KEGG   Bison bison bison (American bison): 104980493
Entry
104980493         CDS       T08726                                 
Symbol
PLCG1
Name
(RefSeq) LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis00562  Inositol phosphate metabolism
bbis01100  Metabolic pathways
bbis01521  EGFR tyrosine kinase inhibitor resistance
bbis04012  ErbB signaling pathway
bbis04014  Ras signaling pathway
bbis04015  Rap1 signaling pathway
bbis04020  Calcium signaling pathway
bbis04062  Chemokine signaling pathway
bbis04064  NF-kappa B signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04070  Phosphatidylinositol signaling system
bbis04072  Phospholipase D signaling pathway
bbis04360  Axon guidance
bbis04370  VEGF signaling pathway
bbis04517  IgSF CAM signaling
bbis04613  Neutrophil extracellular trap formation
bbis04650  Natural killer cell mediated cytotoxicity
bbis04658  Th1 and Th2 cell differentiation
bbis04659  Th17 cell differentiation
bbis04660  T cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04666  Fc gamma R-mediated phagocytosis
bbis04670  Leukocyte transendothelial migration
bbis04722  Neurotrophin signaling pathway
bbis04750  Inflammatory mediator regulation of TRP channels
bbis04919  Thyroid hormone signaling pathway
bbis04933  AGE-RAGE signaling pathway in diabetic complications
bbis04935  Growth hormone synthesis, secretion and action
bbis05012  Parkinson disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05135  Yersinia infection
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05171  Coronavirus disease - COVID-19
bbis05200  Pathways in cancer
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
bbis05214  Glioma
bbis05223  Non-small cell lung cancer
bbis05225  Hepatocellular carcinoma
bbis05231  Choline metabolism in cancer
bbis05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bbis05417  Lipid and atherosclerosis
Module
bbis_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    104980493 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    104980493 (PLCG1)
   04014 Ras signaling pathway
    104980493 (PLCG1)
   04015 Rap1 signaling pathway
    104980493 (PLCG1)
   04370 VEGF signaling pathway
    104980493 (PLCG1)
   04064 NF-kappa B signaling pathway
    104980493 (PLCG1)
   04066 HIF-1 signaling pathway
    104980493 (PLCG1)
   04020 Calcium signaling pathway
    104980493 (PLCG1)
   04070 Phosphatidylinositol signaling system
    104980493 (PLCG1)
   04072 Phospholipase D signaling pathway
    104980493 (PLCG1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    104980493 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    104980493 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    104980493 (PLCG1)
   04660 T cell receptor signaling pathway
    104980493 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    104980493 (PLCG1)
   04659 Th17 cell differentiation
    104980493 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    104980493 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    104980493 (PLCG1)
   04670 Leukocyte transendothelial migration
    104980493 (PLCG1)
   04062 Chemokine signaling pathway
    104980493 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    104980493 (PLCG1)
   04919 Thyroid hormone signaling pathway
    104980493 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    104980493 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    104980493 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    104980493 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104980493 (PLCG1)
   05206 MicroRNAs in cancer
    104980493 (PLCG1)
   05205 Proteoglycans in cancer
    104980493 (PLCG1)
   05231 Choline metabolism in cancer
    104980493 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104980493 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    104980493 (PLCG1)
   05214 Glioma
    104980493 (PLCG1)
   05223 Non-small cell lung cancer
    104980493 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    104980493 (PLCG1)
   05171 Coronavirus disease - COVID-19
    104980493 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104980493 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    104980493 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    104980493 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    104980493 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104980493 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    104980493 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    104980493 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbis04131]
    104980493 (PLCG1)
Enzymes [BR:bbis01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     104980493 (PLCG1)
Membrane trafficking [BR:bbis04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    104980493 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    104980493 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 104980493
NCBI-ProteinID: XP_010827539
Ensembl: ENSBBBG00000003546
UniProt: A0A6P3GL86
LinkDB
Position
Unknown
AA seq 1248 aa
MHGTSRQLKCSPVVEGKVGFEAHLHIYLLVDIREIKEIRPGKTSRDFDRYQEDPAFRPDQ
SHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYS
VDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYS
AQKTMDLPFLEASALRAGERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRD
PLREIEEPYFFLDEFVTFLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQ
FSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFV
ASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKH
KKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEET
SSDQGNEDEEEPKEASGSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSF
LVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLXFDSLYDLITHYQQVP
LRCNEFEMRLSEPGPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYA
ISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEK
IGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEK
QEGGWWRGDYGGKKQLWFPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQI
AVRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMM
ERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQY
NRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYV
LQPSVMRDEAFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDS
IKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGL
KTGYRAVPLKNNYSEGLELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHG
RAREGSFEARYQQPFEDFRISQEHLADHFDGRDRRTPRRTRVNGDSRL
NT seq 3747 nt   +upstreamnt  +downstreamnt
atgcacgggaccagcaggcagttgaagtgcagcccagtggttgaaggcaaggttgggttt
gaagcccacttgcacatctatctcctggttgacattcgtgaaatcaaggagatccgccca
gggaagacctcacgggatttcgatcgctaccaagaggatcctgcttttcgaccggaccag
tcccactgcttcgtcatcctgtatggaatggaattccgcctgaagaccctgagcctccaa
gccacgtctgaggacgaagtgaacatgtggatcaagggcctgacttggctgatggaggac
acattgcaggcagccacacccctgcagattgagaggtggctgcggaagcagttctactca
gtggaccggaaccgtgaggaccggatatcggccaaggacctgaagaacatgctgtcccag
gtcaactaccgggtccccaacatgcgcttcctccgggagcggctgacggacctggagcag
cgcaccagtgacatcacctacgggcagtttgcacagctgtaccgcagcctcatgtacagc
gcccagaagacgatggaccttcctttcctggaagccagcgccctgagggcgggggagcgg
ccggagctgtgccgggtgtcccttcctgagttccagcagttcctcctcgagtaccaaggg
gagctgtgggcggtggaccggctccaggtgcaggagttcatgctcagcttcctccgagac
cccttgcgagagattgaggagccttacttcttcctggacgagttcgtcaccttcctgttc
tccaaggagaacagcatatggaactcgcagctagacgaggtgtgccccgacaccatgaac
aaccccctgtcccactactggatctcctcctcgcacaacacgtacctgaccggggaccag
ttctccagcgagtcctccctggaagcctacgctcgctgtctgcggatgggctgccgttgc
attgagttggactgctgggacggcccggatgggatgccggtcatttaccatggacacact
ctgaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcacgcctttgtg
gcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcccagcagagg
aacatggcccagtatttcaaaaaggtgcttggggacacactcctcaccaagcccgtggat
attgcagccgacgggctcccctcccccaaccagctcaagaggaagatccttatcaagcac
aagaagttggctgagggcagtgcctacgaggaggtgccaacatcagtgatgtactctgag
aacgacatcagcaactccatcaagaatggcatcctctacctggaagaccctgtgaaccat
gagtggtacccccactacttcgtcctgaccagcagcaagatctactactcggaggagacc
agcagcgaccagggcaacgaggatgaggaggagcccaaggaggccagtggcagcacagag
ctgcactccaacgagaagtggttccacgggaagcttggggcgggccgggatgggcggcac
atcgccgagcgcctgctcacggagtactgcattgagaccggggcccccgacggctccttc
cttgtgcgcgagagcgagacctttgtgggcgactacactctgtccttctggcggaatggc
aaagtgcagcactgccggatccactcccggcaggacgcaggcacccccaagttcttcctg
acggacaacctcngcttcgactccctctatgacctcatcacgcactaccagcaggtgccc
ctgcgctgcaacgaatttgagatgcgcctctcagagccgggcccgcagaccaacgcgcac
gagagcaaagagtggtaccacgccagcctgaccagagcgcaggccgagcacatgctgatg
cgtgtacccagggacggggccttcctggtgcggaaacggaacgagcccaactcctacgcc
atctccttccgggctgagggcaagatcaagcactgccgcgtccagcaggagggccagacc
gtgatgctgggcaactcagagtttgacagccttgtcgacctcatcagctactatgagaag
cacccactgtaccgcaagatgaagctgcgctaccccatcaatgaggaggctctggagaag
atcggcacagctgagcctgactacggcgcgctgtacgagggccgcaaccctggcttctat
gtggaggcgaaccccatgcccacgttcaagtgcgccgtcaaagctctcttcgactacaaa
gcgcagcgggaggacgagctgacattcaccaagagtgccatcatccagaacgtggagaag
caggagggaggctggtggcggggtgactacggcgggaagaagcagctgtggttcccttca
aactacgtggaggaaatggtcagcccggcggccctggagcccgagagggagcacttggac
gagaacagcccactcggggacttgctccggggggtcctggatgtgccagcttgtcagata
gccgtccgtcccgagggcaagaacaaccggctgttcgtcttctccatcagcatggcctcg
gtggcacactggtccctggatgtggctgccgactcgcaagaagagctgcaggactgggtg
aagaagatccgggaggtggcgcagacagcggatgccaggctcaccgagggcaagatgatg
gagcggaggaagaagatcgccctagagctctcagagctcgtcgtctactgccggcctgtc
cctttcgacgaagagaagattggcaccgaacgggcctgctaccgcgacatgtcgtccttc
ccggagaccaaggccgagaagtatgtgaacaaggccaaaggcaagaagttcctccagtac
aaccgcctgcagctctcccgcatctaccctaagggccagcggctggactcctccaattac
gaccccctgcccatgtggatctgcggcagccagcttgtggccctcaacttccagacccca
gacaaacccatgcagatgaaccaggccctgttcctggccggcgggcactgtggctatgtg
ctgcagcccagcgtcatgcgcgatgaggccttcgatccctttgacaagagcagcctccgt
gggctggagccgtgcgccatctgcatcgaggtgctgggggcccggcacctgccgaagaac
ggccgaggcatcgtgtgtccttttgtggagatcgaggtggccggagccgagtatgacagc
atcaagcagaagacagagttcgtggtggacaatggactgaaccccgtgtggccagccaag
cccttccacttccagattagtaaccccgagttcgccttcctgcgcttcgtggtctatgag
gaggacatgtttagtgaccagaacttcctagctcaggctaccttcccagtgaagggtctg
aagacaggctacagagcggtgcctctgaagaacaactacagtgagggcctggagctggcc
tccctgctcgtcaagattgacgtgttccctgccaagcaggagaacggcgacctcagcccc
ttcgggggtgcgtccctgcgggagcggagctgtgacgcctcgggcccgctgttccacggc
cgggcccgggagggctcctttgaagctcgctaccagcagccctttgaggacttccgcatc
tcccaggagcatctcgcagaccattttgacggtcgggatcgcaggaccccacgcaggact
cgggtcaacggagacagccgcctctag

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