KEGG   ORTHOLOGY: K08045
Entry
K08045                      KO                                     

Symbol
ADCY5
Name
adenylate cyclase 5 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05012  Parkinson disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05032  Morphine addiction
map05034  Alcoholism
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Disease
H02389  Familial dyskinesia with facial myokymia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08045  ADCY5; adenylate cyclase 5
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04371 Apelin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04072 Phospholipase D signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04024 cAMP signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04022 cGMP-PKG signaling pathway
    K08045  ADCY5; adenylate cyclase 5
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08045  ADCY5; adenylate cyclase 5
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08045  ADCY5; adenylate cyclase 5
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08045  ADCY5; adenylate cyclase 5
   04062 Chemokine signaling pathway
    K08045  ADCY5; adenylate cyclase 5
  09152 Endocrine system
   04911 Insulin secretion
    K08045  ADCY5; adenylate cyclase 5
   04923 Regulation of lipolysis in adipocytes
    K08045  ADCY5; adenylate cyclase 5
   04912 GnRH signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04913 Ovarian steroidogenesis
    K08045  ADCY5; adenylate cyclase 5
   04915 Estrogen signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04914 Progesterone-mediated oocyte maturation
    K08045  ADCY5; adenylate cyclase 5
   04921 Oxytocin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04926 Relaxin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04935 Growth hormone synthesis, secretion and action
    K08045  ADCY5; adenylate cyclase 5
   04918 Thyroid hormone synthesis
    K08045  ADCY5; adenylate cyclase 5
   04928 Parathyroid hormone synthesis, secretion and action
    K08045  ADCY5; adenylate cyclase 5
   04916 Melanogenesis
    K08045  ADCY5; adenylate cyclase 5
   04924 Renin secretion
    K08045  ADCY5; adenylate cyclase 5
   04925 Aldosterone synthesis and secretion
    K08045  ADCY5; adenylate cyclase 5
   04927 Cortisol synthesis and secretion
    K08045  ADCY5; adenylate cyclase 5
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08045  ADCY5; adenylate cyclase 5
   04270 Vascular smooth muscle contraction
    K08045  ADCY5; adenylate cyclase 5
  09154 Digestive system
   04970 Salivary secretion
    K08045  ADCY5; adenylate cyclase 5
   04971 Gastric acid secretion
    K08045  ADCY5; adenylate cyclase 5
   04972 Pancreatic secretion
    K08045  ADCY5; adenylate cyclase 5
   04976 Bile secretion
    K08045  ADCY5; adenylate cyclase 5
  09156 Nervous system
   04724 Glutamatergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04727 GABAergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04725 Cholinergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04728 Dopaminergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04726 Serotonergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04723 Retrograde endocannabinoid signaling
    K08045  ADCY5; adenylate cyclase 5
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08045  ADCY5; adenylate cyclase 5
  09149 Aging
   04211 Longevity regulating pathway
    K08045  ADCY5; adenylate cyclase 5
   04213 Longevity regulating pathway - multiple species
    K08045  ADCY5; adenylate cyclase 5
