KEGG   Bison bison bison (American bison): 104998445
Entry
104998445         CDS       T08726                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis01521  EGFR tyrosine kinase inhibitor resistance
bbis01522  Endocrine resistance
bbis01524  Platinum drug resistance
bbis04012  ErbB signaling pathway
bbis04014  Ras signaling pathway
bbis04015  Rap1 signaling pathway
bbis04024  cAMP signaling pathway
bbis04062  Chemokine signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04068  FoxO signaling pathway
bbis04070  Phosphatidylinositol signaling system
bbis04071  Sphingolipid signaling pathway
bbis04072  Phospholipase D signaling pathway
bbis04081  Hormone signaling
bbis04140  Autophagy - animal
bbis04150  mTOR signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04152  AMPK signaling pathway
bbis04210  Apoptosis
bbis04211  Longevity regulating pathway
bbis04213  Longevity regulating pathway - multiple species
bbis04218  Cellular senescence
bbis04360  Axon guidance
bbis04370  VEGF signaling pathway
bbis04380  Osteoclast differentiation
bbis04510  Focal adhesion
bbis04550  Signaling pathways regulating pluripotency of stem cells
bbis04611  Platelet activation
bbis04613  Neutrophil extracellular trap formation
bbis04620  Toll-like receptor signaling pathway
bbis04625  C-type lectin receptor signaling pathway
bbis04630  JAK-STAT signaling pathway
bbis04650  Natural killer cell mediated cytotoxicity
bbis04660  T cell receptor signaling pathway
bbis04662  B cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04666  Fc gamma R-mediated phagocytosis
bbis04668  TNF signaling pathway
bbis04670  Leukocyte transendothelial migration
bbis04722  Neurotrophin signaling pathway
bbis04725  Cholinergic synapse
bbis04750  Inflammatory mediator regulation of TRP channels
bbis04810  Regulation of actin cytoskeleton
bbis04910  Insulin signaling pathway
bbis04914  Progesterone-mediated oocyte maturation
bbis04915  Estrogen signaling pathway
bbis04917  Prolactin signaling pathway
bbis04919  Thyroid hormone signaling pathway
bbis04923  Regulation of lipolysis in adipocytes
bbis04926  Relaxin signaling pathway
bbis04929  GnRH secretion
bbis04930  Type II diabetes mellitus
bbis04931  Insulin resistance
bbis04932  Non-alcoholic fatty liver disease
bbis04933  AGE-RAGE signaling pathway in diabetic complications
bbis04935  Growth hormone synthesis, secretion and action
bbis04960  Aldosterone-regulated sodium reabsorption
bbis04973  Carbohydrate digestion and absorption
bbis05010  Alzheimer disease
bbis05017  Spinocerebellar ataxia
bbis05020  Prion disease
bbis05100  Bacterial invasion of epithelial cells
bbis05135  Yersinia infection
bbis05142  Chagas disease
bbis05146  Amoebiasis
bbis05160  Hepatitis C
bbis05161  Hepatitis B
bbis05162  Measles
bbis05163  Human cytomegalovirus infection
bbis05164  Influenza A
bbis05165  Human papillomavirus infection
bbis05166  Human T-cell leukemia virus 1 infection
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05168  Herpes simplex virus 1 infection
bbis05169  Epstein-Barr virus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05171  Coronavirus disease - COVID-19
bbis05200  Pathways in cancer
bbis05203  Viral carcinogenesis
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
bbis05207  Chemical carcinogenesis - receptor activation
bbis05208  Chemical carcinogenesis - reactive oxygen species
bbis05210  Colorectal cancer
bbis05211  Renal cell carcinoma
bbis05212  Pancreatic cancer
bbis05213  Endometrial cancer
bbis05214  Glioma
bbis05215  Prostate cancer
bbis05218  Melanoma
bbis05220  Chronic myeloid leukemia
bbis05221  Acute myeloid leukemia
bbis05222  Small cell lung cancer
bbis05223  Non-small cell lung cancer
bbis05224  Breast cancer
bbis05225  Hepatocellular carcinoma
bbis05226  Gastric cancer
bbis05230  Central carbon metabolism in cancer
bbis05231  Choline metabolism in cancer
bbis05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bbis05415  Diabetic cardiomyopathy
bbis05417  Lipid and atherosclerosis
bbis05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    104998445 (PIK3R1)
   04014 Ras signaling pathway
    104998445 (PIK3R1)
   04015 Rap1 signaling pathway
    104998445 (PIK3R1)
   04370 VEGF signaling pathway
    104998445 (PIK3R1)
   04630 JAK-STAT signaling pathway
    104998445 (PIK3R1)
   04668 TNF signaling pathway
    104998445 (PIK3R1)
