Bison bison bison (American bison): 105001032 Help Entry 105001032         CDS       T08726                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism bbis  Bison bison bison (American bison) Pathway bbis00230   Purine metabolism bbis01100   Metabolic pathways bbis01522   Endocrine resistance bbis04015   Rap1 signaling pathway bbis04020   Calcium signaling pathway bbis04022   cGMP-PKG signaling pathway bbis04024   cAMP signaling pathway bbis04062   Chemokine signaling pathway bbis04072   Phospholipase D signaling pathway bbis04081   Hormone signaling bbis04082   Neuroactive ligand signaling bbis04114   Oocyte meiosis bbis04211   Longevity regulating pathway bbis04213   Longevity regulating pathway - multiple species bbis04261   Adrenergic signaling in cardiomyocytes bbis04270   Vascular smooth muscle contraction bbis04371   Apelin signaling pathway bbis04540   Gap junction bbis04611   Platelet activation bbis04713   Circadian entrainment bbis04714   Thermogenesis bbis04723   Retrograde endocannabinoid signaling bbis04724   Glutamatergic synapse bbis04725   Cholinergic synapse bbis04727   GABAergic synapse bbis04750   Inflammatory mediator regulation of TRP channels bbis04911   Insulin secretion bbis04912   GnRH signaling pathway bbis04913   Ovarian steroidogenesis bbis04914   Progesterone-mediated oocyte maturation bbis04915   Estrogen signaling pathway bbis04916   Melanogenesis bbis04918   Thyroid hormone synthesis bbis04921   Oxytocin signaling pathway bbis04922   Glucagon signaling pathway bbis04923   Regulation of lipolysis in adipocytes bbis04925   Aldosterone synthesis and secretion bbis04926   Relaxin signaling pathway bbis04927   Cortisol synthesis and secretion bbis04928   Parathyroid hormone synthesis, secretion and action bbis04934   Cushing syndrome bbis04935   Growth hormone synthesis, secretion and action bbis04970   Salivary secretion bbis04971   Gastric acid secretion bbis04972   Pancreatic secretion bbis04976   Bile secretion bbis05032   Morphine addiction bbis05163   Human cytomegalovirus infection bbis05166   Human T-cell leukemia virus 1 infection bbis05200   Pathways in cancer bbis05207   Chemical carcinogenesis - receptor activation bbis05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bbis00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     105001032 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     105001032 (ADCY2)    04371 Apelin signaling pathway     105001032 (ADCY2)    04020 Calcium signaling pathway     105001032 (ADCY2)    04072 Phospholipase D signaling pathway     105001032 (ADCY2)    04024 cAMP signaling pathway     105001032 (ADCY2)    04022 cGMP-PKG signaling pathway     105001032 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     105001032 (ADCY2)    04081 Hormone signaling     105001032 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     105001032 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     105001032 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     105001032 (ADCY2)    04062 Chemokine signaling pathway     105001032 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     105001032 (ADCY2)    04922 Glucagon signaling pathway     105001032 (ADCY2)    04923 Regulation of lipolysis in adipocytes     105001032 (ADCY2)    04912 GnRH signaling pathway     105001032 (ADCY2)    04913 Ovarian steroidogenesis     105001032 (ADCY2)    04915 Estrogen signaling pathway     105001032 (ADCY2)    04914 Progesterone-mediated oocyte maturation     105001032 (ADCY2)    04921 Oxytocin signaling pathway     105001032 (ADCY2)    04926 Relaxin signaling pathway     105001032 (ADCY2)    04935 Growth hormone synthesis, secretion and action     105001032 (ADCY2)    04918 Thyroid hormone synthesis     105001032 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     105001032 (ADCY2)    04916 Melanogenesis     105001032 (ADCY2)    04925 Aldosterone synthesis and secretion     105001032 (ADCY2)    04927 Cortisol synthesis and secretion     105001032 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     105001032 (ADCY2)    04270 Vascular smooth muscle contraction     105001032 (ADCY2)   09154 Digestive system    04970 Salivary secretion     105001032 (ADCY2)    04971 Gastric acid secretion     105001032 (ADCY2)    04972 Pancreatic secretion     105001032 (ADCY2)    04976 Bile secretion     105001032 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     105001032 (ADCY2)    04727 GABAergic synapse     105001032 (ADCY2)    04725 Cholinergic synapse     105001032 (ADCY2)    04723 Retrograde endocannabinoid signaling     105001032 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     105001032 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     105001032 (ADCY2)    04213 Longevity regulating pathway - multiple species     105001032 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     105001032 (ADCY2)    04714 Thermogenesis     105001032 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105001032 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     