KEGG   Bos indicus (zebu cattle): 109561418
Entry
109561418         CDS       T04792                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu01522  Endocrine resistance
biu01524  Platinum drug resistance
biu04012  ErbB signaling pathway
biu04014  Ras signaling pathway
biu04015  Rap1 signaling pathway
biu04024  cAMP signaling pathway
biu04062  Chemokine signaling pathway
biu04066  HIF-1 signaling pathway
biu04068  FoxO signaling pathway
biu04070  Phosphatidylinositol signaling system
biu04071  Sphingolipid signaling pathway
biu04072  Phospholipase D signaling pathway
biu04081  Hormone signaling
biu04140  Autophagy - animal
biu04150  mTOR signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04152  AMPK signaling pathway
biu04210  Apoptosis
biu04211  Longevity regulating pathway
biu04213  Longevity regulating pathway - multiple species
biu04218  Cellular senescence
biu04360  Axon guidance
biu04370  VEGF signaling pathway
biu04380  Osteoclast differentiation
biu04510  Focal adhesion
biu04550  Signaling pathways regulating pluripotency of stem cells
biu04611  Platelet activation
biu04613  Neutrophil extracellular trap formation
biu04620  Toll-like receptor signaling pathway
biu04625  C-type lectin receptor signaling pathway
biu04630  JAK-STAT signaling pathway
biu04650  Natural killer cell mediated cytotoxicity
biu04660  T cell receptor signaling pathway
biu04662  B cell receptor signaling pathway
biu04664  Fc epsilon RI signaling pathway
biu04666  Fc gamma R-mediated phagocytosis
biu04668  TNF signaling pathway
biu04670  Leukocyte transendothelial migration
biu04722  Neurotrophin signaling pathway
biu04725  Cholinergic synapse
biu04750  Inflammatory mediator regulation of TRP channels
biu04810  Regulation of actin cytoskeleton
biu04910  Insulin signaling pathway
biu04914  Progesterone-mediated oocyte maturation
biu04915  Estrogen signaling pathway
biu04917  Prolactin signaling pathway
biu04919  Thyroid hormone signaling pathway
biu04923  Regulation of lipolysis in adipocytes
biu04926  Relaxin signaling pathway
biu04929  GnRH secretion
biu04930  Type II diabetes mellitus
biu04931  Insulin resistance
biu04932  Non-alcoholic fatty liver disease
biu04933  AGE-RAGE signaling pathway in diabetic complications
biu04935  Growth hormone synthesis, secretion and action
biu04960  Aldosterone-regulated sodium reabsorption
biu04973  Carbohydrate digestion and absorption
biu05010  Alzheimer disease
biu05017  Spinocerebellar ataxia
biu05020  Prion disease
biu05100  Bacterial invasion of epithelial cells
biu05135  Yersinia infection
biu05142  Chagas disease
biu05146  Amoebiasis
biu05160  Hepatitis C
biu05161  Hepatitis B
biu05162  Measles
biu05163  Human cytomegalovirus infection
biu05164  Influenza A
biu05165  Human papillomavirus infection
biu05166  Human T-cell leukemia virus 1 infection
biu05167  Kaposi sarcoma-associated herpesvirus infection
biu05168  Herpes simplex virus 1 infection
biu05169  Epstein-Barr virus infection
biu05170  Human immunodeficiency virus 1 infection
biu05171  Coronavirus disease - COVID-19
biu05200  Pathways in cancer
biu05203  Viral carcinogenesis
biu05205  Proteoglycans in cancer
biu05206  MicroRNAs in cancer
biu05207  Chemical carcinogenesis - receptor activation
biu05208  Chemical carcinogenesis - reactive oxygen species
biu05210  Colorectal cancer
biu05211  Renal cell carcinoma
biu05212  Pancreatic cancer
biu05213  Endometrial cancer
biu05214  Glioma
biu05215  Prostate cancer
biu05218  Melanoma
biu05220  Chronic myeloid leukemia
biu05221  Acute myeloid leukemia
biu05222  Small cell lung cancer
biu05223  Non-small cell lung cancer
biu05224  Breast cancer
biu05225  Hepatocellular carcinoma
biu05226  Gastric cancer
biu05230  Central carbon metabolism in cancer
biu05231  Choline metabolism in cancer
biu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
biu05415  Diabetic cardiomyopathy
biu05417  Lipid and atherosclerosis
biu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109561418 (PIK3R2)
   04014 Ras signaling pathway
    109561418 (PIK3R2)
   04015 Rap1 signaling pathway
    109561418 (PIK3R2)
   04370 VEGF signaling pathway
    109561418 (PIK3R2)
   04630 JAK-STAT signaling pathway
    109561418 (PIK3R2)
   04668 TNF signaling pathway
    109561418 (PIK3R2)
   04066 HIF-1 signaling pathway
    109561418 (PIK3R2)
   04068 FoxO signaling pathway
    109561418 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    109561418 (PIK3R2)
   04072 Phospholipase D signaling pathway
