Bison bison bison (American bison): 104987936 Help Entry 104987936         CDS       T08726                                  Symbol IL6 Name (RefSeq) interleukin-6   KO K05405   interleukin 6 Organism bbis  Bison bison bison (American bison) Pathway bbis01521   EGFR tyrosine kinase inhibitor resistance bbis01523   Antifolate resistance bbis04060   Cytokine-cytokine receptor interaction bbis04061   Viral protein interaction with cytokine and cytokine receptor bbis04066   HIF-1 signaling pathway bbis04068   FoxO signaling pathway bbis04151   PI3K-Akt signaling pathway bbis04218   Cellular senescence bbis04620   Toll-like receptor signaling pathway bbis04621   NOD-like receptor signaling pathway bbis04623   Cytosolic DNA-sensing pathway bbis04625   C-type lectin receptor signaling pathway bbis04630   JAK-STAT signaling pathway bbis04640   Hematopoietic cell lineage bbis04657   IL-17 signaling pathway bbis04659   Th17 cell differentiation bbis04668   TNF signaling pathway bbis04672   Intestinal immune network for IgA production bbis04931   Insulin resistance bbis04932   Non-alcoholic fatty liver disease bbis04933   AGE-RAGE signaling pathway in diabetic complications bbis04936   Alcoholic liver disease bbis05010   Alzheimer disease bbis05020   Prion disease bbis05022   Pathways of neurodegeneration - multiple diseases bbis05132   Salmonella infection bbis05133   Pertussis bbis05134   Legionellosis bbis05135   Yersinia infection bbis05142   Chagas disease bbis05143   African trypanosomiasis bbis05144   Malaria bbis05146   Amoebiasis bbis05152   Tuberculosis bbis05161   Hepatitis B bbis05162   Measles bbis05163   Human cytomegalovirus infection bbis05164   Influenza A bbis05166   Human T-cell leukemia virus 1 infection bbis05167   Kaposi sarcoma-associated herpesvirus infection bbis05168   Herpes simplex virus 1 infection bbis05169   Epstein-Barr virus infection bbis05171   Coronavirus disease - COVID-19 bbis05200   Pathways in cancer bbis05202   Transcriptional misregulation in cancer bbis05321   Inflammatory bowel disease bbis05323   Rheumatoid arthritis bbis05332   Graft-versus-host disease bbis05410   Hypertrophic cardiomyopathy bbis05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     104987936 (IL6)    04668 TNF signaling pathway     104987936 (IL6)    04066 HIF-1 signaling pathway     104987936 (IL6)    04068 FoxO signaling pathway     104987936 (IL6)    04151 PI3K-Akt signaling pathway     104987936 (IL6)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     104987936 (IL6)    04061 Viral protein interaction with cytokine and cytokine receptor     104987936 (IL6)  09140 Cellular Processes   09143 Cell growth and death    04218 Cellular senescence     104987936 (IL6)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     104987936 (IL6)    04620 Toll-like receptor signaling pathway     104987936 (IL6)    04621 NOD-like receptor signaling pathway     104987936 (IL6)    04623 Cytosolic DNA-sensing pathway     104987936 (IL6)    04625 C-type lectin receptor signaling pathway     104987936 (IL6)    04659 Th17 cell differentiation     104987936 (IL6)    04657 IL-17 signaling pathway     104987936 (IL6)    04672 Intestinal immune network for IgA production     104987936 (IL6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     104987936 (IL6)    05202 Transcriptional misregulation in cancer     104987936 (IL6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     104987936 (IL6)    05161 Hepatitis B     104987936 (IL6)    05171 Coronavirus disease - COVID-19     104987936 (IL6)    05164 Influenza A     104987936 (IL6)    05162 Measles     104987936 (IL6)    05168 Herpes simplex virus 1 infection     104987936 (IL6)    05163 Human cytomegalovirus infection     104987936 (IL6)    05167 Kaposi sarcoma-associated herpesvirus infection     104987936 (IL6)    05169 Epstein-Barr virus infection     104987936 (IL6)   09171 Infectious disease: bacterial    05132 Salmonella infection     104987936 (IL6)    05135 Yersinia infection     104987936 (IL6)    05133 Pertussis     104987936 (IL6)    05134 Legionellosis     104987936 (IL6)    05152 Tuberculosis     104987936 (IL6)   09174 Infectious disease: parasitic    05146 Amoebiasis     104987936 (IL6)    05144 Malaria     104987936 (IL6)    05142 Chagas disease     104987936 (IL6)    05143 African trypanosomiasis     104987936 (IL6)   09163 Immune disease    05323 Rheumatoid arthritis     104987936 (IL6)    05321 Inflammatory bowel disease     104987936 (IL6)    05332 Graft-versus-host disease     104987936 (IL6)   09164 Neurodegenerative disease    05010 Alzheimer disease     104987936 (IL6)    05020 Prion disease     104987936 (IL6)    05022 Pathways of neurodegeneration - multiple diseases     104987936 (IL6)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     104987936 (IL6)    05410 Hypertrophic cardiomyopathy     104987936 (IL6)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     104987936 (IL6)    04932 Non-alcoholic fatty liver disease     104987936 (IL6)    04931 Insulin resistance     104987936 (IL6)    04933 AGE-RAGE signaling pathway in diabetic complications     104987936 (IL6)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     104987936 (IL6)    01523 Antifolate resistance     104987936 (IL6)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:bbis04052]     104987936 (IL6) Cytokines and neuropeptides [BR:bbis04052]  Cytokines   Interleukins    104987936 (IL6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IL6 GCSF IL23 ADIP Lipoprotein_6 Motif Other DBs NCBI-GeneID:  104987936 NCBI-ProteinID:  XP_010837340 Ensembl:  ENSBBBG00000016329 UniProt:  A0A6P3HFH0 LinkDB All DBs Position Unknown AA seq 208 aa AA seqDB search MNSRFTSAFTPFAVSLGLLLVMTSAFPTPGPLGEDFKNDTTPGRLLLTTPEKTEALIKRM VDKISAMRKEICEKNDECESSKETLAENKLNLPKMEEKDGCFQSGFNQAICLIKTTAGLL EYQIYLDYLQNEYEGNQENVRDLRKNIRTLIQILKQKIADLITTPATNTDLLEKMQSSNE WVKNAKIILILRNLENFLQFSLRAIRMK NT seq 627 nt NT seq  +upstreamnt  +downstreamnt atgaactcccgcttcacaagcgccttcactccattcgctgtctccctggggctgctcctg gtgatgacttctgctttccctaccccgggtcccctgggagaagatttcaaaaatgacacc accccaggcagactacttctgaccactccagagaaaaccgaagctctcattaagcgcatg gtcgacaaaatctctgcaatgagaaaggagatatgtgagaagaatgatgagtgtgaaagc agcaaggagacactggcagaaaataagctgaatcttccaaaaatggaggaaaaggacgga tgcttccaatctgggttcaatcaggcgatttgcttgatcaaaaccactgctggtcttctg gagtatcagatatacctggactacctccagaacgagtatgagggaaatcaggaaaatgtc agggatttgaggaaaaatatcagaacactgatccagatcctgaagcagaagatcgcagat ctaataaccactccagccacaaacactgacctgctggagaagatgcagtcttcaaacgag tgggtaaagaacgcaaagattatcctcatcctgagaaaccttgagaatttcctgcagttc agcctgagagctattcggatgaagtag

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