   04066 HIF-1 signaling pathway
    104998445 (PIK3R1)
   04068 FoxO signaling pathway
    104998445 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    104998445 (PIK3R1)
   04072 Phospholipase D signaling pathway
    104998445 (PIK3R1)
   04071 Sphingolipid signaling pathway
    104998445 (PIK3R1)
   04024 cAMP signaling pathway
    104998445 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    104998445 (PIK3R1)
   04152 AMPK signaling pathway
    104998445 (PIK3R1)
   04150 mTOR signaling pathway
    104998445 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    104998445 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    104998445 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    104998445 (PIK3R1)
   04218 Cellular senescence
    104998445 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    104998445 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    104998445 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    104998445 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104998445 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    104998445 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    104998445 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    104998445 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    104998445 (PIK3R1)
   04660 T cell receptor signaling pathway
    104998445 (PIK3R1)
   04662 B cell receptor signaling pathway
    104998445 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    104998445 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    104998445 (PIK3R1)
   04670 Leukocyte transendothelial migration
    104998445 (PIK3R1)
   04062 Chemokine signaling pathway
    104998445 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    104998445 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    104998445 (PIK3R1)
   04929 GnRH secretion
    104998445 (PIK3R1)
   04915 Estrogen signaling pathway
    104998445 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    104998445 (PIK3R1)
   04917 Prolactin signaling pathway
    104998445 (PIK3R1)
   04926 Relaxin signaling pathway
    104998445 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    104998445 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    104998445 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    104998445 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    104998445 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    104998445 (PIK3R1)
   04722 Neurotrophin signaling pathway
    104998445 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    104998445 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    104998445 (PIK3R1)
   04380 Osteoclast differentiation
    104998445 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    104998445 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    104998445 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104998445 (PIK3R1)
   05206 MicroRNAs in cancer
    104998445 (PIK3R1)
   05205 Proteoglycans in cancer
    104998445 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    104998445 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    104998445 (PIK3R1)
   05203 Viral carcinogenesis
    104998445 (PIK3R1)
   05230 Central carbon metabolism in cancer
    104998445 (PIK3R1)
   05231 Choline metabolism in cancer
    104998445 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    104998445 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    104998445 (PIK3R1)
   05212 Pancreatic cancer
    104998445 (PIK3R1)
   05225 Hepatocellular carcinoma
    104998445 (PIK3R1)
   05226 Gastric cancer
    104998445 (PIK3R1)
   05214 Glioma
    104998445 (PIK3R1)
   05221 Acute myeloid leukemia
    104998445 (PIK3R1)
   05220 Chronic myeloid leukemia
    104998445 (PIK3R1)
   05218 Melanoma
    104998445 (PIK3R1)
   05211 Renal cell carcinoma
    104998445 (PIK3R1)
   05215 Prostate cancer
    104998445 (PIK3R1)
   05213 Endometrial cancer
    104998445 (PIK3R1)
   05224 Breast cancer
    104998445 (PIK3R1)
   05222 Small cell lung cancer
    104998445 (PIK3R1)
   05223 Non-small cell lung cancer
    104998445 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104998445 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    104998445 (PIK3R1)
   05161 Hepatitis B
    104998445 (PIK3R1)
   05160 Hepatitis C
