Bos indicus (zebu cattle): 109571355 Help Entry 109571355         CDS       T04792                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism biu  Bos indicus (zebu cattle) Pathway biu04022   cGMP-PKG signaling pathway biu04068   FoxO signaling pathway biu04081   Hormone signaling biu04140   Autophagy - animal biu04150   mTOR signaling pathway biu04151   PI3K-Akt signaling pathway biu04152   AMPK signaling pathway biu04211   Longevity regulating pathway biu04213   Longevity regulating pathway - multiple species biu04722   Neurotrophin signaling pathway biu04910   Insulin signaling pathway biu04920   Adipocytokine signaling pathway biu04923   Regulation of lipolysis in adipocytes biu04930   Type II diabetes mellitus biu04931   Insulin resistance biu04932   Non-alcoholic fatty liver disease biu04935   Growth hormone synthesis, secretion and action biu04960   Aldosterone-regulated sodium reabsorption biu05010   Alzheimer disease biu05206   MicroRNAs in cancer biu05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:biu00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     109571355 (IRS1)    04022 cGMP-PKG signaling pathway     109571355 (IRS1)    04151 PI3K-Akt signaling pathway     109571355 (IRS1)    04152 AMPK signaling pathway     109571355 (IRS1)    04150 mTOR signaling pathway     109571355 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     109571355 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     109571355 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     109571355 (IRS1)    04923 Regulation of lipolysis in adipocytes     109571355 (IRS1)    04920 Adipocytokine signaling pathway     109571355 (IRS1)    04935 Growth hormone synthesis, secretion and action     109571355 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     109571355 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     109571355 (IRS1)   09149 Aging    04211 Longevity regulating pathway     109571355 (IRS1)    04213 Longevity regulating pathway - multiple species     109571355 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     109571355 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     109571355 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     109571355 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     109571355 (IRS1)    04932 Non-alcoholic fatty liver disease     109571355 (IRS1)    04931 Insulin resistance     109571355 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  109571355 NCBI-ProteinID:  XP_019833328 UniProt:  A0A6P5D5E9 LinkDB All DBs Position 2:complement(119389217..119457259) Genome browser AA seq 1237 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN GHYILPRGGNGHRYVPAAGLGTSPALPGEEAAGAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDTSSLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSGGSSSGAAPSGSSYGKLWTNGVGGHHSHALPHPKLPVES GSGKLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEL EEPRHHQHLRLSSSSGRLLYTAAAEDSSSSTSSDSLGGGYCGARPEPGLPHLHHQVLQAH LPRKVDTAAQTNNRLARPTRLSLGDPKASTLPRAREQQPPPPLLLPPEPKSPGEYVNIEF GSDQPGYLSGPVASHSSPSIRCPSQLQPAPREEDTGAEEYMNMDLGPGRRATWQKSVGVQ PGRVGPAPPGAASVCRPTRAVPSSCGDYMTMQMGGPRQSYVDTSPVAPISYADMRTGVVV EDASLPXATAAAPSSSSTASVSSTAPPXGTGELAARSALLGGPSAFTRVNLSPNRNQSAK VIRADPQGCRRRHSSETFSSTPSATRVGNTMPFGAGAAVGGSGGGSSSSAEDVKRHSSAS FENVWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFKQRPQECPPQPQPPPLP APHQPLASSQSGPTSRSSEDLSAYASITFQKQPEDLQ NT seq 3714 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagactgacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgattcttcgtgctgcgggcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtckagcgccccc aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcagacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac cacgacggggccgcggcgcctggggcgggaggcggcgggggcagctgcagtggcagctcc ggcctcggggaggccggtgaggacttgagctacggggacgtgcccccaggacccgccttc aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gckgcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactcagagaacttc ttcttcatcgaagtgggccgttccgcagtgacgggccccggggagttctggatgcaggtg gacgactccgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg agcgatgagttccgccctagaagcaagagccagtcctcctccaactgctccaaccccatc agtgtgcccctgcggaggcaccacctcaacaaccctccacccagccaggtggggctgacc cgccgctcgcgcaccgagagcatcacagccacctccccggccagcttggtgggcgggaag cagggctccttccgcgtgcgtgcctccagtgatggcgaaggcaccatgtctcgccccgcc tcagtggacggcagtcctgtgagtcctagcaccaacaggacccacgcccaccgccatcga ggcagctcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcttct cgctgctcgccttccgccaccagccccgtcagtctgtcgtccagcagcacgagtggccat ggctccacctcagactgcctcttcccgcggcggtctagtgcttctgtgtctggttccccc agtgatggcggcttcatctcctccgatgagtatggctccagtccctgcgatttccgaagt tccttccgcagcgtcaccccagattccctgggccacaccccgcccgcccggggtgaggag gagctaagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat ggtcactacattttgccccggggtggcaatggtcaccgctacgtgccagccgccggcttg ggcacgagcccagccctgccaggagaagaagcagccggtgcggcagatctggataatcgg ttccgaaaacggactcactctgcgggcacttcgcctaccatttcccaccagaaaaccccg tctcagtcctctgtggcttccattgaggaatataccgaaatgatgcccgcttacccacca ggaggtggcagtggaggccgagtacccagctaccggcactccgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgggggccaccaccgc ccagacacctccagccttcacactgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccggcagccggaaaggcagtggggactacatgcccatgagccccaagagcgtg tctgccccgcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaac ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccagc agcggtggcagcagcagcggtgccgccccttctgggagcagctatggcaagctttggaca aacggggtagggggccaccactctcacgccctgccacaccccaaacttccggtggagagc ggtagtggcaaactcttgtcttgtacaggtgactacatgaacatgtcgcccgtcggggac tccaacaccagcagcccctccgactgctattatggccccgaggacccccagcacaagccc gtcctctcctactactcattgccaaggtcctttaagcacacccagcgtcctggggagctg gaggagccccggcaccaccagcacctccgcctttcctcaagttccggtcgactsctctac actgcggccgcagaagattcctcttcgtccaccagcagcgacagcctgggcgggggatac tgtggggctcggccggagcccggcctcccgcatctccatcatcaggtcctgcaggcccat ctgcctcgaaaggtggacacagctgcccagaccaacaaccgcctggctcggcccacgagg ctgtctctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagccaccg ccccccttgctgctccctccggagcccaagagcccaggggagtatgtgaatattgaattt gggagcgatcagccaggctacttatcgggcccggtggcgtcccacagctcgccttccatc aggtgtccgtcccagctccagccagctcccagagaggaggatacgggcgcagaagagtat atgaacatggacctggggccgggccggagggccacctggcagaagagcgtgggggtccag cccggcagggtgggcccggcgccccctggagctgctagcgtgtgcaggccgactagggca gtgcccagcagctgcggcgactacatgaccatgcagatgggtggtccccggcagagctac gtggacacctcacctgtcgcgcccatcagctacgccgacatgcggacgggcgtcgttgtg gaggatgccagcttgcccrgggccaccgcggccgctccctcctcatcttcgacagcctct gtttcctccactgcgcctcctcsgggaacaggggagctggcggcccgctcggccctcctg gggggcccgagcgccttcacgcgggtgaacctcagtcccaaccgcaaccagagtgccaaa gtgatccgtgccgaccctcaagggtgcaggaggcggcacagctccgagaccttctcctct acrcccagtgccacccgggtgggcaacacgatgcccttcggagctggggctgccgtcggg ggcagcggtggcggcagcagcagcagcgccgaggatgtcaaacgccacagctctgcttcc ttcgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagctggcccaa gtgtgcggggccgctgggggtttggagaatggtcttaactacatagacctggatttggtc aaggacttcaaacagcgccctcaagagtgcccacctcaaccgcagcctcctccactcccg gcccctcatcagcctctggccagtagtcagagcggccccaccagccgctccagcgaggat ctaagcgcctatgccagcatcactttccagaagcagccagaggacctccagtag

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