KEGG   Bubalus bubalis (water buffalo): 102395384
Entry
102395384         CDS       T05912                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub01521  EGFR tyrosine kinase inhibitor resistance
bbub01522  Endocrine resistance
bbub01524  Platinum drug resistance
bbub04012  ErbB signaling pathway
bbub04014  Ras signaling pathway
bbub04015  Rap1 signaling pathway
bbub04024  cAMP signaling pathway
bbub04062  Chemokine signaling pathway
bbub04066  HIF-1 signaling pathway
bbub04068  FoxO signaling pathway
bbub04070  Phosphatidylinositol signaling system
bbub04071  Sphingolipid signaling pathway
bbub04072  Phospholipase D signaling pathway
bbub04081  Hormone signaling
bbub04140  Autophagy - animal
bbub04150  mTOR signaling pathway
bbub04151  PI3K-Akt signaling pathway
bbub04152  AMPK signaling pathway
bbub04210  Apoptosis
bbub04211  Longevity regulating pathway
bbub04213  Longevity regulating pathway - multiple species
bbub04218  Cellular senescence
bbub04360  Axon guidance
bbub04370  VEGF signaling pathway
bbub04380  Osteoclast differentiation
bbub04510  Focal adhesion
bbub04550  Signaling pathways regulating pluripotency of stem cells
bbub04611  Platelet activation
bbub04613  Neutrophil extracellular trap formation
bbub04620  Toll-like receptor signaling pathway
bbub04625  C-type lectin receptor signaling pathway
bbub04630  JAK-STAT signaling pathway
bbub04650  Natural killer cell mediated cytotoxicity
bbub04660  T cell receptor signaling pathway
bbub04662  B cell receptor signaling pathway
bbub04664  Fc epsilon RI signaling pathway
bbub04666  Fc gamma R-mediated phagocytosis
bbub04668  TNF signaling pathway
bbub04670  Leukocyte transendothelial migration
bbub04722  Neurotrophin signaling pathway
bbub04725  Cholinergic synapse
bbub04750  Inflammatory mediator regulation of TRP channels
bbub04810  Regulation of actin cytoskeleton
bbub04910  Insulin signaling pathway
bbub04914  Progesterone-mediated oocyte maturation
bbub04915  Estrogen signaling pathway
bbub04917  Prolactin signaling pathway
bbub04919  Thyroid hormone signaling pathway
bbub04923  Regulation of lipolysis in adipocytes
bbub04926  Relaxin signaling pathway
bbub04929  GnRH secretion
bbub04930  Type II diabetes mellitus
bbub04931  Insulin resistance
bbub04932  Non-alcoholic fatty liver disease
bbub04933  AGE-RAGE signaling pathway in diabetic complications
bbub04935  Growth hormone synthesis, secretion and action
bbub04960  Aldosterone-regulated sodium reabsorption
bbub04973  Carbohydrate digestion and absorption
bbub05010  Alzheimer disease
bbub05017  Spinocerebellar ataxia
bbub05020  Prion disease
bbub05100  Bacterial invasion of epithelial cells
bbub05135  Yersinia infection
bbub05142  Chagas disease
bbub05146  Amoebiasis
bbub05160  Hepatitis C
bbub05161  Hepatitis B
bbub05162  Measles
bbub05163  Human cytomegalovirus infection
bbub05164  Influenza A
bbub05165  Human papillomavirus infection
bbub05166  Human T-cell leukemia virus 1 infection
bbub05167  Kaposi sarcoma-associated herpesvirus infection
bbub05168  Herpes simplex virus 1 infection
bbub05169  Epstein-Barr virus infection
bbub05170  Human immunodeficiency virus 1 infection
bbub05171  Coronavirus disease - COVID-19
bbub05200  Pathways in cancer
bbub05203  Viral carcinogenesis
bbub05205  Proteoglycans in cancer
bbub05206  MicroRNAs in cancer
bbub05207  Chemical carcinogenesis - receptor activation
bbub05208  Chemical carcinogenesis - reactive oxygen species
bbub05210  Colorectal cancer
bbub05211  Renal cell carcinoma
bbub05212  Pancreatic cancer
bbub05213  Endometrial cancer
bbub05214  Glioma
bbub05215  Prostate cancer
bbub05218  Melanoma
bbub05220  Chronic myeloid leukemia
bbub05221  Acute myeloid leukemia
bbub05222  Small cell lung cancer
bbub05223  Non-small cell lung cancer
bbub05224  Breast cancer
bbub05225  Hepatocellular carcinoma
bbub05226  Gastric cancer
bbub05230  Central carbon metabolism in cancer
bbub05231  Choline metabolism in cancer
bbub05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bbub05415  Diabetic cardiomyopathy
