KEGG   Bubalus bubalis (water buffalo): 102401744
Entry
102401744         CDS       T05912                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub01521  EGFR tyrosine kinase inhibitor resistance
bbub01522  Endocrine resistance
bbub04010  MAPK signaling pathway
bbub04012  ErbB signaling pathway
bbub04014  Ras signaling pathway
bbub04015  Rap1 signaling pathway
bbub04022  cGMP-PKG signaling pathway
bbub04024  cAMP signaling pathway
bbub04066  HIF-1 signaling pathway
bbub04068  FoxO signaling pathway
bbub04071  Sphingolipid signaling pathway
bbub04072  Phospholipase D signaling pathway
bbub04140  Autophagy - animal
bbub04148  Efferocytosis
bbub04150  mTOR signaling pathway
bbub04151  PI3K-Akt signaling pathway
bbub04210  Apoptosis
bbub04218  Cellular senescence
bbub04270  Vascular smooth muscle contraction
bbub04370  VEGF signaling pathway
bbub04371  Apelin signaling pathway
bbub04540  Gap junction
bbub04550  Signaling pathways regulating pluripotency of stem cells
bbub04613  Neutrophil extracellular trap formation
bbub04620  Toll-like receptor signaling pathway
bbub04650  Natural killer cell mediated cytotoxicity
bbub04660  T cell receptor signaling pathway
bbub04662  B cell receptor signaling pathway
bbub04664  Fc epsilon RI signaling pathway
bbub04720  Long-term potentiation
bbub04722  Neurotrophin signaling pathway
bbub04730  Long-term depression
bbub04810  Regulation of actin cytoskeleton
bbub04910  Insulin signaling pathway
bbub04912  GnRH signaling pathway
bbub04915  Estrogen signaling pathway
bbub04916  Melanogenesis
bbub04917  Prolactin signaling pathway
bbub04919  Thyroid hormone signaling pathway
bbub04921  Oxytocin signaling pathway
bbub04926  Relaxin signaling pathway
bbub04929  GnRH secretion
bbub04934  Cushing syndrome
bbub04935  Growth hormone synthesis, secretion and action
bbub05010  Alzheimer disease
bbub05022  Pathways of neurodegeneration - multiple diseases
bbub05132  Salmonella infection
bbub05135  Yersinia infection
bbub05160  Hepatitis C
bbub05161  Hepatitis B
bbub05163  Human cytomegalovirus infection
bbub05164  Influenza A
bbub05165  Human papillomavirus infection
bbub05166  Human T-cell leukemia virus 1 infection
bbub05167  Kaposi sarcoma-associated herpesvirus infection
bbub05170  Human immunodeficiency virus 1 infection
bbub05200  Pathways in cancer
bbub05205  Proteoglycans in cancer
bbub05206  MicroRNAs in cancer
bbub05207  Chemical carcinogenesis - receptor activation
bbub05208  Chemical carcinogenesis - reactive oxygen species
bbub05210  Colorectal cancer
bbub05211  Renal cell carcinoma
bbub05213  Endometrial cancer
bbub05214  Glioma
bbub05215  Prostate cancer
bbub05216  Thyroid cancer
bbub05218  Melanoma
bbub05219  Bladder cancer
bbub05220  Chronic myeloid leukemia
bbub05221  Acute myeloid leukemia
bbub05223  Non-small cell lung cancer
bbub05224  Breast cancer
bbub05225  Hepatocellular carcinoma
bbub05226  Gastric cancer
bbub05230  Central carbon metabolism in cancer
bbub05231  Choline metabolism in cancer
bbub05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102401744 (MAP2K2)
   04012 ErbB signaling pathway
    102401744 (MAP2K2)
   04014 Ras signaling pathway
    102401744 (MAP2K2)
   04015 Rap1 signaling pathway
    102401744 (MAP2K2)
   04370 VEGF signaling pathway
    102401744 (MAP2K2)
   04371 Apelin signaling pathway
    102401744 (MAP2K2)
   04066 HIF-1 signaling pathway
    102401744 (MAP2K2)
   04068 FoxO signaling pathway
    102401744 (MAP2K2)
   04072 Phospholipase D signaling pathway
    102401744 (MAP2K2)
   04071 Sphingolipid signaling pathway
    102401744 (MAP2K2)
   04024 cAMP signaling pathway
    102401744 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    102401744 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    102401744 (MAP2K2)
   04150 mTOR signaling pathway
    102401744 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102401744 (MAP2K2)
   04148 Efferocytosis
    102401744 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    102401744 (MAP2K2)
   04218 Cellular senescence
    102401744 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102401744 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102401744 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102401744 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102401744 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    102401744 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    102401744 (MAP2K2)
   04660 T cell receptor signaling pathway
    102401744 (MAP2K2)
   04662 B cell receptor signaling pathway
    102401744 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    102401744 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102401744 (MAP2K2)
   04929 GnRH secretion
    102401744 (MAP2K2)