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08045  ADCY5; adenylate cyclase 5
   04714 Thermogenesis
    K08045  ADCY5; adenylate cyclase 5
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08045  ADCY5; adenylate cyclase 5
   05207 Chemical carcinogenesis - receptor activation
    K08045  ADCY5; adenylate cyclase 5
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08045  ADCY5; adenylate cyclase 5
   05163 Human cytomegalovirus infection
    K08045  ADCY5; adenylate cyclase 5
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08045  ADCY5; adenylate cyclase 5
  09165 Substance dependence
   05030 Cocaine addiction
    K08045  ADCY5; adenylate cyclase 5
   05031 Amphetamine addiction
    K08045  ADCY5; adenylate cyclase 5
   05032 Morphine addiction
    K08045  ADCY5; adenylate cyclase 5
   05034 Alcoholism
    K08045  ADCY5; adenylate cyclase 5
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08045  ADCY5; adenylate cyclase 5
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08045  ADCY5; adenylate cyclase 5
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08045  ADCY5; adenylate cyclase 5
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08045  ADCY5; adenylate cyclase 5
Other DBs
RN: R00089 R00434
GO: 0004016
Genes
HSA: 111(ADCY5)
PTR: 470905(ADCY5)
PPS: 100989177(ADCY5)
GGO: 101150181(ADCY5)
PON: 100454138(ADCY5)
NLE: 100580455(ADCY5)
MCC: 715897(ADCY5)
MCF: 102135142(ADCY5)
CSAB: 103228169(ADCY5)
CATY: 105589787(ADCY5)
PANU: 101014828(ADCY5)
RRO: 104668142(ADCY5)
RBB: 108517430(ADCY5)
TFN: 117083400(ADCY5)
PTEH: 111544335(ADCY5)
CJC: 100412782(ADCY5)
SBQ: 101049747(ADCY5)
MMUR: 105879870(ADCY5)
MMU: 224129(Adcy5)
MCAL: 110311373(Adcy5)
MPAH: 110329393(Adcy5)
RNO: 64532(Adcy5)
MCOC: 116085856(Adcy5)
MUN: 110547229(Adcy5)
CGE: 100765958(Adcy5)
PLEU: 114704841(Adcy5)
NGI: 103741989(Adcy5)
HGL: 101702436(Adcy5)
CCAN: 109701078(Adcy5)
OCU: 100009315(ADCY5)
OPI: 101526286(ADCY5)
TUP: 102490639(ADCY5)
CFA: 403859(ADCY5)
VVP: 112913504(ADCY5)
VLG: 121501047(ADCY5)
AML: 100482519(ADCY5)
UMR: 103678826(ADCY5)
UAH: 113252326(ADCY5)
ORO: 101380824(ADCY5)
ELK: 111155044
MPUF: 101673819(ADCY5)
EJU: 114199416(ADCY5)
MLX: 118007016(ADCY5)
FCA: 101100749(ADCY5)
PYU: 121036524(ADCY5)
PBG: 122491521(ADCY5)
PTG: 102969833(ADCY5)
PPAD: 109266493(ADCY5)
AJU: 106984082(ADCY5)
HHV: 120237362(ADCY5)
BTA: 505740(ADCY5)
BOM: 102276460(ADCY5)
BIU: 109555842(ADCY5)
BBUB: 102405387(ADCY5)
CHX: 102189798(ADCY5)
OAS: 105602258(ADCY5)
ODA: 120870754(ADCY5)
CCAD: 122444643(ADCY5)
SSC: 100155970(ADCY5)
CFR: 102503785(ADCY5)
CBAI: 105081635(ADCY5)
CDK: 105090284(ADCY5)
BACU: 103006764(ADCY5)
LVE: 103091169(ADCY5)
OOR: 101283178(ADCY5)
DLE: 111171650(ADCY5)
PCAD: 102983319(ADCY5)
ECB: 100070498(ADCY5)
EPZ: 103563830(ADCY5)
EAI: 106823728(ADCY5)
MYB: 102257731(ADCY5)
MYD: 102760678(ADCY5)
MMYO: 118676734(ADCY5)
MNA: 107527242(ADCY5)
HAI: 109387200(ADCY5)
DRO: 112320488(ADCY5)
SHON: 118990736(ADCY5)
AJM: 119039523(ADCY5)
MMF: 118617134(ADCY5)
PALE: 102897495(ADCY5)
PGIG: 120586714(ADCY5)
RAY: 107518038(ADCY5)
MJV: 108396721(ADCY5)
TOD: 119257456(ADCY5)
LAV: 100670244(ADCY5)
TMU: 101346041
MDO: 100019274(ADCY5)
PCW: 110208122(ADCY5)
OAA: 114811232(ADCY5)
GGA: 395340(ADCY5)
PCOC: 116227376(ADCY5)
MGP: 100547372(ADCY5)
CJO: 107316827(ADCY5)
NMEL: 110399200(ADCY5)
APLA: 101794067(ADCY5)
ACYG: 106029894(ADCY5)
TGU: 100220777(ADCY5)
LSR: 110468293(ADCY5)
SCAN: 103814312(ADCY5)
PMOA: 120497513(ADCY5)
OTC: 121337991(ADCY5)
PRUF: 121356628(ADCY5)
GFR: 102031760(ADCY5)
FAB: 101807084(ADCY5)
PHI: 102107286(ADCY5)
PMAJ: 107207500(ADCY5)
CCAE: 111932249(ADCY5)