105001032 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     105001032 (ADCY2)    05163 Human cytomegalovirus infection     105001032 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     105001032 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     105001032 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     105001032 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     105001032 (ADCY2) Enzymes [BR:bbis01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      105001032 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  105001032 NCBI-ProteinID:  XP_010855452 Ensembl:  ENSBBBG00000016455 UniProt:  A0A6P3IV76 LinkDB All DBs Position Unknown AA seq 1023 aa AA seqDB search MTEVEDHVAFLITVPTALAIFFAIFILVCVESVFKKLLRLFSLVIWICLVAMGYLFMCFG GTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGAKEHLV WQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLL PAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSP GELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEA IKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHIS SVTLQHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKM RASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKR FEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKIIEKEYRATALPAFKYYVTCAC LIFFCIFIVQVLVLPKTSILGISFGAAFLSLAFILFVCFAGQLLQCSKKASASLLWLLKS SGIIANRPWPRISLTVITTAIILTMAVFNMFFLSDSEETILPTANASNTSLSGASNQAAI LRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMAALVGYNTIFLHTHAPLLDDY SQVLFERPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETM ENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKE GLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEPERQYM HIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVA SRMDSTGVLDKIQVTEETSIILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSN LTS NT seq 3072 nt NT seq  +upstreamnt  +downstreamnt atgacggaagttgaagaccacgtggcatttttaatcacagttccgactgccctggcgatc ttctttgcgatcttcatcctggtgtgcgtggagtcggtgtttaagaagctgctgcgcctc ttctctttggtgatatggatctgcctcgtggccatgggctacttgttcatgtgtttcggg ggcaccgtctctccctgggaccaggtgtcgttcttcctcttcatcatcttcgtggtgtac accatgctgcccttcaacatgcgagatgccatcatcgccagtgtcctcacctcctcttct cacaccatcgtgctgagcgtctgcctgtctgcaacaccaggggccaaggagcacctggtc tggcagatcctggccaacgtgatcatcttcatctgcgggaacctggcgggggcataccat aagcacctcatggagctcgctctgcagcagacgtatcaggacacgtgcaactgcatcaag tcccggatcaagttggaatttgaaaaacgtcagcaggagcggctgctgctgtccctgctg ccggcacacatagccatggagatgaaagcggagatcatccagaggctgcagggccccaaa gccggccagatggagaacaccaacaacttccacaacctctacgtcaagcggcacaccaac gtcagtatcctctatgcggacattgttgggttcacccgtctggccagtgactgctcccct ggagagctcgtccatatgctgaatgaactctttggaaagttcgatcaaattgcaaaggag aatgaatgcatgagaataaaaattttaggagactgctactactgtgtgtccggactgcct atatctctccctaaccatgccaagaattgtgtgaaaatgggactggatatgtgtgaagcc ataaagaaagtgagggacgccaccggagtagacatcaacatgcgcgtgggagtgcattct gggaacgtgctgtgcggcgtgatcgggctgcagaagtggcagtacgacgtgtggtcacat gacgtcaccctggccaaccacatggaagctggaggggtccctggacgtgttcacatttct tctgttaccctgcaacacttgaatggagcttacaaagtggaagaaggcgatggtgacatc agagacccgtatttaaagcaacatttggtgaaaacttactttgtaatcaaccccaaggga gagcggcggagccctcagcacctctttaggcctcgacacacccttgacggagcgaagatg agggcttctgtccgcatgacccggtacctggagtcctggggggcggccaagccctttgca cacctgcatcacagagacagcatgactacggagaacggcaagatcagcaccacggatgta ccaatgggtcagcataattttcaaaatcgcaccttaagaaccaagtcacaaaagaaaaga tttgaagaggaattaaatgaaaggatgattcaagcaattgatggaatcaatgcacaaaag caatggctcaagtccgaagacattcagagaatctcattgcttttctacaataaaataata gaaaaagaataccgagccaccgcgctgccggccttcaagtattacgtgacttgcgcttgc ctgatcttcttctgcatctttatcgtgcaggttctggtcttacccaaaacgtccattctc ggaatttcctttggagcggcgtttctctcacttgcctttatccttttcgtctgctttgct ggacagcttttgcaatgcagcaagaaagcatctgcttctctcctgtggcttttaaagtca tcgggcatcatcgccaaccggccctggcctcggatctccctgacggtcatcaccacagcc atcatattgaccatggccgtgttcaatatgtttttcctgagtgactcagaggaaacaatt cttccgactgccaacgcgtccaacacaagtctttctggcgcaagtaaccaggcagcaatt ctgcgtgcgcaaaatttgtttttcctgccgtactttatatacagctgcatcctcgggctg atctcctgttccgtcttcctgcgtgtgaattacgagctgaagatgctgatcatgatggca gccttggtgggctacaacaccatcttcctccacactcacgctcccctcctggacgactac agccaggtcctgttcgagagaccaggcatttggaaagacctaaagaccatgggctcagta tctctctttatatttttcatcacactgcttgttctgggcagacagaatgaatattactgt aggttagacttcttatggaagaacaagttcaaaaaagagcgggaggagatagaaaccatg gagaacttgaaccgagtgctgctggagaacgtgcttcctgcgcacgtggctgagcacttc ctggcgcggagcctgaagaacgaggagttataccaccagtcctacgactgcgtctgcgtc atgtttgcctccattcctgatttcaaagaattctatacagaatcagacgtgaacaaggag ggtttggaatgccttcggctcctgaacgagatcattgccgactttgatgatctgctctcc aagccgaagttcagtggcgttgaaaagatcaagaccatcggcagcacgtacatggcagcg acaggtctgagcgcggtgcccagccaggagcacgcccaggagccggagaggcagtacatg cacattggcaccatggtggagtttgcatttgccctggtggggaagctggatgccatcaac aagcactccttcaatgacttcaagttacgagtaggtattaaccatggccctgtcatagcc ggtgtgattggagctcagaagccgcagtatgacatctggggcaacaccgtcaatgtggcc agcaggatggacagcaccggagtcctggacaaaatccaggtgacagaggagacgagcatc atcctacagaccctaggctacacgtgcacgtgtcggggaatcatcaacgtgaaaggaaag ggggacctgaagacctacttcgtcaacacggagatgtcacggtccctttctcagagcaac ctgacctcctga

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