KEGG   Bos mutus (wild yak): 102286868
Entry
102286868         CDS       T02919                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
bom  Bos mutus (wild yak)
Pathway
bom01521  EGFR tyrosine kinase inhibitor resistance
bom01522  Endocrine resistance
bom01524  Platinum drug resistance
bom04012  ErbB signaling pathway
bom04014  Ras signaling pathway
bom04015  Rap1 signaling pathway
bom04024  cAMP signaling pathway
bom04062  Chemokine signaling pathway
bom04066  HIF-1 signaling pathway
bom04068  FoxO signaling pathway
bom04070  Phosphatidylinositol signaling system
bom04071  Sphingolipid signaling pathway
bom04072  Phospholipase D signaling pathway
bom04081  Hormone signaling
bom04140  Autophagy - animal
bom04150  mTOR signaling pathway
bom04151  PI3K-Akt signaling pathway
bom04152  AMPK signaling pathway
bom04210  Apoptosis
bom04211  Longevity regulating pathway
bom04213  Longevity regulating pathway - multiple species
bom04218  Cellular senescence
bom04360  Axon guidance
bom04370  VEGF signaling pathway
bom04380  Osteoclast differentiation
bom04510  Focal adhesion
bom04550  Signaling pathways regulating pluripotency of stem cells
bom04611  Platelet activation
bom04613  Neutrophil extracellular trap formation
bom04620  Toll-like receptor signaling pathway
bom04625  C-type lectin receptor signaling pathway
bom04630  JAK-STAT signaling pathway
bom04650  Natural killer cell mediated cytotoxicity
bom04660  T cell receptor signaling pathway
bom04662  B cell receptor signaling pathway
bom04664  Fc epsilon RI signaling pathway
bom04666  Fc gamma R-mediated phagocytosis
bom04668  TNF signaling pathway
bom04670  Leukocyte transendothelial migration
bom04722  Neurotrophin signaling pathway
bom04725  Cholinergic synapse
bom04750  Inflammatory mediator regulation of TRP channels
bom04810  Regulation of actin cytoskeleton
bom04910  Insulin signaling pathway
bom04914  Progesterone-mediated oocyte maturation
bom04915  Estrogen signaling pathway
bom04917  Prolactin signaling pathway
bom04919  Thyroid hormone signaling pathway
bom04923  Regulation of lipolysis in adipocytes
bom04926  Relaxin signaling pathway
bom04929  GnRH secretion
bom04930  Type II diabetes mellitus
bom04931  Insulin resistance
bom04932  Non-alcoholic fatty liver disease
bom04933  AGE-RAGE signaling pathway in diabetic complications
bom04935  Growth hormone synthesis, secretion and action
bom04960  Aldosterone-regulated sodium reabsorption
bom04973  Carbohydrate digestion and absorption
bom05010  Alzheimer disease
bom05017  Spinocerebellar ataxia
bom05020  Prion disease
bom05100  Bacterial invasion of epithelial cells
bom05135  Yersinia infection
bom05142  Chagas disease
bom05146  Amoebiasis
bom05160  Hepatitis C
bom05161  Hepatitis B
bom05162  Measles
bom05163  Human cytomegalovirus infection
bom05164  Influenza A
bom05165  Human papillomavirus infection
bom05166  Human T-cell leukemia virus 1 infection
bom05167  Kaposi sarcoma-associated herpesvirus infection
bom05168  Herpes simplex virus 1 infection
bom05169  Epstein-Barr virus infection
bom05170  Human immunodeficiency virus 1 infection
bom05171  Coronavirus disease - COVID-19
bom05200  Pathways in cancer
bom05203  Viral carcinogenesis
bom05205  Proteoglycans in cancer
bom05206  MicroRNAs in cancer
bom05207  Chemical carcinogenesis - receptor activation
bom05208  Chemical carcinogenesis - reactive oxygen species
bom05210  Colorectal cancer
bom05211  Renal cell carcinoma
bom05212  Pancreatic cancer
bom05213  Endometrial cancer
bom05214  Glioma
bom05215  Prostate cancer
bom05218  Melanoma
bom05220  Chronic myeloid leukemia
bom05221  Acute myeloid leukemia
bom05222  Small cell lung cancer
bom05223  Non-small cell lung cancer
bom05224  Breast cancer
bom05225  Hepatocellular carcinoma
bom05226  Gastric cancer
bom05230  Central carbon metabolism in cancer
bom05231  Choline metabolism in cancer
bom05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bom05415  Diabetic cardiomyopathy
bom05417  Lipid and atherosclerosis
bom05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bom00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102286868 (PIK3R2)
   04014 Ras signaling pathway
    102286868 (PIK3R2)
   04015 Rap1 signaling pathway
    102286868 (PIK3R2)
   04370 VEGF signaling pathway
    102286868 (PIK3R2)
   04630 JAK-STAT signaling pathway
    102286868 (PIK3R2)
   04668 TNF signaling pathway
    102286868 (PIK3R2)
   04066 HIF-1 signaling pathway
    102286868 (PIK3R2)
   04068 FoxO signaling pathway
