KEGG   ORTHOLOGY: K07187
Entry
K07187                      KO                                     
Symbol
IRS2
Name
insulin receptor substrate 2
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04081  Hormone signaling
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04022 cGMP-PKG signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04152 AMPK signaling pathway
    K07187  IRS2; insulin receptor substrate 2
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K07187  IRS2; insulin receptor substrate 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07187  IRS2; insulin receptor substrate 2
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04923 Regulation of lipolysis in adipocytes
    K07187  IRS2; insulin receptor substrate 2
   04920 Adipocytokine signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04935 Growth hormone synthesis, secretion and action
    K07187  IRS2; insulin receptor substrate 2
  09149 Aging
   04211 Longevity regulating pathway
    K07187  IRS2; insulin receptor substrate 2
   04213 Longevity regulating pathway - multiple species
    K07187  IRS2; insulin receptor substrate 2
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07187  IRS2; insulin receptor substrate 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07187  IRS2; insulin receptor substrate 2
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K07187  IRS2; insulin receptor substrate 2
   04932 Non-alcoholic fatty liver disease
    K07187  IRS2; insulin receptor substrate 2
   04931 Insulin resistance
    K07187  IRS2; insulin receptor substrate 2
Genes
HSA: 8660(IRS2)
PTR: 452657(IRS2)
PPS: 100982406(IRS2)
GGO: 101127585(IRS2)
PON: 100452233(IRS2)
PPYG: 129011530(IRS2)
NLE: 100583956(IRS2)
HMH: 116467557(IRS2)
SSYN: 129463687(IRS2)
MCC: 698536(IRS2)
MCF: 102122241(IRS2)
MTHB: 126940155
MNI: 105485304(IRS2)
CSAB: 103214788(IRS2)
CATY: 105584904(IRS2)
PANU: 101011176(IRS2)
TGE: 112610905(IRS2)
RRO: 104679253(IRS2)
RBB: 108527055(IRS2)
TFN: 117063516(IRS2)
PTEH: 111546313(IRS2)
CANG: 105505962(IRS2)
CJC: 100404822(IRS2)
SBQ: 101038649(IRS2)
CIMI: 108284872(IRS2)
ANAN: 105709100(IRS2)
MMUR: 105864251(IRS2)
LCAT: 123648877(IRS2)
PCOQ: 105805133(IRS2)
OGA: 100951299(IRS2)
MMU: 384783(Irs2)
MCAL: 110300614(Irs2)
MPAH: 110336729(Irs2)
RNO: 29376(Irs2)
MCOC: 116068902(Irs2)
ANU: 117721708(Irs2)
ASYL: 127668414(Irs2)
MUN: 110548880(Irs2)
CGE: 100771848(Irs2)
MAUA: 101839047(Irs2)
PROB: 127220248(Irs2)
PLEU: 114695106(Irs2)
MORG: 121462188(Irs2)
MFOT: 126498321
AAMP: 119813278(Irs2)
NGI: 103751690(Irs2)
HGL: 101719081(Irs2)
CCAN: 109700963(Irs2)
DSP: 122122851(Irs2)
PLOP: 125348108(Irs2)
NCAR: 124984569
MMMA: 107140739(Irs2)
ITI: 101956314(Irs2)
OCU: 103349113
OPI: 101527103(IRS2)
GVR: 103597238(IRS2)
CFA: 485548(IRS2)
CLUD: 112655863(IRS2)
VVP: 112927496(IRS2)
VLG: 121476873(IRS2)
NPO: 129516510(IRS2)
AML: 100477685(IRS2)
UMR: 121101279(IRS2)
UAH: 113251536(IRS2)
UAR: 123776714(IRS2)
