KEGG   Bison bison bison (American bison): 104991731
Entry
104991731         CDS       T08726                                 
Symbol
ADCY8
Name
(RefSeq) LOW QUALITY PROTEIN: adenylate cyclase type 8
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis00230  Purine metabolism
bbis01100  Metabolic pathways
bbis01522  Endocrine resistance
bbis04015  Rap1 signaling pathway
bbis04020  Calcium signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04062  Chemokine signaling pathway
bbis04072  Phospholipase D signaling pathway
bbis04081  Hormone signaling
bbis04082  Neuroactive ligand signaling
bbis04114  Oocyte meiosis
bbis04211  Longevity regulating pathway
bbis04213  Longevity regulating pathway - multiple species
bbis04261  Adrenergic signaling in cardiomyocytes
bbis04270  Vascular smooth muscle contraction
bbis04371  Apelin signaling pathway
bbis04540  Gap junction
bbis04611  Platelet activation
bbis04713  Circadian entrainment
bbis04714  Thermogenesis
bbis04720  Long-term potentiation
bbis04723  Retrograde endocannabinoid signaling
bbis04724  Glutamatergic synapse
bbis04725  Cholinergic synapse
bbis04727  GABAergic synapse
bbis04742  Taste transduction
bbis04750  Inflammatory mediator regulation of TRP channels
bbis04911  Insulin secretion
bbis04912  GnRH signaling pathway
bbis04913  Ovarian steroidogenesis
bbis04914  Progesterone-mediated oocyte maturation
bbis04915  Estrogen signaling pathway
bbis04916  Melanogenesis
bbis04918  Thyroid hormone synthesis
bbis04921  Oxytocin signaling pathway
bbis04923  Regulation of lipolysis in adipocytes
bbis04925  Aldosterone synthesis and secretion
bbis04926  Relaxin signaling pathway
bbis04927  Cortisol synthesis and secretion
bbis04928  Parathyroid hormone synthesis, secretion and action
bbis04934  Cushing syndrome
bbis04935  Growth hormone synthesis, secretion and action
bbis04970  Salivary secretion
bbis04971  Gastric acid secretion
bbis04972  Pancreatic secretion
bbis04976  Bile secretion
bbis05032  Morphine addiction
bbis05163  Human cytomegalovirus infection
bbis05166  Human T-cell leukemia virus 1 infection
bbis05200  Pathways in cancer
bbis05207  Chemical carcinogenesis - receptor activation
bbis05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    104991731 (ADCY8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    104991731 (ADCY8)
   04371 Apelin signaling pathway
    104991731 (ADCY8)
   04020 Calcium signaling pathway
    104991731 (ADCY8)
   04072 Phospholipase D signaling pathway
    104991731 (ADCY8)
   04024 cAMP signaling pathway
    104991731 (ADCY8)
   04022 cGMP-PKG signaling pathway
    104991731 (ADCY8)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    104991731 (ADCY8)
   04081 Hormone signaling
    104991731 (ADCY8)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    104991731 (ADCY8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    104991731 (ADCY8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104991731 (ADCY8)
   04062 Chemokine signaling pathway
    104991731 (ADCY8)
  09152 Endocrine system
   04911 Insulin secretion
    104991731 (ADCY8)
   04923 Regulation of lipolysis in adipocytes
    104991731 (ADCY8)
   04912 GnRH signaling pathway
    104991731 (ADCY8)
   04913 Ovarian steroidogenesis
    104991731 (ADCY8)
   04915 Estrogen signaling pathway
    104991731 (ADCY8)
   04914 Progesterone-mediated oocyte maturation
    104991731 (ADCY8)
   04921 Oxytocin signaling pathway
    104991731 (ADCY8)
   04926 Relaxin signaling pathway
    104991731 (ADCY8)
   04935 Growth hormone synthesis, secretion and action
    104991731 (ADCY8)
   04918 Thyroid hormone synthesis
