatitis C
bbis05161  Hepatitis B
bbis05163  Human cytomegalovirus infection
bbis05164  Influenza A
bbis05165  Human papillomavirus infection
bbis05166  Human T-cell leukemia virus 1 infection
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05200  Pathways in cancer
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
bbis05207  Chemical carcinogenesis - receptor activation
bbis05208  Chemical carcinogenesis - reactive oxygen species
bbis05210  Colorectal cancer
bbis05211  Renal cell carcinoma
bbis05213  Endometrial cancer
bbis05214  Glioma
bbis05215  Prostate cancer
bbis05216  Thyroid cancer
bbis05218  Melanoma
bbis05219  Bladder cancer
bbis05220  Chronic myeloid leukemia
bbis05221  Acute myeloid leukemia
bbis05223  Non-small cell lung cancer
bbis05224  Breast cancer
bbis05225  Hepatocellular carcinoma
bbis05226  Gastric cancer
bbis05230  Central carbon metabolism in cancer
bbis05231  Choline metabolism in cancer
bbis05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    104979900 (MAP2K2)
   04012 ErbB signaling pathway
    104979900 (MAP2K2)
   04014 Ras signaling pathway
    104979900 (MAP2K2)
   04015 Rap1 signaling pathway
    104979900 (MAP2K2)
   04370 VEGF signaling pathway
    104979900 (MAP2K2)
   04371 Apelin signaling pathway
    104979900 (MAP2K2)
   04066 HIF-1 signaling pathway
    104979900 (MAP2K2)
   04068 FoxO signaling pathway
    104979900 (MAP2K2)
   04072 Phospholipase D signaling pathway
    104979900 (MAP2K2)
   04071 Sphingolipid signaling pathway
    104979900 (MAP2K2)
   04024 cAMP signaling pathway
    104979900 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    104979900 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    104979900 (MAP2K2)
   04150 mTOR signaling pathway
    104979900 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    104979900 (MAP2K2)
   04148 Efferocytosis
    104979900 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    104979900 (MAP2K2)
   04218 Cellular senescence
    104979900 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    104979900 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    104979900 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    104979900 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    104979900 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    104979900 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    104979900 (MAP2K2)
   04660 T cell receptor signaling pathway
    104979900 (MAP2K2)
   04662 B cell receptor signaling pathway
    104979900 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    104979900 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    104979900 (MAP2K2)
   04929 GnRH secretion
    104979900 (MAP2K2)
   04912 GnRH signaling pathway
    104979900 (MAP2K2)
   04915 Estrogen signaling pathway
    104979900 (MAP2K2)
   04917 Prolactin signaling pathway
    104979900 (MAP2K2)
   04921 Oxytocin signaling pathway
    104979900 (MAP2K2)
   04926 Relaxin signaling pathway
    104979900 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    104979900 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    104979900 (MAP2K2)
   04916 Melanogenesis
    104979900 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    104979900 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    104979900 (MAP2K2)
   04730 Long-term depression
    104979900 (MAP2K2)
   04722 Neurotrophin signaling pathway
    104979900 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104979900 (MAP2K2)
   05206 MicroRNAs in cancer
    104979900 (MAP2K2)
   05205 Proteoglycans in cancer
    104979900 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    104979900 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    104979900 (MAP2K2)
   05230 Central carbon metabolism in cancer
    104979900 (MAP2K2)
   05231 Choline metabolism in cancer
    104979900 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104979900 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    104979900 (MAP2K2)