    109561418 (PIK3R2)
   04071 Sphingolipid signaling pathway
    109561418 (PIK3R2)
   04024 cAMP signaling pathway
    109561418 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    109561418 (PIK3R2)
   04152 AMPK signaling pathway
    109561418 (PIK3R2)
   04150 mTOR signaling pathway
    109561418 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    109561418 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109561418 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    109561418 (PIK3R2)
   04218 Cellular senescence
    109561418 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109561418 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    109561418 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109561418 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109561418 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    109561418 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    109561418 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    109561418 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    109561418 (PIK3R2)
   04660 T cell receptor signaling pathway
    109561418 (PIK3R2)
   04662 B cell receptor signaling pathway
    109561418 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    109561418 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    109561418 (PIK3R2)
   04670 Leukocyte transendothelial migration
    109561418 (PIK3R2)
   04062 Chemokine signaling pathway
    109561418 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109561418 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    109561418 (PIK3R2)
   04929 GnRH secretion
    109561418 (PIK3R2)
   04915 Estrogen signaling pathway
    109561418 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    109561418 (PIK3R2)
   04917 Prolactin signaling pathway
    109561418 (PIK3R2)
   04926 Relaxin signaling pathway
    109561418 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    109561418 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    109561418 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109561418 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109561418 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    109561418 (PIK3R2)
   04722 Neurotrophin signaling pathway
    109561418 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109561418 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    109561418 (PIK3R2)
   04380 Osteoclast differentiation
    109561418 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    109561418 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    109561418 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109561418 (PIK3R2)
   05206 MicroRNAs in cancer
    109561418 (PIK3R2)
   05205 Proteoglycans in cancer
    109561418 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    109561418 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    109561418 (PIK3R2)
   05203 Viral carcinogenesis
    109561418 (PIK3R2)
   05230 Central carbon metabolism in cancer
    109561418 (PIK3R2)
   05231 Choline metabolism in cancer
    109561418 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109561418 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109561418 (PIK3R2)
   05212 Pancreatic cancer
    109561418 (PIK3R2)
   05225 Hepatocellular carcinoma
    109561418 (PIK3R2)
   05226 Gastric cancer
    109561418 (PIK3R2)
   05214 Glioma
    109561418 (PIK3R2)
   05221 Acute myeloid leukemia
    109561418 (PIK3R2)
   05220 Chronic myeloid leukemia
    109561418 (PIK3R2)
   05218 Melanoma
    109561418 (PIK3R2)
   05211 Renal cell carcinoma
    109561418 (PIK3R2)
   05215 Prostate cancer
    109561418 (PIK3R2)
   05213 Endometrial cancer
    109561418 (PIK3R2)
   05224 Breast cancer
    109561418 (PIK3R2)
   05222 Small cell lung cancer
    109561418 (PIK3R2)
   05223 Non-small cell lung cancer
    109561418 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109561418 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    109561418 (PIK3R2)
   05161 Hepatitis B
    109561418 (PIK3R2)
   05160 Hepatitis C
    109561418 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    109561418 (PIK3R2)
   05164 Influenza A
    109561418 (PIK3R2)
   05162 Measles
    109561418 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    109561418 (PIK3R2)
   05163 Human cytomegalovirus infection
    109561418 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109561418 (PIK3R2)
   05169 Epstein-Barr virus infection