    104991731 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    104991731 (ADCY8)
   04916 Melanogenesis
    104991731 (ADCY8)
   04925 Aldosterone synthesis and secretion
    104991731 (ADCY8)
   04927 Cortisol synthesis and secretion
    104991731 (ADCY8)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104991731 (ADCY8)
   04270 Vascular smooth muscle contraction
    104991731 (ADCY8)
  09154 Digestive system
   04970 Salivary secretion
    104991731 (ADCY8)
   04971 Gastric acid secretion
    104991731 (ADCY8)
   04972 Pancreatic secretion
    104991731 (ADCY8)
   04976 Bile secretion
    104991731 (ADCY8)
  09156 Nervous system
   04724 Glutamatergic synapse
    104991731 (ADCY8)
   04727 GABAergic synapse
    104991731 (ADCY8)
   04725 Cholinergic synapse
    104991731 (ADCY8)
   04720 Long-term potentiation
    104991731 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    104991731 (ADCY8)
  09157 Sensory system
   04742 Taste transduction
    104991731 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    104991731 (ADCY8)
  09149 Aging
   04211 Longevity regulating pathway
    104991731 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    104991731 (ADCY8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    104991731 (ADCY8)
   04714 Thermogenesis
    104991731 (ADCY8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104991731 (ADCY8)
   05207 Chemical carcinogenesis - receptor activation
    104991731 (ADCY8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104991731 (ADCY8)
   05163 Human cytomegalovirus infection
    104991731 (ADCY8)
  09165 Substance dependence
   05032 Morphine addiction
    104991731 (ADCY8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    104991731 (ADCY8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    104991731 (ADCY8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    104991731 (ADCY8)
Enzymes [BR:bbis01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     104991731 (ADCY8)
SSDB
Motif
Pfam: Guanylate_cyc Adcy_cons_dom AC_N TBK1_ULD
Other DBs
NCBI-GeneID: 104991731
NCBI-ProteinID: XP_010842620
Ensembl: ENSBBBG00000022858
UniProt: A0A6P3HVR2
LinkDB
Position
Unknown
AA seq 1252 aa
MELSDVRCLSGSEELYTIHPTPPAGDSGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGG
GNGSSSKASDPGGGGPNHHHASQLSGDSALPLYALGPGEPAHGTGGPKVFPERSGSGSAS
GSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR
KXXXXXNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH
TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT
SLMQVVLQAVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA
RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD
VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA
HCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK
LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPE
DIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH
VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA
FIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN
ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT
GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKE
ASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV
ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD
ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK
HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI
LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL
VQSLNRQRQKQLLNENNNTGIIKSHYNRRTLLTPSGPEPGAPAEGADKSELP
NT seq 3759 nt   +upstreamnt  +downstreamnt
atggagctctccgatgtgcgctgcctgagcggcagcgaggaactgtacaccatccacccg
acgcccccggccggcgacagcgggagcggctcccggccgcagcggctgctgtggcagacg
gcggtgcggcacatcaccgagcagcgcttcatccatgggcaccgcggcggcggcggtggc
gggaacggaagctccagcaaagcctcggaccccggaggcggcggacccaaccaccaccac
