KEGG   Bos mutus (wild yak): 102280296
Entry
102280296         CDS       T02919                                 
Symbol
PIK3R3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
bom  Bos mutus (wild yak)
Pathway
bom01521  EGFR tyrosine kinase inhibitor resistance
bom01522  Endocrine resistance
bom01524  Platinum drug resistance
bom04012  ErbB signaling pathway
bom04014  Ras signaling pathway
bom04015  Rap1 signaling pathway
bom04024  cAMP signaling pathway
bom04062  Chemokine signaling pathway
bom04066  HIF-1 signaling pathway
bom04068  FoxO signaling pathway
bom04070  Phosphatidylinositol signaling system
bom04071  Sphingolipid signaling pathway
bom04072  Phospholipase D signaling pathway
bom04081  Hormone signaling
bom04140  Autophagy - animal
bom04150  mTOR signaling pathway
bom04151  PI3K-Akt signaling pathway
bom04152  AMPK signaling pathway
bom04210  Apoptosis
bom04211  Longevity regulating pathway
bom04213  Longevity regulating pathway - multiple species
bom04218  Cellular senescence
bom04360  Axon guidance
bom04370  VEGF signaling pathway
bom04380  Osteoclast differentiation
bom04510  Focal adhesion
bom04550  Signaling pathways regulating pluripotency of stem cells
bom04611  Platelet activation
bom04613  Neutrophil extracellular trap formation
bom04620  Toll-like receptor signaling pathway
bom04625  C-type lectin receptor signaling pathway
bom04630  JAK-STAT signaling pathway
bom04650  Natural killer cell mediated cytotoxicity
bom04660  T cell receptor signaling pathway
bom04662  B cell receptor signaling pathway
bom04664  Fc epsilon RI signaling pathway
bom04666  Fc gamma R-mediated phagocytosis
bom04668  TNF signaling pathway
bom04670  Leukocyte transendothelial migration
bom04722  Neurotrophin signaling pathway
bom04725  Cholinergic synapse
bom04750  Inflammatory mediator regulation of TRP channels
bom04810  Regulation of actin cytoskeleton
bom04910  Insulin signaling pathway
bom04914  Progesterone-mediated oocyte maturation
bom04915  Estrogen signaling pathway
bom04917  Prolactin signaling pathway
bom04919  Thyroid hormone signaling pathway
bom04923  Regulation of lipolysis in adipocytes
bom04926  Relaxin signaling pathway
bom04929  GnRH secretion
bom04930  Type II diabetes mellitus
bom04931  Insulin resistance
bom04932  Non-alcoholic fatty liver disease
bom04933  AGE-RAGE signaling pathway in diabetic complications
bom04935  Growth hormone synthesis, secretion and action
bom04960  Aldosterone-regulated sodium reabsorption
bom04973  Carbohydrate digestion and absorption
bom05010  Alzheimer disease
bom05017  Spinocerebellar ataxia
bom05020  Prion disease
bom05100  Bacterial invasion of epithelial cells
bom05135  Yersinia infection
bom05142  Chagas disease
bom05146  Amoebiasis
bom05160  Hepatitis C
bom05161  Hepatitis B
bom05162  Measles
bom05163  Human cytomegalovirus infection
bom05164  Influenza A
bom05165  Human papillomavirus infection
bom05166  Human T-cell leukemia virus 1 infection
bom05167  Kaposi sarcoma-associated herpesvirus infection
bom05168  Herpes simplex virus 1 infection
bom05169  Epstein-Barr virus infection
bom05170  Human immunodeficiency virus 1 infection
bom05171  Coronavirus disease - COVID-19
bom05200  Pathways in cancer
bom05203  Viral carcinogenesis
bom05205  Proteoglycans in cancer
bom05206  MicroRNAs in cancer
bom05207  Chemical carcinogenesis - receptor activation
bom05208  Chemical carcinogenesis - reactive oxygen species
bom05210  Colorectal cancer
bom05211  Renal cell carcinoma
bom05212  Pancreatic cancer
bom05213  Endometrial cancer
bom05214  Glioma
bom05215  Prostate cancer
bom05218  Melanoma
bom05220  Chronic myeloid leukemia
bom05221  Acute myeloid leukemia
bom05222  Small cell lung cancer
bom05223  Non-small cell lung cancer
bom05224  Breast cancer
bom05225  Hepatocellular carcinoma
bom05226  Gastric cancer
bom05230  Central carbon metabolism in cancer
bom05231  Choline metabolism in cancer
bom05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bom05415  Diabetic cardiomyopathy
bom05417  Lipid and atherosclerosis
