KEGG   ORTHOLOGY: K08042
Entry
K08042                      KO                                     

Symbol
ADCY2
Name
adenylate cyclase 2 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04922  Glucagon signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08042  ADCY2; adenylate cyclase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04371 Apelin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04020 Calcium signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04072 Phospholipase D signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04024 cAMP signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04022 cGMP-PKG signaling pathway
    K08042  ADCY2; adenylate cyclase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08042  ADCY2; adenylate cyclase 2
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08042  ADCY2; adenylate cyclase 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08042  ADCY2; adenylate cyclase 2
   04062 Chemokine signaling pathway
    K08042  ADCY2; adenylate cyclase 2
  09152 Endocrine system
   04911 Insulin secretion
    K08042  ADCY2; adenylate cyclase 2
   04922 Glucagon signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04923 Regulation of lipolysis in adipocytes
    K08042  ADCY2; adenylate cyclase 2
   04912 GnRH signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04913 Ovarian steroidogenesis
    K08042  ADCY2; adenylate cyclase 2
   04915 Estrogen signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04914 Progesterone-mediated oocyte maturation
    K08042  ADCY2; adenylate cyclase 2
   04921 Oxytocin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04926 Relaxin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04935 Growth hormone synthesis, secretion and action
    K08042  ADCY2; adenylate cyclase 2
   04918 Thyroid hormone synthesis
    K08042  ADCY2; adenylate cyclase 2
   04928 Parathyroid hormone synthesis, secretion and action
    K08042  ADCY2; adenylate cyclase 2
   04916 Melanogenesis
    K08042  ADCY2; adenylate cyclase 2
   04925 Aldosterone synthesis and secretion
    K08042  ADCY2; adenylate cyclase 2
   04927 Cortisol synthesis and secretion
    K08042  ADCY2; adenylate cyclase 2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08042  ADCY2; adenylate cyclase 2
   04270 Vascular smooth muscle contraction
    K08042  ADCY2; adenylate cyclase 2
  09154 Digestive system
   04970 Salivary secretion
    K08042  ADCY2; adenylate cyclase 2
   04971 Gastric acid secretion
    K08042  ADCY2; adenylate cyclase 2
   04972 Pancreatic secretion
    K08042  ADCY2; adenylate cyclase 2
   04976 Bile secretion
    K08042  ADCY2; adenylate cyclase 2
  09156 Nervous system
   04724 Glutamatergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04727 GABAergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04725 Cholinergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04723 Retrograde endocannabinoid signaling
    K08042  ADCY2; adenylate cyclase 2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08042  ADCY2; adenylate cyclase 2
  09149 Aging
   04211 Longevity regulating pathway
    K08042  ADCY2; adenylate cyclase 2
   04213 Longevity regulating pathway - multiple species
    K08042  ADCY2; adenylate cyclase 2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08042  ADCY2; adenylate cyclase 2
   04714 Thermogenesis
    K08042  ADCY2; adenylate cyclase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08042  ADCY2; adenylate cyclase 2
