Bison bison bison (American bison): 104984593 Help Entry 104984593         CDS       T08726                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism bbis  Bison bison bison (American bison) Pathway bbis00230   Purine metabolism bbis01100   Metabolic pathways bbis01522   Endocrine resistance bbis04015   Rap1 signaling pathway bbis04022   cGMP-PKG signaling pathway bbis04024   cAMP signaling pathway bbis04062   Chemokine signaling pathway bbis04072   Phospholipase D signaling pathway bbis04081   Hormone signaling bbis04082   Neuroactive ligand signaling bbis04114   Oocyte meiosis bbis04211   Longevity regulating pathway bbis04213   Longevity regulating pathway - multiple species bbis04261   Adrenergic signaling in cardiomyocytes bbis04270   Vascular smooth muscle contraction bbis04371   Apelin signaling pathway bbis04540   Gap junction bbis04611   Platelet activation bbis04713   Circadian entrainment bbis04714   Thermogenesis bbis04723   Retrograde endocannabinoid signaling bbis04724   Glutamatergic synapse bbis04725   Cholinergic synapse bbis04726   Serotonergic synapse bbis04727   GABAergic synapse bbis04728   Dopaminergic synapse bbis04750   Inflammatory mediator regulation of TRP channels bbis04911   Insulin secretion bbis04912   GnRH signaling pathway bbis04913   Ovarian steroidogenesis bbis04914   Progesterone-mediated oocyte maturation bbis04915   Estrogen signaling pathway bbis04916   Melanogenesis bbis04918   Thyroid hormone synthesis bbis04921   Oxytocin signaling pathway bbis04923   Regulation of lipolysis in adipocytes bbis04924   Renin secretion bbis04925   Aldosterone synthesis and secretion bbis04926   Relaxin signaling pathway bbis04927   Cortisol synthesis and secretion bbis04928   Parathyroid hormone synthesis, secretion and action bbis04934   Cushing syndrome bbis04935   Growth hormone synthesis, secretion and action bbis04970   Salivary secretion bbis04971   Gastric acid secretion bbis04972   Pancreatic secretion bbis04976   Bile secretion bbis05012   Parkinson disease bbis05030   Cocaine addiction bbis05031   Amphetamine addiction bbis05032   Morphine addiction bbis05034   Alcoholism bbis05163   Human cytomegalovirus infection bbis05166   Human T-cell leukemia virus 1 infection bbis05200   Pathways in cancer bbis05207   Chemical carcinogenesis - receptor activation bbis05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bbis00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     104984593 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     104984593 (ADCY5)    04371 Apelin signaling pathway     104984593 (ADCY5)    04072 Phospholipase D signaling pathway     104984593 (ADCY5)    04024 cAMP signaling pathway     104984593 (ADCY5)    04022 cGMP-PKG signaling pathway     104984593 (ADCY5)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     104984593 (ADCY5)    04081 Hormone signaling     104984593 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     104984593 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     104984593 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     104984593 (ADCY5)    04062 Chemokine signaling pathway     104984593 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     104984593 (ADCY5)    04923 Regulation of lipolysis in adipocytes     104984593 (ADCY5)    04912 GnRH signaling pathway     104984593 (ADCY5)    04913 Ovarian steroidogenesis     104984593 (ADCY5)    04915 Estrogen signaling pathway     104984593 (ADCY5)    04914 Progesterone-mediated oocyte maturation     104984593 (ADCY5)    04921 Oxytocin signaling pathway     104984593 (ADCY5)    04926 Relaxin signaling pathway     104984593 (ADCY5)    04935 Growth hormone synthesis, secretion and action     104984593 (ADCY5)    04918 Thyroid hormone synthesis     104984593 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     104984593 (ADCY5)    04916 Melanogenesis     104984593 (ADCY5)    04924 Renin secretion     104984593 (ADCY5)    04925 Aldosterone synthesis and secretion     104984593 (ADCY5)    