ELK: 111147115
LLV: 125094825
MPUF: 101689279(IRS2)
MNP: 132002951(IRS2)
MLK: 131813562(IRS2)
NVS: 122907240(IRS2)
ORO: 101381397(IRS2)
EJU: 114196636(IRS2)
ZCA: 113919723(IRS2)
NSU: 110585808(IRS2)
LWW: 102741876(IRS2)
FCA: 101095791(IRS2)
PYU: 121024217(IRS2)
PBG: 122484873(IRS2)
PVIV: 125171008(IRS2)
LRUF: 124513679
LGF: 123599725(IRS2)
AJU: 113601123
PPAD: 109264073(IRS2)
PUC: 125933954
PLEZ: 122214992(IRS2)
HHV: 120228369(IRS2)
BTA: 100300012(IRS2)
BOM: 138990232(IRS2)
BIU: 109567100(IRS2)
BBUB: 102405314(IRS2)
BBIS: 104982211(IRS2)
CHX: 108637286(IRS2)
OAS: 106991367(IRS2)
BTAX: 128057660(IRS2)
CSUM: 138089251(IRS2)
ODA: 120883252(IRS2)
CCAD: 122447361(IRS2)
MREE: 136144194(IRS2)
OVR: 110140062(IRS2)
MBEZ: 129556507(IRS2)
SSC: 110255858(IRS2)
CFR: 116668634(IRS2)
CDK: 116157131(IRS2)
BACU: 103005810(IRS2)
BMUS: 118883967(IRS2)
LVE: 103088704(IRS2)
OOR: 101276950(IRS2)
LALB: 132508829(IRS2)
DLE: 111176387(IRS2)
PCAD: 112064787(IRS2)
PSIU: 116743032(IRS2)
NASI: 112405567(IRS2)
ECB: 100146249(IRS2)
EPZ: 103540833(IRS2)
EAI: 106838201(IRS2)
MYB: 102249810(IRS2)
MYD: 102753060(IRS2)
MMYO: 118651692(IRS2)
MLF: 102429074(IRS2)
MDT: 132228536(IRS2)
MYUM: 139006078(IRS2)
PKL: 118730740(IRS2)
EFUS: 103288306(IRS2)
MNA: 107530378(IRS2)
DRO: 112321408(IRS2)
SHON: 118981568(IRS2)
AJM: 119042698(IRS2)
PDIC: 114508468(IRS2)
PHAS: 123807405(IRS2)
MMF: 118622304(IRS2)
PPAM: 129071212(IRS2)
HAI: 109383948(IRS2)
RFQ: 117021767(IRS2)
PALE: 102898575(IRS2)
PGIG: 120605338(IRS2)
PVP: 105301327(IRS2)
RAY: 107511114(IRS2)
MJV: 108403230(IRS2)
TOD: 119259653(IRS2)
SARA: 101552515(IRS2)
SFUM: 130019109(IRS2)
SETR: 126015552(IRS2)
LAV: 100676904(IRS2)
TMU: 101345051
ETF: 101640484(IRS2)
DNM: 101425165(IRS2)
MDO: 100023831(IRS2) 100025395(IRS4)
GAS: 123242631(IRS2) 123253748
SHR: 100924829(IRS2) 100931354(IRS4)
PCW: 110194742(IRS4) 110196696(IRS2)
TVP: 118833028(IRS4) 118845896(IRS2)
PBRV: 138165782(IRS2) 138170994(IRS4)
OAA: 114805830(IRS2)
TACU: 119929505(IRS4) 119941263(IRS2)
GGA: 101749060(IRS2) 422347(IRS4)
PCOC: 116229775(IRS4) 116242784(IRS2)
MGP: 100540702(IRS4) 100548754(IRS2)
CJO: 107307936(IRS2) 107312783(IRS4)
TPAI: 128075836(IRS4) 128092214(IRS2)
LMUT: 125693375(IRS2) 125699912(IRS4)
NMEL: 110391172 110403269(IRS4) 110407441(IRS2)
APLA: 101801905 101804723(IRS2)
ACYG: 106038523(IRS4) 106044455(IRS2)
CATA: 118245459(IRS4) 118257481(IRS2)
AFUL: 116493009(IRS2) 116494470(IRS4)
TGU: 100220894(IRS2) 100223674(IRS4)
LSR: 110478760(IRS2) 110480059(IRS4)
SCAN: 103812665(IRS2) 103816520(IRS4)
PMOA: 120504647(IRS2) 120506231(IRS4)
OTC: 121331759(IRS4) 121343099(IRS2)
PRUF: 121356275(IRS2) 121363155(IRS4)
ATRC: 139591691(IRS2) 139597300(IRS4)
GFR: 102041556(IRS4) 102044059(IRS2)
FAB: 101807499(IRS4) 101814066(IRS2)
OMA: 130252108(IRS2) 130253226(IRS4)
PHI: 102103569(IRS4) 102111858(IRS2)
PMAJ: 107203717(IRS4) 107208306(IRS2)
CCAE: 111928696(IRS4) 111945898
CCW: 104686328(IRS2) 104694453(IRS4)
CBRC: 103621654(IRS4)