bom05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bom00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102280296 (PIK3R3)
   04014 Ras signaling pathway
    102280296 (PIK3R3)
   04015 Rap1 signaling pathway
    102280296 (PIK3R3)
   04370 VEGF signaling pathway
    102280296 (PIK3R3)
   04630 JAK-STAT signaling pathway
    102280296 (PIK3R3)
   04668 TNF signaling pathway
    102280296 (PIK3R3)
   04066 HIF-1 signaling pathway
    102280296 (PIK3R3)
   04068 FoxO signaling pathway
    102280296 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    102280296 (PIK3R3)
   04072 Phospholipase D signaling pathway
    102280296 (PIK3R3)
   04071 Sphingolipid signaling pathway
    102280296 (PIK3R3)
   04024 cAMP signaling pathway
    102280296 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    102280296 (PIK3R3)
   04152 AMPK signaling pathway
    102280296 (PIK3R3)
   04150 mTOR signaling pathway
    102280296 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102280296 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102280296 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    102280296 (PIK3R3)
   04218 Cellular senescence
    102280296 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102280296 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    102280296 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102280296 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102280296 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    102280296 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    102280296 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    102280296 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    102280296 (PIK3R3)
   04660 T cell receptor signaling pathway
    102280296 (PIK3R3)
   04662 B cell receptor signaling pathway
    102280296 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    102280296 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    102280296 (PIK3R3)
   04670 Leukocyte transendothelial migration
    102280296 (PIK3R3)
   04062 Chemokine signaling pathway
    102280296 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102280296 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    102280296 (PIK3R3)
   04929 GnRH secretion
    102280296 (PIK3R3)
   04915 Estrogen signaling pathway
    102280296 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    102280296 (PIK3R3)
   04917 Prolactin signaling pathway
    102280296 (PIK3R3)
   04926 Relaxin signaling pathway
    102280296 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    102280296 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    102280296 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102280296 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102280296 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    102280296 (PIK3R3)
   04722 Neurotrophin signaling pathway
    102280296 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102280296 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    102280296 (PIK3R3)
   04380 Osteoclast differentiation
    102280296 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    102280296 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    102280296 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102280296 (PIK3R3)
   05206 MicroRNAs in cancer
    102280296 (PIK3R3)
   05205 Proteoglycans in cancer
    102280296 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    102280296 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    102280296 (PIK3R3)
   05203 Viral carcinogenesis
    102280296 (PIK3R3)
   05230 Central carbon metabolism in cancer
    102280296 (PIK3R3)
   05231 Choline metabolism in cancer
    102280296 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102280296 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102280296 (PIK3R3)
   05212 Pancreatic cancer
    102280296 (PIK3R3)
   05225 Hepatocellular carcinoma
    102280296 (PIK3R3)
   05226 Gastric cancer
    102280296 (PIK3R3)
   05214 Glioma
    102280296 (PIK3R3)
   05221 Acute myeloid leukemia
    102280296 (PIK3R3)