   05225 Hepatocellular carcinoma
    104979900 (MAP2K2)
   05226 Gastric cancer
    104979900 (MAP2K2)
   05214 Glioma
    104979900 (MAP2K2)
   05216 Thyroid cancer
    104979900 (MAP2K2)
   05221 Acute myeloid leukemia
    104979900 (MAP2K2)
   05220 Chronic myeloid leukemia
    104979900 (MAP2K2)
   05218 Melanoma
    104979900 (MAP2K2)
   05211 Renal cell carcinoma
    104979900 (MAP2K2)
   05219 Bladder cancer
    104979900 (MAP2K2)
   05215 Prostate cancer
    104979900 (MAP2K2)
   05213 Endometrial cancer
    104979900 (MAP2K2)
   05224 Breast cancer
    104979900 (MAP2K2)
   05223 Non-small cell lung cancer
    104979900 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104979900 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    104979900 (MAP2K2)
   05161 Hepatitis B
    104979900 (MAP2K2)
   05160 Hepatitis C
    104979900 (MAP2K2)
   05164 Influenza A
    104979900 (MAP2K2)
   05163 Human cytomegalovirus infection
    104979900 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104979900 (MAP2K2)
   05165 Human papillomavirus infection
    104979900 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    104979900 (MAP2K2)
   05135 Yersinia infection
    104979900 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104979900 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    104979900 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    104979900 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    104979900 (MAP2K2)
   01522 Endocrine resistance
    104979900 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbis01001]
    104979900 (MAP2K2)
Enzymes [BR:bbis01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     104979900 (MAP2K2)
Protein kinases [BR:bbis01001]
 Serine/threonine kinases: STE group
  STE7 family
   104979900 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 104979900
NCBI-ProteinID: XP_010826753
UniProt: A0A6P3G4Q4
LinkDB
Position
Unknown
AA seq 464 aa
METTRRMRTCSVGGGSLRLVRTRRDEGRVPARLPQVVALARASASVRLRWLRRPRSRGFS
PGDLWGPSAQIRSTAHLRRLAIAEGPSPTSEGASEAHLVDLQKKLEELELDEQQKKRLEA
FLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQII
RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIA
VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSP
ERLQGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPPSISP
RPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAE
RADLKMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1395 nt   +upstreamnt  +downstreamnt
atggaaaccacaaggcgcatgcgcacttgctcggtgggaggaggcagcctcaggctggtg
cgcacgcgtcgggacgaggggcgggtaccagcacggctcccccaggtggtggctctcgcg
agagcgtcagcctctgtccggcttcggtggctgcggcggccccgatcccgtggcttcagc
cccggcgacctttggggcccctcggcccagatccgcagcaccgcccatcttcgtcgcctc
gccatcgccgagggcccgtcccctaccagcgagggcgcctccgaagcacatctggtggac
ctccagaagaagctagaggagctagagctcgacgagcagcagaagaagcggctggaagcc
ttccttacccagaaggccaaggttggtgagctcaaggacgatgactttgaacggatctcc
gagctgggagctggcaatggcggagtggtcaccaaggtccagcacagaccttcgggcctc
atcatggccagaaagctgatccacctggagatcaagccggccatccggaaccagatcatc
cgagagctacaggtgctgcatgagtgcaactccccatacattgtgggcttctacggggcc
ttctacagcgacggcgagatcagcatctgcatggagcacatggatggcggctccctggac
caggtgttgaaagaagccaagagaatccctgaagagatcctgggcaaggtcagcattgcg
gttctgcggggcctggcatacctccgggagaaacaccagatcatgcaccgagacgtgaag
ccgtccaacatcctggtcaactcccggggggagatcaagctgtgtgacttcggggtgagc
ggccagctcatcgactccatggccaactccttcgtggggacacggtcctacatgtctccg
gagcggctacaaggcacacactactcggtgcagtcagacatctggagcatgggcctgtcc
ctggtggaactgtccatcggcaggtaccccatccccccgccggacgccaaggagctggag
gccatattcggccggcccatggttgatggcgcagaaggagaacctcctagcatctctcca
cggccgaggccccccggacgccccatcagcggtcacgggatggacagccggcctgccatg
gcgatctttgagctgctggactacattgtgaacgagcctcctcccaagctgcccaacggc
gtgttcacccaggacttccaggagtttgtaaataaatgcctaattaagaacccagctgag
cgagcagacctgaagatgctcatgaaccacaccttcatcaagcggtccgaggtggaagaa
gtggattttgctggctggttgtgtaaaacactgcggctaaaccagcccagcacgcccaca
cgcaccgccgtgtga

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