    102286868 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    102286868 (PIK3R2)
   04072 Phospholipase D signaling pathway
    102286868 (PIK3R2)
   04071 Sphingolipid signaling pathway
    102286868 (PIK3R2)
   04024 cAMP signaling pathway
    102286868 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    102286868 (PIK3R2)
   04152 AMPK signaling pathway
    102286868 (PIK3R2)
   04150 mTOR signaling pathway
    102286868 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102286868 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102286868 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    102286868 (PIK3R2)
   04218 Cellular senescence
    102286868 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102286868 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102286868 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102286868 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102286868 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    102286868 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    102286868 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    102286868 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    102286868 (PIK3R2)
   04660 T cell receptor signaling pathway
    102286868 (PIK3R2)
   04662 B cell receptor signaling pathway
    102286868 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    102286868 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    102286868 (PIK3R2)
   04670 Leukocyte transendothelial migration
    102286868 (PIK3R2)
   04062 Chemokine signaling pathway
    102286868 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102286868 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    102286868 (PIK3R2)
   04929 GnRH secretion
    102286868 (PIK3R2)
   04915 Estrogen signaling pathway
    102286868 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    102286868 (PIK3R2)
   04917 Prolactin signaling pathway
    102286868 (PIK3R2)
   04926 Relaxin signaling pathway
    102286868 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    102286868 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    102286868 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102286868 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102286868 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    102286868 (PIK3R2)
   04722 Neurotrophin signaling pathway
    102286868 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102286868 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    102286868 (PIK3R2)
   04380 Osteoclast differentiation
    102286868 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    102286868 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    102286868 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102286868 (PIK3R2)
   05206 MicroRNAs in cancer
    102286868 (PIK3R2)
   05205 Proteoglycans in cancer
    102286868 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    102286868 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    102286868 (PIK3R2)
   05203 Viral carcinogenesis
    102286868 (PIK3R2)
   05230 Central carbon metabolism in cancer
    102286868 (PIK3R2)
   05231 Choline metabolism in cancer
    102286868 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102286868 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102286868 (PIK3R2)
   05212 Pancreatic cancer
    102286868 (PIK3R2)
   05225 Hepatocellular carcinoma
    102286868 (PIK3R2)
   05226 Gastric cancer
    102286868 (PIK3R2)
   05214 Glioma
    102286868 (PIK3R2)
   05221 Acute myeloid leukemia
    102286868 (PIK3R2)
   05220 Chronic myeloid leukemia
    102286868 (PIK3R2)
   05218 Melanoma
    102286868 (PIK3R2)
   05211 Renal cell carcinoma
    102286868 (PIK3R2)
   05215 Prostate cancer
    102286868 (PIK3R2)
   05213 Endometrial cancer
    102286868 (PIK3R2)
   05224 Breast cancer
    102286868 (PIK3R2)
   05222 Small cell lung cancer
    102286868 (PIK3R2)
   05223 Non-small cell lung cancer
    102286868 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102286868 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    102286868 (PIK3R2)
   05161 Hepatitis B
    102286868 (PIK3R2)
   05160 Hepatitis C
    102286868 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    102286868 (PIK3R2)
   05164 Influenza A
    102286868 (PIK3R2)
   05162 Measles
    102286868 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    102286868 (PIK3R2)
   05163 Human cytomegalovirus infection