bbub05417  Lipid and atherosclerosis
bbub05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102395384
   04014 Ras signaling pathway
    102395384
   04015 Rap1 signaling pathway
    102395384
   04370 VEGF signaling pathway
    102395384
   04630 JAK-STAT signaling pathway
    102395384
   04668 TNF signaling pathway
    102395384
   04066 HIF-1 signaling pathway
    102395384
   04068 FoxO signaling pathway
    102395384
   04070 Phosphatidylinositol signaling system
    102395384
   04072 Phospholipase D signaling pathway
    102395384
   04071 Sphingolipid signaling pathway
    102395384
   04024 cAMP signaling pathway
    102395384
   04151 PI3K-Akt signaling pathway
    102395384
   04152 AMPK signaling pathway
    102395384
   04150 mTOR signaling pathway
    102395384
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102395384
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102395384
  09143 Cell growth and death
   04210 Apoptosis
    102395384
   04218 Cellular senescence
    102395384
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102395384
   04550 Signaling pathways regulating pluripotency of stem cells
    102395384
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102395384
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102395384
   04613 Neutrophil extracellular trap formation
    102395384
   04620 Toll-like receptor signaling pathway
    102395384
   04625 C-type lectin receptor signaling pathway
    102395384
   04650 Natural killer cell mediated cytotoxicity
    102395384
   04660 T cell receptor signaling pathway
    102395384
   04662 B cell receptor signaling pathway
    102395384
   04664 Fc epsilon RI signaling pathway
    102395384
   04666 Fc gamma R-mediated phagocytosis
    102395384
   04670 Leukocyte transendothelial migration
    102395384
   04062 Chemokine signaling pathway
    102395384
  09152 Endocrine system
   04910 Insulin signaling pathway
    102395384
   04923 Regulation of lipolysis in adipocytes
    102395384
   04929 GnRH secretion
    102395384
   04915 Estrogen signaling pathway
    102395384
   04914 Progesterone-mediated oocyte maturation
    102395384
   04917 Prolactin signaling pathway
    102395384
   04926 Relaxin signaling pathway
    102395384
   04935 Growth hormone synthesis, secretion and action
    102395384
   04919 Thyroid hormone signaling pathway
    102395384
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102395384
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102395384
  09156 Nervous system
   04725 Cholinergic synapse
    102395384
   04722 Neurotrophin signaling pathway
    102395384
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102395384
  09158 Development and regeneration
   04360 Axon guidance
    102395384
   04380 Osteoclast differentiation
    102395384
  09149 Aging
   04211 Longevity regulating pathway
    102395384
   04213 Longevity regulating pathway - multiple species
    102395384
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102395384
   05206 MicroRNAs in cancer
    102395384
   05205 Proteoglycans in cancer
    102395384
   05207 Chemical carcinogenesis - receptor activation
    102395384
   05208 Chemical carcinogenesis - reactive oxygen species
    102395384
   05203 Viral carcinogenesis
    102395384
   05230 Central carbon metabolism in cancer
    102395384
   05231 Choline metabolism in cancer
    102395384
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102395384
  09162 Cancer: specific types
   05210 Colorectal cancer
    102395384
   05212 Pancreatic cancer
    102395384
   05225 Hepatocellular carcinoma
    102395384
   05226 Gastric cancer
    102395384
   05214 Glioma
    102395384
   05221 Acute myeloid leukemia
    102395384
   05220 Chronic myeloid leukemia
    102395384
   05218 Melanoma
    102395384
   05211 Renal cell carcinoma
    102395384
   05215 Prostate cancer
    102395384
   05213 Endometrial cancer
    102395384
   05224 Breast cancer
    102395384
   05222 Small cell lung cancer
    102395384