   05207 Chemical carcinogenesis - receptor activation
    K08042  ADCY2; adenylate cyclase 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08042  ADCY2; adenylate cyclase 2
   05163 Human cytomegalovirus infection
    K08042  ADCY2; adenylate cyclase 2
  09165 Substance dependence
   05032 Morphine addiction
    K08042  ADCY2; adenylate cyclase 2
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08042  ADCY2; adenylate cyclase 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08042  ADCY2; adenylate cyclase 2
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08042  ADCY2; adenylate cyclase 2
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08042  ADCY2; adenylate cyclase 2
Other DBs
RN: R00089 R00434
GO: 0004016
Genes
HSA: 108(ADCY2)
PTR: 100608010(ADCY2)
PPS: 100992014(ADCY2)
GGO: 101141389(ADCY2)
PON: 100445431(ADCY2)
NLE: 100600367(ADCY2)
MCC: 695328(ADCY2)
MCF: 102130114(ADCY2)
CSAB: 103214981(ADCY2)
CATY: 105585972(ADCY2)
PANU: 101006754(ADCY2)
RRO: 104674083(ADCY2)
RBB: 108536960(ADCY2)
TFN: 117064735(ADCY2)
PTEH: 111546755(ADCY2)
CJC: 100385658(ADCY2)
SBQ: 101043334(ADCY2)
MMUR: 105859934(ADCY2)
MMU: 210044(Adcy2)
MCAL: 110307661(Adcy2)
MPAH: 110328764(Adcy2)
RNO: 81636(Adcy2)
MCOC: 116083593(Adcy2)
MUN: 110550962
CGE: 100773811(Adcy2)
PLEU: 114696121(Adcy2)
NGI: 103735350(Adcy2)
HGL: 101718304(Adcy2)
CCAN: 109695818(Adcy2)
OCU: 100009201(ADCY2)
OPI: 101528674(ADCY2)
TUP: 102492353(ADCY2)
CFA: 478624(ADCY2)
VVP: 112934273(ADCY2)
VLG: 121477531(ADCY2)
AML: 100473195(ADCY2)
UMR: 103679250(ADCY2)
UAH: 113260807(ADCY2)
ORO: 101365382(ADCY2)
ELK: 111153427
MPUF: 101674868(ADCY2)
EJU: 114223681(ADCY2)
MLX: 118006264(ADCY2)
FCA: 101094327(ADCY2)
PYU: 121042416(ADCY2)
PBG: 122495529(ADCY2)
PTG: 102949732(ADCY2)
PPAD: 109267830(ADCY2)
AJU: 106971248(ADCY2)
HHV: 120225093(ADCY2)
BTA: 510708(ADCY2)
BOM: 102274117(ADCY2)
BIU: 109574822(ADCY2)
BBUB: 102412622(ADCY2)
CHX: 102171922(ADCY2)
OAS: 101102089(ADCY2)
ODA: 120879368(ADCY2)
CCAD: 122454210(ADCY2)
SSC: 100517503(ADCY2)
CFR: 102510993(ADCY2)
CBAI: 105081234(ADCY2)
CDK: 105094039(ADCY2)
BACU: 103020085(ADCY2)
LVE: 103084817(ADCY2)
OOR: 101286207(ADCY2)
DLE: 111178556(ADCY2)
PCAD: 102991224(ADCY2)
ECB: 100071337(ADCY2)
EPZ: 103562505
EAI: 106823001(ADCY2)
MYB: 102260356(ADCY2)
MYD: 102774384(ADCY2)
MMYO: 118656192(ADCY2)
MNA: 107540528(ADCY2)
HAI: 109375976(ADCY2)
DRO: 112321008(ADCY2)
SHON: 118998674(ADCY2)
AJM: 119049317(ADCY2)
MMF: 118642779(ADCY2)
PALE: 102893265(ADCY2)
PGIG: 120586284(ADCY2)
RAY: 107502700(ADCY2)
TOD: 119260631(ADCY2)
LAV: 100673570(ADCY2)
TMU: 101360334
MDO: 100013164(ADCY2)
SHR: 100922434(ADCY2)
PCW: 110220436(ADCY2)
OAA: 100089708(ADCY2)
GGA: 420935(ADCY2)
PCOC: 116226507(ADCY2)
MGP: 100540738(ADCY2)
CJO: 107309543(ADCY2)
NMEL: 110394300(ADCY2)
APLA: 101803512(ADCY2)
ACYG: 106036531(ADCY2)
TGU: 100223820(ADCY2)
LSR: 110479527(ADCY2)
SCAN: 103815408(ADCY2)
PMOA: 120504898(ADCY2)
OTC: 121339726(ADCY2)
PRUF: 121358032(ADCY2)
GFR: 102038853(ADCY2)
FAB: 101808400(ADCY2)
PHI: 102113898(ADCY2)
PMAJ: 107199935(ADCY2)
CCAE: 111925673(ADCY2)
CCW: 104685925(ADCY2)
ETL: 114055132(ADCY2)
FPG: 101911647(ADCY2)
FCH: 102049688(ADCY2)
CLV: 102097532(ADCY2)
EGZ: 104126191(ADCY2)
NNI: 104018888(ADCY2)
ACUN: 113476067(ADCY2)
PADL: 103915154(ADCY2)
AAM: 106492356(ADCY2)
AROW: 112974051(ADCY2)
NPD: 112955254(ADCY2)
DNE: 112982724(ADCY2)
ASN: 102383838(ADCY2)
AMJ: 102562034(ADCY2)
