Bos mutus (wild yak): 138990232 Help Entry 138990232         CDS       T02919                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism bom  Bos mutus (wild yak) Pathway bom04022   cGMP-PKG signaling pathway bom04068   FoxO signaling pathway bom04081   Hormone signaling bom04140   Autophagy - animal bom04152   AMPK signaling pathway bom04211   Longevity regulating pathway bom04213   Longevity regulating pathway - multiple species bom04910   Insulin signaling pathway bom04920   Adipocytokine signaling pathway bom04923   Regulation of lipolysis in adipocytes bom04930   Type II diabetes mellitus bom04931   Insulin resistance bom04932   Non-alcoholic fatty liver disease bom04935   Growth hormone synthesis, secretion and action bom05010   Alzheimer disease bom05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     138990232 (IRS2)    04022 cGMP-PKG signaling pathway     138990232 (IRS2)    04152 AMPK signaling pathway     138990232 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     138990232 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     138990232 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     138990232 (IRS2)    04923 Regulation of lipolysis in adipocytes     138990232 (IRS2)    04920 Adipocytokine signaling pathway     138990232 (IRS2)    04935 Growth hormone synthesis, secretion and action     138990232 (IRS2)   09149 Aging    04211 Longevity regulating pathway     138990232 (IRS2)    04213 Longevity regulating pathway - multiple species     138990232 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     138990232 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     138990232 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     138990232 (IRS2)    04932 Non-alcoholic fatty liver disease     138990232 (IRS2)    04931 Insulin resistance     138990232 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  138990232 NCBI-ProteinID:  XP_070236845 LinkDB All DBs Position 12:72617536..72647674 Genome browser AA seq 1324 aa AA seqDB search MASPPEHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA GAGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAAATSGSCSASLPGALGGSAGAAA ADDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVT LQLMSIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFE FRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSAC RVRTASEGDGGAAAAAAGAGAGAAAGSPLSPGPVRAPLSRSHTLSGGRAGKAALAPAGGG LQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHPQRPSSGSAS ASGSPSDPGFMSLDEYGSSPGDLRVYCGHRSNTPESIAETPPARDGSAGELYGYMTMERP LSHCGGRAYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSG SSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYVPMTPGVALLGTGS GSCKSDDYMPMSPTSVSAPKQILQPRPVPAALPPAGATVPPPASAAGRAFPGTAGGYKTG SPAESSPEDSGYMRMWCGSKLSMESADSKLLPNGDYLNMSPSDAGTAGTPPDFFSAAGET LRCVPGYCYSSLPRSYKAPHACHGDSDQYVLMSSPVGRVLEEEQLEPPPGPAQPASAFPA AAAGSGHPQPLHPVMPSSGRPGGGGGSRPDGFLAQRCRAVRPTRLSLEGLPALPRMHEYP LPPEPRSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSGD SRQRSPLSDYMNLDFSSPKSPQPGAQGRDPVGSLDALLSPEASVYPPLPPRPAAPSSALQ PLPPPPPPGELYRLPAAPASQGPGAASSSSSDTGDNSDYTEMAFGVAATPPQPIAAPPKP DGARVSSPVSGLKRLSLMDQVSGVEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETFS STTTVTPVSPSFAHTPKRHNSASVENVSLRKGSEGGGGGGSVLGGGDEPPSSPRQLPPPT PQQARAWTPAQPSGGLVGCPGGSSSPMRRETSAGFQNGLNYIAIDVRDEPGLSPPLQQHP HAQTGDRSAWGRTRSLGGLISAVGAGSPAGVCGGPGPGALPAANAYASIDFLTHHLKEAT VVKE NT seq 3975 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccggagcacgggccccccgggccggcgggcggggacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggcgacgaggcg ggcgcgggcgggggcccggcgccgcagccgccgcggctcgagtactacgagagcgagaag aagtggcggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctgaac atcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgag tacttcgccgtggcagccgagaacgagcaggagcaggagggctggtaccgcgcgctcacc gacctggtcagcgagggccgcgcgggcgccggggacgcgccccccgccgccgccgccacc tccgggtcctgcagcgcctccctgcccggcgccctgggcggctcggcgggcgccgctgcg gccgatgacagctacgggctggtggcgcccgccacggccgcctaccgcgaggtgtggcag gtgaacctgaagcccaagggtctgggccagagcaagaacctgacgggcgtgtaccgcctg tgcctgtcggcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtgacg ctgcagctcatgagcatccgccgctgcggccactcggacagcttcttcttcatcgaggtg ggccgctcggccgtgacgggccccggagagctgtggatgcaggcggatgactcggtggtg gcgcagaacatccacgagaccatcctggaggccatgaaggcgctcaaggagctcttcgag ttccggccgcgcagcaagagccagtcgtccggctcgtcggctacgcaccccatcagcgtg cccggcgcgcgccgccaccaccacttggtcaacctgcccccgagccagacgggactggtg cgccgctcgcgcaccgacagcctggcggccaccccgcccgccgccaagtgcagcgcgtgc cgggtgcgcacagccagcgaaggcgacggcggcgccgcggcggcggcggcgggggcgggg gccggggcggcggcgggcagccccctgagcccgggcccggtgcgcgcgcccctgagccgc tcgcacacgctgagcggcggccgcgcgggcaaggcggcgctggcgccggcagggggcggc ctgcagcacagccgctccatgtccatgcccgtggcgcactcgcccccggcggccaccagc cccggcagcctgtcgtccagcagcgggcacggctcgggctcctacccgccgccccccggc ccgcacccgcacctgcagcaccctctgcacccccagcgcccctccagcggcagcgcctcg gcctcgggctcccccagcgaccccggcttcatgtccttggacgagtatggttccagcccc ggggacctgagggtctactgcggccaccggagcaacacgcccgagtccatcgctgagacg cccccggcgcgggacggcagcgcgggcgagctgtacggctacatgaccatggagaggccg ctgagccactgcggcggccgcgcctaccgcagggtctctggggacggcgccccggacttg gaccgagggctgaggaagcggacttactcgctgaccacgcctgcccggcagcggccggtg ccccagccgtcctccgcgtccctggacgagtacaccttgatgcgggccaccttctcgggc agctccggccgcctgtgcccatcctgccccgcctcttctcccaaagtggcctaccaccct taccccgaggactacggcgacatcgagattggctcgcaccgcagctccagcagtaacctg ggcacggacgatggctacgtgcccatgacccccggcgtggccctcctggggacgggcagc gggagctgcaagagcgacgactacatgcccatgagccccaccagcgtgtcggccccgaaa cagatcctgcagccgcgccccgtgcccgccgccttgccccctgctggggccacggttccc ccgcccgcatcggcagccggcagagccttcccgggcaccgcgggcggctacaagaccggc tccccggccgagagctcccccgaggacagcgggtacatgcgcatgtggtgcggttccaag ctgtccatggagagcgccgacagcaagctgctgcccaacggggactacctcaacatgtcc cccagcgatgcgggcacggcgggcaccccgcccgacttcttctcggccgcgggggagacg ctgcggtgcgtgcccggctactgctacagctccttgccccgctcctacaaggcccctcac gcctgccacggcgacagtgaccagtacgtgctcatgagctcgccagtgggccgggtcctg gaggaggagcagctggagccaccccccggccccgcgcagccggccagtgccttcccggcc gcggcggctggcagcggccacccccagccacttcaccccgtcatgccttcttctgggagg cccggcggtggcggaggcagccgccccgacggcttcctagcccagcgctgccgggcagtg cggcccacgcgcctgtccctggaggggctgccggccctgccccgcatgcacgagtacccg ctgccccccgagcccaggagtcctggcgagtacatcaacatcgacttcggggaggccggc gcgcgcctgtcaccccccgcgcccccgctcctggcctcggccgcctcgtcgtcctcgctg ttgtccgccagcagcccagcctcgtccctgggctccggcaccccgggcacaagcggggac agccggcagcgctccccgctctccgactatatgaacctcgacttcagctcgcccaagtcg ccgcagccaggcgcccagggccgggaccctgtgggctccttggacgccttgctgtccccc gaggcctccgtgtacccgccgctgcccccgcgcccggccgccccctcctcggccctgcag ccgctgcccccgccgcccccaccaggcgagctgtaccgcctgcctgcggcacccgcctcc cagggcccaggcgcggcctcctcctcgtcctcggacacgggggacaacagtgactacaca gagatggccttcggcgtggccgccaccccgccgcaaccgatcgcggcgcccccgaagccc gacggtgcccgcgtgagcagccctgtgtccggcctcaagaggctgagcctcatggatcag gtgtcgggggtcgaggccttcctgcaggccggccagcccccagacccgcaccggggggcc aaggtcatccgtgcggacccccaggggggccgccgccgccacagctccgagaccttctcc tcgaccaccactgtgacccccgtgtccccatcctttgctcacacccccaagcgtcacaac tcggcctcggtggagaacgtctctctcaggaaaggcagcgaagggggcgggggcgggggc agcgtcctgggtgggggcgatgagcccccctcgtcgccccgccagttgcctccgccaacg cctcagcaagcgcgggcctggacgccggctcagcccagcggcggcctggtcggctgtccc gggggcagcagctcgccgatgcgccgggagacctccgccggcttccagaacggcctcaac tacatcgccatcgacgtgagggacgagccagggctgtcgccgcccctgcagcagcacccg cacgcgcagacgggcgacaggagcgcctggggccgcacccgaagcctcgggggtctcatc agcgccgtgggtgccggtagccctgccggggtgtgcggagggccgggccccggcgccctg cccgcggccaacgcctacgccagcatcgacttcttgacgcatcacctgaaagaggccacg gtggtgaaagagtga

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