Bubalus bubalis (water buffalo): 102391024 Help Entry 102391024         CDS       T05912                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism bbub  Bubalus bubalis (water buffalo) Pathway bbub04010   MAPK signaling pathway bbub04014   Ras signaling pathway bbub04015   Rap1 signaling pathway bbub04022   cGMP-PKG signaling pathway bbub04066   HIF-1 signaling pathway bbub04068   FoxO signaling pathway bbub04072   Phospholipase D signaling pathway bbub04081   Hormone signaling bbub04150   mTOR signaling pathway bbub04151   PI3K-Akt signaling pathway bbub04152   AMPK signaling pathway bbub04211   Longevity regulating pathway bbub04213   Longevity regulating pathway - multiple species bbub04520   Adherens junction bbub04910   Insulin signaling pathway bbub04913   Ovarian steroidogenesis bbub04923   Regulation of lipolysis in adipocytes bbub04930   Type II diabetes mellitus bbub04931   Insulin resistance bbub04932   Non-alcoholic fatty liver disease bbub04960   Aldosterone-regulated sodium reabsorption bbub05010   Alzheimer disease bbub05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bbub00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102391024 (INSR)    04014 Ras signaling pathway     102391024 (INSR)    04015 Rap1 signaling pathway     102391024 (INSR)    04066 HIF-1 signaling pathway     102391024 (INSR)    04068 FoxO signaling pathway     102391024 (INSR)    04072 Phospholipase D signaling pathway     102391024 (INSR)    04022 cGMP-PKG signaling pathway     102391024 (INSR)    04151 PI3K-Akt signaling pathway     102391024 (INSR)    04152 AMPK signaling pathway     102391024 (INSR)    04150 mTOR signaling pathway     102391024 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     102391024 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     102391024 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     102391024 (INSR)    04923 Regulation of lipolysis in adipocytes     102391024 (INSR)    04913 Ovarian steroidogenesis     102391024 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102391024 (INSR)   09149 Aging    04211 Longevity regulating pathway     102391024 (INSR)    04213 Longevity regulating pathway - multiple species     102391024 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102391024 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102391024 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102391024 (INSR)    04932 Non-alcoholic fatty liver disease     102391024 (INSR)    04931 Insulin resistance     102391024 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bbub01001]     102391024 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:bbub04090]     102391024 (INSR) Enzymes [BR:bbub01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      102391024 (INSR) Protein kinases [BR:bbub01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    102391024 (INSR) CD molecules [BR:bbub04090]  Proteins   102391024 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 FN3_DSCAM-DSCAML_C Kinase-like B2 Motif Other DBs NCBI-GeneID:  102391024 NCBI-ProteinID:  XP_006046856 LinkDB All DBs Position 9:94980755..95126869 Genome browser AA seq 1382 aa AA seqDB search MGAGGGRGAAAVLLMVVVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPTRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDARPSRKRRALGDVGNVTAAMPTLLGF PNTSSTSTPTSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCV SRRHYALERGCRLRGLLPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIG PLIFVFLFSVVIGSICLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR EKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKG FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEME FEDMESVPLDRSSHVQREEAGGRDGGSALGLKRNYDEHIPYTHMNGGKKNGRILTLPRSN PS NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgggcgccgggggcgggaggggggcggcagccgtgctactgatggtggtcgtcgccgcg ctgctggtgggcgccgcgggccacctgtaccctggagaagtgtgccccggtatggatatc cggaataatctcacccggctgcatgagctggccaactgctcggtcatcgaaggacatttg