   05220 Chronic myeloid leukemia
    102280296 (PIK3R3)
   05218 Melanoma
    102280296 (PIK3R3)
   05211 Renal cell carcinoma
    102280296 (PIK3R3)
   05215 Prostate cancer
    102280296 (PIK3R3)
   05213 Endometrial cancer
    102280296 (PIK3R3)
   05224 Breast cancer
    102280296 (PIK3R3)
   05222 Small cell lung cancer
    102280296 (PIK3R3)
   05223 Non-small cell lung cancer
    102280296 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102280296 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    102280296 (PIK3R3)
   05161 Hepatitis B
    102280296 (PIK3R3)
   05160 Hepatitis C
    102280296 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    102280296 (PIK3R3)
   05164 Influenza A
    102280296 (PIK3R3)
   05162 Measles
    102280296 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    102280296 (PIK3R3)
   05163 Human cytomegalovirus infection
    102280296 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102280296 (PIK3R3)
   05169 Epstein-Barr virus infection
    102280296 (PIK3R3)
   05165 Human papillomavirus infection
    102280296 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102280296 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    102280296 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102280296 (PIK3R3)
   05142 Chagas disease
    102280296 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102280296 (PIK3R3)
   05017 Spinocerebellar ataxia
    102280296 (PIK3R3)
   05020 Prion disease
    102280296 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102280296 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    102280296 (PIK3R3)
   05415 Diabetic cardiomyopathy
    102280296 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102280296 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    102280296 (PIK3R3)
   04931 Insulin resistance
    102280296 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102280296 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102280296 (PIK3R3)
   01524 Platinum drug resistance
    102280296 (PIK3R3)
   01522 Endocrine resistance
    102280296 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bom04131]
    102280296 (PIK3R3)
Membrane trafficking [BR:bom04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102280296 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Cupin_8 Exonuc_VII_L
Other DBs
NCBI-GeneID: 102280296
NCBI-ProteinID: XP_005894275
UniProt: L8IQQ2
LinkDB
Position
3:97825479..97931318
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAITNGIKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELISHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRKEGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYGSLKELVLHYQRTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagccattacaaatggaataaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggtaaatgacaaattgcgg
gacatgccagatggtaccttcttggtcagagatgcctcaaccaaaatgcagggagattac
actttgaccttgcggaagggaggcaataataagctaataaagatttatcatcgagatggt
aaatatggcttttctgatcctctgacatttaattctgtggtggagctcattagccactat
catcatgaatctcttgcccagtacaatcccaaacttgatgtgaaactgatgtacccagtg
tccagataccaacaggatcagttggtaaaagaagataatattgatgctgtcggtaaaaaa
ctgcaggagtatcactctcagtatcaggaaaagagtaaagaatatgacagactatatgaa
gaatataccagaacatcccaggaaatacagatgaagaggactgcaattgaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcatacacaagaacaacatagcaaagaatat
attgagcgatttcgaaaagaagggaatgaaaaggaaattgaacgaattatgatgaattat
gacaagctgaaatcacgtctgggtgagattcatgatagcaaaatgcgtcttgaacaggat
ttgaagaaacaagctttggataaccgagaaatagataaaaaaatgaatagtatcaaacct
gacctgatccagctgcgcaagatccgagatcagcaccttgtgtggctcaatcacaaagga
gtgagacagaagcgcctaaatgcctggctgggaatcaagaatgaggatgctgatgagacc
tattttatcaatgaggaagatgaaaacctgccccattatgatgagaaaacctggtttgtt
gaggatatcaaccgagtacaagcagaggacttgctctatgggaaacctgacggtgcattc
ttaatccgtgagagtagcaagaaaggatgttatgcttgctctgtggtcgccgatggggag
gtgaagcactgcgtcatctacagcaccgctcggggctacggcttcgcggagccctacaac
ctgtacggctccctgaaggagctggtgctccactaccagcggacgtccctcgtgcagcac
aacgactctctcaacgtcaggctcgcctaccctgtccacgcacagatgccctcgctctgc
agataa

DBGET integrated database retrieval system