    109561418 (PIK3R2)
   05165 Human papillomavirus infection
    109561418 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    109561418 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    109561418 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109561418 (PIK3R2)
   05142 Chagas disease
    109561418 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109561418 (PIK3R2)
   05017 Spinocerebellar ataxia
    109561418 (PIK3R2)
   05020 Prion disease
    109561418 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109561418 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    109561418 (PIK3R2)
   05415 Diabetic cardiomyopathy
    109561418 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109561418 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    109561418 (PIK3R2)
   04931 Insulin resistance
    109561418 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109561418 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109561418 (PIK3R2)
   01524 Platinum drug resistance
    109561418 (PIK3R2)
   01522 Endocrine resistance
    109561418 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:biu04131]
    109561418 (PIK3R2)
Membrane trafficking [BR:biu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109561418 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9
Other DBs
NCBI-GeneID: 109561418
NCBI-ProteinID: XP_019819413
UniProt: A0A6P5C1S5
LinkDB
Position
7:complement(4993040..5005701)
AA seq 724 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRXXGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPILVKLVEAIERTGLDSYRPEPPAVRTDWSLSDVEQWDAAALSDGVKGFLLALPA
PLVTPEAAAEAHRALREAAGPVGPALEPPTLPLHHALTLRFLLQHLGRVAGRAPAPGPAV
RALGATFGPLLLRAPPPPSPPPGGAPDGTEPTPDFPALLVEKLLQEHLEEQEVAPPALPP
KPPKTKPAPTGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGE
YTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYP
VSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAF
NETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQ
ELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQ
YSLMEXEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGD
TKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPP
PAAR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atggctggccctgagggcttccaataccgtgcattgtacccattccgccgggagcggccg
gaggacctggagctgcttccgggtgatgtgctggtggtgagcagggccgccctgcaggcg
ctgggcgtggccgagggcaacgagcgctgcccgcagagcgtaggctggatgcctggcctc
aatgagcgtacccggcagcgcggcgacttccctggcacctatgtggagttcctggggccc
gtggccctggcccggcctggccctcgccnnnnnggcccccgcccactgcccgccaggccc
cgagacgggccccctgagccaggccttacactccctgacctacccgagcagttctccccc
cctgatgtggctccccctatcctggtgaagctggtggaggccattgaacggacagggctg
gacagctacaggcctgagccacccgccgtgcgcacagactggtccctgagtgatgtggag
cagtgggatgcggcagccctgtcagatggtgtgaaaggcttcctgctggcgctgccagcg
cccctcgtgacacccgaggctgcggccgaggcacaccgagccctgcgggaggctgcgggg
cccgtggggccggcgttggagcccccgacgctgccactgcaccatgcgctcacgctgcgc
ttcctgctccagcacctgggccgggtggccgggcgcgccccagccccrggccccgcggtc
cgtgccctgggcgccaccttcgggccgctgctgctacgcgcgccgccgccgccctctccg
ccgccagggggcgcacccgacgggaccgagcccacccccgactttcctgcgctgctggtg
gagaagctgcttcaggaacatctggaggagcaggaggttgcccccccagcactgccacca
aaaccccccaagacaaagccagcccccacaggcctggccaatgggggcagcccaccctcc
ctgcaggacgccgagtggtactggggtgacatctccagggaggaggtaaacgagaaactg
cgggacacgcccgatggcaccttcctggtccgagatgcctccagcaagatccagggagag
tacacgctgaccctcaggaaaggcggaaacaacaagctgatcaaggtcttccaccgagat
gggcactacggcttctcggagccgctcaccttctgctctgtcgtggacctcatcacccac
taccgccatgagtcactggcccagtacaacgccaagctggacacgcggctcctctaccca
gtgtccaagtaccaacaggaccagatcgtcaaggaggacagcgtggaggcggtgggtgcc
cagctcaaggtctaccaccagcagtaccaggacaagagccgcgagtacgaccagctctac
gaggagtacacacgcacctcccaggaactgcagatgaagcgcacagccatcgaagccttc
aatgagaccatcaagatctttgaagagcagggccagacgcaggagaagtgcagcaaggaa
tacctggagcgcttccgacgtgagggcaatgagaaagaaatgcagaggatcctgctaaac
tcggagcggctcaagtctcgcattgccgagatccacgagagtcgcacaaagctggagcag
gagctgcgggcacaggcctctgacaaccgagagatcgacaagcgcatgaacagcctcaag
ccagacctcatgcagttgcgcaagatccgagaccagtaccttgtgtggctcactcagaag
ggtgcccggcagaagaaaatcaacgaatggttggggatcaagaacgagactgaggaccag
tactcactgatggagsatgaggatgacctcccccaccacgaggaacgcacctggtatgta
ggcaagatcaaccgcacccaagctgaggaaatgctgagtggcaagcgggacggtaccttc
ctcatccgtgagagcagccagcggggttgctacgcctgttctgtggtggtggacggggat
accaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcggagccctacaac
ctgtacgggtccctgaaggagctcgtcctccactaccagcacgcctcgctggtgcagcac
aacgacgcgctgaccgtcacgctcgcccaccccgtgcgcgcccccggccctgggcccccg
ccggctgcgcgctga

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