   05223 Non-small cell lung cancer
    102395384
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102395384
   05170 Human immunodeficiency virus 1 infection
    102395384
   05161 Hepatitis B
    102395384
   05160 Hepatitis C
    102395384
   05171 Coronavirus disease - COVID-19
    102395384
   05164 Influenza A
    102395384
   05162 Measles
    102395384
   05168 Herpes simplex virus 1 infection
    102395384
   05163 Human cytomegalovirus infection
    102395384
   05167 Kaposi sarcoma-associated herpesvirus infection
    102395384
   05169 Epstein-Barr virus infection
    102395384
   05165 Human papillomavirus infection
    102395384
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102395384
   05100 Bacterial invasion of epithelial cells
    102395384
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102395384
   05142 Chagas disease
    102395384
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102395384
   05017 Spinocerebellar ataxia
    102395384
   05020 Prion disease
    102395384
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102395384
   05418 Fluid shear stress and atherosclerosis
    102395384
   05415 Diabetic cardiomyopathy
    102395384
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102395384
   04932 Non-alcoholic fatty liver disease
    102395384
   04931 Insulin resistance
    102395384
   04933 AGE-RAGE signaling pathway in diabetic complications
    102395384
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102395384
   01524 Platinum drug resistance
    102395384
   01522 Endocrine resistance
    102395384
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbub04131]
    102395384
Membrane trafficking [BR:bbub04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102395384
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act Cupin_8 Exonuc_VII_L
Other DBs
NCBI-GeneID: 102395384
NCBI-ProteinID: XP_044801005
LinkDB
Position
6:99645385..99749349
AA seq 504 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPGSMGSIDGTEERSATHSQCHLERRV
AQMFSTPHPVLEERHPTKTLPPKPPKPMTSAITNGIKDSSVSLQDAEWYWGDISREEVND
KLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELI
SHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDR
LYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRKEGNEKEIERIM
MNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLN
HKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPD
GAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSL
VQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1515 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagggagcatgggttcg
attgatggcacggaagaaaggagtgccactcattcacagtgccaccttgaaagaagggtg
gcacagatgttctctaccccccaccctgtcctagaggaaaggcatccaacaaaaactctt
ccaccaaagccacctaagccaatgacttcagccattacaaatggaataaaggacagttct
gtttctcttcaggatgcagaatggtactggggggatatttcaagggaggaggtaaatgac
aaattgcgggacatgccagatggtaccttcttggtcagagatgcctcaaccaaaatgcag
ggagattacactttgaccttgcggaagggaggcaataataagctaataaagatttatcat
cgagatggtaaatatggcttttctgatcctctgacatttaattctgtggtggagctcatt
agccactatcatcatgaatctcttgcccagtacaatcccaaacttgatgtgaaactgatg
tacccagtgtccagataccaacaggatcagttggtaaaagaagataatattgatgctgtc
ggtaaaaaactgcaggagtatcactctcagtatcaggaaaagagtaaagaatatgacaga
ctatatgaagaatataccagaacatcccaggaaatacagatgaagaggactgcaattgaa
gcttttaatgaaacaattaaaatatttgaagagcagtgtcatacacaagaacaacatagc
aaagaatatattgagcgatttcgaaaagaagggaatgaaaaggaaattgaacgaattatg
atgaattatgacaagttgaaatcacgtctgggtgagattcatgatagcaaaatgcgtctt
gaacaggatttgaagaaacaagctttggataaccgagaaatagataaaaaaatgaatagt
atcaaacctgacctgatccagctgcgcaagatccgagatcagcaccttgtgtggctcaat
cacaaaggagtgagacagaagcgcctaaatgcctggctgggaatcaagaatgaggatgct
gatgagacctattttatcaatgaggaagatgaaaacctgccccattatgatgagaaaacc
tggtttgttgaggatatcaaccgagtacaagcagaggacttgctttatgggaaacctgac
ggtgcattcttaatccgtgagagtagcaagaaaggatgttatgcttgctctgtggtcgcc
gatggagaggtgaagcactgtgtcatctacagcactgctcggggctacggcttcgcagag
ccctacaacctgtacagctccctgaaggagctggtgctccactaccagcagacgtccctc
gtgcagcacaacgactctctcaacgtcaggctcgcctaccctgtccacgcacagatgccc
tcgctctgcagataa

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