    104998445 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    104998445 (PIK3R1)
   05164 Influenza A
    104998445 (PIK3R1)
   05162 Measles
    104998445 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    104998445 (PIK3R1)
   05163 Human cytomegalovirus infection
    104998445 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104998445 (PIK3R1)
   05169 Epstein-Barr virus infection
    104998445 (PIK3R1)
   05165 Human papillomavirus infection
    104998445 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    104998445 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    104998445 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    104998445 (PIK3R1)
   05142 Chagas disease
    104998445 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104998445 (PIK3R1)
   05017 Spinocerebellar ataxia
    104998445 (PIK3R1)
   05020 Prion disease
    104998445 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104998445 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    104998445 (PIK3R1)
   05415 Diabetic cardiomyopathy
    104998445 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    104998445 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    104998445 (PIK3R1)
   04931 Insulin resistance
    104998445 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    104998445 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    104998445 (PIK3R1)
   01524 Platinum drug resistance
    104998445 (PIK3R1)
   01522 Endocrine resistance
    104998445 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbis04131]
    104998445 (PIK3R1)
Membrane trafficking [BR:bbis04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    104998445 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 SH3_9 Laminin_I CCDC113_CCDC96_CC
Other DBs
NCBI-GeneID: 104998445
NCBI-ProteinID: XP_010851902
Ensembl: ENSBBBG00000013088
UniProt: A0A6P3IIZ2
LinkDB
Position
Unknown
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEAKPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGPSKTEADSEQQASTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDTASLDLEMFDVH
VLADAFKRYLLDLPNPVIPVAVSSELISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSELFSPLLFRFPAASSENTEHLIKIIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNETEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgccgaggggtaccagtaccgggcgctgtacgactataagaaggagcgggaagaa
gacattgacttgcacctgggggacatattgactgtgaacaaagggtccttagtcgctctt
ggattcagtgatggacaggaagccaagcctgaagaaattggctggttaaatggctataac
gagacgacaggggagaggggagactttccgggaacttacgtagaatatattggaaggaaa
aagatctcacctcccacaccaaagccccggccacctcgaccccttcctgttgccccaggt
ccttcaaaaactgaagcagacagtgagcaacaagcttccactctcccagaccttgcagag
cagttcgcaccccctgacgttgctccaccgcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccagccgag
ttacgacagcttcttgattgtgataccgcttccttggacttggagatgttcgatgtgcac
gttttagctgacgccttcaaacgctatctcctggacttaccgaatcctgtcattccggta
gccgtttccagtgaactgatttctttagccccagaagtgcagagttctgaagaatacatc
cagctgttgaagaaactcattaggtcgcccagcatacctcatcagtactggctcacactg
cagtatttgctaaaacatttcttcaagctctctcaaacgtccagcaaaaatcttctgaat
gcaagagtactttctgaactcttcagccctctgcttttcagattcccagcagcaagttct
gagaatactgaacacctcataaaaattatagaaatcttaatctccaccgaatggaatgaa
cgccagcctgcaccagcactgcctcccaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtctttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagacacagctgacgggacctttttggtacgagacgca
tctactaaaatgcacggggattacacgcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatatggcttctctgacccattaaccttcaactct
gtggttgaactaataaaccactaccggaatgaatctctagctcagtataatcccaaactg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaagactatacccgaacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaacc
caggagcggtacagcaaagaatacatagaaaagttcaaacgtgaaggcaacgagacggaa
atccaaaggattatgcataattatgaaaagttaaagtctcgaatcagtgaaattgtcgac
agcagaaggagattggaagaggacttgaagaagcaggcggctgagtatcgtgagattgac
aaacgcatgaacagcattaaaccagacctcattcagctaagaaagacgagagaccaatac
ttgatgtggttgactcagaaaggtgttcggcagaagaaattgaacgagtggctgggcaat
gaaaacactgaagaccaatattcgctggtagaagatgatgaggatttgccccaccacgat
gagaagacttggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagacggcacttttcttgtccgggaaagcagtaaacagggctgctacgcctgctct
gtggtggtggacggcgaggtcaagcactgcgtcatcaacaagacggccacgggctacggc
ttcgccgagccctacaacctgtacagctccctcaaggagctggtgctccactaccagcac
acctctctcgtgcagcacaacgactccctcaacgtcacactagcctacccggtgtacgcg
cagcagaggcgatga

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