cagattctgttgatgttcaaaacgagacctgaggacttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacttgttccccaacctcacggttatccgaggctcgcgcctcttctttaattatgcgctg gtcatctttgagatggttcacttgaaggagcttggcctctacaacctgatgaacatcacc cgggggtctgtccgcattgagaagaacaatgaactctgctacttggccaccatcgactgg tctcgcatcctggattccgtggaggataattatatcgtgctgaacaaagacgacaatgag gagtgtggggacatttgtccaggcaccgccaagggcaaaaccaactgccctgccactgtc atcaacgggcaatttgtggagcggtgctggacacacagccactgccagaaagtgtgtccg accatctgcaagtcacatggctgcacctctgagggtctctgctgccacagcgagtgcttg ggcaactgctcagagcccgacgaccccaccaagtgtgtggcctgtcgaaacttctacctg gacggcaggtgcgtggagacctgcccgcccccttactaccacttccaagactggcgctgc gtgaacttcagcttctgccaggacctgcacaacaaatgcaagaactctcggaggcaaggc tgccaccagtatgtcattcacaataacaagtgcatccctgagtgcccctctggctacacg atgaactccagcaacttgatgtgtaccccttgcctgggcccctgtcccaaggtatgccac ctcctggaaggcgagaagaccatcgattcggtgacatctgcccaggagctccgaggctgc accatcatcaatggaagcttaatcatcaacatccgagggggcaacaacctggcagctgag ctagaggccaaccttggactcattgaagaaatttcaggatatctgaaaatccgccggtcc tatgccctggtgtcactttccttcttccggaagttacgtctgattcgaggggagaccttg gaaattgggaactactctttctacgccttggacaaccagaacctaaggcagctgtgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcctgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag agaaatgacattgctctaaagaccaatggggaccaggcatcctgtgaaaatgaattactt aaattttcttacattcggacatcttatgacaagatcttgctgaaatgggagccgtattgg cctcctgacttccgagacctcctggggttcatgttgttctacaaagaggccccttaccag aacgtgacagaattcgatgggcaggatgcgtgcggctccaacagctggacagtggtggat attgacccgcctacgaggtccaacgaccccaagtcacagaaccaccccgggtggctgatg cgtggtctcaagccctggacccagtatgccatctttgtcaagaccctggtcaccttttct gatgaacgccgtacatacggggccaagagtgacatcatctatgtccagacagacgccact aatccttccgtgcccctggatcccatctcagtttctaactcctcgtcccagattattctg aagtggaagcctccctccgaccccaacggcaatatcacacactacttggtgttctgggag agacaggcggaagacagtgagctgtatgagctggattattgcctcaaagggttgaagctg ccctcccggacctggtctccaccgttcgagtcggagggctcccagaagcacaaccagagt gagtatgaggagtctgctggcgaatgctgctcctgcccgaagaccgactcgcagatcctc aaggagctggaggagtcctcgttcaggaaaacgtttgaagattacctgcacaacgtggtt ttcatccccagaaaatcatcttcaggccctgttgccgaggacgctaggccttcgaggaaa cgcagagcccttggtgacgtggggaatgtgacagcagccatgcccacccttctggggttc cccaatacctcctctaccagcacgcccacgagctcggaggagcacagacccttcgagaaa gtggtgaacaaggagtcgctggtcatctccggcctgcgtcactttactggctatcgcatc gagcttcaggcttgcaaccaagattcccccgaggagaggtgtagcgtggctgcctatgtc agcgccaggaccatgcctgaagccaaggcagatgatattgtcggccccgtgacccatgaa atcttcgagaacaacgtcgttcacttgatgtggcaggagcccaaggaacccaacggtctg attgtgctgtatgaagtgagttaccgacgatacggcgaggaggagctgcacctctgtgtc tcccgccggcattatgctctggagcgcggctgccggctgcgcgggctgctgcctgggaat tacagcgtgcgagttcgggccacctccctggcaggcaatgggtcttggacggaagccacc tatttttacgtgacagactatttagacgtgccatcaaatattgcaaaaatcatcatcggt cccctcatctttgtctttctcttcagtgttgtgattggaagtatttgtctattcctgaga aagaggcagccagatgggccactgggaccactgtatgcttcttcaaacccagagtacctc agtgccagcgatgtgtttccatgctctgtgtatgtgccggacgagtgggaggtgcctcga gagaagatcacactcctgcgagaattggggcaaggctcctttggcatggtgtacgagggc aacgccagggacattgtcaagggtgaggcagagacccgcgtggcagtgaagacggtcaac gaatcagccagcctgcgagagcggatcgagtttctcaacgaggcttcggtcatgaagggc ttcacctgccaccatgtggtccgcctcctgggggtggtgtccaaaggccagccaacgctg gtggtgatggagttgatggctcacggagacctgaagagttacctccgttccctgcggcct gaggctgagaataaccccggccgccctccccctaccctgcaagaaatgattcagatggcg gcagagatcgccgatgggatggcatacctgaatgctaagaagttcgtgcaccgggatctt gcagcccggaactgcatggtcgcccacgactttaccgtcaaaattggagacttcggaatg acaagagacatctatgaaacggattactaccggaaagggggcaaaggtctgctccccgtg cggtggatggcacctgaatccctgaaggacggagtcttcaccacctcttcagacatgtgg tcttttggtgtggtcctttgggaaattaccagcttggcagaacagccttaccaaggtcta tcaaatgagcaggtgctgaaatttgtcatggatggagggtacctggatcaacctgacaat tgtccagagagagtcaccgacctgatgcggatgtgctggcagttcaaccccaagatgcgt ccaaccttcctggagatcgtggacctgctcaaggatgacctgcaccccagctttcccgaa gtgtccttcttccacagcgaggagaacaaggcgcccgagagcgaggagctggaaatggag tttgaggacatggagagcgtgcccctggaccggtcctcgcacgtgcagagagaggaggcc gggggccgggatggagggtcggcgctggggctaaagcgaaactatgacgagcacatcccc tacacccacatgaacgggggcaagaaaaacggacggattctgactttgccccggtcaaat ccttcctaa

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