   04912 GnRH signaling pathway
    102401744 (MAP2K2)
   04915 Estrogen signaling pathway
    102401744 (MAP2K2)
   04917 Prolactin signaling pathway
    102401744 (MAP2K2)
   04921 Oxytocin signaling pathway
    102401744 (MAP2K2)
   04926 Relaxin signaling pathway
    102401744 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    102401744 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    102401744 (MAP2K2)
   04916 Melanogenesis
    102401744 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102401744 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    102401744 (MAP2K2)
   04730 Long-term depression
    102401744 (MAP2K2)
   04722 Neurotrophin signaling pathway
    102401744 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102401744 (MAP2K2)
   05206 MicroRNAs in cancer
    102401744 (MAP2K2)
   05205 Proteoglycans in cancer
    102401744 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    102401744 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    102401744 (MAP2K2)
   05230 Central carbon metabolism in cancer
    102401744 (MAP2K2)
   05231 Choline metabolism in cancer
    102401744 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102401744 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102401744 (MAP2K2)
   05225 Hepatocellular carcinoma
    102401744 (MAP2K2)
   05226 Gastric cancer
    102401744 (MAP2K2)
   05214 Glioma
    102401744 (MAP2K2)
   05216 Thyroid cancer
    102401744 (MAP2K2)
   05221 Acute myeloid leukemia
    102401744 (MAP2K2)
   05220 Chronic myeloid leukemia
    102401744 (MAP2K2)
   05218 Melanoma
    102401744 (MAP2K2)
   05211 Renal cell carcinoma
    102401744 (MAP2K2)
   05219 Bladder cancer
    102401744 (MAP2K2)
   05215 Prostate cancer
    102401744 (MAP2K2)
   05213 Endometrial cancer
    102401744 (MAP2K2)
   05224 Breast cancer
    102401744 (MAP2K2)
   05223 Non-small cell lung cancer
    102401744 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102401744 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    102401744 (MAP2K2)
   05161 Hepatitis B
    102401744 (MAP2K2)
   05160 Hepatitis C
    102401744 (MAP2K2)
   05164 Influenza A
    102401744 (MAP2K2)
   05163 Human cytomegalovirus infection
    102401744 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102401744 (MAP2K2)
   05165 Human papillomavirus infection
    102401744 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102401744 (MAP2K2)
   05135 Yersinia infection
    102401744 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102401744 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    102401744 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102401744 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102401744 (MAP2K2)
   01522 Endocrine resistance
    102401744 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbub01001]
    102401744 (MAP2K2)
Enzymes [BR:bbub01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102401744 (MAP2K2)
Protein kinases [BR:bbub01001]
 Serine/threonine kinases: STE group
  STE7 family
   102401744 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Seadorna_VP7 Kdo APH
Other DBs
NCBI-GeneID: 102401744
NCBI-ProteinID: XP_025149007
LinkDB
Position
9:complement(91286096..91309185)
AA seq 403 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEAHLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPPSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMAHPGTYRSPGDHDESDFRQPEVSSLSRPLQMSLDWHPLL
NT seq 1212 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtctcctaccagcgagggcgcctccgaagcacacctggtggacctccagaagaag
ctagaggagctagagctcgacgagcagcagaagaagcggctggaagccttccttacccag
aaggccaaggttggcgagctcaaggacgatgacttcgaacggatctccgagctgggagcc
ggcaatggcggagtggtcaccaaggtccagcacagaccttcgggcctcatcatggccaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgagagctacag
gtgctgcatgagtgcaactccccgtacattgtgggcttctacggggccttctacagcgac
ggtgagatcagcatctgcatggagcacatggatggcggctccttggaccaggtgttgaaa
gaagccaagagaatccctgaagagatcctgggcaaggtcagcatcgcggttctgcggggc
ctggcatacctccgagagaaacaccagatcatgcaccgagacgtgaagccgtccaacatc
ctggtcaactcccggggggagatcaagctgtgtgacttcggggtgagcggccagctcatc
gactccatggccaactccttcgtggggacacggtcctacatgtctccggagcggctacaa
ggcacccactactcggtgcagtcagacatctggagcatgggcctgtccctggtggaactg
tccatcggcaggtaccccatccccccgccggacgccaaggagctggaggccatattcggc
cggcccatggttgatggcgcagaaggagaacctcccagcatctcgccacggccgaggccc
cccggacgccccatcagcggtcacgggatggacagccggcctgccatggcgatctttgag
ctgctggactacattgtgaacgagcctcctcccaagctgcccaacggtgtgttcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagctgagcgagcagacctg
aagatgctcatggctcatccaggaacataccggagccctggagaccacgacgaaagtgac
tttcgacagcccgaggtctcctctctatcgcgccccctgcaaatgtccctagactggcac
cctctgctctga

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