ACOE: 138104752(IRS2) 138110465(IRS4)
ETL: 114059692(IRS4) 114073373(IRS2)
ZAB: 102061645(IRS4) 102068148(IRS2)
ZLE: 135445848(IRS2) 135447985(IRS4)
ACHL: 103802148
SVG: 106857269(IRS2) 106859351(IRS4)
MMEA: 130573325 130588974(IRS2)
HRT: 120748563(IRS2) 120761978(IRS4)
SATI: 136358030(IRS2) 136370597(IRS4)
CCIC: 134049969(IRS4) 134058028(IRS2)
FPG: 101918515(IRS4) 101924402(IRS2)
FCH: 102046894(IRS2) 102052095(IRS4)
CCRI: 104157181(IRS2)
NNT: 104413293
SHAB: 115604134(IRS2) 115613255(IRS4)
ACUN: 113478507(IRS2) 113479916(IRS4)
TALA: 104369142(IRS4) 116962659(IRS2)
ACHC: 115333517(IRS4) 115334514(IRS2)
HALD: 104320710
HLE: 104832692(IRS4) 104836952(IRS2)
HHAR: 128135197(IRS2) 128153625(IRS4)
CSTI: 104554070
LDI: 104354435
MNB: 103774421
DPUB: 104298641(IRS2) 104299562(IRS4)
PPUS: 135175522(IRS2) 135184009(IRS4)
AVIT: 104269958
BRHI: 104493854
EGZ: 104133285(IRS4)
NNI: 104012562(IRS2) 104023330(IRS4)
PCRI: 104034411(IRS2)
PCAO: 104040909(IRS2)
PADL: 103920154(IRS4)
AFOR: 103895631(IRS4) 103896302(IRS2)
FGA: 104081894
GSTE: 104260229
CLV: 102089452(IRS2) 102090441
MUI: 104545604
PGUU: 104472464
PLET: 104628182
EHS: 104505637
CMAC: 104485024
CUCA: 104058372(IRS4) 128851265(IRS2)
TEO: 104380608
BREG: 104635578
OHA: 104339082(IRS4)
ACAR: 104520301
CPEA: 104388287(IRS4)
CVF: 104290216(IRS4)
RTD: 128901105(IRS2) 128914737(IRS4)
CRID: 134516848(IRS2) 134520884(IRS4)
AROW: 112976657(IRS2) 112977320(IRS4)
NPD: 112944527(IRS4) 112945131(IRS2)
TGT: 104579875
DNE: 112984528(IRS2) 112992577
SCAM: 104150940(IRS4)
ASN: 102374791(IRS2) 102382907(IRS4)
AMJ: 102558545(IRS4) 102565350(IRS2)
CPOO: 109306322(IRS2) 109313719(IRS4)
GGN: 109300745(IRS4) 109303148(IRS2)
PSS: 102457842(IRS4)
CMY: 102934421(IRS2) 102943497(IRS4)
CCAY: 125638833(IRS2) 125643230(IRS4)
DCC: 119849243(IRS2) 119861304(IRS4)
CPIC: 101945214(IRS2) 101951320(IRS4)
TST: 117870803(IRS2) 117882623(IRS4)
CABI: 116815629(IRS2) 116829393(IRS4)
MRV: 120371966(IRS4) 120404286(IRS2)
ACS: 100555020(irs4) 103279765(irs2)
ASAO: 132762950(IRS4) 132781035(IRS2)
PVT: 110074287(IRS4) 110090941(IRS2)
SUND: 121919404(IRS2) 121936111(IRS4)
PBI: 103051591(IRS2) 103052062
PMUR: 107296125(IRS2) 107298766
CTIG: 120300362(IRS2) 120310372(IRS4)
TSR: 106548513(IRS4) 106552209(IRS2)
PGUT: 117675956(IRS4)
APRI: 131198139(IRS2) 131205088(IRS4)
PTEX: 113437883(IRS4) 113440909(IRS2)
NSS: 113416615(IRS4) 113419573(IRS2)
VKO: 123022003(IRS4)
PMUA: 114588807(IRS4) 114593451(IRS2)
PRAF: 128406222(IRS4) 128409819(IRS2)
ZVI: 118082626(IRS2) 118084286(IRS4)
HCG: 128335495(IRS4) 128339990(IRS2)
GJA: 107114014(IRS4) 107120743
EMC: 129325940(IRS2) 129341159(IRS4)
XLA: 108708462 108709741 399388(irs4.S) 495836(irs4.L)
XTR: 100196925(irs4) 100498409
NPR: 108787450(IRS2) 108788816
RTEM: 120913724(IRS4) 120926366(IRS2)
BBUF: 120995798(IRS2) 121009307(IRS4)
BGAR: 122919924 122931021(IRS2)
PWL: 138249972(IRS2) 138261961(IRS4)
GSH: 117360932(IRS4) 117362702(IRS2)
