Balaenoptera musculus (blue whale): 118892655
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Entry
118892655 CDS
T09887
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
bmus
Balaenoptera musculus (blue whale)
Pathway
bmus01521
EGFR tyrosine kinase inhibitor resistance
bmus01522
Endocrine resistance
bmus04010
MAPK signaling pathway
bmus04012
ErbB signaling pathway
bmus04014
Ras signaling pathway
bmus04015
Rap1 signaling pathway
bmus04022
cGMP-PKG signaling pathway
bmus04024
cAMP signaling pathway
bmus04066
HIF-1 signaling pathway
bmus04068
FoxO signaling pathway
bmus04071
Sphingolipid signaling pathway
bmus04072
Phospholipase D signaling pathway
bmus04140
Autophagy - animal
bmus04148
Efferocytosis
bmus04150
mTOR signaling pathway
bmus04151
PI3K-Akt signaling pathway
bmus04210
Apoptosis
bmus04218
Cellular senescence
bmus04270
Vascular smooth muscle contraction
bmus04370
VEGF signaling pathway
bmus04371
Apelin signaling pathway
bmus04540
Gap junction
bmus04550
Signaling pathways regulating pluripotency of stem cells
bmus04613
Neutrophil extracellular trap formation
bmus04620
Toll-like receptor signaling pathway
bmus04650
Natural killer cell mediated cytotoxicity
bmus04660
T cell receptor signaling pathway
bmus04662
B cell receptor signaling pathway
bmus04664
Fc epsilon RI signaling pathway
bmus04720
Long-term potentiation
bmus04722
Neurotrophin signaling pathway
bmus04730
Long-term depression
bmus04810
Regulation of actin cytoskeleton
bmus04910
Insulin signaling pathway
bmus04912
GnRH signaling pathway
bmus04915
Estrogen signaling pathway
bmus04916
Melanogenesis
bmus04917
Prolactin signaling pathway
bmus04919
Thyroid hormone signaling pathway
bmus04921
Oxytocin signaling pathway
bmus04926
Relaxin signaling pathway
bmus04929
GnRH secretion
bmus04934
Cushing syndrome
bmus04935
Growth hormone synthesis, secretion and action
bmus05010
Alzheimer disease
bmus05022
Pathways of neurodegeneration - multiple diseases
bmus05132
Salmonella infection
bmus05135
Yersinia infection
bmus05160
Hepatitis C
bmus05161
Hepatitis B
bmus05163
Human cytomegalovirus infection
bmus05164
Influenza A
bmus05165
Human papillomavirus infection
bmus05166
Human T-cell leukemia virus 1 infection
bmus05167
Kaposi sarcoma-associated herpesvirus infection
bmus05170
Human immunodeficiency virus 1 infection
bmus05200
Pathways in cancer
bmus05205
Proteoglycans in cancer
bmus05206
MicroRNAs in cancer
bmus05207
Chemical carcinogenesis - receptor activation
bmus05208
Chemical carcinogenesis - reactive oxygen species
bmus05210
Colorectal cancer
bmus05211
Renal cell carcinoma
bmus05213
Endometrial cancer
bmus05214
Glioma
bmus05215
Prostate cancer
bmus05216
Thyroid cancer
bmus05218
Melanoma
bmus05219
Bladder cancer
bmus05220
Chronic myeloid leukemia
bmus05221
Acute myeloid leukemia
bmus05223
Non-small cell lung cancer
bmus05224
Breast cancer
bmus05225
Hepatocellular carcinoma
bmus05226
Gastric cancer
bmus05230
Central carbon metabolism in cancer
bmus05231
Choline metabolism in cancer
bmus05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
bmus00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
118892655 (MAP2K2)
04012 ErbB signaling pathway
118892655 (MAP2K2)
04014 Ras signaling pathway
118892655 (MAP2K2)
04015 Rap1 signaling pathway
118892655 (MAP2K2)
04370 VEGF signaling pathway
118892655 (MAP2K2)
04371 Apelin signaling pathway
118892655 (MAP2K2)
04066 HIF-1 signaling pathway
118892655 (MAP2K2)
04068 FoxO signaling pathway
118892655 (MAP2K2)
04072 Phospholipase D signaling pathway
118892655 (MAP2K2)
04071 Sphingolipid signaling pathway
118892655 (MAP2K2)
04024 cAMP signaling pathway
118892655 (MAP2K2)
04022 cGMP-PKG signaling pathway
118892655 (MAP2K2)
04151 PI3K-Akt signaling pathway
118892655 (MAP2K2)
04150 mTOR signaling pathway
118892655 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
118892655 (MAP2K2)
04148 Efferocytosis
118892655 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
118892655 (MAP2K2)
04218 Cellular senescence
118892655 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
118892655 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
118892655 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
118892655 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
118892655 (MAP2K2)
04620 Toll-like receptor signaling pathway
118892655 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
118892655 (MAP2K2)
04660 T cell receptor signaling pathway
118892655 (MAP2K2)
04662 B cell receptor signaling pathway
118892655 (MAP2K2)
04664 Fc epsilon RI signaling pathway
118892655 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
118892655 (MAP2K2)
04929 GnRH secretion
118892655 (MAP2K2)