    102286868 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102286868 (PIK3R2)
   05169 Epstein-Barr virus infection
    102286868 (PIK3R2)
   05165 Human papillomavirus infection
    102286868 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102286868 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    102286868 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102286868 (PIK3R2)
   05142 Chagas disease
    102286868 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102286868 (PIK3R2)
   05017 Spinocerebellar ataxia
    102286868 (PIK3R2)
   05020 Prion disease
    102286868 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102286868 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    102286868 (PIK3R2)
   05415 Diabetic cardiomyopathy
    102286868 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102286868 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    102286868 (PIK3R2)
   04931 Insulin resistance
    102286868 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102286868 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102286868 (PIK3R2)
   01524 Platinum drug resistance
    102286868 (PIK3R2)
   01522 Endocrine resistance
    102286868 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bom04131]
    102286868 (PIK3R2)
Membrane trafficking [BR:bom04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102286868 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9 ATG11
Other DBs
NCBI-GeneID: 102286868
NCBI-ProteinID: XP_070229418
LinkDB
Position
7:46325214..46337919
AA seq 724 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPESGLTLPDLPEQFSP
PDVAPPILVKLVEAIERTGLDSYRPEPPAVRTDWSLSDVEQWDAAALSDGVKGFLLALPA
PLVTPEAAAEAHRALREAAGPVGPALEPPTLPLHHALTLRFLLQHLGRVAGRAPAPGPAV
RALGATFGPLLLRAPPPPSPPPGGAPDGTEPTPDFPALLVEKLLQEHLEEQEVAPPALPP
KPPKTKPAPTGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGE
YTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYP
VSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAF
NETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQ
ELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQ
YSLMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGD
TKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPP
PAAR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atggctggccctgagggcttccaataccgtgcattgtacccattccgccgggagcggccg
gaggacctggagctgcttccgggtgatgtgctggtggtgagcagggccgccctgcaggcg
ctgggcgtggccgagggcaacgagcgctgcccgcagagcgtaggctggatgcctggcctc
aatgagcgtacccggcagcgcggcgacttccctggcacctatgtggagttcctggggccc
gtggccctggcccggcctggccctcgcccacgtggcccccgcccactgcccgccaggccc
cgagacgggccccctgagtcaggccttacactccctgacctacccgagcagttctccccc
cctgatgtggctccccctatcctggtgaagctggtggaggccattgaacggacagggctg
gacagctacaggcctgagccacctgccgtgcgcacagactggtccctgagtgatgtggag
cagtgggatgcggcagccctgtcagatggtgtgaaaggcttcctgctggcgctgccagcg
cccctcgtgacacccgaggctgcggccgaggcacaccgagccctgcgggaggctgcgggg
cccgtggggccggccttggagcccccgacgctgccactgcaccatgcgctcacgctgcgc
ttcctgctccagcacctgggccgggtggccgggcgcgccccagccccgggccccgcggtc
cgtgccctgggcgccaccttcgggccgctactgctacgcgcgccgccgccgccctctccg
ccgccagggggcgcacccgacgggaccgagcccactcctgactttccggcgctgctggtg
gagaagctgcttcaggaacatctggaggagcaggaggttgcccccccagcactgccacca
aaaccccccaagacaaagccagcccccacaggcctggccaatgggggcagcccaccctcc
ctgcaggacgccgagtggtactggggtgacatctccagggaggaggtaaacgagaaactt
cgggacacgcccgatggcaccttcctggtccgagatgcctccagcaagatccagggagag
tacacgctgaccctcaggaagggcggaaacaacaagctgatcaaggtcttccaccgagat
gggcactatggcttctcggagccgctcaccttctgctctgtcgtggacctcatcacccac
taccgccatgagtcactggcccagtacaacgccaagctggacacgcggctcctctacccg
gtgtccaagtaccaacaggaccagatcgtcaaggaggacagcgtggaggcggtgggtgcc
cagctcaaggtctaccaccagcagtaccaggacaagagccgcgagtacgaccagctctac
gaggagtacacacgcacctcccaggaactgcagatgaagcgcacagccatcgaagccttc
aatgagaccatcaagatctttgaagagcagggccagacgcaggagaagtgcagcaaggaa
tatctggagcgcttccgacgtgagggcaatgagaaagaaatgcagaggatcctgctaaac
tcggagcggctcaagtctcgcattgccgagatccacgagagccgcacaaagctggagcag
gagctgcgggcacaggcctctgacaaccgagagatcgacaagcgcatgaacagcctcaag
ccagacctcatgcagttgcgcaagatccgagaccagtaccttgtgtggctcactcagaag
ggtgcccggcagaagaaaatcaacgaatggttggggatcaagaacgagactgaggaccag
tactcactgatggaggatgaggatgacctcccccaccacgaggaacgcacctggtatgta
ggcaagatcaaccgcacccaagctgaggaaatgctgagtggcaagcgggacggtaccttc
ctcatccgtgagagcagccagcggggttgctacgcctgttctgtggtggtggacggggac
accaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcggagccctacaac
ctgtacgggtccctgaaggagctcgtcctccactaccagcacgcctcgctggtgcagcac
aacgacgcgctgaccgtcacgctcgcccaccccgtgcgcgcccccggccctgggcccccg
ccggctgcgcgctga

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