gcgtcgcagctgtccggcgactcggcgctgcccctctacgcgctgggccctggggagcca
gcgcacggcaccggcggccccaaagtcttcccggaacgcagcgggagcggcagcgccagc
ggcagcggcggcgggggagacctgggcttcctgcacctcgactgcgccccgagcaactcg
gatttcttcctcaatgggggctacagctaccgaggggtcattttccccaccctgcgcaac
tccttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagaggcgc
aaannnnnnnnnnnnnnnaacgtgctggacgtgctgaccaaactcaccctcctggttctc
cacttgagcctggcctcggcccccatggacccgctcaagggcatcctgctgggcttcttc
accggcatagaggtggtgatctgcgccctggtggtggtcagaaaggacaccacctcgcac
acatacctgcagtacagcggtgtggtcacttgggtggccatgaccacccagatcttagca
gcagggctcggctatgggctcctgggagacggcatcggctacgtgctcttcacccttttt
gccacctacagcatgctgccgctgccgctcacctgggccatcctggccggcctaggcacc
tctttgatgcaggtggtcctccaagcggtcatccccaggctggcggtcatttccatcaat
caggttgtggcccaggcagtgttattcatgtgtatgaacacagctggaatcttcatcagt
tacctgtcagaccgggcccagcgccaagccttcctggagacacggaggtgtgtggaggcc
aggctgcgcctggagacggaaaaccaaagacaggagcgacttgtgctgtccgtgcttcct
cgttttgttgtcctggagatgatcaatgacatgaccaacgtggaagacgagcacctacag
catcagttccaccggatctacatccatcgatacgagaatgtcagtattctttttgcagat
gttaaaggatttaccaacctctccacgaccttgtctgctcaggagctggtcaggatgctc
aacgagctctttgccagatttgatcgactggcccatgagcatcactgccttcgtattaaa
atcctgggggactgctactactgcgtttcaggacttcctgagccccgccaggaccacgcc
cactgctgtgttgaaatgggcctcagcatgatcaaaactatcaggtatgtgcgatcaagg
acaaagcacgatgttgacatgcggattggaatccactcgggctcggtgctgtgcggcgtg
ttgggtcttcggaagtggcagtttgatgtctggtcttgggatgtggacatcgcgaacaaa
cttgaatctggaggaatccccgggcggattcacatttccaaagccacgctggactgcctc
aacggtgactataatgtggaagagggtcacggtaaagagaggaatgaattcttgaggaag
cataatatagagacctatttaattaagcagcctgaggagagtctgctgtctttgcctgaa
gacatcgtcaaggagtctgtgagctcctcagacaggagaaacagcggggcgacgttcaca
gagggatcttggagccctgaactgcccttcgataacatagtggggaaacagaacactctg
gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat
gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt
ggtgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc
ctggagcacaagtattctcaaatgagggatgaagtattcaaatcaaacttggtctgtgcg
tttatcgttcttctatttatcacggcaatacaaagcttgcttccttcttcaagggtgatg
cccatggccatccagttttccatcctgatcatgctgcactcagctctggtcctcatcact
acggcagaggattacaagtgtttgcccctagtcctccggaaaacctgctgttggattaac
gagacctatttggccaggaacgtcatcatctttgcatccatcttgattaatttcctgggc
gccatcctaaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgact
ttcaattcctcagctgtgtttacagatatctgctcctacccagagtactttgtcttcacg
ggggtgctggccatggtgacctgtgcggttttcctccgactcaactctgtccttaagctg
gctgtgctcctgatcatgattgccatctacgccctgctgaccgagaccatctatgcaggc
ctctttctgcgctacgacaacctgaaccacagcggagaagatttcctggggaccaaggaa
gcgtcactgctgctaatggccatgtttcttcttgccgttttctaccatggacagcagctg
gagtacacagcccgcctggacttcctgtggcgagtccaggccaaagaggagatcaacgag
atgaaggagctgagggagcacaatgagaacatgctgcggaacatcctgcccagccacgtg
gcccgccacttcctggagaaggaccgggacaatgaggagctgtattctcaatcctatgac
gccgtcggggtgatgtttgcctccatcccggggtttgcagacttttactctcagaccgaa
atgaacaaccaaggagtggagtgcctccgcctactgaatgagatcattgctgacttcgat
gagctgcttggtgaagaccggtttcaagacattgaaaagattaagaccattggtagtacc
tacatggccgtgtcaggcctgtcacctgaaaagcagcaatgcgaggataagtgggggcat
ttgtgcgccctggccgacttctccctcgccctgactgaaagcatccaggagatcaacaag
cattccttcaacaatttcgagctccggattggcatcagccacggctcagtggtagccggt
gtcatcggcgctaagaaaccacagtacgacatttggggcaaaaccgtgaacctggcgagt
cggatggacagcacaggggtcagcggcaggatccaggtcccggaggagacctacctcatc
ctgaaggaccagggctttgcctttgactaccgaggggagatctatgtgaagggcatcagc
gaacaggaagggaaaatcaaaacgtactttctcctgggaagagtccagcccaaccccttc
atcctgccccccaggagactgcccgggcagtactccttggccgcggtcgtcctgggcctc
gtccagtctctcaacaggcagaggcagaagcagctgctgaacgagaacaacaacacgggc
attatcaagagccactacaaccggcggactttgctgacacccagcgggcccgagccggga
gccccagccgaaggcgccgacaagtccgagttgccataa

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