04912 GnRH signaling pathway
118892655 (MAP2K2)
04915 Estrogen signaling pathway
118892655 (MAP2K2)
04917 Prolactin signaling pathway
118892655 (MAP2K2)
04921 Oxytocin signaling pathway
118892655 (MAP2K2)
04926 Relaxin signaling pathway
118892655 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
118892655 (MAP2K2)
04919 Thyroid hormone signaling pathway
118892655 (MAP2K2)
04916 Melanogenesis
118892655 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
118892655 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
118892655 (MAP2K2)
04730 Long-term depression
118892655 (MAP2K2)
04722 Neurotrophin signaling pathway
118892655 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
118892655 (MAP2K2)
05206 MicroRNAs in cancer
118892655 (MAP2K2)
05205 Proteoglycans in cancer
118892655 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
118892655 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
118892655 (MAP2K2)
05230 Central carbon metabolism in cancer
118892655 (MAP2K2)
05231 Choline metabolism in cancer
118892655 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
118892655 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
118892655 (MAP2K2)
05225 Hepatocellular carcinoma
118892655 (MAP2K2)
05226 Gastric cancer
118892655 (MAP2K2)
05214 Glioma
118892655 (MAP2K2)
05216 Thyroid cancer
118892655 (MAP2K2)
05221 Acute myeloid leukemia
118892655 (MAP2K2)
05220 Chronic myeloid leukemia
118892655 (MAP2K2)
05218 Melanoma
118892655 (MAP2K2)
05211 Renal cell carcinoma
118892655 (MAP2K2)
05219 Bladder cancer
118892655 (MAP2K2)
05215 Prostate cancer
118892655 (MAP2K2)
05213 Endometrial cancer
118892655 (MAP2K2)
05224 Breast cancer
118892655 (MAP2K2)
05223 Non-small cell lung cancer
118892655 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
118892655 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
118892655 (MAP2K2)
05161 Hepatitis B
118892655 (MAP2K2)
05160 Hepatitis C
118892655 (MAP2K2)
05164 Influenza A
118892655 (MAP2K2)
05163 Human cytomegalovirus infection
118892655 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
118892655 (MAP2K2)
05165 Human papillomavirus infection
118892655 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
118892655 (MAP2K2)
05135 Yersinia infection
118892655 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
118892655 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
118892655 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
118892655 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
118892655 (MAP2K2)
01522 Endocrine resistance
118892655 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bmus01001
]
118892655 (MAP2K2)
Enzymes [BR:
bmus01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
118892655 (MAP2K2)
Protein kinases [BR:
bmus01001
]
Serine/threonine kinases: STE group
STE7 family
118892655 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
CAMSAP_CC1
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
118892655
NCBI-ProteinID:
XP_036703289
UniProt:
A0A8B8X155
LinkDB
All DBs
Position
3:168171860..168195869
Genome browser
AA seq
458 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMSSVVPDQMFSPRRLCPRGSLGHIWGRLWLSHLGGLLASSGSGQGFCFTPRSARDAP
QRNHAFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq
1377 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctgcagaagaag
ctagaggagctagaacttgatgagcagcagaagaagcggctggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgactttgaaaggatctcggagctgggagcc
gggaacggtggggtggtcaccaaggtccagcacagaccctcgggcctcatcatggcaaga
aagctgatccacctggagatcaagccagccatccggaaccagatcatccgtgagctgcag
gtgctgcatgagtgtaactccccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggtggctccctggaccaggtgttgaaa
gaagccaagagaatccccgaagagatcctggggaaggtcagcatcgcggttctgcggggc
ctggcgtatctccgggagaagcaccagatcatgcaccgagatgtgaagccatccaacatc
cttgtcaactcccgaggggagatcaagctgtgcgactttggggtgagcgggcagctcatc
gactccatggccaactccttcgtggggacgcggtcctacatgtctccggagcggctgcaa
ggcactcactactcggtgcagtcagacatctggagcatgggcctgtccctggtagagctg
tccattggaaggtaccccatccccccgccggacgccaaggagctggaggccatatttggc
cggcccatggtcgacggcgcggaaggagagcctcacagcatctcgccgcggccgagaccc
cccggacgccccatcagcggtcatgggatggacagccggccggccatggcaatctttgag
ctgctggactacatcgtgaacgagcctcctcccaagctgcccaacggcgtcttcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagcagagcgagcagatctg
aagatgctcatgagttccgtggttccagatcagatgttctcacccaggcgactctgcccc
cgtggatccctgggccacatctggggacgtctgtggttgtcacacctggggggactcctg
gcgtcgagcgggtcggggcagggattctgcttcacaccccgcagtgcccgggacgcccca
cagaggaaccacgccttcatcaagcggtccgaggtggaagaagtggattttgccggctgg
ttgtgtaaaacgctgcggctgaaccagcccagcacgcccacgcgcaccgccgtctga
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integrated database retrieval system