04927 Cortisol synthesis and secretion     104984593 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     104984593 (ADCY5)    04270 Vascular smooth muscle contraction     104984593 (ADCY5)   09154 Digestive system    04970 Salivary secretion     104984593 (ADCY5)    04971 Gastric acid secretion     104984593 (ADCY5)    04972 Pancreatic secretion     104984593 (ADCY5)    04976 Bile secretion     104984593 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     104984593 (ADCY5)    04727 GABAergic synapse     104984593 (ADCY5)    04725 Cholinergic synapse     104984593 (ADCY5)    04728 Dopaminergic synapse     104984593 (ADCY5)    04726 Serotonergic synapse     104984593 (ADCY5)    04723 Retrograde endocannabinoid signaling     104984593 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     104984593 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     104984593 (ADCY5)    04213 Longevity regulating pathway - multiple species     104984593 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     104984593 (ADCY5)    04714 Thermogenesis     104984593 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     104984593 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     104984593 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     104984593 (ADCY5)    05163 Human cytomegalovirus infection     104984593 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     104984593 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     104984593 (ADCY5)    05031 Amphetamine addiction     104984593 (ADCY5)    05032 Morphine addiction     104984593 (ADCY5)    05034 Alcoholism     104984593 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     104984593 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     104984593 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     104984593 (ADCY5) Enzymes [BR:bbis01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      104984593 (ADCY5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  104984593 NCBI-ProteinID:  XP_010832710 UniProt:  A0A6P3H299 LinkDB All DBs Position Unknown AA seq 1418 aa AA seqDB search MLSAGFLLCNYPPKHSCPPSPGCIGLTNCISIFPGAEAAARLCEPRPERRGGRGGGGRRG CGGRSGGGGGGKRARRKERRERPEQRRARGVHGAPRARLPRLSPERPRGAAAALWPAPLC WLHLSPGSRSLDAVLPGRSPPALGRNGGGAAPDSALSLVLLRPAAVGPQPAARSLGLEES ARQPSWAGGSGPAPLRFGGRVAPSPPRGKGAHFVSTPGPLPSRPNCLLAVRAAGLRLGRV CECRAQALQAPGRCRPQGHLSVPPRPQLRSLSSSTRARSPDVPLRAAQQLQQSPLPQLGA NSLSDLGLPTRIFSHFSPRGCVRPRSVELGLEERRGKGRAADDLEAGAVEEDEGAGDGGS SAGAGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVL VCLVMLAFHAARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDHMGLACYALIAVVLA VQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQ DQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERL LLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELV MTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLV REVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATL NYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNP PHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESSNPEDEVDEFLGRAIDARSIDR LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSVFMLS FYLTCFLLLTLVVFVSVIYSCVKLFPAPLQTLSRKIVRSKMNSTLVGVFTITLVFLSAFV NMFTCNSKDLFGCLGDEHNISASQVNACHVVESAVNYSLGDEQGFCGSSWPNCNFPEYFT YSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLVVEVPGVTLFDNADLLVTANAIDFNN NGTSQCPEHPTKVALKVVTPIIISVFVLALYLHAQQSQATEEKEEMEELQAYNRRLLHNI LPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEI IADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMK YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTD MYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPPS NT seq 4257 nt NT seq  +upstreamnt  +downstreamnt atgctgtctgcggggttcttgctctgtaactatccaccaaagcattcctgtccgcccagc cctggttgcatcggcctcaccaactgcatctccatctttcccggggcggaggcggccgcg cgcctctgtgagccgaggcccgagcggcgcggggggcggggaggcggcgggaggagggga tgcggagggcgctccggcggcggcggcggcggcaagcgggcgagaaggaaggagcggcgc gagcggccggagcagcgcagggcccgaggcgtgcatggcgcgccgcgagcccggctcccg cggctctccccggagcgcccccggggcgcagcagcggctctctggccggcccctctctgc