CPOO: 109314286(ADCY2)
GGN: 109298362(ADCY2)
PSS: 102444057(ADCY2)
CMY: 102930552(ADCY2)
CPIC: 101952054(ADCY2)
TST: 117872756
CABI: 116828360(ADCY2)
ACS: 100555265(adcy2)
PVT: 110089596
PBI: 103050340(ADCY2)
PMUR: 107297625(ADCY2)
TSR: 106545186
PGUT: 117662380(ADCY2)
PMUA: 114601220(ADCY2)
ZVI: 118077623(ADCY2)
GJA: 107108835(ADCY2)
DRE: 557902(adcy2b) 563724(adcy2a)
IPU: 108272199(Adcy2) 108272792(ADCY2)
NCC: 104952475 104962256(adcy2)
CGOB: 115020798(adcy2)
ELY: 117263948(adcy2b) 117265672(adcy2a)
PLEP: 121946261(adcy2a) 121957695(adcy2b)
SLUC: 116041211(adcy2b) 116049201(adcy2a)
ECRA: 117946352(adcy2a) 117957152(adcy2b)
PFLV: 114556982 114568098(adcy2)
PPUG: 119197448(adcy2a) 119219461
MSAM: 119897894(adcy2a) 119907366(adcy2b)
CUD: 121513506(adcy2a) 121524111(adcy2b)
OAU: 116313447(adcy2b) 116329362(adcy2a)
OML: 112136286(adcy2b) 112143511(adcy2a)
XCO: 114141804 114156097(adcy2)
CVG: 107084393 107091823(adcy2)
CTUL: 119791316(adcy2a) 119792954(adcy2b)
KMR: 108232311(adcy2a) 108238708(adcy2b)
POV: 109631507(adcy2) 109632042
XGL: 120783631(adcy2a) 120786774(adcy2b)
HCQ: 109508262 109521934(adcy2)
OTW: 112229303(adcy2b) 112265839
SALP: 111954801(adcy2) 111955524
ELS: 105012408(adcy2)
AANG: 118225550(adcy2a) 118234313(adcy2b)
LOC: 102696921(adcy2)
CMK: 103183192
RTP: 109920424(adcy2)
BFO: 118417332
BBEL: 109481983
SPU: 575180
APLC: 110980095
SKO: 102803250
DME: Dmel_CG7978(Ac76E)
DER: 6545709
DSE: 6619425
DSI: Dsimw501_GD14841(Dsim_GD14841)
DAN: 6506248
DSR: 110189922
DPE: 6599071
DMN: 108152507
DWI: 6638793
DGR: 6557116
DAZ: 108614292
DNV: 108651863
DHE: 111604449
DVI: 6622821
CCAT: 101458244
BOD: 106621071
MDE: 101893904
SCAC: 106091398
LCQ: 111683625
ACOZ: 120955519
AARA: 120900861
AAG: 5571159
AALB: 109418769
CPII: 120425270
AME: 552216
ACER: 107992970
BIM: 100745521
BBIF: 117207730
BVK: 117238217
BVAN: 117159965
BTER: 100647623
CCAL: 108631101
OBB: 114880740
MGEN: 117228009
NMEA: 116428151
CGIG: 122404122
SOC: 105197184
MPHA: 105835065
AEC: 105143483
ACEP: 105617405
PBAR: 105425936
VEM: 105559069
HST: 105184375
DQU: 106746346
CFO: 105250746
FEX: 115233348
LHU: 105670932
PGC: 109855918
OBO: 105285379
PCF: 106792130
NVI: 100118148
CSOL: 105367877
TPRE: 106651693
MDL: 103577402
TCA: 660403
ATD: 109608976
LDC: 111507767
NVL: 108567526
OTU: 111424772
BMOR: 101737606
BMAN: 114243277
MSEX: 115452886
BANY: 112043432
PMAC: 106718962
PPOT: 106100281
PXU: 106121310
PRAP: 110995397
ZCE: 119840764
HAW: 110373694
TNL: 113497935
API: 100164066
DNX: 107167195
AGS: 114123846
RMD: 113553384
BTAB: 109030143
DCI: 103508920
CLEC: 106667432
HHAL: 106691350
NLU: 111045768
ZNE: 110829129
CSEC: 111868923
FCD: 110849688
PVM: 113818924
DSV: 119436082
RSAN: 119372661
RMP: 119185511
VDE: 111251320
VJA: 111272620
PTEP: 107452662
PCAN: 112577004
BGT: 106067294
GAE: 121388686
CRG: 105336030
MYI: 110458458
PMAX: 117337564
 » show all
Reference
PMID:1427768
  Authors
Stengel D, Parma J, Gannage MH, Roeckel N, Mattei MG, Barouki R, Hanoune J
  Title
Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.
  Journal
Hum Genet 90:126-30 (1992)
DOI:10.1007/BF00210755
  Sequence
[hsa:108]
Reference
  Authors
Hardin M, Zielinski J, Wan ES, Hersh CP, Castaldi PJ, Schwinder E, Hawrylkiewicz I, Sliwinski P, Cho MH, Silverman EK
  Title
CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.
  Journal
Am J Respir Cell Mol Biol 47:203-8 (2012)
DOI:10.1165/rcmb.2012-0011OC
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