DRE: 100329897(irs4a) 393285(irs2a) 572001(irs2b) 794462
PTET: 122326567(irs4a) 122349609 122349701(irs2a) 122351325(irs2b)
LROH: 127152685(irs4a) 127168883 127170612(irs2b) 127180721(irs2a)
OMC: 131529070(irs4a) 131542623(irs2a) 131543823 131547069(irs2b)
PPRM: 120473670(irs4a) 120477286 120487082(irs2b) 120495327(irs2a)
RKG: 130085838(irs2b) 130087827(irs2a) 130091191 130096832(irs4a)
MAMB: 125252736(irs4a) 125265406 125269983(irs2b) 125272323(irs2a)
CERY: 137013086(irs4a) 137031178 137032045(irs2a) 137036496(irs2b)
TROS: 130551433 130555712(irs2b) 130570466(irs4a)
TDW: 130407956(irs4a) 130420717 130427189(irs2b)
MANU: 129423659(irs4a) 129448490 129451750(irs2b)
PDAB: 135776692(irs4a) 135778646 135782572(irs2b)
IPU: 108258957(irs2a) 108266735(irs2b) 108267420 108278674(irs4a)
IFU: 128601981(irs2a) 128608673(irs2b) 128610183 128622068(irs4a)
SMEO: 124377984(irs2a) 124382775(irs2b) 124387138 124398449(irs4a)
TFD: 113647569(irs4a) 113648782(irs2a) 113654441(irs2b) 113654717
TVC: 132839124(irs2a) 132848733 132850096(irs2b) 132859736(irs4a)
CGAR: 128506157(irs2a) 128517068(irs4a) 128523928(irs2b) 128524553
NGRA: 132866149(irs2a) 132887955 132891765(irs2b) 132895752(irs4a)
AMEX: 103025363 103025582(irs4a) 103030138(irs2a) 103034135(irs2b)
CMAO: 118798413(irs2a) 118820113(irs4a) 118824744(irs2b) 118826746
CHAR: 105892967(irs2b) 105895554 105902399(irs4a)
SPIL: 134060131 134078441(irs2b) 134080824(irs4a)
SLUC: 116044568(irs2a) 116046847(irs2b) 116053173
CVE: 137868258(irs2b) 137874512 137878831(irs2a)
SSEN: 122761160(irs2a) 122763946(irs2b) 122767273
SSOE: 131448425(irs2a) 131455495(irs2b) 131455996
ENY: 140351372 140359615(irs2b) 140371443(irs4b)
OEP: 134007186(irs2a) 134009655 134017489(irs2b)
LOC: 102682802(irs2) 102693755(irs4)
ARUT: 117407256(irs2b) 117412261
PSEX: 120524638(irs2b)
LCM: 102364884(IRS2) 102366705(IRS4)
CMK: 103178654(irs2b) 103179604
LERI: 129698328(irs2b) 129702352
PMRN: 116956300
LRJ: 133357147
BBEL: 109465793
ARUN: 117300700
AAMU: 139949601
AFIL: 140149668
PFLL: 139115770
FAS: 105265590
AGB: 108904873
PCHN: 125029151
LSM: 121129521(chico)
PPOI: 119100198
RSAN: 119396415
RMP: 119174621
DFR: 124495248
PMAX: 117316183
 » show all
Reference
  Authors
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G
  Title
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
  Journal
Diabetes Metab Res Rev 16:434-41 (2000)
DOI:10.1002/1520-7560(2000)9999:9999<::AID-DMRR159>3.0.CO;2-8
Reference
  Authors
Hashimoto S, Kubota N, Sato H, Sasaki M, Takamoto I, Kubota T, Nakaya K, Noda M, Ueki K, Kadowaki T
  Title
Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.
  Journal
Diabetes 64:876-86 (2015)
DOI:10.2337/db14-0432
  Sequence
[mmu:384783]
Reference
  Authors
Vassen L, Wegrzyn W, Klein-Hitpass L
  Title
Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene.
  Journal
Mol Endocrinol 13:485-94 (1999)
DOI:10.1210/mend.13.3.0256
  Sequence
[hsa:8660]
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