tggctgcatctgagtcccggctctcgatctctggatgccgtgctccctgggagaagcccg cctgcgttggggcggaacggcggcggcgctgcgccggattccgccctcagcctagtcctt ctgcgcccggccgcggtgggcccgcagccggcggcaaggagcctggggcttgaggagtcg gcacgacagccctcctgggccggcgggtccgggccagccccgctccgttttgggggaagg gtcgctcccagtccgccgcgagggaagggcgcccacttcgtctccacgccgggacccctg ccgagccgtcctaactgccttctcgccgtgcgtgccgctggtctccgcttaggcagagtc tgcgagtgccgcgcccaggcattgcaagccccggggaggtgccgcccgcaaggacacctc tccgtcccgcctcgtccgcaactccggtccttgtcgagctcgacgcgagctaggagtccg gacgtccctctgcgcgcggctcagcagctccagcagtccccgctgccccagctcggagcc aactccctctcggacctggggctcccgacgcggattttcagccacttctcacctcggggc tgtgtgcgcccccgttcggtggagctaggcctggaggagcggcgtggcaagggccgcgcg gccgacgatctggaggccggcgccgtcgaggaagacgaaggggccggggatgggggcagc tcggcaggcgcgggcgcggggcctggcgcggtgctgtcgctgggcgcctgctgcctggca ctgctgcagatattccgctctaagaagttcccatcggacaagctggagcggctgtaccag cgctacttcttccgtctgaaccagagcagcctcacaatgctcatggctgtgctggtgctc gtgtgcctagtcatgttggccttccacgcggcacggcccccgctgcagctgccctacctg gccgtcctagcggccgccgtgggtgtgatcctcgttatggccgtgctctgcaaccgcgcc gccttccaccaggaccacatgggcctggcctgctacgcgcttatcgccgtggtgctggcc gtccaggtggtgggcctgttgctgccccagccgcgcagtgcctccgagggcatctggtgg actgtgtttttcatctatacgatctacacgctcctgcccgtgcgcatgcgggctgcggta ctcagcggggtgctcctgtccgccctccacctggccatcgccctgcgcaccaacgcccag gatcagttcctgctcaagcagctcgtctccaacgtcctcattttctcctgcaccaacatt gtgggtgtgtgcacccactacccggctgaggtctcgcagaggcaggccttccaggagacc cgggagtgcatccaggcacggctccactcacagcgggagaaccagcagcaggagcggctc ctgctgtctgtccttccccgtcacgttgccatggagatgaaagccgacatcaacgccaaa caggaggatatgatgttccataagatttacatccagaaacatgacaacgtgagcatcctg tttgctgacatcgagggtttcaccagcctggcatcccagtgcactgcccaggagctggtc atgaccctcaacgagctcttcgcccgcttcgacaagctggctgcggagaatcactgttta cgtattaagatcctgggagattgttattactgtgtctcagggctgcctgaagccagggct gaccacgcccactgctgcgtggagatgggcatggacatgatcgaggccatctcgctggtc cgggaggtgacaggtgtgaacgtgaacatgcgtgtgggaattcacagcgggagagtgcac tgcggtgtcctcggcctcaggaagtggcagttcgatgtctggtctaacgatgtcacactg gccaaccacatggaggctggaggcaaggcgggacgcatccacatcaccaaggctactctc aactacttgaatggtgactacgaagtggagccaggctgtgggggcgagcgcaacgcctac ctcaaggagcacagtatcgagacctttctcatcctgcgctgcacccagaagcggaaagaa gagaaggccatgattgccaagatgaaccgtcagagaaccaactccatcgggcacaacccg ccccactggggggccgagcgccccttctataaccacctggggggcaaccaggtgtccaag gagatgaagcggatgggctttgaagaccccaaggacaagaatgcccaggaaagttcgaac cctgaggatgaagtggatgaatttctgggccgtgccattgatgccaggagcatcgacagg ctgcgatctgaacatgttcgcaagttcctcttgaccttcagggagcctgacttagagaag aagtactccaagcaggtggatgaccgatttggtgcctacgtggcctgtgcctcgctcgtc ttcctcttcatctgctttgtccagatcaccattgtgccccactccgtgttcatgttgagt ttctacctgacctgtttcctgctgctgaccttggtggtgtttgtgtccgtgatctattct tgcgtgaagctcttcccagccccgctgcagacgctctccaggaagatcgtgcggtccaag atgaacagcaccctggtgggggtgttcaccatcaccctcgtgttcctgtcggcttttgtc aacatgttcacgtgcaactccaaggacctgtttggctgcctgggggacgagcacaacatc agtgccagtcaggtcaatgcatgccacgtggtggagtcggccgtcaactacagtctgggt gacgagcagggcttctgcggcagctcctggcccaactgcaacttccccgagtacttcacc tatagcgtgctgctcagcctgctggcctgctccgtgttcctgcagatcagctgcatcggg aagctggtgctcatgctggccatcgagctcatctacgtgctcgtcgttgaggtgcccggt gtcacgctctttgacaatgccgacctactggtcacggccaacgccatagacttcaacaac aacgggacctcccagtgccctgagcatccaaccaaggtggcgctgaaggtggtgacgccc atcatcatctccgtcttcgtgctggccctgtacctgcatgcccagcagtcccaggccacg gaggagaaggaggagatggaggagctgcaggcctacaaccggcggctgctgcacaacatt ctgcccaaggacgtggccgcacacttcctggcccgcgaacggcgcaacgacgagctctac tatcagtcgtgcgagtgcgtggccgtcatgttcgcctccatcgccaacttctctgagttc tatgtggaactagaggccaacaacgagggcgtcgagtgcctgcggctgctcaacgagatc atcgcagactttgacgagatcattagtgaggaccggttcaggcagctggaaaagatcaag accatcggcagcacctacatggccgcctccggcctcaatgactccacctacgacaaggtg ggcaagacccacatcaaagccctggccgacttcgccatgaagttgatggaccaaatgaag tacatcaacgagcactctttcaacaacttccagatgaagattgggctcaatattggcccc gtggtggcgggtgtgattggagcccgcaagcctcagtacgacatctggggcaatacggtg aacgtggccagccgcatggacagcaccggtgtgcccgaccgcatccaggtcaccacagac atgtaccaggtgctggccgccaatacgtaccagctggagtgccggggtgtggtcaaggtc aagggcaaaggcgagatgatgacctacttcctcaatggaggacccccgcccagttag

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