Bos mutus (wild yak): 102284664 Help Entry 102284664         CDS       T02919                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism bom  Bos mutus (wild yak) Pathway bom04022   cGMP-PKG signaling pathway bom04068   FoxO signaling pathway bom04081   Hormone signaling bom04140   Autophagy - animal bom04150   mTOR signaling pathway bom04151   PI3K-Akt signaling pathway bom04152   AMPK signaling pathway bom04211   Longevity regulating pathway bom04213   Longevity regulating pathway - multiple species bom04722   Neurotrophin signaling pathway bom04910   Insulin signaling pathway bom04920   Adipocytokine signaling pathway bom04923   Regulation of lipolysis in adipocytes bom04930   Type II diabetes mellitus bom04931   Insulin resistance bom04932   Non-alcoholic fatty liver disease bom04935   Growth hormone synthesis, secretion and action bom04960   Aldosterone-regulated sodium reabsorption bom05010   Alzheimer disease bom05206   MicroRNAs in cancer bom05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     102284664 (IRS1)    04022 cGMP-PKG signaling pathway     102284664 (IRS1)    04151 PI3K-Akt signaling pathway     102284664 (IRS1)    04152 AMPK signaling pathway     102284664 (IRS1)    04150 mTOR signaling pathway     102284664 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     102284664 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102284664 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     102284664 (IRS1)    04923 Regulation of lipolysis in adipocytes     102284664 (IRS1)    04920 Adipocytokine signaling pathway     102284664 (IRS1)    04935 Growth hormone synthesis, secretion and action     102284664 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102284664 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     102284664 (IRS1)   09149 Aging    04211 Longevity regulating pathway     102284664 (IRS1)    04213 Longevity regulating pathway - multiple species     102284664 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     102284664 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     102284664 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102284664 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102284664 (IRS1)    04932 Non-alcoholic fatty liver disease     102284664 (IRS1)    04931 Insulin resistance     102284664 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  102284664 NCBI-ProteinID:  XP_070241890 LinkDB All DBs Position 2:20879923..20952418 Genome browser AA seq 1237 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN GHYILPRGGNGHRYVPAAGLGTSPALPGEEAAGAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDTSSLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSGGSSSGAAPSGSSYGKLWTNGVGGHHSHALPHPKLPVES GSGKLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEL EEPRHHQHLRLSSSSGRLLYTAAAEDSSSSTSSDSLGGGYCGARPEPGLPHLHHQVLQAH LPRKVDTAAQTNNRLARPTRLSLGDPKASTLPRAREQQPPPPLLLPPEPKSPGEYVNIEF GSDQPGYLSGPVASHSSPSIRCPSQLQPAPREEDTGAEEYMNMDLGPGRRATWQKSVGVQ PGRVGPAPPGAASVCRPTRAVPSSCGDYMTMQMGGPRQSYVDTSPVAPISYADMRTGVVV EDASLPGATAAAPSSSSTASVSSTAPPPGTGELAARSALLGGPSAFTRVNLSPNRNQSAK VIRADPQGCRRRHSSETFSSTPSATRVGNTMPFGAGAAVGGSGGGSSSSAEDVKRHSSAS FENVWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFKQRPQECPPQPQPPPLP APHQPLASSQSGPTSRSSEDLSAYASITFQKQPEDLQ NT seq 3714 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagactgacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgattcttcgtgctgcgggcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcagacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac cacgacggggccgcggcgcctggggcgggaggcggcgggggcagctgcagtggcagctcc ggcctcggagaggcgggtgaggacttgagctacggggacgtgcccccaggacccgccttc aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactcagagaacttc ttcttcatcgaagtgggccgttccgcagtgacgggccccggggagttctggatgcaggtg gacgactccgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg agcgatgagttccgccctagaagcaagagccagtcctcctccaactgctccaaccccatc agtgtgcccctgcggaggcaccacctcaacaaccctccacccagccaggtggggctgacc cgccgctcgcgcaccgagagcatcacagccacctccccggccagcttggtgggcgggaag cagggctccttccgcgtgcgtgcctccagtgatggcgaaggcaccatgtctcgccccgcc tcagtggacggcagtcctgtgagtcctagcaccaacaggacccacgcccaccgccatcga ggcagctcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcttct cgctgctcgccttccgccaccagccccgtcagtctgtcgtccagcagcacgagtggccat ggctccacctcagactgcctcttcccgcggcggtctagtgcttctgtgtctggttccccc agtgatggcggcttcatctcctccgatgagtatggctccagtccctgcgatttccgaagt tccttccgcagcgtcaccccagattccctgggccacaccccgcccgcccggggtgaggag gagctaagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat ggtcactacattttgccccggggtggcaatggtcaccgctacgtgccagccgccggcttg ggcacgagcccagccctgccaggagaagaagcagccggtgcggcagatctggataatcgg ttccgaaaacggactcactctgcgggcacctcgcctaccatttcccaccagaaaaccccg tctcagtcctctgtggcttccattgaggaatataccgaaatgatgcccgcttacccacca ggaggtggcagtggaggccgagtacccagctaccggcactccgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgggggccaccaccgc ccagacacctccagccttcacactgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccggcagccggaaaggcagtggggactacatgcccatgagccccaagagcgtg tctgccccgcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaac ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccagc agcggtggcagcagcagcggtgccgccccttctgggagcagctatggcaagctttggaca aacggggtagggggccaccactctcacgccctgccacaccccaaacttccggtggagagc ggtagtggcaaactcttgtcttgtacaggtgactacatgaacatgtcgcccgtcggggac tccaacaccagcagcccctccgactgctattatggccccgaggacccccagcacaagccc gtcctctcctactactcattgccaaggtcctttaagcacacccagcgtcctggggagctg gaggagccccggcaccaccagcacctccgcctttcctcaagttccggtcgactcctctac actgcggccgcagaagattcctcttcgtccaccagcagcgacagcctgggcgggggatac tgtggggctcggccggagcccggcctcccgcatctccatcatcaggtcctgcaggcccat ctgcctcgaaaggtggacacagctgcccagaccaacaaccgcctggctcggcccacgagg ctgtctctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagccaccg ccccccttgctgctccctccggagcccaagagcccaggggagtatgtgaatattgaattt gggagcgatcagccaggctacttatcgggcccggtggcgtcccacagctcgccttccatc aggtgtccgtcccagctccagccagctcccagagaggaggatacgggcgcagaagagtat atgaacatggacctggggccgggccggagggccacctggcagaagagcgtgggggtccag cccggcagggtgggcccggcgccccctggagctgctagcgtgtgcaggccgactagggca gtgcccagcagctgcggcgactacatgaccatgcagatgggtggtccccggcagagctac gtggacacctcacctgtcgcgcccatcagctacgccgacatgcggacgggcgtcgttgtg gaggatgccagcttgcccggggccaccgcggccgctccctcctcatcttcgacagcctct gtttcctccactgcgcctcctccgggaacaggggagctggcggcccgctcggccctcctg gggggcccgagcgccttcacgcgggtgaacctcagtcccaaccgcaaccagagtgccaaa gtgatccgtgccgaccctcaagggtgcaggaggcggcacagctccgagaccttctcctct acgcccagtgccacccgggtgggcaacacgatgcccttcggagctggggctgccgtcggg ggcagcggtggcggcagcagcagcagcgccgaggatgtcaaacgccacagctctgcttcc ttcgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagctggcccaa gtgtgcggggccgctgggggtttggagaatggtcttaactacatagacctggatttggtc aaggacttcaaacagcgccctcaagagtgcccacctcaaccgcagcctcctccactcccg gcccctcatcagcctctggccagtagtcagagcggccccaccagccgctccagcgaggat ctaagcgcctatgccagcatcactttccagaagcagccagaggacctccagtag

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