CCW: 104694019(ADCY5)
ETL: 114058103(ADCY5)
FPG: 101922323(ADCY5)
FCH: 102049855(ADCY5)
CLV: 102085466(ADCY5)
EGZ: 104128107(ADCY5)
NNI: 104018815(ADCY5)
ACUN: 113482358(ADCY5)
PADL: 103919638(ADCY5)
AAM: 106499045(ADCY5)
AROW: 112973826(ADCY5)
NPD: 112960094(ADCY5)
DNE: 112994245(ADCY5)
ASN: 102387635
AMJ: 102562224(ADCY5)
CPOO: 109322645(ADCY5)
GGN: 109301418(ADCY5)
PSS: 102461993(ADCY5)
CMY: 102937309(ADCY5)
CPIC: 101950146(ADCY5)
TST: 117885025(ADCY5)
CABI: 116834742(ADCY5)
ACS: 100558125(adcy5)
PVT: 110083012(ADCY5)
PBI: 103060584(ADCY5)
PMUR: 107285748
TSR: 106553086(ADCY5)
PGUT: 117668834(ADCY5)
PMUA: 114603889(ADCY5)
ZVI: 118091724(ADCY5)
GJA: 107113906
XLA: 108701255 108702898(adcy5.S)
XTR: 100490464(adcy5)
NPR: 108801019
DRE: 562619(adcy5)
IPU: 108266230(adcy5)
PHYP: 113525981(adcy5)
AMEX: 103026414(adcy5)
EEE: 113567484(adcy5)
TRU: 101070040(adcy5)
LCO: 104918228(adcy5)
ELY: 117251312(adcy5)
PLEP: 121948834(adcy5)
SLUC: 116067017(adcy5)
ECRA: 117952804(adcy5)
PFLV: 114563925(adcy5)
GAT: 120834348(adcy5)
PPUG: 119228462(adcy5)
MSAM: 119904436(adcy5)
CUD: 121522472(adcy5)
MZE: 101480556(adcy5)
ONL: 100698700(adcy5)
OAU: 116314774(adcy5)
OLA: 101174709(adcy5)
OML: 112154945(adcy5)
XMA: 102229859(adcy5)
XCO: 114147875(adcy5)
XHE: 116722709(adcy5)
PRET: 103478500(adcy5)
CVG: 107101604(adcy5)
CTUL: 119778488(adcy5)
NFU: 107389655(adcy5)
KMR: 108238863(adcy5)
AOCE: 111573705(adcy5)
CSEM: 103391879(adcy5)
POV: 109637957
LCF: 108897108(adcy5)
SDU: 111218374(adcy5)
SLAL: 111657529(adcy5)
XGL: 120801527(adcy5)
HCQ: 109521852
BPEC: 110156638(adcy5)
MALB: 109974016(adcy5)
SASA: 106582348(adcy5) 106586396
OTW: 112224860 112238548(adcy5)
OMY: 110501809 110520268(adcy5)
ELS: 105016121(adcy5)
PKI: 111851750(adcy5)
AANG: 118223221(adcy5)
LOC: 102689480(adcy5)
LCM: 102353581(ADCY5)
BFO: 118425098
BBEL: 109488308
CIN: 778532
SCLV: 120337426
SPU: 582776
APLC: 110979349
SKO: 100376780
AME: 726514
BIM: 100747315
BBIF: 117216992
BTER: 100645307
CCAL: 108628661
OBB: 114879773
MGEN: 117220940
NMEA: 116426026
CGIG: 122401699
SOC: 105204551
MPHA: 105838640
AEC: 105154476
ACEP: 105621266
PBAR: 105430765
VEM: 105563054
HST: 105191454
DQU: 106750327
CFO: 105258714
FEX: 115235810
LHU: 105679715
PGC: 109857578
OBO: 105275369
PCF: 106791020
MDL: 103580107
CCIN: 107270651
TCA: 659486
DPA: 109540307
ATD: 109594012
AGB: 108907225
NVL: 108568296
BMOR: 101739615
BMAN: 114247436
PMAC: 106715905
PPOT: 106099561
PXU: 106113903
PRAP: 111003341
ZCE: 119835849
HAW: 110379459
PXY: 105387103
API: 100160451
DNX: 107169163
RMD: 113549620
BTAB: 109042497
HHAL: 106679834
ZNE: 110830589
CSEC: 111863049
FCD: 110843276
DPX: DAPPUDRAFT_39757(Adcy1)
DMK: 116923526
PVM: 113822760
HAZT: 108683339
EAF: 111714019
DSV: 119442339
RSAN: 119387173
RMP: 119159572
VDE: 111245001
VJA: 111265391
CSCU: 111624573
PTEP: 107439050
SDM: 118188448
PCAN: 112563595
BGT: 106061562
GAE: 121381879
CRG: 105346394
MYI: 110463711
PMAX: 117343741
OBI: 106882760
LAK: 106171289
NVE: 5517880
EPA: 110245505
ADF: 107356750
AMIL: 114970122
PDAM: 113666552
SPIS: 111343062
DGT: 114520988
HMG: 100210301
 » show all
Reference
  Authors
Ludwig MG, Seuwen K
  Title
Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.
  Journal
J Recept Signal Transduct Res 22:79-110 (2002)
DOI:10.1081/RRS-120014589
  Sequence
[hsa:111]
Reference
  Authors
Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD
  Title
Raf kinase activation of adenylyl cyclases: isoform-selective regulation.
  Journal
Mol Pharmacol 66:921-8 (2004)
DOI:10.1124/mol.66.4.921
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